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Volumn 2014, Issue 7, 2014, Pages

Humanized PA14 (a monoclonal CCR5 antibody) for treatment of people with HIV infection

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; PRO 140; VIRUS RNA; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; MONOCLONAL ANTIBODY; PRO-140 MONOCLONAL ANTIBODY;

EID: 84922392690     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD008439.pub3     Document Type: Review
Times cited : (11)

References (30)
  • 1
    • 85041834895 scopus 로고    scopus 로고
    • Study of intravenous PRO 140 or placebo in adult patients with HIV
    • [A phase Ib, double-blind, randomized, dose-cohort escalation study of intravenous PRO 140 or placebo in adult patients with HIV-1 infection]. accessed 23 July 2014ISRCTN45537485
    • ISRCTN45537485. Study of intravenous PRO 140 or placebo in adult patients with HIV [A phase Ib, double-blind, randomized, dose-cohort escalation study of intravenous PRO 140 or placebo in adult patients with HIV-1 infection]. Current Controlled Trials (http://controlled-trials.com/ISRCTN45537485/ISRCTN45537485) accessed 23 July 2014.
    • Current Controlled Trials
  • 3
    • 77951916324 scopus 로고    scopus 로고
    • Anti-HIV-1 activity of weekly or biweekly treatment with subcutaneous PRO 140, a CCR5 monoclonal antibody
    • PUBMED: 20377413]
    • Jacobson JM, Thompson MA, Lalezari JP, Saag MS, Zingman BS, D'Ambrosio P, et al. Anti-HIV-1 activity of weekly or biweekly treatment with subcutaneous PRO 140, a CCR5 monoclonal antibody. Journal of Infectious Diseases 2010;201(10):1481-7. [PUBMED: 20377413]
    • (2010) Journal of Infectious Diseases , vol.201 , Issue.10 , pp. 1481-1487
    • Jacobson, J.M.1    Thompson, M.A.2    Lalezari, J.P.3    Saag, M.S.4    Zingman, B.S.5    D'Ambrosio, P.6
  • 4
    • 85041857675 scopus 로고    scopus 로고
    • Study of PRO 140 by Subcutaneous Administration in Adult Subjects With HIV -1 Infection
    • NCT00642707ClinicalTrials.gov accessed 23 July 2014
    • NCT00642707. Study of PRO 140 by Subcutaneous Administration in Adult Subjects With HIV -1 Infection. ClinicalTrials.gov (http://www.clinicaltrials.gov/ct2/show/NCT00642707?term=NCT00642707&rank=1) accessed 23 July 2014.
  • 6
    • 85041803501 scopus 로고    scopus 로고
    • A phase 2a, randomized, double-blind, placebo-controlled study of PRO 140 by intravenous administration in adult subjects with human immunodeficiency virus type 1 infection
    • NCT00613379clinicaltrials.gov accessed 23 July 2014
    • NCT00613379. A phase 2a, randomized, double-blind, placebo-controlled study of PRO 140 by intravenous administration in adult subjects with human immunodeficiency virus type 1 infection. clinicaltrials.gov (http://www.clinicaltrials.gov/ct2/show/NCT00613379?term=NCT00613379&rank=1) accessed 23 July 2014.
  • 7
    • 84865632808 scopus 로고    scopus 로고
    • Clinical studies with chemokine receptor-5 (CCR5)-inhibitors
    • Boesecke C, Pett SL. Clinical studies with chemokine receptor-5 (CCR5)-inhibitors. Current Opinion in HIV and AIDS 2012;7(5):456-62.
    • (2012) Current Opinion in HIV and AIDS , vol.7 , Issue.5 , pp. 456-462
    • Boesecke, C.1    Pett, S.L.2
  • 8
    • 0037321703 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 attachment, coreceptor, and fusion inhibitors are active against both direct and trans infection of primary cells
    • Ketas TJ, Frank I, Klasse PJ, Sullivan BM, Gardner JP, Spenlehauer C, et al. Human immunodeficiency virus type 1 attachment, coreceptor, and fusion inhibitors are active against both direct and trans infection of primary cells. Journal of Virology 2003;77(4):2762-7.
