Placental PAGs: Gene origins, expression patterns, and use as markers of pregnancy

Reproduction

Volumn 149, Issue 3, 2015, Pages R115-R126

  Wallace, Rhianna M ^a   Pohler, Ky G ^a   Smith, Michael F ^a   Green, Jonathan A ^a  

^a UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLACENTA PROTEIN; PREGNANCY ASSOCIATED PROTEIN; GLYCOPROTEIN;

GENE EXPRESSION; GENE FUNCTION; GENETIC MARKER; LIVESTOCK; MATERNAL BLOOD; NONHUMAN; PLACENTA; PLACENTA FUNCTION; PREGNANCY; PRIORITY JOURNAL; REVIEW; UTERUS; ANIMAL; ARTIODACTYLA; FEMALE; GENETICS; METABOLISM;

ARTIODACTYLA; BOVIDAE; CETARTIODACTYLA;

ANIMALS; ARTIODACTYLA; FEMALE; GENE EXPRESSION; GLYCOPROTEINS; PLACENTA; PREGNANCY; PREGNANCY PROTEINS;

EID: 84922371149     PISSN: 14701626     EISSN: 17417899     Source Type: Journal    
DOI: 10.1530/REP-14-0485     Document Type: Review

References (102)

1. Austin KJ, King CP, Vierk J.E., Sasser RG & Hansen TR 1999 Pregnancy-specific protein B induces release of an alpha chemokine in bovine endometrium. Endocrinology 140 542-545. (doi:10.1210/endo.140.1.6608)
2. Barbato O, Sousa NM, Klisch K, Clerget E., Debenedetti A, Barile VL, Malfatti A & Beckers JF 2008 Isolation of new pregnancy-associated glycoproteins from water buffalo (Bubalus bubalis) placenta by Vicia villosa affinity chromatography. Research in Veterinary Science 85 457-466. (doi:10.1016/j.rvsc.2008.01.004)
3. Bériot M, Tchimbou AF, Barbato O, Beckers J-F & de Sousa NM 2014 Identification of pregnancy-associated glycoproteins and α-fetoprotein in fallow deer (Dama dama) placenta. Acta Veterinaria Scandinavica 56 4. (doi:10.1186/1751-0147-56-4)
4. Brandt GA, Parks TE, Killian G, Ealy AD & Green JA 2007 A cloning and expression analysis of pregnancy-associated glycoproteins expressed in trophoblasts of the white-tail deer placenta. Molecular Reproduction and Development 74 1355-1362. (doi:10.1002/mrd.20669)
5. Breukelman SP, Perényi Z, Taverne M.A., Jonker H., van der Weijden GC, Vos PL, de Ruigh L, Dieleman SJ, Beckers JF & Szenci O 2012 Characterisation of pregnancy losses after embryo transfer by measuring plasma progesterone and bovine pregnancy-associated glycoprotein-1 concentrations. Veterinary Journal 194 71-76. (doi:10.1016/j.tvjl.2012. 02.020)
6. Butler JE, Hamilton WC, Sasser R.G., Ruder CA, Hass GM & Williams RJ 1982 Detection and partial characterization of two bovine pregnancy-specific proteins. Biology of Reproduction 26 925-933. (doi:10.1095/biolreprod26.5.925)
7. Chavatte-Palmer P, de Sousa N, Laigre P, Camous S., Ponter AA, Beckers JF & Heyman Y 2006 Ultrasound fetal measurements and pregnancy associated glycoprotein secretion in early pregnancy in cattle recipients carrying somatic clones. Theriogenology 66 829-840. (doi:10.1016/j. theriogenology.2006.01.061)
8. Constant F, Camous S, Chavatte-Palmer P, Heyman Y., de Sousa N, Richard C, Beckers JF & Guillomot M 2011 Altered secretion of pregnancy-associated glycoproteins during gestation in bovine somatic clones. Theriogenology 76 1006-1021. (doi:10.1016/j.theriogenology.2011.04.029)
9. Cordoba MC, Sartori R & Fricke PM 2001 Assessment of a commercially available early conception factor (ECF) test for determining pregnancy status of dairy cattle. Journal of Dairy Science 84 1884-1889. (doi:10.3168/jds.S0022-0302(01)74629-2)
10. Davies DR 1990 The structure and function of the aspartic proteinases. Annual Review of Biophysics and Biophysical Chemistry 19 189-215. (doi:10.1146/annurev.bb.19.060190.001201)
11. Del Vecchio RP, Sasser RG & Randel RD 1990 Effect of pregnancy-specific protein B on prostaglandin F2α and prostaglandin E2 release by day 16-perifused bovine endometrial tissue. Prostaglandins 40 271-282. (doi:10.1016/0090-6980(90)90015-N)
12. Del Vecchio RP, Sutherland WD & Sasser RG 1995 Effect of pregnancy-specific protein B on luteal cell progesterone, prostaglandin, and oxytocin production during two stages of the bovine estrous cycle. Journal of Animal Science 73 2662-2668.
