Task-evoked substantia nigra hyperactivity associated with prefrontal hypofunction, prefrontonigral disconnectivity and nigrostriatal connectivity predicting psychosis severity in medication naïve first episode schizophrenia

Schizophrenia Research

Volumn 159, Issue 2-3, 2014, Pages 521-526

  Yoon, Jong H ^a,b   Westphal, Andrew J ^c   Minzenberg, Michael J ^d,e   Niendam, Tara ^c   Ragland, J Daniel ^c   Lesh, Tyler ^c   Solomon, Marjorie ^c   Carter, Cameron S ^c  

^a STANFORD UNIVERSITY   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Basal ganglia; Dopamine; FMRI; Prefrontal cortex; Psychosis; Striatum; Substantia nigra

Indexed keywords

DOPAMINE; NEUROLEPTIC AGENT;

ADULT; ARTICLE; CAUDATE NUCLEUS; CHRONICITY; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; DISEASE SEVERITY; DOPAMINE RELEASE; EVOKED RESPONSE; FEMALE; FIRST EPISODE SCHIZOPHRENIA; FRONTAL CORTEX; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HYPERACTIVITY; MALE; NERVE CELL NETWORK; NIGRONEOSTRIATAL SYSTEM; PATHOPHYSIOLOGY; POSITIVE SYNDROME; PREDICTION; PREFRONTAL CORTEX; SCHIZOPHRENIA; SUBSTANTIA NIGRA; TASK PERFORMANCE; CONNECTOME; NEOSTRIATUM; NUCLEAR MAGNETIC RESONANCE IMAGING; PSYCHOSIS; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

ADULT; CONNECTOME; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; NEOSTRIATUM; PREFRONTAL CORTEX; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; SEVERITY OF ILLNESS INDEX; SUBSTANTIA NIGRA; YOUNG ADULT;

EID: 84922417255     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2014.09.022     Document Type: Article

References (44)

