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Volumn 126, Issue 6, 2014, Pages 33-48

Sodium glucose co-transporter 2 inhibitors and their mechanism for improving glycemia in patients with type 2 diabetes

Author keywords

Antihyperglycemic agent; Mechanism of action; Sodium glucose co transporter 2 (SGLT2) inhibitor; Type 2 diabetes mellitus

Indexed keywords

CANAGLIFLOZIN; DAPAGLIFLOZIN; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SODIUM GLUCOSE COTRANSPORTER 2; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; 2-(3-(4-ETHOXYBENZYL)-4-CHLOROPHENYL)-6-HYDROXYMETHYLTETRAHYDRO-2H-PYRAN-3,4,5-TRIOL; ANTIDIABETIC AGENT; BENZHYDRYL DERIVATIVE; GLUCOSE BLOOD LEVEL; GLUCOSIDE; SLC5A2 PROTEIN, HUMAN; THIOPHENE DERIVATIVE;

EID: 84922394494     PISSN: 00325481     EISSN: 19419260     Source Type: Journal    
DOI: 10.3810/pgm.2014.10.2819     Document Type: Article
Times cited : (34)

References (77)
  • 1
    • 84964075789 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention. 2011 National Diabetes Fact Sheet, Accessed February 7
    • Centers for Disease Control and Prevention. 2011 National Diabetes Fact Sheet. http://www.cdc.gov/diabetes/pubs/factsheet11.htm. Accessed February 7, 2012.
    • (2012)
  • 2
    • 84864870066 scopus 로고    scopus 로고
    • Characteristics associated with poor glycemic control among adults with self-reported diagnosed diabetes—National Health and Nutrition Examination Survey, United States, 2007–2010
    • Ali MK, Bullard KM, Imperatore G, Barker L, Gregg EW. Characteristics associated with poor glycemic control among adults with self-reported diagnosed diabetes—National Health and Nutrition Examination Survey, United States, 2007–2010. MMWR Surveill Summ. 2012;61(2):32–37.
    • (2012) MMWR Surveill Summ , vol.61 , Issue.2 , pp. 32-37
    • Ali, M.K.1    Bullard, K.M.2    Imperatore, G.3    Barker, L.4    Gregg, E.W.5
  • 3
    • 84975856269 scopus 로고    scopus 로고
    • Economic costs of diabetes
    • American Diabetes Association
    • American Diabetes Association. Economic costs of diabetes in the U.S. in 2012. Diabetes Care. 2013;36(4):1033–1046.
    • (2013) Diabetes Care , vol.36 , Issue.4 , pp. 1033-1046
  • 4
    • 84885106475 scopus 로고    scopus 로고
    • Diabetes: 8 strategies to put into practice
    • Adler RN, Harlan DM. Diabetes: 8 strategies to put into practice. J Fam Pract. 2013;62(10):542–547.
    • (2013) J Fam Pract , vol.62 , Issue.10 , pp. 542-547
    • Adler, R.N.1    Harlan, D.M.2
  • 5
    • 0042825242 scopus 로고    scopus 로고
    • Microvascular complications at time of diagnosis of type 2 diabetes are similar among diabetic patients detected by targeted screening and patients newly diagnosed in general practice: The Hoorn screening study
    • Spijkerman AM, Dekker JM, Nijpels G, et al. Microvascular complications at time of diagnosis of type 2 diabetes are similar among diabetic patients detected by targeted screening and patients newly diagnosed in general practice: the Hoorn screening study. Diabetes Care. 2003;26(9):2604–2608.
    • (2003) Diabetes Care , vol.26 , Issue.9 , pp. 2604-2608
    • Spijkerman, A.M.1    Dekker, J.M.2    Nijpels, G.3
  • 6
    • 64649104158 scopus 로고    scopus 로고
    • Banting Lecture. From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus
    • Defronzo RA. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009;58(4):773–795.
    • (2009) Diabetes , vol.58 , Issue.4 , pp. 773-795
    • Defronzo, R.A.1
  • 7
    • 83655193529 scopus 로고    scopus 로고
    • The role of the kidneys in glucose homeostasis: A new path towards normalizing glycaemia
    • Defronzo RA, Davidson JA, Del Prato S. The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia. Diabetes Obes Metab. 2012;14(1):5–14.
    • (2012) Diabetes Obes Metab , vol.14 , Issue.1 , pp. 5-14
    • Defronzo, R.A.1    Davidson, J.A.2    Del Prato, S.3
  • 8
    • 0034853485 scopus 로고    scopus 로고
    • Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes
    • Kahn SE. Clinical review 135: the importance of beta-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab. 2001;86(9):4047–4058.