13. Del Vecchio RP, Sutherland WD & Sasser RG 1996 Bovine luteal cell production in vitro of prostaglandin E2, oxytocin and progesterone in response to pregnancy-specific protein B and prostaglandin F2α. Journal of Reproduction and Fertility 107 131-136. (doi:10.1530/jrf.0.1070131)
14. Duello TM, Byatt JC & Bremel RD 1986 Immunohistochemical localization of placental lactogen in binucleate cells of bovine placentomes. Endocrinology 119 1351-1355. (doi:10.1210/endo-119-3-1351)
15. Dunbar MM, Wong TS, Ruder-Montgomery CA, Chew CA & Sasser RG 1990 Partial characterization of the immunosuppressive properties of pregnancy-specific protein B (PSPB). Theriogenology 33 (Suppl 1) 220. (doi:10.1016/0093-691X(90)90644-9)
16. Dunn BM 2002 Structure and mechanism of the pepsin-like family of aspartic peptidases. Chemical Reviews 102 4431-4458. (doi:10.1021/cr010167q)
17. Echternkamp SE, Vonnahme KA, Green JA & Ford SP 2006 Increased vascular endothelial growth factor and pregnancy-associated glyco-proteins, but not insulin-like growth factor-I, in maternal blood of cows gestating twin fetuses. Journal of Animal Science 84 2057-2064. (doi:10. 2527/jas.2005-714)
18. Egen TE, Ealy AD, Landon L.A., Roberts RM & Green JA 2009 Autoimmunization of ewes against pregnancy-associated glycoproteins does not interfere with the establishment and maintenance of pregnancy. Animal 3 850-857. (doi:10.1017/S1751731109004145)
19. Faria TN, Deb S, Kwok S.C., Talamantes F & Soares MJ 1990 Ontogeny of placental lactogen-I and placental lactogen-II expression in the developing rat placenta. Developmental Biology 141 279-291. (doi:10.1016/0012-1606(90)90384-U)
20. Fu Q, Cheng J, Gao Y., Zhang Y, Chen X & Xie J 2015 Protease-activated receptor 4: a critical participator in inflammatory response. Inflammation. In press. (doi:10.1007/s10753-014-9999-6)
21. Garbayo JM, Green JA, Mannekin M, Beckers J-F, Kiesling DO, Ealy AD & Roberts RM 2000 Caprine pregnancy-associated glycoproteins (PAG): their cloning, expression and evolutionary relationship to other PAG. Molecular Reproduction and Development 57 311-322. (doi:10.1002/1098-2795(200012)57:4!311::AID-MRD2O3.0.CO;2-F)
22. Ghaffari Laleh V, Ghaffari Laleh R, Pirany N & Moghadaszadeh Ahrabi M 2008 Measurement of EPF for detection of cow pregnancy using rosette inhibition test. Theriogenology 70 105-107. (doi:10.1016/j.theriogenology.2008.02.003)
23. Gifford CA, Racicot K, Clark D.S., Austin KJ, Hansen TR, Lucy MC, Davies CJ & Ott TL 2007 Regulation of Interferon-stimulated genes in peripheral blood leukocytes in pregnant and bred, nonpregnant dairy cows. Journal of Dairy Science 90 274-280. (doi:10.3168/jds.S0022-0302(07)72628-0)
24. Giordano JO, Guenther JN, Lopes G Jr & Fricke PM 2012 Changes in serum pregnancy-associated glycoprotein, pregnancy-specific protein B, and progesterone concentrations before and after induction of pregnancy loss in lactating dairy cows. Journal of Dairy Science 95 683-697. (doi:10.3168/jds.2011-4609)
25. Green JA, Xie S & Roberts RM 1998 Pepsin-related molecules secreted by trophoblast. Reviews of Reproduction 3 62-69. (doi:10.1530/ror.0. 0030062)
