Testicular effects following in utero exposure to the antivirals acyclovir and ganciclovir in rats

Toxicological Sciences

Volumn 139, Issue 1, 2014, Pages 220-233

  Nihi, Fabíola ^a   Moreira, Davyson ^b   Lourenço, Ana Carolina Santos ^a   Gomes, Caroline ^a   Araujo, Samanta Luiza ^a   Zaia, Renata Mercer ^a   Trevisani, Natalia Botelho ^a   Pinto, Leonardo de Athayde ^a   Moura Costa, Daniele Dietrich ^a   de Morais, Rosana Nogueira ^a   Paumgartten, Francisco José Roma ^b   Martino Andrade, Anderson Joel ^a  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Acyclovir; Ganciclovir; Gestation; Rats; Testis

Indexed keywords

ACICLOVIR; GANCICLOVIR; TESTOSTERONE; ANTIVIRUS AGENT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOGENITAL DISTANCE; ANTIVIRAL THERAPY; ARTICLE; BODY WEIGHT; BULBOCAVERNOSUS MUSCLE; CELL COUNT; CELL VACUOLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MEGADOSE; EPIDIDYMIS; FEMALE; FETOTOXICITY; FETUS; GERM CELL; HISTOLOGY; MALE; MATERNAL TREATMENT; NONHUMAN; PRENATAL DRUG EXPOSURE; PROSTATE VENTRAL LOBE; RAT; REPRODUCTIVE TOXICITY; SEMINAL VESICLE; SEMINIFEROUS TUBULE; SERTOLI CELL; SERTOLI CELL ONLY SYNDROME; SPERMATID; TESTIS DEVELOPMENT; TESTIS SIZE; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL; THYMUS; TUNICA ALBUGINEA; VAS DEFERENS; WEANING; ANIMAL; DRUG EFFECTS; ENVIRONMENTAL EXPOSURE; PREGNANCY; TESTIS; TOXICITY;

ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; FEMALE; GANCICLOVIR; MALE; MATERNAL EXPOSURE; PREGNANCY; RATS; TESTIS;

EID: 84922394252     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu024     Document Type: Article

References (26)