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.9 , pp. 4047-4058
    • Kahn, S.E.1
  • 9
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2012;35(6):1364–1379.
    • (2012) Diabetes Care , vol.35 , Issue.6 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 10
    • 79651473537 scopus 로고    scopus 로고
    • Renal glucose reabsorption inhibitors to treat diabetes
    • Bailey CJ. Renal glucose reabsorption inhibitors to treat diabetes. Trends Pharmacol Sci. 2011;32(2):63–71.
    • (2011) Trends Pharmacol Sci , vol.32 , Issue.2 , pp. 63-71
    • Bailey, C.J.1
  • 12
    • 77949287535 scopus 로고    scopus 로고
    • Sodium-glucose co-transport inhibitors: Progress and therapeutic potential in type 2 diabetes mellitus
    • Neumiller JJ, White JR Jr, Campbell RK. Sodium-glucose co-transport inhibitors: progress and therapeutic potential in type 2 diabetes mellitus. Drugs. 2010;70(4):377–385.
    • (2010) Drugs , vol.70 , Issue.4 , pp. 377-385
    • Neumiller, J.J.1    White, J.R.2    Campbell, R.K.3
  • 13
    • 80052362968 scopus 로고    scopus 로고
    • Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes
    • Abdul-Ghani MA, Norton L, Defronzo RA. Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes. Endocr Rev. 2011;32(4):515–531.
    • (2011) Endocr Rev , vol.32 , Issue.4 , pp. 515-531
    • Abdul-Ghani, M.A.1    Norton, L.2    Defronzo, R.A.3
  • 14
    • 77954242599 scopus 로고    scopus 로고
    • SGLT2 inhibition—a novel strategy for diabetes treatment
    • Chao EC, Henry RR. SGLT2 inhibition—a novel strategy for diabetes treatment. Nat Rev Drug Discov. 2010;9(7):551–559.
    • (2010) Nat Rev Drug Discov , vol.9 , Issue.7 , pp. 551-559
    • Chao, E.C.1    Henry, R.R.2
  • 15
    • 67649359913 scopus 로고    scopus 로고
    • From victim to ally: The kidney as an emerging target for the treatment of diabetes mellitus
    • Bays H. From victim to ally: the kidney as an emerging target for the treatment of diabetes mellitus. Curr Med Res Opin. 2009;25(3):671–681.
    • (2009) Curr Med Res Opin , vol.25 , Issue.3 , pp. 671-681
    • Bays, H.1
  • 16
    • 76249133903 scopus 로고    scopus 로고
    • Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: Therapeutic implications
    • Gerich JE. Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications. Diabet Med. 2010;27(2):136–142.
    • (2010) Diabet Med , vol.27 , Issue.2 , pp. 136-142
    • Gerich, J.E.1
  • 17
    • 67349189212 scopus 로고    scopus 로고
    • Renal sodium-glucose transport: Role in diabetes mellitus and potential clinical implications
    • Bakris GL, Fonseca VA, Sharma K, Wright EM. Renal sodium-glucose transport: role in diabetes mellitus and potential clinical implications. Kidney Int. 2009;75(12):1272–1277.
    • (2009) Kidney Int , vol.75 , Issue.12 , pp. 1272-1277
    • Bakris, G.L.1    Fonseca, V.A.2    Sharma, K.3    Wright, E.M.4
  • 18
    • 75149196250 scopus 로고    scopus 로고
    • Sodium glucose cotransporter 2 inhibitors as a new treatment for diabetes mellitus
    • Nair S, Wilding JP. Sodium glucose cotransporter 2 inhibitors as a new treatment for diabetes mellitus. J Clin Endocrinol Metab. 2010;95(1):34–42.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.1 , pp. 34-42
    • Nair, S.1    Wilding, J.P.2
  • 19
    • 33644688031 scopus 로고    scopus 로고
    • Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes
    • Rahmoune H, Thompson PW, Ward JM, Smith CD, Hong G, Brown J. Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes. Diabetes. 2005;54(12):3427–3434.
    • (2005) Diabetes , vol.54 , Issue.12 , pp. 3427-3434
    • Rahmoune, H.1    Thompson, P.W.2    Ward, J.M.3    Smith, C.D.4    Hong, G.5    Brown, J.6
  • 20
    • 84555186977 scopus 로고    scopus 로고
    • Na()-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucosedependent incretin secretion
    • Gorboulev V, Schurmann A, Vallon V, et al. Na()-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucosedependent incretin secretion. Diabetes. 2012;61(1):187–196.