26. Green JA, Xie S, Quan X., Bao B, Gan X, Mathialagan N., Beckers J-F & Roberts RM 2000 Pregnancy-associated bovine and ovine glycoproteins exhibit spatially and temporally distinct expression patterns during pregnancy. Biology of Reproduction 62 1624-1631. (doi:10.1095/biolreprod62.6.1624)
27. Green JA, Parks TE, Avalle M.P., Telugu BP, McLain AL, Peterson AJ, McMillan W, Mathialagan N., Xie S, Hook RR et al. 2005 The establishment of an ELISA for the detection of pregnancy-associated glycoproteins (PAGs) in the serum of pregnant cows and heifers. Theriogenology 63 1481-1503. (doi:10.1016/j.theriogenology.2004.07. 011)
28. Green JC, Okamura CS, Poock SE & Lucy MC 2010 Measurement of interferon-tau (IFN-τ) stimulated gene expression in blood leukocytes for pregnancy diagnosis within 18-20d after insemination in dairy cattle. Animal Reproduction Science 121 24-33. (doi:10.1016/j.anireprosci.2010.05.010)
29. Guruprasad K, Blundell TL, Xie S, Green J., Szafranska B, Nagel RJ, McDowell K, Baker CB & Roberts RM 1996 Comparative modelling and analysis of amino acid substitutions suggests that the family of pregnancy-associated glycoproteins includes both active and inactive aspartic proteinases. Protein Engineering 9 849-856. (doi:10.1093/protein/9.10.849)
30. Hansen PJ 2013 Physiology and Endocrinology Symposium: maternal immunological adjustments to pregnancy and parturition in ruminants and possible implications for postpartum uterine health: is there a prepartum-postpartum nexus? Journal of Animal Science 91 1639-1649. (doi:10.2527/jas.2012-5934)
31. Hashizume K, Ishiwata H, Kizaki K., Yamada O, Takahashi T, Imai K., Patel O, Akagi S, Shimizu M., Takahashi S et al. 2002 Implantation and placental development in somatic cell clone recipient cows. Cloning and Stem Cells 4 197-209. (doi:10.1089/15362300260339485)
32. Heyman Y, Chavatte-Palmer P, LeBourhis D., Camous S, Vignon X & Renard J 2002 Frequency and occurrence of late-gestation losses from cattle cloned embryos. Biology of Reproduction 66 6-13. (doi:10.1095/biolreprod66.1.6)
33. Hill JR, Burghardt RC, Jones K, Long C.R., Looney CR, Shin T, Spencer TE, Thompson J.A., Winger QA & Westhusin ME 2000 Evidence for placental abnormality as the major cause of mortality in first-trimester somatic cell cloned bovine fetuses. Biology of Reproduction 63 1787-1794. (doi:10.1095/biolreprod63.6.1787)
34. Hoeben D, Burvenich C, Massart-Leen AM, Lenjou M., Nijs G, Van Bockstaele D & Beckers JF 1999 In vitro effect of ketone bodies, glucocorticosteroids and bovine pregnancy-associated glycoprotein on cultures of bone marrow progenitor cells of cows and calves. Veterinary Immunology and Immunopathology 68 229-240. (doi:10.1016/S0165-2427(99)00031-8)
35. Hoeben D, Monfardini E, Opsomer G., Burvenich C, Dosogne H, De Kruif A & Beckers JF 2000 Chemiluminescence of bovine polymorpho-nuclear leucocytes during the periparturient period and relation with metabolic markers and bovine pregnancy-associated glycoprotein. Journal of Dairy Research 67 249-259. (doi:10.1017/S00220299 00004052)
