A chemically sulfated polysaccharide derived from Ganoderma lucidum induces mitochondrial-mediated apoptosis in human osteosarcoma MG63 cells

Tumor Biology

Volumn 35, Issue 10, 2014, Pages 9919-9926

  Sun, Zhenchang ^a   Huang, Kai ^a   Fu, Xiaorui ^a   Zhou, Zhiyuan ^a   Cui, Yingying ^a   Li, Haopeng ^b  

^a THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Anticancer; Ganoderma lucidum; Sulfated polysaccharide

Indexed keywords

ANTINEOPLASTIC AGENT; FUNGAL POLYSACCHARIDE;

APOPTOSIS; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECTS; DRUG SCREENING; FLOW CYTOMETRY; GANODERMA LUCIDUM; HUMAN; METABOLISM; OSTEOSARCOMA; TUMOR CELL LINE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; FLOW CYTOMETRY; FUNGAL POLYSACCHARIDES; HUMANS; OSTEOSARCOMA; REISHI;

EID: 84922392307     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1007/s13277-014-2217-1     Document Type: Article

References (39)

1. Cheng JJ, Huang NK, Lur HS, Kuo CL, Lu MK. Characterization and biological functions of sulfated polysaccharides from sulfated-salt treatment of Antrodia cinnamomea. Process Biochem. 2009;44:453–9.
2. Gern RM, Wisbeck E, Rampinelli JR, Ninow JL, Furlan SA. Alternative medium for production of Pleurotus ostreatus biomass and potential antitumor polysaccharides. Bioresour Technol. 2008;99:76–82.
3. Guo S, Mao W, Han Y, Zhang X, Yang C, Chen Y, et al. Structural characteristics and antioxidant activities of the extracellular polysaccharides produced by marine bacterium Edwardsiella tarda. Bioresour Technol. 2010;101:4729–32.
4. Sun Y, Liang H, Zhang X, Tong H, Liu J. Structural elucidation and immunological activity of a polysaccharide from the fruiting body of Armillaria mellea. Bioresour Technol. 2009;100:1860–3.
5. Yang XB, Gao XD, Han F, Tan RX. Sulfation of a polysaccharide produced by a marine filamentous fungus Phoma herbarum YS4108 alters its antioxidant properties in vitro. Biochim Biophys Acta. 2005;1725:120–7.
6. Barahona T, Encinas MV, Mansilla A, Matsuhiro B, Zúñiga EA. A sulfated galactan with antioxidant capacity from the green variant of tetrasporic Gigartina skottsbergii (Gigartinales, Rhodophyta). Carbohydr Res. 2012;347:114–20.
7. Nie X, Shi B, Ding Y, Tao W. Preparation of a chemically sulfated polysaccharide derived from Grifola frondosa and its potential biological activities. Int J Biol Macromol. 2006;39:228–33.
8. Alban S, Franz G. Characterization of the anticoagulant actions of a semisynthetic curdlan sulfate. Thromb Res. 2000;99:377–88.
9. Soeda S, Ohmagari Y, Shimeno H, Nagamatsu A. Preparation of oversulfated fucoidan fragments and evaluation of their antithrombotic activities. Thromb Res. 1993;72:247–56.
10. Bandyopadhyay SS, Navid MH, Ghosh T, Schnitzler P, Ray B. Structural features and in vitro antiviral activities of sulfated polysaccharides from Sphacelaria indica. Phytochemistry. 2011;72:276–83.
11. Ghosh T, Chattopadhyay K, Marschall M, Karmakar P, Mandal P, Ray B. Focus on antivirally active sulfated polysaccharides: from structure–activity analysis to clinical evaluation. Glycobiology. 2009;19:2–15.
12. Chen T, Li B, Li YY, Zhao CD, Shen JM, Zhang HX. Catalytic synthesis and antitumor activities of sulfated polysaccharide from Gynostemma pentaphyllum Makino. Carbohydr Polym. 2011;83:554–60.
13. Wang X, Zhang L. Physicochemical properties and antitumor activities for sulfated derivatives of lentinan. Carbohydr Res. 2009;344:2209–16.
14. Wang Y, Peng Y, Wei X, Yang Z, Xiao J, Jin Z. Sulfation of tea polysaccharides: Synthesis, characterization and hypoglycemic activity. Int J Biol Macromol. 2010;46:270–4.
15. Vogl H, Paper DH, Franz G. Sulfation of Chinese lacquer polysaccharides in different solvents. Carbohydr Polym. 2000;41:185–90.