    • (2012) Diabetes , vol.61 , Issue.1 , pp. 187-196
    • Gorboulev, V.1    Schurmann, A.2    Vallon, V.3
  • 21
    • 78651349221 scopus 로고    scopus 로고
    • Biology of human sodium glucose transporters
    • Wright EM, Loo DD, Hirayama BA. Biology of human sodium glucose transporters. Physiol Rev. 2011;91(2):733–794.
    • (2011) Physiol Rev , vol.91 , Issue.2 , pp. 733-794
    • Wright, E.M.1    Loo, D.D.2    Hirayama, B.A.3
  • 23
    • 33748064644 scopus 로고    scopus 로고
    • Renal glucose excretion as a function of blood glucose concentration in subjects with type 2 diabetes—results of a hyperglycaemic glucose clamp study
    • Rave K, Nosek L, Posner J, Heise T, Roggen K, van Hoogdalem EJ. Renal glucose excretion as a function of blood glucose concentration in subjects with type 2 diabetes—results of a hyperglycaemic glucose clamp study. Nephrol Dial Transplant. 2006;21(8):2166–2171.
    • (2006) Nephrol Dial Transplant , vol.21 , Issue.8 , pp. 2166-2171
    • Rave, K.1    Nosek, L.2    Posner, J.3    Heise, T.4    Roggen, K.5    Van Hoogdalem, E.J.6
  • 24
    • 84891865819 scopus 로고    scopus 로고
    • Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes
    • Defronzo RA, Hompesch M, Kasichayanula S, et al. Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes. Diabetes Care. 2013;36(10):3169–3176.
    • (2013) Diabetes Care , vol.36 , Issue.10 , pp. 3169-3176
    • Defronzo, R.A.1    Hompesch, M.2    Kasichayanula, S.3
  • 25
    • 64749094872 scopus 로고
    • Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose
    • Farber SJ, Berger EY, Earle DP. Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose. J Clin Invest. 1951;30(2):125–129.
    • (1951) J Clin Invest , vol.30 , Issue.2 , pp. 125-129
    • Farber, S.J.1    Berger, E.Y.2    Earle, D.P.3
  • 26
    • 84860252876 scopus 로고    scopus 로고
    • Canagliflozin improves glycemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin
    • Devineni D, Morrow L, Hompesch M, et al. Canagliflozin improves glycemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin. Diabetes Obes Metab. 2012;14(6):539–545.
    • (2012) Diabetes Obes Metab , vol.14 , Issue.6 , pp. 539-545
    • Devineni, D.1    Morrow, L.2    Hompesch, M.3
  • 27
    • 84880320337 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in subjects with type 2 diabetes mellitus
    • Devineni D, Curtin CR, Polidori D, et al. Pharmacokinetics and pharmacodynamics of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in subjects with type 2 diabetes mellitus. J Clin Pharmacol. 2013;53(6):601–610.
    • (2013) J Clin Pharmacol , vol.53 , Issue.6 , pp. 601-610
    • Devineni, D.1    Curtin, C.R.2    Polidori, D.3
  • 28
    • 0036627887 scopus 로고    scopus 로고
    • Is hepatic glucose production increased in type 2 diabetes mellitus?
    • Beck-Nielsen H, Hother-Nielsen O, Staehr P. Is hepatic glucose production increased in type 2 diabetes mellitus? Curr Diab Rep. 2002;2(3):231–236.
    • (2002) Curr Diab Rep , vol.2 , Issue.3 , pp. 231-236
    • Beck-Nielsen, H.1    Hother-Nielsen, O.2    Staehr, P.3
  • 29
    • 38549182041 scopus 로고    scopus 로고
    • Na() -glucose transporter-2 messenger ribonucleic acid expression in kidney of diabetic rats correlates with glycemic levels: Involvement of hepatocyte nuclear factor-1alpha expression and activity
    • Freitas HS, Anhe GF, Melo KF, et al. Na() -glucose transporter-2 messenger ribonucleic acid expression in kidney of diabetic rats correlates with glycemic levels: involvement of hepatocyte nuclear factor-1alpha expression and activity. Endocrinology. 2008;149(2):717–724.
    • (2008) Endocrinology , vol.149 , Issue.2 , pp. 717-724
    • Freitas, H.S.1    Anhe, G.F.2    Melo, K.F.3
  • 30
    • 0023275573 scopus 로고
    • Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats
    • Rossetti L, Smith D, Shulman GI, Papachristou D, Defronzo RA. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest. 1987;79(5):1510–1515.