36. Hughes AL, Green JA, Garbayo JM & Roberts RM 2000 Adaptive diversification within a large family of recently duplicated, placentally-expressed genes. PNAS 97 3319-3323. (doi:10.1073/pnas. 97.7.3319)
37. Hughes AL, Green JA, Piontkivska H & Roberts RM 2003 Aspartic proteinase phylogeny and the origin of pregnancy-associated glyco-proteins. Molecular Biology and Evolution 20 1940-1945. (doi:10.1093/molbev/msg217)
38. Humblot P, Camous S, Martal J., Charlery J, Jeanguyot N, Thibier M & Sasser RG 1988 Diagnosis of pregnancy by radioimmunoassay of a pregnancy-specific protein in the plasma of dairy cows. Theriogenology 30 257-268. (doi:10.1016/0093-691X(88)90175-6)
39. Kehrli ME, Nonnecke BJ & Roth JA 1989 Alterations in bovine peripheral blood neutrophil function during the periparturient period. American Journal of Veterinary Research 50 207-214.
40. Kimura J, Sasaki M, Endo H & Fukuta K 2004 Anatomical and histological characterization of the female reproductive organs of mouse deer (Tragulidae). Placenta 25 705-711. (doi:10.1016/j.placenta.2004.02.009)
41. King GJ 1993 Comparative placentation in ungulates. Journal of Experimental Zoology 266 588-602. (doi:10.1002/jez.1402660609)
42. Kiracofe GH, Wright JM, Schalles R.R., Ruder CA, Parish S & Sasser RG 1993 Pregnancy-specific protein B in serum of postpartum beef cows. Journal of Animal Science 71 2199-2205.
43. Klisch K, Jeanrond E, Pang P-C, Pich A, Schuler G., Dantzer V, Kowalewski MP & Dell A 2008 A tetraantennary glycan with bisecting N-acetylglucosamine and the Sda antigen is the predominant N-glycan on bovine pregnancy-associated glycoproteins. Glycobiology 18 42-52. (doi:10.1093/glycob/cwm113)
44. LeBlanc SJ 2013 Short communication: Field evaluation of a pregnancy confirmation test using milk samples in dairy cows. Journal of Dairy Science 96 2345-2348. (doi:10.3168/jds.2012-6414)
45. Lee CS, Gogolin-Ewens K, White TR & Brandon MR 1985 Studies on the distribution of binucleate cells in the placenta of sheep with a monoclonal antibody SBU-3. Journal of Anatomy 140 565-576.
46. Lee RS, Peterson AJ, Donnison M.J., Ravelich S., Ledgard AM, Li N, Oliver JE, Miller A.L., Tucker FC, Breier B et al. 2004 Cloned cattle fetuses with the same nuclear genetics are more variable than contemporary half-siblings resulting from artificial insemination and exhibit fetal and placental growth deregulation even in the first trimester. Biology of Reproduction 70 1-11. (doi:10.1095/biolreprod.103.020982)
47. Liu WJ, Peltier MR & Hansen PJ 1999 Binding of ovine uterine serpin to lymphocytes. American Journal of Reproductive Immunology 41 428-432. (doi:10.1111/j.1600-0897.1999.tb00458.x)
48. Lobago F, Bekana M, Gustafsson H., Beckers JF, Yohannes G, Aster Y & Kindahl H 2009 Serum profiles of pregnancy-associated glycoprotein, oestrone sulphate and progesterone during gestation and some factors influencing the profiles in Ethiopian Borana and crossbred cattle. Reproduction in Domestic Animals 44 685-692. (doi:10.1111/j.1439-0531.2007.01049.x)
49. Low BG & Hansen PJ 1988 Immunosuppressive actions of steroids and prostaglandins secreted by the placenta and uterus of the cow and sheep. American Journal of Reproductive Immunology and Microbiology 18 71-75.
