Caspase-3 deficiency results in disrupted synaptic homeostasis and impaired attention control

Journal of Neuroscience

Volumn 35, Issue 5, 2015, Pages 2118-2132

  Lo, Shih Ching ^a   Wang, Yuanyuan ^a   Weber, Martin ^a   Larson, Jessica L ^b   Scearce Levie, Kimberly ^a   Sheng, Morgan ^a  

^a Departments of Neuroscience   (United States)

^b GENENTECH INC   (United States)

Author keywords

ADHD; Attention control; Caspase 3; Homeostatic synaptic plasticity; LTD; Novelty habituation

Indexed keywords

ACTIN; AMPA RECEPTOR; CASPASE 3; GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 2; GLUTAMATE RECEPTOR 5; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IONOTROPIC RECEPTOR; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN FOS; PROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATTENTION DEFICIT DISORDER; ATTENTIONAL SET SHIFT TASK; COGNITION; CONTROLLED STUDY; DENTATE GYRUS; DISTRACTIBILITY; EYELID REFLEX; FEAR; FEMALE; HABITUATION; HIPPOCAMPAL NEURONAL CULTURE; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; IMPULSIVENESS; LOCOMOTION; MALE; MORRIS WATER MAZE TEST; MOUSE; NERVE CELL PLASTICITY; NEUROMODULATION; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; RIGIDITY; ROTAROD TEST; SPATIAL LEARNING; TAIL SUSPENSION TEST; TRAINING; VISUAL DISCRIMINATION LEARNING TEST; WESTERN BLOTTING; WHOLE CELL PATCH CLAMP; ANIMAL; ATTENTION; C57BL MOUSE; DEFICIENCY; GENE DELETION; GENETICS; MAZE TEST; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SYNAPSE;

ANIMALS; ATTENTION; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CASPASE 3; DENTATE GYRUS; GENE DELETION; HOMEOSTASIS; MAZE LEARNING; MICE; MICE, INBRED C57BL; NEURONAL PLASTICITY; SYNAPSES;

EID: 84922375265     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3280-14.2015     Document Type: Article

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