    • (1987) J Clin Invest , vol.79 , Issue.5 , pp. 1510-1515
    • Rossetti, L.1    Smith, D.2    Shulman, G.I.3    Papachristou, D.4    Defronzo, R.A.5
  • 31
    • 0032850016 scopus 로고    scopus 로고
    • T-1095, an inhibitor of renal Na-glucose cotransporters, may provide a novel approach to treating diabetes
    • Oku A, Ueta K, Arakawa K, et al. T-1095, an inhibitor of renal Na-glucose cotransporters, may provide a novel approach to treating diabetes. Diabetes. 1999;48(9):1794–1800.
    • (1999) Diabetes , vol.48 , Issue.9 , pp. 1794-1800
    • Oku, A.1    Ueta, K.2    Arakawa, K.3
  • 32
    • 84877710926 scopus 로고    scopus 로고
    • Validation of a novel method for determining the renal threshold for glucose excretion in untreated and canagliflozin-treated subjects with type 2 diabetes mellitus
    • Polidori D, Sha S, Ghosh A, Plum-Mörschel L, Heise T, Rothenberg P. Validation of a novel method for determining the renal threshold for glucose excretion in untreated and canagliflozin-treated subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2013;98(5):E867–E871.
    • (2013) J Clin Endocrinol Metab , vol.98 , Issue.5 , pp. E867-E871
    • Polidori, D.1    Sha, S.2    Ghosh, A.3    Plum-Mörschel, L.4    Heise, T.5    Rothenberg, P.6
  • 33
    • 84963998143 scopus 로고    scopus 로고
    • INVOKANA™ (canagliflozin) tablets, for oral use [package insert]. Titusville, NJ: Janssen Pharmaceuticals
    • INVOKANA™ (canagliflozin) tablets, for oral use [package insert]. Titusville, NJ: Janssen Pharmaceuticals; 2013.
    • (2013)
  • 34
    • 84963998148 scopus 로고    scopus 로고
    • FARXIGA™ (dapagliflozin) tablets, for oral use [package insert]. Princeton, NJ: Bristol-Myers Squibb Company
    • FARXIGA™ (dapagliflozin) tablets, for oral use [package insert]. Princeton, NJ: Bristol-Myers Squibb Company; 2014.
    • (2014)
  • 35
    • 84892477577 scopus 로고    scopus 로고
    • Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: A 24-week, randomized, placebo-controlled trial
    • Kovacs CS, Seshiah V, Swallow R, et al. Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: a 24-week, randomized, placebo-controlled trial. Diabetes Obes Metab. 2013;16(2):147–158.
    • (2013) Diabetes Obes Metab , vol.16 , Issue.2 , pp. 147-158
    • Kovacs, C.S.1    Seshiah, V.2    Swallow, R.3
  • 36
    • 84885952950 scopus 로고    scopus 로고
    • Empagliflozin as add-on to metformin plus sulfonylurea in patients with type 2 diabetes: A 24-week, randomized, double-blind, placebo-controlled trial
    • Haring HU, Merker L, Seewaldt-Becker E, et al. Empagliflozin as add-on to metformin plus sulfonylurea in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial. Diabetes Care. 2013;36(11):3396–3404.
    • (2013) Diabetes Care , vol.36 , Issue.11 , pp. 3396-3404
    • Haring, H.U.1    Merker, L.2    Seewaldt-Becker, E.3
  • 37
    • 84876344111 scopus 로고    scopus 로고
    • Efficacy and safety of ipragliflozin in patients with type 2 diabetes inadequately controlled on metformin: A dose-finding study
    • Wilding JP, Ferrannini E, Fonseca VA, Wilpshaar W, Dhanjal P, Houzer A. Efficacy and safety of ipragliflozin in patients with type 2 diabetes inadequately controlled on metformin: a dose-finding study. Diabetes Obes Metab. 2013;15(5):403–409.
    • (2013) Diabetes Obes Metab , vol.15 , Issue.5 , pp. 403-409
    • Wilding, J.P.1    Ferrannini, E.2    Fonseca, V.A.3    Wilpshaar, W.4    Dhanjal, P.5    Houzer, A.6
  • 38
    • 84876899238 scopus 로고    scopus 로고
    • Active- and placebocontrolled dose-finding study to assess the efficacy, safety, and tolerability of multiple doses of ipragliflozin in patients with type 2 diabetes mellitus
    • Fonseca VA, Ferrannini E, Wilding JP, et al. Active- and placebocontrolled dose-finding study to assess the efficacy, safety, and tolerability of multiple doses of ipragliflozin in patients with type 2 diabetes mellitus. J Diabetes Complications. 2013;27(3):268–273.
    • (2013) J Diabetes Complications , vol.27 , Issue.3 , pp. 268-273
    • Fonseca, V.A.1    Ferrannini, E.2    Wilding, J.P.3
  • 39
    • 84872733237 scopus 로고    scopus 로고
    • Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects
    • Miao Z, Nucci G, Amin N, et al. Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects. Drug Metab Dispos. 2013;41(2):445–456.
