Pepsin in saliva for the diagnosis of gastro-oesophageal reflux disease

Gut

Volumn 64, Issue 3, 2015, Pages 373-380

  Hayat, Jamal O ^a,b   Gabieta Somnez, Shirley ^a   Yazaki, Etsuro ^a   Kang, Jin Yong ^b   Woodcock, Andrew ^c   Dettmar, Peter ^c   Mabary, Jerry ^d   Knowles, Charles H ^a   Sifrim, Daniel ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^c RD Biomed Limited   (United Kingdom)

^d Sandhill Scientific Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPSIN A;

ADULT; AGED; ARTICLE; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; CORRELATIONAL STUDY; DIAGNOSTIC TEST; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DOUBLE BLIND PROCEDURE; DOWN REGULATION; ESOPHAGEAL PH MONITORING; ESOPHAGUS DISEASE; ESOPHAGUS PH; FEMALE; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMAN; HYPERTENSIVE ESOPHAGUS; IMPEDANCE; INCREASED ACID EXPOSURE TIME; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PROTEIN ANALYSIS; QUESTIONNAIRE; REFERENCE VALUE; REFLUX DISEASE QUESTIONNAIRE; SALIVA LEVEL; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; SYMPTOM ASSOCIATION PROBABILITY; SYMPTOMATOLOGY; UPREGULATION; CASE CONTROL STUDY; CHEMISTRY; EATING; MIDDLE AGED; SALIVA; YOUNG ADULT;

ADULT; CASE-CONTROL STUDIES; EATING; FEMALE; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMANS; MALE; MIDDLE AGED; PEPSIN A; REFERENCE VALUES; SALIVA; SENSITIVITY AND SPECIFICITY; SURVEYS AND QUESTIONNAIRES; YOUNG ADULT;

EID: 84922386502     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2014-307049     Document Type: Article

References (35)