16. Alban S, Franz G. Gas-liquid chromatography-mass spectrometry analysis of anticoagulant active curdlan sulfates. Semin Thromb Hemost. 1994;20:152–8.
17. Zhang M, Zhang L, Wang Y, Cheung PC. Chain conformation of sulfated derivatives of beta-glucan from sclerotia of Pleurotus tuber-regium. Carbohydr Res. 2003;338:2863–70.
18. Wang L, Huang H, Wei Y, Li X, Chen Z. Characterization and anti-tumor activities of sulfated polysaccharide SRBPS2a obtained from defatted rice bran. Int J Biol Macromol. 2009;45:427–31.
19. Wei D, Wei Y, Cheng W, Zhang L. Sulfated modification, characterization and antitumor activities of Radix hedysari polysaccharide. Int J Biol Macromol. 2012;51:471–6.
20. Lin ZB. Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum. J Pharmacol Sci. 2005;99:144–53.
21. Wang YY, Khoo KH, Chen ST, Lin CC, Wong CH, Lin CH. Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities. Bioorg Med Chem. 2002;10:1057–62.
22. Zhang J, Tang Q, Zhou C, Jia W, Da Silva L, Nguyen LD, et al. GLIS, a bioactive proteoglycan fraction from Ganoderma lucidum, displays anti-tumour activity by increasing both humoral and cellular immune response. Life Sci. 2010;87:628–37.
23. Zhang J, Liu YJ, Park HS, Mia YM, Kim GS. Antitumor activity of sulfated extracellular polysaccharides of Ganoderma lucidum from the submerged fermentation broth. Carbohydr Polym. 2012;87:1539–44.
24. Wang J, Zhang L, Yu Y, Cheung PC. Enhancement of antitumor activities in sulfated and carboxymethylated polysaccharides of Ganoderma lucidum. J Agric Food Chem. 2009;57:10565–72.
25. Ye LB, Zhang JS, Zhou S, Wang S, Wu D, Pan YJ. Preparation of a novel sulfated glycopeptide complex and inhibiting L1210 cell lines property in vitro. Carbohydr Polym. 2009;77:276–9.
26. Liu Y, Wang F. Structural characterization of an active polysaccharide from Phellinus ribis. Carbohydr Polym. 2007;70:386–92.
27. Lu Y, Wang D, Hu Y, Huang X, Wang J. Sulfated modification of epimedium polysaccharide and effects of the modifiers on cellular infectivity of IBDV. Carbohydr Polym. 2008;71:180–6.
28. Miao S, Mao X, Pei R, Miao S, Xiang C, Lv Y, et al. Lepista sordida polysaccharide induces apoptosis of Hep-2 cancer cells via mitochondrial pathway. Int J Biol Macromol. 2013;61:97–101.
29. Wu J, Zhou J, Lang Y, Yao L, Xu H, Shi H, et al. A polysaccharide from Armillaria mellea exhibits strong in vitro anticancer activity via apoptosis-involved mechanisms. Int J Biol Macromol. 2012;51:663–7.
30. Walker JM. The bicinchoninic acid (BCA) assay for protein quantitation. Methods Mol Biol. 1994;32:5–8.
31. Pastorino JG, Tafani M, Farber JL. Tumor necrosis factor induces phosphorylation and translocation of BAD through a phosphatidylinositide-3-OH kinase-dependent pathway. J Biol Chem. 1999;274:19411–6.
32. Yang HL, Chen CS, Chang WH, Lu FJ, Lai YC, Chen CC, et al. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata. Cancer Lett. 2006;231:215–27.
33. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, et al. Molecular characterization of mitochondrial apoptosis-inducing factors. Nature. 1999;397:441–6.
34. Hengartner MO. The biochemistry of apoptosis. Nature. 2000;407:770–6.
35. Liu X, Kim CN, Yang J, Jemmerson R, Wang X. Induction of apoptotic program in cell free extracts: requirement for dATP and cytochrome c. Cell. 1996;86:147–57.
36. Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281:1309–12.
37. Thornberry NA, Lazebnik Y. Caspases: enemies within. Science. 1998;281:1312–6.
38. Wolf BB, Green DR. Suicidal tendencies: apoptotic cell death by caspase family proteinases. J Biol Chem. 1999;274:20049–52.
39. Yu HY, Jin CY, Kim KS, Lee YC, Park SH, Kim GY, et al. Oleifolioside A mediates caspase-independent human cervical carcinoma HeLa cell apoptosis involving nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. J Agric Food Chem. 2012;60:5400–6.