Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin

Nature

Volumn 445, Issue 7126, 2007, Pages 433-436

  Pan, Fan ^a   Sun, Luo ^a,c   Kardian, David B ^b   Whartenby, Katharine A ^b   Pardoll, Drew M ^b   Liu, Jun O ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c NEW ENGLAND BIOLABS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CARABIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; INTERLEUKIN 2; PROTEIN; RAS PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN; ENZYME ACTIVITY; FEEDBACK MECHANISM; INHIBITOR; PHOSPHATASE; PROTEIN;

ADAPTIVE IMMUNITY; ANIMAL CELL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; RNA INTERFERENCE; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 33846542686     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05476     Document Type: Article

References (27)

1. Liu, J. O. The yins of T cell activation. Sci. STKE 2005, re1 (2005).
2. Liu, J. et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66, 807-815 (1991).
3. Crabtree, G. R. & Clipstone, N. A. Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu. Rev. Biochem. 63, 1045-1083 (1994).
4. Rao, A., Luo, C. &Hogan, P. G. Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15, 707-747 (1997).
5. Downward, J., Graves, J. D., Warne, P. H., Rayter, S.& Cantrell, D. A. Stimulation of p21ras upon T-cell activation. Nature 346, 719-723 (1990).
6. Woodrow, M., Clipstone, N. A. & Cantrell, D. p21ras and calcineurin synergize to regulate the nuclear factor of activated T cells. J. Exp. Med. 178, 1517-1522 (1993).
7. Cantrell, D. A. GTPases and T cell activation. Immunol. Rev. 192, 122-130 (2003).
8. Sun, L. et al. Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes. Immunity 8, 703-711 (1998).
9. Lai, M. M., Burnett, P. E., Wolosker, H., Blackshaw, S. & Snyder, S. H. Cain, a novel physiologic protein inhibitor of calcineurin. J. Biol. Chem. 273, 18325-18331 (1998).
10. Rothermel, B. et al. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J. Biol. Chem. 275, 8719-8725 (2000).
11. Kingsbury, T. J. & Cunningham, K. W. A conserved family of calcineurin regulators. Genes Dev. 14, 1595-1604 (2000).
12. Gorlach, J. et al. Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. EMBO J. 19, 3618-3629 (2000).
13. Ryeom, S., Greenwald, R. J., Sharpe, A. H. & McKeon, F. The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin. Nature Immunol. 4, 874-881 (2003).
14. Youn, H.-D., Sun, L., Prywes, R. & Liu, J. O. Apoptosis of T lymphocytes mediated by calcium-induced release of the transcription factor MEF2. Science 286, 790-793 (1999).
15. Han, A. et al. Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2. Nature 422, 730-734 (2003).
16. Pan, F., Means, A. R.&Liu, J. O. Calmodulin-dependent protein kinase IVregulates nuclear export of Cabin1 during T-cell activation. EMBO J. 24, 2104-2113 (2005).
17. Fearon, E. R. et al. Karyoplasmic interaction selection strategy: a general strategy to detect protein-protein interactions in mammalian cells. Proc. Natl Acad. Sci. USA 89, 7958-7962 (1992).
18. Manalan, A. S. & Klee, C. B. Activation of calcineurin by limited proteolysis. Proc. Natl Acad. Sci. USA 80, 4291-4295 (1983).
19. Shaw, K. T. et al. Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. Proc. Natl Acad. Sci. USA 92, 11205-11209 (1995).
20. Shibasaki, F., Price, E. R., Milan, D. & McKeon, F. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4. Nature 382, 370-373 (1996).
21. Anderson, D. H. & Chamberlain, M. D. Assay and stimulation of the Rab5 GTPase by the p85 α subunit of phosphatidylinositol 3-kinase. Methods Enzymol. 403, 552-561 (2005).
22. Albert, S., Will, E. & Gallwitz, D. Identification of the catalytic domains and their functionally critical arginine residues of two yeast GTPase-activating proteins specific for Ypt/Rab transport GTPases. EMBO J. 18, 5216-5225 (1999).
23. Taylor, S. J. & Shalloway, D. Cell cycle-dependent activation of Ras. Curr. Biol. 6, 1621-1627 (1996).
24. Leevers, S. J. & Marshall, C. J. Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein. EMBO J. 11, 569-574 (1992).
25. Cui, Y. et al. Immunotherapy of established tumors using bone marrow transplantation with antigen gene-modified hematopoietic stem cells. Nature Med. 9, 952-958 (2003).
26. Neilson, J. R., Winslow, M. M., Hur, E. M. & Crabtree, G. R. Calcineurin B1 is essential for positive but not negative selection during thymocyte development. Immunity 20, 255-266 (2004).
27. Fischer, A. M., Katayama, C. D., Pages, G., Pouyssegur, J. & Hedrick, S. M. The role of Erk1 and Erk2 in multiple stages of T cell development. Immunity 23, 431-443 (2005).