50. Majewska M, Panasiewicz G, Majewski M & Szafrańska B 2006 Localization of chorionic pregnancy-associated glycoprotein family in the pig. Reproductive Biology 6 205-230.
51. Majewska M, Panasiewicz G & Szafranska B 2011 Pregnancy-associated glycoprotein (PAG) family localized in chorionic cells within the epitheliochorial/diffuse placenta of the alpaca (Lama pacos). Acta Histochemica 113 570-577. (doi:10.1016/j.acthis.2010.06.002)
52. Mathialagan N & Hansen TR 1996 Pepsin-inhibitory activity of the uterine serpins. PNAS 93 13653-13658. (doi:10.1073/pnas.93.24.13653)
53. Melo de Sousa N, Zongo M, Pitala W, Boly H, Sawadogo L, Sanon M, Ricardo de Figueiredo J, Goncalves PBD, El Amiri B, Perenyi Z et al. 2003 Pregnancy-associated glycoprotein concentrations during pregnancy and the postpartum period in Azawak Zebu cattle. Theriogenology 59 1131-1142. (doi:10.1016/S0093-691X(02)01160-3)
54. Mercadante PM, Waters KM, Mercadante V.R., Lamb GC, Elzo MA, Johnson SE, Rae D.O., Yelich JV & Ealy AD 2013 Subspecies differences in early fetal development and plasma pregnancy-associated glyco-protein concentrations in cattle. Journal of Animal Science 91 3693-3701. (doi:10.2527/jas.2012-6130)
55. Mialon MM, Camous S, Renand G., Martal J & Menissier F 1993 Peripheral concentrations of a 60-kDa pregnancy serum protein during gestation and after calving and in relationship to embryonic mortality in cattle. Reproduction, Nutrition, Development 33 269-282. (doi:10.1051/rnd:19930309)
56. Mialon MM, Renand G, Camous S., Martal J & Menissier F 1994 Detection of pregnancy by radioimmunoassay of a pregnancy serum protein (PSP60) in cattle. Reproduction, Nutrition, Development 34 65-72. (doi:10.1051/rnd:19940107)
57. Moussad EE, Rageh MA, Wilson A.K., Geisert RD & Brigstock DR 2002 Temporal and spatial expression of connective tissue growth factor (CCN2; CTGF) and transforming growth factor beta type 1 (TGF-β1) at the utero-placental interface during early pregnancy in the pig. Journal of Clinical Pathology: Molecular Pathology 55 186-192. (doi:10.1136/mp.55.3.186)
58. Munger JS, Harpel JG, Giancotti FG & Rifkin DB 1998 Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin αvβ1. Molecular Biology of the Cell 9 2627-2638. (doi:10.1091/mbc.9.9.2627)
59. Nebel RL 1988 On-farm milk progesterone tests. Journal of Dairy Science 71 1682-1690. (doi:10.3168/jds.S0022-0302(88)79733-7)
60. Patel O, Sulon J, Beckers J., Takahashi T, Hirako M, Sasaki N & Domeki I 1997 Plasma bovine pregnancy-associated glycoprotein concentrations throughout gestation in relationship to fetal number in the cow. European Journal of Endocrinology 137 423-428. (doi:10.1530/eje.0.1370423)
61. Patel OV, Yamada O, Kizaki K., Todoroki J, Takahashi T, Imai K., Schuler LA & Hashizume K 2004a Temporospatial expression of placental lactogen and prolactin-related protein-1 genes in the bovine placenta and uterus during pregnancy. Molecular Reproduction and Development 69 146-152. (doi:10.1002/mrd.20119)
62. Patel OV, Yamada O, Kizaki K., Takahashi T, Imai K & Hashizume K 2004b Quantitative analysis throughout pregnancy of placentomal and interplacentomal expression of pregnancy-associated glycoproteins-1 and -9 in the cow. Molecular Reproduction and Development 67 257-263. (doi:10.1002/mrd.20017)
63. Peltier MR, Liu WJ & Hansen PJ 2000 Regulation of lymphocyte proliferation by uterine serpin: interleukin-2 mRNA production, CD25 expression and responsiveness to interleukin-2. Proceedings of the Society for Experimental Biology and Medicine 223 75-81. (doi:10.1046/j.1525-1373.2000.22310.x)
64. Pereira FTV, Oliveira LJ, Barreto RdSN, Mess A, Perecin F., Bressan FF, Mesquita LG, Miglino MA, Pimentel J.R., Neto PF et al. 2013 Fetal-maternal interactions in the synepitheliochorial placenta using the eGFP cloned cattle model. PLoS ONE 8 e64399. (doi:10.1371/journal.pone. 0064399)
65. Perényi ZS, Szenci O, Sulon J., Drion PV & Beckers JF 2002 Comparison of the ability of three radioimmunoassay to detect pregnancy-associated glycoproteins in bovine plasma. Reproduction in Domestic Animals 37 100-104.