    • (2013) Drug Metab Dispos , vol.41 , Issue.2 , pp. 445-456
    • Miao, Z.1    Nucci, G.2    Amin, N.3
  • 40
    • 84877922239 scopus 로고    scopus 로고
    • Ipragliflozin and other sodium-glucose cotransporter-2 (SGLT2) inhibitors in the treatment of type 2 diabetes: Preclinical and clinical data
    • Kurosaki E, Ogasawara H. Ipragliflozin and other sodium-glucose cotransporter-2 (SGLT2) inhibitors in the treatment of type 2 diabetes: preclinical and clinical data. Pharmacol Ther. 2013;139(1): 51–59.
    • (2013) Pharmacol Ther , vol.139 , Issue.1 , pp. 51-59
    • Kurosaki, E.1    Ogasawara, H.2
  • 41
    • 84885954870 scopus 로고    scopus 로고
    • Empagliflozin monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes: A randomised, double-blind, placebo-controlled, phase 3 trial
    • Roden M, Weng J, Eilbracht J, et al. Empagliflozin monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes: a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2013;1:208–219.
    • (2013) Lancet , vol.1 , pp. 208-219
    • Roden, M.1    Weng, J.2    Eilbracht, J.3
  • 42
    • 67349180574 scopus 로고    scopus 로고
    • Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects
    • Komoroski B, Vachharajani N, Boulton D, et al. Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects. Clin Pharmacol Ther. 2009;85(5):520–526.
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.5 , pp. 520-526
    • Komoroski, B.1    Vachharajani, N.2    Boulton, D.3
  • 43
    • 84878947970 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeks’ treatment with empagliflozin once daily in patients with type 2 diabetes
    • Heise T, Seewaldt-Becker E, Macha S, et al. Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeks’ treatment with empagliflozin once daily in patients with type 2 diabetes. Diabetes Obes Metab. 2013;15(7):613–621.
    • (2013) Diabetes Obes Metab , vol.15 , Issue.7 , pp. 613-621
    • Heise, T.1    Seewaldt-Becker, E.2    Macha, S.3
  • 44
    • 56749160374 scopus 로고    scopus 로고
    • Twenty-one additional cases of familial renal glucosuria: Absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion
    • Calado J, Sznajer Y, Metzger D, et al. Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion. Nephrol Dial Transplant. 2008;23(12):3874–3879.
    • (2008) Nephrol Dial Transplant , vol.23 , Issue.12 , pp. 3874-3879
    • Calado, J.1    Sznajer, Y.2    Metzger, D.3
  • 45
    • 10744229025 scopus 로고    scopus 로고
    • Molecular analysis of the SGLT2 gene in patients with renal glucosuria
    • Santer R, Kinner M, Lassen CL, et al. Molecular analysis of the SGLT2 gene in patients with renal glucosuria. J Am Soc Nephrol. 2003;14(11):2873–2882.
    • (2003) J am Soc Nephrol , vol.14 , Issue.11 , pp. 2873-2882
    • Santer, R.1    Kinner, M.2    Lassen, C.L.3
  • 46
    • 75749094398 scopus 로고    scopus 로고
    • Familial renal glucosuria and SGLT2: From a mendelian trait to a therapeutic target
    • Santer R, Calado J. Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target. Clin J Am Soc Nephrol. 2010;5(1):133–141.
    • (2010) Clin J am Soc Nephrol , vol.5 , Issue.1 , pp. 133-141
    • Santer, R.1    Calado, J.2
  • 47
    • 79956331954 scopus 로고    scopus 로고
    • Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects
    • Sha S, Devineni D, Ghosh A, et al. Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects. Diabetes Obes Metab. 2011;13(7): 669–672.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.7 , pp. 669-672
    • Sha, S.1    Devineni, D.2    Ghosh, A.3
  • 48
    • 84857099986 scopus 로고    scopus 로고
    • Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models
    • Liang Y, Arakawa K, Ueta K, et al. Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models. PLoS ONE. 2012;7(2):e30555.
    • (2012) Plos ONE , vol.7 , Issue.2 , pp. e30555
    • Liang, Y.1    Arakawa, K.2    Ueta, K.3
  • 49
    • 0024507794 scopus 로고
    • Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: Contributions of excessive hepatic glucose production and impaired tissue glucose uptake
    • DeFronzo RA, Ferrannini E, Simonson DC. Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake. Metabolism. 1989;38(4):387–395.