    • (2003) Journal of Virology , vol.77 , Issue.4 , pp. 2762-2767
    • Ketas, T.J.1    Frank, I.2    Klasse, P.J.3    Sullivan, B.M.4    Gardner, J.P.5    Spenlehauer, C.6
  • 9
    • 34249889344 scopus 로고    scopus 로고
    • Cell surface expression of CCR5 and other host factors influence the inhibition of HIV-1 infection of human lymphocytes by CCR5 ligands
    • Ketas TJ, Kuhmann SE, Palmer A, Zurita J, He W, Ahuja SK, et al. Cell surface expression of CCR5 and other host factors influence the inhibition of HIV-1 infection of human lymphocytes by CCR5 ligands. Virology 2007;364(2):281-290.
    • (2007) Virology , vol.364 , Issue.2 , pp. 281-290
    • Ketas, T.J.1    Kuhmann, S.E.2    Palmer, A.3    Zurita, J.4    He, W.5    Ahuja, S.K.6
  • 11
    • 10744223857 scopus 로고    scopus 로고
    • The acceptability of an investigational vaginal microbicide, PRO 2000 Gel, among women in a phase I clinical trial
    • Morrow K, Rosen R, Richter L, Emans A, Forbes A, Day J, et al. The acceptability of an investigational vaginal microbicide, PRO 2000 Gel, among women in a phase I clinical trial. Journal of Womens Health 2003;12(7):655-66.
    • (2003) Journal of Womens Health , vol.12 , Issue.7 , pp. 655-666
    • Morrow, K.1    Rosen, R.2    Richter, L.3    Emans, A.4    Forbes, A.5    Day, J.6
  • 12
    • 33749517200 scopus 로고    scopus 로고
    • Potent antiviral synergy between monoclonal antibody and small-molecule CCR5 inhibitors of human immunodeficiency virus type 1
    • Murga JD, Franti M, Pevear DC, Maddon PJ, Olson WC. Potent antiviral synergy between monoclonal antibody and small-molecule CCR5 inhibitors of human immunodeficiency virus type 1. Antimicrobial Agents and Chemotherapy 2006;50(10):3289-96.
    • (2006) Antimicrobial Agents and Chemotherapy , vol.50 , Issue.10 , pp. 3289-3296
    • Murga, J.D.1    Franti, M.2    Pevear, D.C.3    Maddon, P.J.4    Olson, W.C.5
  • 13
    • 45449092969 scopus 로고    scopus 로고
    • Neutralizing antibody and anti-retroviral drug sensitivities of HIV-1 isolates resistant to small molecule CCR5 inhibitors
    • Pugach P, Ketas TJ, Michael E, Moore JP. Neutralizing antibody and anti-retroviral drug sensitivities of HIV-1 isolates resistant to small molecule CCR5 inhibitors. Virology 2008;377(2):401-7.
    • (2008) Virology , vol.377 , Issue.2 , pp. 401-407
    • Pugach, P.1    Ketas, T.J.2    Michael, E.3    Moore, J.P.4
  • 14
    • 20744442398 scopus 로고    scopus 로고
    • Virus isolates during acute and chronic human immunodeficiency virus type 1 infection show distinct patterns of sensitivity to entry inhibitors
    • Rusert P, Kuster H, Joos B, Misselwitz B, Gujer C, Leemann C, et al. Virus isolates during acute and chronic human immunodeficiency virus type 1 infection show distinct patterns of sensitivity to entry inhibitors. Journal of Virology 2005;79(13):8454-69.
    • (2005) Journal of Virology , vol.79 , Issue.13 , pp. 8454-8469
    • Rusert, P.1    Kuster, H.2    Joos, B.3    Misselwitz, B.4    Gujer, C.5    Leemann, C.6
  • 15
    • 33746571624 scopus 로고    scopus 로고
    • Susceptibility of pediatric HIV-1 isolates to recombinant CD4-IgG2 (PRO 542) and humanized mAb to the chemokine receptor CCR5 (PRO 140)
    • Shearer WT, DeVille JG, Samson PM, Moye JH Jr, Fletcher CV, Church JA, et al. Susceptibility of pediatric HIV-1 isolates to recombinant CD4-IgG2 (PRO 542) and humanized mAb to the chemokine receptor CCR5 (PRO 140). Journal of Allergy and Clinical Immunology 2006;118(2):518-21.