66. Perry GA, Smith MF, Lucy M.C., Green JA, Parks TE, MacNeil MD, Roberts AJ & Geary TW 2005 Relationship between follicle size at insemination and pregnancy success. PNAS 102 5268-5273. (doi:10.1073/pnas.0501700102)
67. Pohler KG, Geary TW, Johnson C.L., Atkins JA, Jinks EM, Busch DC, Green J.A., MacNeil MD & Smith MF 2013 Circulating bovine pregnancy associated glycoproteins are associated with late embryonic/fetal survival but not ovulatory follicle size in suckled beef cows. Journal of Animal Science 91 4158-4167. (doi:10.2527/jas.2013-6348)
68. Rifkin DB, Mazzieri R, Munger J.S., Noguera I & Sung J 1999 Proteolytic control of growth factor availability. APMIS:S:: Acta Pathologica, Micro-biologica, et Immunologica Scandinavica 107 80-85. (doi:10.1111/j.1699-0463.1999.tb01529.x)
69. Ruder CA, Stellflug JN, Dahmen JJ & Sasser RG 1988 Detection of pregnancy in sheep by radioimmunoassay of sera for pregnancy-specific protein B. Theriogenology 29 905-912. (doi:10.1016/0093-691X (88)90227-0)
70. Saad AM, Concha C & Astrom G 1989 Alterations in neutrophil phagocytosis and lymphocyte blastogenesis in dairy cows around parturition. Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health 36 337-345. (doi:10.1111/j.1439-0450.1989. tb00612.x)
71. Sasser RG, Ruder CA, Ivani K.A., Butler JE & Hamilton WC 1986 Detection of pregnancy by radioimmunoassay of a novel pregnancy-specific protein in serum of cows and a profile of serum concentrations during gestation. Biology of Reproduction 35 936-942. (doi:10.1095/biolre-prod35.4.936)
72. Sasser RG, Crock J & Ruder-Montgomery CA 1989 Characteristics of pregnancy-specific protein B in cattle. Journal of Reproduction and Fertility. Supplement 37 109-113.