    • (1989) Metabolism , vol.38 , Issue.4 , pp. 387-395
    • Defronzo, R.A.1    Ferrannini, E.2    Simonson, D.C.3
  • 50
    • 84877865378 scopus 로고    scopus 로고
    • Canagliflozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion: Results of a randomized, placebo-controlled study
    • Polidori D, Sha S, Mudaliar S, et al. Canagliflozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion: results of a randomized, placebo-controlled study. Diabetes Care. 2013;36(8):2154–2161.
    • (2013) Diabetes Care , vol.36 , Issue.8 , pp. 2154-2161
    • Polidori, D.1    Sha, S.2    Mudaliar, S.3
  • 51
    • 84888059660 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin and sulphonylurea: A randomised trial
    • Wilding JP, Charpentier G, Hollander P, et al. Efficacy and safety of canagliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin and sulphonylurea: a randomised trial. Int J Clin Pract. 2013;67(12):1267–1282.
    • (2013) Int J Clin Pract , vol.67 , Issue.12 , pp. 1267-1282
    • Wilding, J.P.1    Charpentier, G.2    Hollander, P.3
  • 52
    • 84874291673 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise
    • Stenlöf K, Cefalu WT, Kim K-A, et al. Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise. Diabetes Obes Metab. 2013;15(4):372–382.
    • (2013) Diabetes Obes Metab , vol.15 , Issue.4 , pp. 372-382
    • Stenlöf, K.1    Cefalu, W.T.2    Kim, K.-A.3
  • 53
    • 84880543926 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin treatment in older subjects with type 2 diabetes mellitus: A randomized trial
    • Bode B, Stenlöf K, Sullivan D, Fung A, Usiskin K. Efficacy and safety of canagliflozin treatment in older subjects with type 2 diabetes mellitus: a randomized trial. Hosp Pract. 2013;41(2):72–84.
    • (2013) Hosp Pract , vol.41 , Issue.2 , pp. 72-84
    • Bode, B.1    Stenlöf, K.2    Sullivan, D.3    Fung, A.4    Usiskin, K.5
  • 54
    • 84876311251 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease
    • Yale JF, Bakris G, Cariou B, et al. Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease. Diabetes Obes Metab. 2013;15(5):463–473.
    • (2013) Diabetes Obes Metab , vol.15 , Issue.5 , pp. 463-473
    • Yale, J.F.1    Bakris, G.2    Cariou, B.3
  • 55
    • 84891784200 scopus 로고    scopus 로고
    • Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: A 52-week, randomized trial
    • Schernthaner G, Gross JL, Rosenstock J, et al. Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: a 52-week, randomized trial. Diabetes Care. 2013;36(9):2508–2515.
    • (2013) Diabetes Care , vol.36 , Issue.9 , pp. 2508-2515
    • Schernthaner, G.1    Gross, J.L.2    Rosenstock, J.3
  • 56
    • 84884167643 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial
    • Cefalu WT, Leiter LA, Yoon KH, et al. Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial. Lancet. 2013;382(9896):941–950.
    • (2013) Lancet , vol.382 , Issue.9896 , pp. 941-950
    • Cefalu, W.T.1    Leiter, L.A.2    Yoon, K.H.3
  • 57
    • 84887997289 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: A randomised trial
    • Lavalle-González FJ, Januszewicz A, Davidson J, et al. Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: a randomised trial. Diabetologia. 2013;56(12):2582–2592.
    • (2013) Diabetologia , vol.56 , Issue.12 , pp. 2582-2592
    • Lavalle-González, F.J.1    Januszewicz, A.2    Davidson, J.3
  • 58
    • 84964003185 scopus 로고    scopus 로고
    • Canagliflozin as an Adjunctive Treatment to Diet and Exercise Alone or Co-administered with Other Antihyperglycemic Agents to Improve Glycemic
    • Janssen Research and Development LLC. Endocrinologic and Metabolic Drugs Advisory Committee January 10, 2013, JNJ-28431754 (Canagliflozin). NDA 204042
    • Janssen Research and Development LLC. Endocrinologic and Metabolic Drugs Advisory Committee January 10, 2013. Canagliflozin as an Adjunctive Treatment to Diet and Exercise Alone or Co-administered with Other Antihyperglycemic Agents to Improve Glycemic Control in Adults with Type 2 Diabetes Mellitus. JNJ-28431754 (Canagliflozin). NDA 204042. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolic- DrugsAdvisoryCommittee/UCM334551.pdf.
    • Control in Adults with Type 2 Diabetes Mellitus
  • 59
    • 77956921439 scopus 로고    scopus 로고
    • Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: A randomized, double-blind, placebo-controlled, phase 3 trial
    • Ferrannini E, Ramos SJ, Salsali A, Tang W, List JF. Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial. Diabetes Care. 2010;33(10):2217–2224.