    • (2006) Journal of Allergy and Clinical Immunology , vol.118 , Issue.2 , pp. 518-521
    • Shearer, W.T.1    DeVille, J.G.2    Samson, P.M.3    Moye, J.H.4    Fletcher, C.V.5    Church, J.A.6
  • 16
    • 79952707085 scopus 로고    scopus 로고
    • The monoclonal CCR5 antibody PRO-140: the promise of once-weekly HIV therapy
    • Tenorio AR. The monoclonal CCR5 antibody PRO-140: the promise of once-weekly HIV therapy. Current HIV/AIDS Reports 2011;8(1):1-3.
    • (2011) Current HIV/AIDS Reports , vol.8 , Issue.1 , pp. 1-3
    • Tenorio, A.R.1
  • 17
    • 0035173073 scopus 로고    scopus 로고
    • Potent, broad-spectrum inhibition of human immunodeficiency virus type 1 by the CCR5 monoclonal antibody PRO 140
    • Trkola A, Ketas TJ, Nagashima KA, Zhao L, Cilliers T, Morris L, et al. Potent, broad-spectrum inhibition of human immunodeficiency virus type 1 by the CCR5 monoclonal antibody PRO 140. Journal of Virology 2001;75(2):579-88.
    • (2001) Journal of Virology , vol.75 , Issue.2 , pp. 579-588
    • Trkola, A.1    Ketas, T.J.2    Nagashima, K.A.3    Zhao, L.4    Cilliers, T.5    Morris, L.6
  • 18
    • 85041835448 scopus 로고    scopus 로고
    • A trial of observed long-acting, anti-HIV treatment with a monoclonal CCR5 antibody (PRO 140) as an adjunct to a new, optimized, oral antiretroviral regimen in HIV-infected injection drug users with viral rebound and documented poor adherence
    • NCT01272258clinicaltrials.gov/show accessed 23 July 2014
    • NCT01272258. A trial of observed long-acting, anti-HIV treatment with a monoclonal CCR5 antibody (PRO 140) as an adjunct to a new, optimized, oral antiretroviral regimen in HIV-infected injection drug users with viral rebound and documented poor adherence. clinicaltrials.gov/show (http://www.clinicaltrials.gov/ct2/show/NCT01272258?term=NCT01272258&rank=1) accessed 23 July 2014.
  • 19
    • 85041844506 scopus 로고    scopus 로고
    • PRO 140
    • accessed 23 July 2014
    • AIDS info. PRO 140. http://www.aidsinfo.nih.gov/accessed 23 July 2014.
  • 20
    • 34249711352 scopus 로고    scopus 로고
    • Access denied? The status of co-receptor inhibition to counter HIV entry
    • Biswas P, Tambussi G, Lazzarin A. Access denied? The status of co-receptor inhibition to counter HIV entry. Expert Opinion on Pharmacotherapy 2007;8(7):923-33.
    • (2007) Expert Opinion on Pharmacotherapy , vol.8 , Issue.7 , pp. 923-933
    • Biswas, P.1    Tambussi, G.2    Lazzarin, A.3
  • 21
    • 84872417999 scopus 로고    scopus 로고
    • Cochrane Handbook for Systematic Reviews of Interventions Version 5.1 [updated March 2011]. The Cochrane Collaboration, 2011
    • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
    • Higgins, J.P.T.1    Green, S.2
  • 22
    • 0038143907 scopus 로고    scopus 로고
    • Determining the relative efficacy of Tenofovir DF using frequent measurements of HIV-1 RNA during a short course of monotherapy in antiretroviral drug naive individuals
    • 9th Conference on Retroviruses and Opportunistic Infections. Seattle
    • Louie M, Hogan C, Hurley A, Captan B, Flaherty J, Lamy P, et al. Determining the relative efficacy of Tenofovir DF using frequent measurements of HIV-1 RNA during a short course of monotherapy in antiretroviral drug naive individuals. 9th Conference on Retroviruses and Opportunistic Infections. Seattle, 2002.
