Carabin protects against cardiac hypertrophy by blocking calcineurin, Ras, and Ca2 dependent protein kinase II signaling

Circulation

Volumn 131, Issue 4, 2015, Pages 390-400

  Bisserier, Malik ^a,b   Berthouze Duquesnes, Magali ^a,b   Breckler, Magali ^a,b   Tortosa, Florence ^a,b   Fazal, Loubina ^a,b   De Régibus, Annélie ^a,b   Laurent, Anne Coline ^a,b   Varin, Audrey ^c,d   Lucas, Alexandre ^a,b   Branchereau, Maxime ^a   Marck, Pauline ^a   Schickel, Jean Nicolas ^e   Deloménie, Claudine ^c,d   Cazorla, Olivier ^f   Soulas Sprauel, Pauline ^e   Crozatier, Bertrand ^c,d   Morel, Eric ^c,d   Heymes, Christophe ^a,b   Lezoualc'h, Frank ^a,b  

^a Université de Toulouse   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d Universite Paris Sud   (France)

^e UNIVERSITÉ DE STRASBOURG   (France)

^f UNIVERSITY OF MONTPELLIER   (France)

Author keywords

heart failure; hypertrophy; signal transduction; ventricular remodeling

Indexed keywords

ADRENERGIC RECEPTOR; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; CALCINEURIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CARABIN; CARDIOVASCULAR AGENT; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HISTONE DEACETYLASE 4; MITOGEN ACTIVATED PROTEIN KINASE; MYOSIN HEAVY CHAIN BETA; PARVOVIRUS VECTOR; PROTEIN; RAB PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG; TBC1D10C PROTEIN, MOUSE;

ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA CONSTRICTION; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FIBROSING ALVEOLITIS; HEART FAILURE; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HEMODYNAMIC STRESS; LUNG CONGESTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CARDIOMEGALY; CELL CULTURE; HUMAN; KNOCKOUT MOUSE; METABOLISM; ONCOGENE RAS; PHYSIOLOGY; RAT;

ANIMALS; CALCINEURIN; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CARDIOMEGALY; CELLS, CULTURED; FEMALE; GENES, RAS; GTPASE-ACTIVATING PROTEINS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCYTES, CARDIAC; RATS; SIGNAL TRANSDUCTION;

EID: 84922435833     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.114.010686     Document Type: Article

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