Morphologic, stereologic, and morphometric evaluation of the nervous system in young cynomolgus monkeys (Macaca Fascicularis) following maternal administration of tanezumab, a monoclonal antibody to nerve growth factor

Toxicological Sciences

Volumn 142, Issue 2, 2014, Pages 463-476

  Butt, Mark ^a   Evans, Mark ^b   Bowman, Christopher J ^b   Cummings, Thomas ^b   Oneda, Satoru ^c   Shelton, David ^b   Zorbas, Mark ^b  

^a LLC   (United States)

^b PFIZER INC   (United States)

^c SNBL USA   (United States)

Author keywords

Cholinergic neurons; Nerve growth factor; Sympathetic ganglia; Tanezumab

Indexed keywords

TANEZUMAB; MONOCLONAL ANTIBODY; NERVE GROWTH FACTOR RECEPTOR;

ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; FOREBRAIN; HISTOGRAM; INFANT MORTALITY; MACACA FASCICULARIS; MICROSCOPY; MORPHOMETRICS; MYELIN SHEATH; MYELINATED NERVE; NERVE FIBER DEGENERATION; NONHUMAN; NONMYELINATED NERVE; NUCLEOLUS; PRENATAL EXPOSURE; PROGENY; SCIATIC NERVE; SPINAL GANGLION; SPINAL ROOT; STELLATE GANGLION; STEREOLOGY; STILLBIRTH; SUPERIOR MESENTERIC GANGLION; SURAL NERVE; SURVIVAL; SYMPATHETIC GANGLION; SYMPATHETIC NERVE CELL; SYMPATHETIC TRUNK; TIBIAL NERVE; TRANSMISSION ELECTRON MICROSCOPY; VAGUS NERVE; VIRUS PNEUMONIA; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL COUNT; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; EMBRYOLOGY; ENVIRONMENTAL EXPOSURE; FEMALE; NERVE CELL; NERVE FIBER; NERVOUS SYSTEM; PATHOLOGY; PREGNANCY; ULTRASTRUCTURE;

ANIMALIA; MACACA FASCICULARIS; RODENTIA;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; AXONS; CELL COUNT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MACACA FASCICULARIS; MATERNAL EXPOSURE; MICROSCOPY, ELECTRON, TRANSMISSION; NERVOUS SYSTEM; NEURONS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RECEPTOR, NERVE GROWTH FACTOR;

EID: 84922468618     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu192     Document Type: Article

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