1. Abi-Dargham A., Gil R., Krystal J., Baldwin R.M., Seibyl J.P., Bowers M., van Dyck C.H., Charney D.S., Innis R.B., Laruelle M. Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort. Am. J. Psychiatry 1998, 155(6):761-767.
2. Agid O., Mamo D., Ginovart N., Vitcu I., Wilson A.A., Zipursky R.B., Kapur S. Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response-a double-blind PET study in schizophrenia. Neuropsychopharmacology 2007, 32(6):1209-1215.
3. Andreasen N.C. Negative symptoms in schizophrenia. Definition and reliability. Arch. Gen. Psychiatry 1982, 39(7):784-788.
4. Andreasen N.C. The Scale for the Assessment of Positive Symptoms (SAPS) 1984, University of Iowa, Iowa City, Iowa.
5. Barch D.M., Carter C.S., Braver T.S., Sabb F.W., MacDonald A., Noll D.C., Cohen J.D. Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia. Arch. Gen. Psychiatry 2001, 58(3):280-288.
6. Barch D.M., Carter C.S., MacDonald A.W., Braver T.S., Cohen J.D. Context-processing deficits in schizophrenia: diagnostic specificity, 4-week course, and relationships to clinical symptoms. J. Abnorm. Psychol. 2003, 112(1):132-143.
7. Bertolino A., Knable M.B., Saunders R.C., Callicott J.H., Kolachana B., Mattay V.S., Bachevalier J., Frank J.A., Egan M., Weinberger D.R. The relationship between dorsolateral prefrontal N-acetylaspartate measures and striatal dopamine activity in schizophrenia. Biol. Psychiatry 1999, 45(6):660-667.
8. Björklund A., Dunnett S. Dopamine neuron systems in the brain: an update. Trends Neurosci. 2007, 30(5):194-202.
9. Braver T.S., Barch D.M., Cohen J.D. Cognition and control in schizophrenia: a computational model of dopamine and prefrontal function. Biol. Psychiatry 1999, 46(3):312-328.
10. Breier A., Su T., Saunders R., Carson R., Kolachana B., De Bartolomeis A., Weinberger D., Weisenfeld N., Malhotra A., Eckelman W. Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method. Proc. Natl. Acad. Sci. 1997, 94(6):2569.
11. Callicott J.H., Mattay V.S., Verchinski B.A., Marenco S., Egan M.F., Weinberger D.R. Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down. Am. J. Psychiatry 2003, 2209-2215.
12. Carlsson A., Waters N., Waters S., Carlsson M.L. Network interactions in schizophrenia - therapeutic implications. Brain Res. Brain Res. Rev. 2000, 31(2-3):342-349.
13. Cohen J.D., Barch D.M., Carter C., Servan-Schreiber D. Context-processing deficits in schizophrenia: converging evidence from three theoretically motivated cognitive tasks. J. Abnorm. Psychol. 1999, 108(1):120-133.
14. Cools R., D'Esposito M. Inverted-U-shaped dopamine actions on human working memory and cognitive control. Biol. Psychiatry 2011, 69(12):e113-e125.
15. D'Ardenne K., Eshel N., Luka J., Lenartowicz A., Nystrom L.E., Cohen J.D. Role of prefrontal cortex and the midbrain dopamine system in working memory updating. Proc. Natl. Acad. Sci. U. S. A. 2012, 109(49):19900-19909.
16. Davis K.L., Kahn R.S., Ko G., Davidson M. Dopamine in schizophrenia: a review and reconceptualization. Am. J. Psychiatry 1991, 148(11):1474-1486.
17. Dixon W.J., Yuen K.K. Trimmin and winsorization: a review. Stat. Pap. 2010, 1-14.
18. Fisher R.A. On the "probable error" of a coefficient of correlation deduced from a small sample. Metron 1921, 1:3-32.
19. Frank M.J. Hold your horses: a dynamic computational role for the subthalamic nucleus in decision making. Neural Netw. 2006, 19(8):1120-1136.
20. Friston K.J., Holmes A., Poline J.B., Price C.J., Frith C.D. Detecting activations in PET and fMRI: levels of inference and power. Neuroimage 1996, 4(3 Pt 1):223-235.
21. Haber S.N. The primate basal ganglia: parallel and integrative networks. J. Chem. Neuroanat. 2003, 26(4):317-330.
22. Hietala J., Syvalahti E., Vuorio K., Rakkolainen V., Bergman J., Haaparanta M., Solin O., Kuoppamaki M., Kirvela O., Ruotsalainen U., et al. Presynaptic dopamine function in striatum of neuroleptic-naive schizophrenic patients. Lancet 1995, 346(8983):1130-1131.
23. Hietala J., Syvalahti E., Vilkman H., Vuorio K., Rakkolainen V., Bergman J., Haaparanta M., Solin O., Kuoppamaki M., Eronen E., Ruotsalainen U., Salokangas R.K. Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia. Schizophr. Res. 1999, 35(1):41-50.