73. Silva E, Sterry RA, Kolb D, Mathialagan N., McGrath MF, Ballam JM & Fricke PM 2007 Accuracy of a pregnancy-associated glycoprotein ELISA to determine pregnancy status of lactating dairy cows twenty-seven days after timed artificial insemination. Journal of Dairy Science 90 4612-4622. (doi:10.3168/jds.2007-0276)
74. Skopets B, Liu WJ & Hansen PJ 1995 Effects of endometrial serpin-like proteins on immune responses in sheep. American Journal of Reproductive Immunology 33 86-93. (doi:10.1111/j.1600-0897.1995.tb01143.x)
75. Szafranska B, Xie S, Green J & Roberts RM 1995 Porcine pregnancy-associated glycoproteins: new members of the aspartic proteinase gene family expressed in trophectoderm. Biology of Reproduction 53 21-28. (doi:10.1095/biolreprod53.1.21)
76. Szafranska B, Miura R, Ghosh D., Ezashi T, Xie S, Roberts RM & Green JA 2001 The gene for porcine pregnancy-associated glycoprotein 2 (poPAG2): its structural organization and analysis of its promoter. Molecular Reproduction and Development 66 137-146. (doi:10.1002/mrd.1070)
77. Szafranska B, Panasiewicz G & Majewska M 2006 Biodiversity of multiple pregnancy-associated glycoprotein (PAG) family: gene cloning and chorionic protein purification in domestic and wild eutherians (Placentalia) - a review. Reproduction, Nutrition, Development 46 481-502. (doi:10.1051/rnd:2006034)
78. Szenci O, Beckers JF, Sulon J, Bevers M.M., Börzsönyi L, Fodor L, Kovács F & Taverne MA 2003 Effect of induction of late embryonic mortality on plasma profiles of pregnancy associated glycoprotein 1 in heifers. Veterinary Journal 165 307-313. (doi:10.1016/S1090-0233(02)00180-6)
79. Tamura K, Stecher G, Peterson D., Filipski A & Kumar S 2013 MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Molecular Biology and Evolution 30 2725-2729. (doi:10.1093/molbev/mst197)
80. Telugu BP & Green JA 2008 Characterization of the peptidase activity of recombinant porcine pregnancy-associated glycoprotein-2. Journal of Biochemistry 144 725-732. (doi:10.1093/jb/mvn127)
81. Telugu BP, Walker A & Green J 2009 Characterization of the bovine pregnancy-associated glycoprotein gene family - analysis of gene sequences, regulatory regions within the promoter and expression of selected genes. BMC Genomics 10 185. (doi:10.1186/1471-2164-10-185)
82. Telugu BP, Palmier MO, Van Doren SR & Green JA 2010 An examination of the proteolytic activity for bovine pregnancy-associated glycoproteins 2 and 12. Biological Chemistry 391 259-270. (doi:10.1515/bc.2010.016)
83. Touzard E, Reinaud P, Dubois O., Guyader-Joly C, Humblot P, Ponsart C & Charpigny G 2013 Specific expression patterns and cell distribution of ancient and modern PAG in bovine placenta during pregnancy. Reproduction 146 347-362. (doi:10.1530/REP-13-0143)
84. Wallace JM, Aitken RP, Cheyne MA & Humblot P 1997 Pregnancy-specific protein B and progesterone concentrations in relation to nutritional regimen, placental mass and pregnancy outcome in growing adolescent ewes carrying singleton fetuses. Journal of Reproduction and Fertility 109 53-58. (doi:10.1530/jrf.0.1090053)
85. Wathes DC & Wooding FB 1980 An electron microscopic study of implantation in the cow. American Journal of Anatomy 159 285-306. (doi:10.1002/aja.1001590305)
86. Weems YS, Lammoglia MA, Vera-Avila HR, Randel R.D., Sasser RG & Weems CW 1998a Effects of luteinizing hormone (LH), PGE2, 8-Epi-PGE1, 8-Epi-PGF2α, trichosanthin and pregnancy specific protein B (PSPB) on secretion of prostaglandin (PG) E (PGE) or F2α (PGF2α) in vitro by corpora lutea (CL) from nonpregnant and pregnant cows. Prostaglandins & Other Lipid Mediators 55 359-376. (doi:10.1016/S0090-6980(98)00030-6)
87. Weems YS, Lammoglia MA, Vera-Avila HR, Randel R.D., King C., Sasser RG & Weems CW 1998b Effect of luteinizing hormone (LH), PGE2, 8-Epi-PGE1, 8-EPI-PGE2, trichosanthin, and pregnancy specific protein B on secretion of progesterone in vitro by corpora lutea (CL) from nonpregnant and pregnant cows. Prostaglandins & Other Lipid Mediators 55 27-42. (doi:10.1016/S0090-6980(98)00003-3)
88. Weems YS, Kim L, Humphreys V., Tsuda V & Weems CW 2003 Effect of luteinizing hormone (LH), pregnancy specific protein B (PSPB), or arachidonic acid (AA) on ovine endometrium of the estrous cycle or placental secretion of prostaglandins E2 (PGE2) and F2α (PGF2α) and progesterone in vitro. Prostaglandins & Other Lipid Mediators 71 55-73. (doi:10.1016/S0090-6980(03)00004-2)
89. Whitworth KM, Spate LD, Li R, Rieke A., Sutovsky P, Green JA & Prather RS 2010 Activation method does not alter abnormal placental gene expression and development in cloned pigs. Molecular Reproduction and Development 77 1016-1030. (doi:10.1002/mrd.21235)
90. Willard ST, Petty SJ, Sasser R.G., White DL & Randel RD 1999 Pregnancy detection and the effects of age, body weight, and previous reproductive performance on pregnancy status and weaning rates of farmed fallow deer (Dama dama). Journal of Animal Science 77 32-38.
