Evaluation of In Silico models for the identification of respiratory sensitizers

Toxicological Sciences

Volumn 142, Issue 2, 2014, Pages 385-394

  Dik, Sander ^a,b   Ezendam, Janine ^a   Cunningham, Albert R ^c,d,e   Carrasquer, Carl Alex ^c   Van Loveren, Henk ^a,b   Rorije, Emiel ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

^d Department of Medicine ^*  (United States)

^e University of Louisville School of Medicine   (United States)

Author keywords

(Q)SAR; Alternatives to animal testing; Chemical allergy; Predictive toxicology; Respiratory sensitization; Tiered approach

Indexed keywords

ACRYLIC ACID DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CYCLOHEXENE DERIVATIVE; ETHANOLAMINE DERIVATIVE; QUINOLINE DERIVATIVE; AIR POLLUTANT; ALLERGEN;

ARTICLE; COMPUTER MODEL; EVALUATION STUDY; HUMAN; MOLECULAR WEIGHT; OCCUPATIONAL ASTHMA; PREDICTION; PREDICTIVE VALUE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RESPIRATORY SENSITIZATION; SENSITIZATION; SKIN SENSITIZATION; STRUCTURE ACTIVITY RELATION; AIR POLLUTANT; ANIMAL TESTING ALTERNATIVE; BIOLOGICAL MODEL; CHEMICAL MODEL; CHEMICALLY INDUCED; CHEMISTRY; COMPUTER SIMULATION; RESPIRATORY TRACT ALLERGY; STATISTICAL ANALYSIS; TOXICITY; TOXICITY TESTING;

ANIMALIA;

AIR POLLUTANTS, OCCUPATIONAL; ALLERGENS; ANIMAL TESTING ALTERNATIVES; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; HUMANS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MOLECULAR WEIGHT; PREDICTIVE VALUE OF TESTS; RESPIRATORY HYPERSENSITIVITY; STRUCTURE-ACTIVITY RELATIONSHIP; TOXICITY TESTS;

EID: 84922418734     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu188     Document Type: Article

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