24. Kapur S., Zipursky R., Jones C., Remington G., Houle S. Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia. Am. J. Psychiatry 2000, 157(4):514-520.
25. Kegeles L.S., Abi-Dargham A., Frankle W.G., Gil R., Cooper T.B., Slifstein M., Hwang D.R., Huang Y., Haber S.N., Laruelle M. Increased synaptic dopamine function in associative regions of the striatum in schizophrenia. Arch. Gen. Psychiatry 2010, 67(3):231-239.
26. Kudlicka A., Clare L., Hindle J.V. Executive functions in Parkinson's disease: systematic review and meta-analysis. Mov. Disord. 2011, 26(13):2305-2315.
27. Laruelle M., Abi-Dargham A., van Dyck C.H., Gil R., D'Souza C.D., Erdos J., McCance E., Rosenblatt W., Fingado C., Zoghbi S.S., Baldwin R.M., Seibyl J.P., Krystal J.H., Charney D.S., Innis R.B. Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proc. Natl. Acad. Sci. U. S. A. 1996, 93(17):9235-9240.
28. Lieberman J.A., Kinon B.J., Loebel A.D. Dopaminergic mechanisms in idiopathic and drug-induced psychoses. Schizophr. Bull. 1990, 16(1):97-110.
29. Lindstrom L.H., Gefvert O., Hagberg G., Lundberg T., Bergstrom M., Hartvig P., Langstrom B. Increased dopamine synthesis rate in medial prefrontal cortex and striatum in schizophrenia indicated by L-(beta-11C) DOPA and PET. Biol. Psychiatry 1999, 46(5):681-688.
30. MacDonald A.W., Carter C.S., Kerns J.G., Ursu S., Barch D.M., Holmes A.J., Stenger V.A., Cohen J.D. Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in never-medicated patients with first-episode psychosis. Am. J. Psychiatry 2005, 162(3):475-484.
31. Manoach D.S. Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings. Schizophr. Res. 2003, 285-298.
32. Meyer-Lindenberg A., Miletich R., Kohn P., Esposito G., Carson R., Quarantelli M., Weinberger D., Berman K. Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia. Nat. Neurosci. 2002, 5(3):267-271.
33. Montague P.R., Hyman S.E., Cohen J.D. Computational roles for dopamine in behavioural control. Nature 2004, 431(7010):760-767.
34. Nestler E.J., Hyman S.E. Animal models of neuropsychiatric disorders. Nat. Neurosci. 2010, 13(10):1161-1169.
35. Overall, J., 1974. Psychological measurements in psychopharmacology. Volume editor: P. Pichot; co-editor: R. Olivier-Martin. Karger, Basel, New York.
36. Reith J., Benkelfat C., Sherwin A., Yasuhara Y., Kuwabara H., Andermann F., Bachneff S., Cumming P., Diksic M., Dyve S.E., Etienne P., Evans A.C., Lal S., Shevell M., Savard G., Wong D.F., Chouinard G., Gjedde A. Elevated dopa decarboxylase activity in living brain of patients with psychosis. Proc. Natl. Acad. Sci. U. S. A. 1994, 91(24):11651-11654.
37. Rissman J., Gazzaley A., D'Esposito M. Measuring functional connectivity during distinct stages of a cognitive task. Neuroimage 2004, 23(2):752-763.
38. Saxe R., Brett M., Kanwisher N. Divide and conquer: a defense of functional localizers. Neuroimage 2006, 30(4):1088-1096. (discussion 1097-1089).
39. Schott B.H., Seidenbecher C.I., Fenker D.B., Lauer C.J., Bunzeck N., Bernstein H.G., Tischmeyer W., Gundelfinger E.D., Heinze H.J., Duzel E. The dopaminergic midbrain participates in human episodic memory formation: evidence from genetic imaging. J. Neurosci. 2006, 26(5):1407-1417.
40. Vul E., Kanwisher N. Begging the Question: The Nonindependence Error in fMRI Data Analysis 2010, MIT Press.
41. Weinberger D. Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiatry 1987, 44:660.
42. Yerkes R., Dodson J. The relation of strength of stimulus to rapidity of habit-formation. J. Comp. Neurol. Psychol. 1908, 459-482.
43. Yoon J.H., Minzenberg M.J., Ursu S., Ryan Walter B.S., Wendelken C., Ragland J.D., Carter C.S. Association of dorsolateral prefrontal cortex dysfunction with disrupted coordinated brain activity in schizophrenia: relationship with impaired cognition, behavioral disorganization, and global function. Am. J. Psychiatry 2008, 165(8):1006-1014.
44. Yoon J.H., Minzenberg M.J., Raouf S., D'Esposito M., Carter C.S. Impaired prefrontal-basal ganglia functional connectivity and substantia nigra hyperactivity in schizophrenia. Biol. Psychiatry 2013, 74(2):122-129.