Comprehensive and quantitative multilocus methylation analysis reveals the susceptibility of specific imprinted differentially methylated regions to aberrant methylation in Beckwith-Wiedemann syndrome with epimutations

Genetics in Medicine

Volumn 16, Issue 12, 2014, Pages 903-912

  Maeda, Toshiyuki ^a,b   Higashimoto, Ken ^b   Jozaki, Kosuke ^c   Yatsuki, Hitomi ^d   Nakabayashi, Kazuhiko ^e   Makita, Yoshio ^f   Tonoki, Hidefumi ^g   Okamoto, Nobuhiko ^h   Takada, Fumio ⁱ   Ohashi, Hirofumi ^j   Migita, Makoto ^c   Kosaki, Rika ^k   Matsubara, Keiko ^l   Ogata, Tsutomu ^a   Matsuo, Muneaki ^j   Hamasaki, Yuhei ^a,b   Ohtsuka, Yasufumi ^a   Nishioka, Kenichi ^a   Joh, Keiichiro ^a   Mukai, Tsunehiro ^l   Hata, Kenichiro ^c   Soejima, Hidenobu ^a   more..

^a SAGA UNIVERSITY   (Japan)

^b SAGA UNIVERSITY   (Japan)

^c NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^d ASAHIKAWA MEDICAL COLLEGE   (Japan)

^e Children's Hospital and Medical Center   (Japan)

^f RESEARCH INSTITUTE FOR MATERNAL AND CHILD HEALTH   (Japan)

^g KITASATO UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^h SAITAMA CHILDREN'S MEDICAL CENTER   (Japan)

ⁱ NIPPON MEDICAL SCHOOL   (Japan)

^j NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^k HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^l NISHIKYUSHU UNIVERSITY   (Japan)

more..

Author keywords

Beckwith Wiedemann syndrome; differentially methylated region; DNA methylation; genomic imprinting; multiple methylation defects

Indexed keywords

BISULFITE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; DNA;

ADULT; ARTICLE; BECKWITH WIEDEMANN SYNDROME; CHROMOSOME ABERRATION; DNA ISOLATION; DNA METHYLATION; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; GENE EXPRESSION; GENE LOCUS; GENETIC SUSCEPTIBILITY; GENOME IMPRINTING; HUMAN; HUMAN GENOME; MAJOR CLINICAL STUDY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MIDDLE AGED; PYROSEQUENCING; QUANTITATIVE ANALYSIS; ADOLESCENT; ALLELE; CHEMISTRY; CHILD; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; INFANT; MASS SPECTROMETRY; MUTATION; NEWBORN; PRESCHOOL CHILD;

ADOLESCENT; ALLELES; BECKWITH-WIEDEMANN SYNDROME; CHILD; CHILD, PRESCHOOL; DNA; DNA METHYLATION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENOMIC IMPRINTING; HUMANS; INFANT; INFANT, NEWBORN; MALE; MUTATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84922491343     PISSN: 10983600     EISSN: 15300366     Source Type: Journal    
DOI: 10.1038/gim.2014.46     Document Type: Article

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