    • (2010) Diabetes Care , vol.33 , Issue.10 , pp. 2217-2224
    • Ferrannini, E.1    Ramos, S.J.2    Salsali, A.3    Tang, W.4    List, J.F.5
  • 60
    • 84963999913 scopus 로고    scopus 로고
    • Bristol-Myers Squibb, AstraZeneca. U.S. Food and Drug Administration Endocrinologic and Metabolic Advisory Committee Background Document: Dapagliflozin, BMS-512148, NDA 202293. Princeton, NJ: Bristol-Myers Squibb; 2011, Accessed April 4
    • Bristol-Myers Squibb, AstraZeneca. U.S. Food and Drug Administration Endocrinologic and Metabolic Advisory Committee Background Document: Dapagliflozin, BMS-512148, NDA 202293. Princeton, NJ: Bristol-Myers Squibb; 2011. http://www.fda.gov/downloads/Advisory-Committees/CommitteesMeetingMaterials/Drugs/Endocrinologicand- MetabolicDrugsAdvisoryCommittee/UCM262996.pdf. Accessed April 4, 2013.
    • (2013)
  • 61
    • 77953857048 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomised, double-blind, placebo-controlled trial
    • Bailey CJ, Gross JL, Pieters A, Bastien A, List JF. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial. Lancet. 2010;375(9733):2223–2233.
    • (2010) Lancet , vol.375 , Issue.9733 , pp. 2223-2233
    • Bailey, C.J.1    Gross, J.L.2    Pieters, A.3    Bastien, A.4    List, J.F.5
  • 62
    • 84873960885 scopus 로고    scopus 로고
    • Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: A randomized, double-blind, placebo-controlled 102-week trial
    • Bailey CJ, Gross JL, Hennicken D, Iqbal N, Mansfield TA, List JF. Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial. BMC Med. 2013;11:43.
    • (2013) BMC Med , vol.11 , pp. 43
    • Bailey, C.J.1    Gross, J.L.2    Hennicken, D.3    Iqbal, N.4    Mansfield, T.A.5    List, J.F.6
  • 63
    • 80155124676 scopus 로고    scopus 로고
    • Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: A randomized, 52-week, double-blind, active-controlled noninferiority trial
    • Nauck MA, Del PS, Meier JJ, et al. Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial. Diabetes Care. 2011;34(9):2015–2022.
    • (2011) Diabetes Care , vol.34 , Issue.9 , pp. 2015-2022
    • Nauck, M.A.1    Del, P.S.2    Meier, J.J.3
  • 64
    • 80052524011 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: A randomized, 24-week, double-blind, placebo-controlled trial
    • Strojek K, Yoon KH, Hruba V, Elze M, Langkilde AM, Parikh S. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: a randomized, 24-week, double-blind, placebo-controlled trial. Diabetes Obes Metab. 2011;13(10):928–938.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.10 , pp. 928-938
    • Strojek, K.1    Yoon, K.H.2    Hruba, V.3    Elze, M.4    Langkilde, A.M.5    Parikh, S.6
  • 65
    • 84858323889 scopus 로고    scopus 로고
    • Long-term efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin: A randomized trial
    • Wilding JP, Woo V, Soler NG, et al. Long-term efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin: a randomized trial. Ann Intern Med. 2012;156(6):405–415.
    • (2012) Ann Intern Med , vol.156 , Issue.6 , pp. 405-415
    • Wilding, J.P.1    Woo, V.2    Soler, N.G.3
  • 66
    • 84862875221 scopus 로고    scopus 로고
    • Effects of dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, on hemoglobin A1c, body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy
    • Rosenstock J, Vico M, Wei L, Salsali A, List JF. Effects of dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, on hemoglobin A1c, body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy. Diabetes Care. 2012;35(7):1473–1478.
    • (2012) Diabetes Care , vol.35 , Issue.7 , pp. 1473-1478
    • Rosenstock, J.1    Vico, M.2    Wei, L.3    Salsali, A.4    List, J.F.5
  • 67
    • 84892488179 scopus 로고    scopus 로고
    • Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: Efficacy and safety over 2 years
    • Wilding JP, Woo V, Rohwedder K, Sugg J, Parikh S. Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: efficacy and safety over 2 years. Diabetes Obes Metab. 2014;16(2):124–136.