    • (2002)
    • Louie, M.1    Hogan, C.2    Hurley, A.3    Captan, B.4    Flaherty, J.5    Lamy, P.6
  • 23
    • 0032576426 scopus 로고    scopus 로고
    • Changing patterns of mortality across Europe in patients infected with HIV-1
    • Mocroft A, Vella S, Benfield TL, Chiesi A, Miller V, Gargalianos P, et al. EuroSIDA Study Group. Changing patterns of mortality across Europe in patients infected with HIV-1. Lancet 1998;352(9142):1725-30.
    • (1998) Lancet , vol.352 , Issue.9142 , pp. 1725-1730
    • Mocroft, A.1    Vella, S.2    Benfield, T.L.3    Chiesi, A.4    Miller, V.5    Gargalianos, P.6
  • 24
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators
    • Palella FJ Jr, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. New England Journal of Medicine 1998;338(13):853-60.
    • (1998) New England Journal of Medicine , vol.338 , Issue.13 , pp. 853-860
    • Palella, F.J.1    Delaney, K.M.2    Moorman, A.C.3    Loveless, M.O.4    Fuhrer, J.5    Satten, G.A.6
  • 25
    • 10644291830 scopus 로고    scopus 로고
    • Effectiveness of generic fixed-dose combinations of highly active antiretroviral therapy for treatment of HIV infection in India
    • Pujari SN, Patel AK, Naik E, Patel KK, Dravid A, Patel JK, et al. Effectiveness of generic fixed-dose combinations of highly active antiretroviral therapy for treatment of HIV infection in India. Journal of Acquired Immune Deficiency Syndromes 2004;37(5):1566-9.
    • (2004) Journal of Acquired Immune Deficiency Syndromes , vol.37 , Issue.5 , pp. 1566-1569
    • Pujari, S.N.1    Patel, A.K.2    Naik, E.3    Patel, K.K.4    Dravid, A.5    Patel, J.K.6
  • 26
    • 79960705415 scopus 로고    scopus 로고
    • Review Manager (RevMan)
    • 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration
    • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
    • (2012)
  • 27
    • 85041801732 scopus 로고    scopus 로고
    • Progenics Pharmaceuticals' HIV drug, PRO 140, receives FDA fast-track designation
    • (accessed 18 June 2009)
    • Richard WK. Progenics Pharmaceuticals' HIV drug, PRO 140, receives FDA fast-track designation. www.natap.org/2006/HIV/022406_02.htm (accessed 18 June 2009).
    • Richard, W.K.1
  • 28
    • 70349636040 scopus 로고    scopus 로고
    • High rates of regimen change due to drug toxicity among a cohort of South Indian adults with HIV infection initiated on generic, first-line antiretroviral treatment
    • Sivadasan A, Abraham OC, Rupali P, Pulimood SA, Rajan J, Rajkumar S, et al. High rates of regimen change due to drug toxicity among a cohort of South Indian adults with HIV infection initiated on generic, first-line antiretroviral treatment. Journal of the Association of Physicians of India 2009;57:384-8.
    • (2009) Journal of the Association of Physicians of India , vol.57 , pp. 384-388
    • Sivadasan, A.1    Abraham, O.C.2    Rupali, P.3    Pulimood, S.A.4    Rajan, J.5    Rajkumar, S.6
  • 29
    • 77950323966 scopus 로고    scopus 로고
    • 09 AIDS epidemic update
    • (accessed 18 November 2009)
    • UNAIDS 2009. 09 AIDS epidemic update. www.search.unaids.org/search.asp?lg=en&search=09%20AIDS%20epidemic%20update (accessed 18 November 2009).
    • (2009)
  • 30
    • 84891344260 scopus 로고    scopus 로고
    • UNAIDS report on the global AIDS epidemic 2013
    • accessed 23 July 2014
    • UNAIDS 2013. UNAIDS report on the global AIDS epidemic 2013. http://www.unaids.org/en/media/unaids/contentassets/documents/epidemiology/2013/gr2013/UNAIDS_Global_Report_2013_en.pdf accessed 23 July 2014.
    • (2013)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.