1. Abercrombie, M. (1946). Estimation of nuclear population from microtome sections. Anat. Rec. 94, 239-247.
2. Anniballo, R., Brehm, R., and Steger, K. (2011). Recognising the Sertoli-cellonly (SCO) syndrome: A case study. Andrologia 43, 78-83.
3. Anniballo, R., Ubaldi, F., Cobellis, L., Sorrentino, M., Rienzi, L., Greco, E., and Tesarik, J. (2000). Criteria predicting the absence of spermatozoa in the Sertoli cell-only syndrome can be used to improve success rates of sperm retrieval. Hum. Reprod. 15, 2269-2277.
4. Boulieu, R., Gallant, C., and Silberstein, N. (1997). Determination of acyclovir in human plasma by high-performance liquid chromatography. J. Chromatogr. B Biomed. Sci. Appl. 693, 233-236.
5. Chahoud, I., and Kwasigrocch, T. E. (1977). Controlled breeding of laboratory animals. In Methods in Prenatal Toxicology, Evaluation of Embryotoxic Effects in Experimental Animals, 1st ed. (D. Neubert, H.-J. Merker and T. E. Kwasigroch, Eds.), pp. 79-91. Georg Thieme Verlag, Stuttgart, German.
6. Chahoud, I., Stahlmann, R., Bochert, G., Dillmann, I., and Noubert, D. (1988). Gross-structural defects in rats after acyclovir application on day 10 of gestation. Arch. Toxicol. 62, 8-14.
7. Culty, M. (2009). Gonocytes, the forgotten cells of the germ cell lineage. Birth Defects Res. C Embryo Today 87, 1-26.
8. Faqi, A. S., Klug, A., Merker, H. J., and Chahoud, I. (1997). Ganciclovir induces reproductive hazards in male rats after short-term exposure. Hum. Exp. Toxicol. 16, 505-511.
9. Gallavan, R. H., Jr,Holson, J. F., Stump, D. G., Knapp, J. F., and Reynolds,V. L. (1999). Interpreting the toxicologic significance of alterations in anogenital distance: Potential for confounding effects of progeny body weights. Reprod. Toxicol. 13, 383-390.
10. Hartmann, J., Chahoud, I., Buerkle, B., and Neubert, D. (1991). Testis hypoplasia in rat offspring prenatally exposed to ganciclovir. Eur. Teratol. Abstr. 25A (Abstract).
11. Haynes, P., Lambert, T. R., and Mitchell, I. D. (1996). Comparative in-vivo genotoxicity of antiviral nucleoside analogues; penciclovir, acyclovir, ganciclovir and the xanthine analogue, caffeine, in the mouse bone marrow micronucleus assay. Mutat. Res. 369, 65-74.
12. Kimberlin, D. W., and Whitley, R. J. (2007). Antiviral therapy of HSV-1 and-2. In Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (A. Arvin, G. Campadelli-Fiume, E. Mocarski, P. S. Moore, B. Roizman, R. Whitley and K. Yamanishi, Eds.). Chapter 64. Cambridge University Press, Cambridge. Available at: http://www.ncbi.nlm.nih.gov/books/NBK47444/. Accessed October 1, 2013.
13. Klug, S., Lewandowski, C., Merker, H. J., Stahlmann, R., Wildi, L., and Neubert, D. (1991). In vitro and in vivo studies on the prenatal toxicity of five virustatic nucleoside analogues in comparison to aciclovir. Arch. Toxicol. 65, 283-291.
14. Laskin, O. L., Longstreth, J. A., Saral, R., deMiranda, P., Keeney, R., and Lietman, P. S. (1982). Pharmacokinetics and tolerance of acyclovir, a new antiherpesvirus agent, in humans. Antimicrob. Agents Chemother. 21, 393-398.
15. Maymon, B. B., Paz, G., Yogev, L., Hauser, R., Schreiber, L., Botchan, A., and Yavetz, H. (2000). Immunohistochemical identification of testicular germ cells-preliminary report. Harefuah 139, 179-182.
16. Micic, S., Ilic, V., Micic, M., Genbacev, O., and Dotlic, R. (1983). Endocrine profile of 45 patients with Sertoli cell only syndrome. Andrologia 15, 228-32.
17. Munro, C. J., Stabenfeldt, G. H., Cragun, J. R., Addiego, L. A., Overstreet, J. W., and Lasley, B. I. (1991). The relationship of serum estradiol and progesterone concentrations to the excretion profiles of their major urinary metabolites as measured by enzyme-immunoassay and radioimmunoassay. Clin. Chem. 37, 838-844.
18. Neyts, J., Jähne, G., Andrei, G., Snoeck, R., Winkler, I., and Clercq, E. D. (1995). In vivo antiherpesvirus activity of N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine. Antimicrob. Agents Chemother. 39, 56-60.
19. O'Shaughnessy, P. J., Hu, L., and Baker, P. J. (2008). Effect of germ cell depletion on levels of specific mRNA transcripts in mouse Sertoli cells and Leydig cells. Reproduction 135, 839-850.
20. Puliyanda, D. P., Silverman, N. S., Lehman, D., Vo, A., Bunnapradist, S., Radha, R. K., Toyoda, M., and Jordan, S. C. (2005). Successful use of oral ganciclovir for the treatment of intrauterine cytomegalovirus infection in a renal allograft recipient. Transpl. Infect. Dis. 7, 71-74.
21. Ross, A. J., and Capel, B. (2005). Signaling at the crossroads of gonad development. Trends Endocrinol. Metab. 16, 19-25.
22. Russell, L. D., Ettlin, R. A., Sinha Hikim, A. P., and Clegg, E. D. (1990). Tissue preparation for evaluation of the testis. In Histological and Histopathological Evaluation of the Testis, 1st ed. (L. D. Russel, R. A. Ettlin and A. P. Sinha Hikim, Eds.), pp. 195-209. Cache River Press, Clearwater, Florida.
23. Scholar, E. M., and Pratt, W. B. (2000). Chemotherapy of viral infections, I. In The Antimicrobial Drugs, 2nd ed. (E. M. Scholar and W. B. Pratt, Eds.), pp. 491-549. Oxford University Press, New York, NY.
24. Shrim, A., Koren, G., Yudin, M. H., Farine, D., and Maternal Fetal Medicine Committee (2012). Management of varicella infection (chickenpox) in pregnancy. J. Obstet. Gynaecol. Can. 34, 287-292.
25. Stahlmann, R., Klug, S., Lewandowski, C., Bochert, G., Chahoud, I., Rahm, U., Merker, H. J., and Neubert, D. (1988). Prenatal toxicity of acyclovir in rats. Arch. Toxicol. 61, 468-479.
26. Stahlmann, R., Korte, M., Van Loveren, H., Vos, J. G., Thiel, R., and Neubert, D. (1992). Abnormal thymus development and impaired function of the immune system in rats after prenatal exposure to aciclovir. Arch. Toxicol. 66, 551-559.