    • (2014) Diabetes Obes Metab , vol.16 , Issue.2 , pp. 124-136
    • Wilding, J.P.1    Woo, V.2    Rohwedder, K.3    Sugg, J.4    Parikh, S.5
  • 68
    • 84896701131 scopus 로고    scopus 로고
    • Dapagliflozin is effective as add-on therapy to sitagliptin with or without metformin: A 24-week, multicenter, randomized, double-blind, placebo-controlled study
    • Jabbour SA, Hardy E, Sugg J, Parikh S. Dapagliflozin is effective as add-on therapy to sitagliptin with or without metformin: a 24-week, multicenter, randomized, double-blind, placebo-controlled study. Diabetes Care. 2013;37(3):740–750.
    • (2013) Diabetes Care , vol.37 , Issue.3 , pp. 740-750
    • Jabbour, S.A.1    Hardy, E.2    Sugg, J.3    Parikh, S.4
  • 69
    • 84897394040 scopus 로고    scopus 로고
    • Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control
    • Kohan DE, Fioretto P, Tang W, List JF. Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control. Kidney Int. 2014;85(4):962–971.
    • (2014) Kidney Int , vol.85 , Issue.4 , pp. 962-971
    • Kohan, D.E.1    Fioretto, P.2    Tang, W.3    List, J.F.4
  • 70
    • 84893299467 scopus 로고    scopus 로고
    • Long-term efficacy and safety of canagliflozin monotherapy in patients with type 2 diabetes inadequately controlled with diet and exercise: Findings from the 52-week CANTATA-M study
    • Stenlöf K, Cefalu WT, Kim KA, et al. Long-term efficacy and safety of canagliflozin monotherapy in patients with type 2 diabetes inadequately controlled with diet and exercise: findings from the 52-week CANTATA-M study. Curr Med Res Opin. 2014;30(2):163–175.
    • (2014) Curr Med Res Opin , vol.30 , Issue.2 , pp. 163-175
    • Stenlöf, K.1    Cefalu, W.T.2    Kim, K.A.3
  • 71
    • 84900823374 scopus 로고    scopus 로고
    • Genital mycotic infections with canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus: A pooled analysis of clinical studies
    • Nyirjesy P, Sobel JD, Fung A, et al. Genital mycotic infections with canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus: a pooled analysis of clinical studies. Curr Med Res Opin. 2014;30(6):1109–1119.
    • (2014) Curr Med Res Opin , vol.30 , Issue.6 , pp. 1109-1119
    • Nyirjesy, P.1    Sobel, J.D.2    Fung, A.3
  • 73
    • 84887147788 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in Japanese patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, 12-week study
    • Inagaki N, Kondo K, Yoshinari T, Maruyama N, Susuta Y, Kuki H. Efficacy and safety of canagliflozin in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, 12-week study. Diabetes Obes Metab. 2013;15(12):1136–1145.
    • (2013) Diabetes Obes Metab , vol.15 , Issue.12 , pp. 1136-1145
    • Inagaki, N.1    Kondo, K.2    Yoshinari, T.3    Maruyama, N.4    Susuta, Y.5    Kuki, H.6
  • 75
    • 84897019959 scopus 로고    scopus 로고
    • Urinary tract infection in randomized Phase III studies of canagliflozin, a sodium glucose cotransporter 2 inhibitor
    • Nicolle LE, Capuano G, Fung A, Usiskin K. Urinary tract infection in randomized Phase III studies of canagliflozin, a sodium glucose cotransporter 2 inhibitor. Postgrad Med. 2014;126(1):7–17.
    • (2014) Postgrad Med , vol.126 , Issue.1 , pp. 7-17
    • Nicolle, L.E.1    Capuano, G.2    Fung, A.3    Usiskin, K.4
  • 76
    • 84906924894 scopus 로고    scopus 로고
    • Safety and tolerability of canagliflozin in patients with type 2 diabetes: Pooled analysis of phase 3 study results
    • Usiskin K, Kline I, Fung A, Mayer C, Meininger G. Safety and tolerability of canagliflozin in patients with type 2 diabetes: pooled analysis of phase 3 study results. Postgrad Med 2014;126(3):16–34.
    • (2014) Postgrad Med , vol.126 , Issue.3 , pp. 16-34
    • Usiskin, K.1    Kline, I.2    Fung, A.3    Mayer, C.4    Meininger, G.5
  • 77
    • 84882276623 scopus 로고    scopus 로고
    • AACE Comprehensive Diabetes Management Algorithm 2013
    • Garber AJ, Abrahamson MJ, Barzilay JI, et al. AACE Comprehensive Diabetes Management Algorithm 2013. Endocr Pract. 2013;19(2):327–336.
    • (2013) Endocr Pract , vol.19 , Issue.2 , pp. 327-336
    • Garber, A.J.1    Abrahamson, M.J.2    Barzilay, J.I.3


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