91. Wood AK, Short RE, Darling A.E., Dusek GL, Sasser RG & Ruder CA 1986 Serum assays for detecting pregnancy in mule and white-tailed deer. Journal of Wildlife Management 50 684-687. (doi:10.2307/3800981)
92. Wooding FB 1983 Frequency and localization of binucleate cells in the placentomes of ruminants. Placenta 4 527-540.
93. Wooding FB 1984 Role of binucleate cells in fetomaternal cell fusion at implantation in the sheep. American Journal of Anatomy 170 233-250. (doi:10.1002/aja.1001700208)
94. Wooding FB, Flint AP, Heap R.B., Morgan G., Buttle HL & Young IR 1986 Control of binucleate cell migration in the placenta of ruminants. Journal of Reproduction and Fertility 76 499-512. (doi:10.1530/jrf.0.0760499)
95. Wooding FB, Roberts RM & Green JA 2005 Light and electron microscope immunocytochemical studies of the distribution of pregnancy-associated glycoproteins (PAGs) throughout pregnancy in the cow: possible functional implications. Placenta 26 807-827. (doi:10.1016/j.placenta.2004.10.014)
96. Wooding FB, Kimura J, Fukuta K & Forhead AJ 2007 A light and electron microscopical study of the Tragulid (mouse deer) placenta. Placenta 28 1039-1048. (doi:10.1016/j.placenta.2007.04.010)
97. Xie SC, Low BG, Nagel R.J., Kramer KK, Anthony RV, Zoli AP, Beckers JF & Roberts RM 1991 Identification of the major pregnancy-specific antigens of cattle and sheep as inactive members of the aspartic proteinase family. PNAS 88 10247-10251. (doi:10.1073/pnas.88.22.10247)
98. Xie S, Green J, Bixby J.B., Szafranska B., DeMartini JC, Hecht S & Roberts RM 1997 The diversity and evolutionary relationships of the pregnancy-associated glycoproteins, an aspartic proteinase subfamily consisting of many trophoblast-expressed genes. PNAS 94 12809-12816. (doi:10.1073/pnas.94.24.12809)
99. Yoshimura M, Ihara Y, Ohnishi A., Ijuhin N, Nishiura T, Kanakura Y., Matsuzawa Y & Taniguchi N 1996 Bisecting N-acetylglucosamine on K562 cells suppresses natural killer cytotoxicity and promotes spleen colonization. Cancer Research 56 412-418.
100. Zhao P, Metcalf M & Bunnett NW 2014 Biased signaling of protease-activated receptors. Frontiers in Endocrinology 5 67. (doi:10.3389/fendo.2014.00067)
101. Zoli AP, Beckers JF, Wouters-Ballman P, Closset J., Falmagne P & Ectors F 1991 Purification and characterization of a bovine pregnancy-associated glycoprotein. Biology of Reproduction 45 1-10. (doi:10.1095/biolre-prod45.1.1)
102. Zoli AP, Guilbault LA, Delahaut P, Ortiz WB & Beckers JF 1992 Radioimmunoassay of a bovine pregnancy-associated glycoprotein in serum: its application for pregnancy diagnosis. Biology of Reproduction 46 83-92. (doi:10.1095/biolreprod46.1.83)