1. Numans ME, Lau J, de Wit NJ, et al. Short-term treatment with proton-pump inhibitors as a test for gastroesophageal reflux disease: a meta-analysis of diagnostic test characteristics. Ann Intern Med 2004; 140:518-27.
2. Bytzer P, Jones R, Vakil N., et al. Limited ability of the proton-pump inhibitor test to identify patients with gastroesophageal reflux disease. Clin Gastroenterol Hepatol 2012; 10:1360-6.
3. Vakil NB, Halling K, Becher A., et al. Systematic review of patient-reported outcome instruments for gastroesophageal reflux disease symptoms. Eur J Gastroenterol Hepatol 2013; 25:2-14.
4. Dent J, Vakil N, Jones R., et al. Accuracy of the diagnosis of GORD by questionnaire, physicians and a trial of proton pump inhibitor treatment: the diamond study. Gut 2010; 59:714-21.
5. Savarino E, Zentilin P, Mastracci L., et al. Microscopic esophagitis distinguishes patients with non-erosive reflux disease from those with functional heartburn. J Gastroenterol 2013; 48:473-82.
6. Vaezi MF, Schroeder PL, Richter JE. Reproducibility of proximal probe pH parameters in 24-hour ambulatory esophageal pH monitoring. Am J Gastroenterol 1997; 92:825-9.
7. Kahrilas PJ, Quigley EM. Clinical esophageal pH recording: a technical review for practice guideline development. Gastroenterology 1996; 110:1982-96.
8. Mainie I, Tutuian R, Shay S., et al. Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring. Gut 2006; 55:1398-402.
9. Bredenoord AJ, Weusten BL, Timmer R, et al. Addition of esophageal impedance monitoring to pH monitoring increases the yield of symptom association analysis in patients off PPI therapy. Am J Gastroenterol 2006; 101:453-9.
10. Zerbib F, Roman S, Ropert A., et al. Esophageal pH-impedance monitoring and symptom analysis in GERD: a study in patients off and on therapy. Am J Gastroenterol 2006; 101:1956-63.
11. Farhath S, He Z, Nakhla T., et al. Pepsin, a marker of gastric contents, is increased in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia. Pediatrics 2008; 121:e253-9.
12. Stovold R, Forrest IA, Corris P.A., et al. Pepsin, a biomarker of gastric aspiration in lung allografts: a putative association with rejection. Am J Respir Crit Care Med 2007; 175:1298-303.
13. Crapko M, Kerschner JE, Syring M, et al. Role of extra-esophageal reflux in chronic otitis media with effusion. Laryngoscope 2007; 117:1419-23.
14. Knight J, Lively MO, Johnston N, et al. Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux. Laryngoscope 2005; 115:1473-8.
15. Yates DH, Krishnan A, Chow S., et al. Non-invasive assessment of exhaled biomarkers in lung transplantation. J Breath Res 2011; 5:024001, 7155/5/2/024001.
16. Kim TH, Lee KJ, Yeo M, et al. Pepsin detection in the sputum/saliva for the diagnosis of gastroesophageal reflux disease in patients with clinically suspected atypical gastroesophageal reflux disease symptoms. Digestion 2008; 77:201-6.
17. Grabowski M, Kasran A, Seys S., et al. Pepsin and bile acids in induced sputum of chronic cough patients. Respir Med 2011; 105:1257-61.
18. Potluri S, Friedenberg F, Parkman H.P., et al. Comparison of a salivary/sputum pepsin assay with 24-hour esophageal pH monitoring for detection of gastric reflux into the proximal esophagus, oropharynx, and lung. Dig Dis Sci 2003; 48:1813-17.
19. Wang L, Liu X, Liu Y.L., et al. Correlation of pepsin-measured laryngopharyngeal reflux disease with symptoms and signs. Otolaryngol Head Neck Surg 2010; 143:765-71.
20. Ward C, Forrest IA, Brownlee I.A., et al. Pepsin like activity in bronchoalveolar lavage fluid is suggestive of gastric aspiration in lung allografts. Thorax 2005; 60:872-4.
21. McNally P, Ervine E, Shields M.D., et al. High concentrations of pepsin in bronchoalveolar lavage fluid from children with cystic fibrosis are associated with high interleukin-8 concentrations. Thorax 2011; 66:140-3.
22. Starosta V, Kitz R, Hartl D., et al. Bronchoalveolar pepsin, bile acids, oxidation, and inflammation in children with gastroesophageal reflux disease. Chest 2007; 132:1557-64.
23. Krishnan U, Mitchell JD, Messina I, et al. Assay of tracheal pepsin as a marker of reflux aspiration. J Pediatr Gastroenterol Nutr 2002; 35:303-8.
24. Saritas Yuksel E, Hong SK, Strugala V, et al. Rapid salivary pepsin test: Blinded assessment of test performance in gastroesophageal reflux disease. Laryngoscope 2012; 122:1312-16.
25. Shaw MJ, Talley NJ, Beebe T.J., et al. Initial validation of a diagnostic questionnaire for gastroesophageal reflux disease. Am J Gastroenterol 2001; 96:52-7.
26. Sifrim D, Castell D, Dent J., et al. Gastro-oesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non-acid, and gas reflux. Gut 2004; 53:1024-31.
27. Weusten BL, Roelofs JM, Akkermans L.M., et al. The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data. Gastroenterology 1994; 107:1741-5.
28. Shay S, Tutuian R, Sifrim D., et al. Twenty-four hour ambulatory simultaneous impedance and pH monitoring: a multicenter report of normal values from 60 healthy volunteers. Am J Gastroenterol 2004; 99:1037-43.
29. Drossman DA. The functional gastrointestinal disorders and the rome III process. Gastroenterology 2006; 130:1377-90.
30. Savarino E, Zentilin P, Mastracci L., et al. Light microscopy is useful to better define NERD and functional heartburn. Gut 2014; 63:368, 2013-305955.
31. de Bortoli N, Savarino E, Furnari M., et al. 657 use of a non-invasive pepsin diagnostic test to detect GERD: correlation with MII-pH evaluation in a series of suspected NERD patients. A pilot study. Gastroenterology 2013; 144: S-118.
32. Emerenziani S, Cicala M, Zhang X., et al. Effect of oesophagitis on proximal extent of gastro-oesophageal reflux. Neurogastroenterol Motil 2007; 19:459-64.
33. Fiorucci S, Distrutti E, Di Matteo F, et al. Circadian variations in gastric acid and pepsin secretion and intragastric bile acid in patients with reflux esophagitis and in healthy controls. Am J Gastroenterol 1995; 90:270-6.
34. Elabiad MT, Zhang J. Detection of pepsinogen in the neonatal lung and stomach by immunohistochemistry. J Pediatr Gastroenterol Nutr 2011; 53:401-3.
35. Vakil N. The initial diagnosis of GERD. Best Pract Res Clin Gastroenterol 2013; 27:365-71.