Aryl organophosphate flame retardants induced cardiotoxicity during zebrafish embryogenesis: By disturbing expression of the transcriptional regulators

Aquatic Toxicology

Volumn 161, Issue , 2015, Pages 25-32

  Du, Zhongkun ^a   Wang, Guowei ^a   Gao, Shixiang ^a   Wang, Zunyao ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Cardiotoxicity; Developmental toxicity; OPFRs; Transcriptional regulators; Zebrafish embryo

Indexed keywords

ALKYL ORGANOPHOSPHATE DERIVATIVE; ARYL ORGANOPHOSPHATE DERIVATIVE; BONE MORPHOGENETIC PROTEIN 4; CRESYL DIPHENYL PHOSPHATE; FLAME RETARDANT; ORGANOPHOSPHATE; TRANSCRIPTION FACTOR NKX2.2; TRANSCRIPTION FACTOR NKX2.5; TRANSCRIPTION FACTOR TBX5; TRIBUTYL PHOSPHATE; TRIETHYL PHOSPHATE; TRIPHENYL PHOSPHATE; TRIS (1,3 DICHLORO 2 PROPYL) PHOSPHATE; TRIS (2 BUTOXYETHYL) PHOSPHATE; TRIS (2 CHLOROETHYL) PHOSPHATE; TRIS (2 CHLOROPROPYL)PHOSPHATE; UNCLASSIFIED DRUG; WATER POLLUTANT;

BIOACCUMULATION; DEVELOPMENTAL BIOLOGY; EMBRYO; ENVIRONMENTAL RISK; FISH; GENE EXPRESSION; HEALTH RISK; ORGANOPHOSPHATE; TOXICITY;

ACUTE TOXICITY; ADULT; ANIMAL TISSUE; ARTICLE; BMP4 GENE; BRADYCARDIA; CARDIOTOXICITY; CONTROLLED STUDY; EC50; EMBRYO; EMBRYO DEVELOPMENT; GENE; HEART DEVELOPMENT; HEART EDEMA; HYDROPHOBICITY; LC50; NKX2 5 GENE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TBX5 GENE; ZEBRA FISH; ANIMAL; ANIMAL EMBRYO; DRUG EFFECTS; EMBRYOLOGY; GENE EXPRESSION REGULATION; HEART; LD50; TOXICITY; WATER POLLUTANT;

DANIO RERIO;

ANIMALS; CARDIOTOXICITY; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; FLAME RETARDANTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; LETHAL DOSE 50; ORGANOPHOSPHATES; WATER POLLUTANTS, CHEMICAL; ZEBRAFISH;

EID: 84922366049     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2015.01.027     Document Type: Article

References (41)

1. Agency for Toxic Substances and Disease Registry (ATSDR), 2009. United States Department of Health and Human Services 2009. Draft Toxicological Profile for Phosphate Ester Flame Retardants (September).
2. Akazawa H., Komuro I. Cardiac transcription factor Csx/Nkx2-5: its role in cardiac development and diseases. Pharmacol. Ther. 2005, 107:252-268.
3. Arrenberg A.B., Stainier D.Y., Baier H., Huisken J. Optogenetic control of cardiac function. Science 2010, 330:971-974.
4. Balci M.M., Akdemir R. NKX2.5 mutations and congenital heart disease: is it a marker of cardiac anomalies?. Int. J. Cardiol. 2011, 147:E44-E45.
5. Cao S., Zeng X., Song H., Li H., Yu Z., Sheng G., Fu J. Levels and distributions of organophosphate flame retardants and plasticizers in sediment from Taihu Lake China. Environ. Toxicol. Chem. 2012, 31:1478-1484.
6. Chen J.N., Fishman M.C. Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation. Development 1996, 122:3809-3816.
7. Chen J.N., vanEeden F.J.M., Warren K.S., Chin A., NussleinVolhard C., Haffter P., Fishman M.C. Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 1997, 124:4373-4382.
8. Covaci A., Harrad S., Abdallah M.A., Ali N., Law R.J., Herzke D., de Wit C.A. Novel brominated flame retardants: a review of their analysis: environmental fate and behaviour. Environ. Int. 2011, 37:532-556.
9. Denvir M.A., Tucker C.S., Mullins J.J. Systolic and diastolic ventricular function in zebrafish embryos: influence of norepenephrine, MS-222 and temperature. BMC Biotechnology 2008, 8:21.
10. Diekmann M., Hultsch V., Nagel R. On the relevance of genotoxicity for fish populations I: effects of a model genotoxicant on zebrafish (Danio rerio) in a complete life-cycle test. Aquat. Toxicol. 2004, 68:13-26.
11. EFRA. European Flame Retardants Association Market 2007. http://www.cefic-efra.org/Content/Defaultasp%3FPageName=openfile&DocRef=2007-01-29-00001.
12. Farhat A., Crump D., Chiu S., Williams K.L., Letcher R.J., Gauthier L.T., Kennedy S.W. In ovo effects of two organophosphate flame retardants-tcpp and tdcpp-on pipping success, development, mrna expression, and thyroid hormone levels in chicken embryos. Toxicol. Sci. 2013, 134:92-102.
13. Finn J., Hui M., Li V., Lorenzi V., de la Paz N., Cheng S.H., Lai-Chan L., Schlenk D. Effects of propranolol on heart rate and development in Japanese medaka (Oryzias latipes) and zebrafish (Danio rerio). Aquat. Toxicol. 2012, 122-123:214-221.
14. Flame retardants online. 2012 Market. http://www.flameretardants-online.com/web/en/106/7ae3d32234954e28e661e506e284da7f.htm.
15. Harvey R.P. NK-2 homeobox genes and heart development. Dev. Biol. 1996, 178:203-216.
16. Fu J., Han J., Zhou B.S., Gong Z.Y., Santos E.M., Huo X.J., Zheng W.L., Liu H.L., Yu H.X., Liu C.S. Toxicogenomic responses of zebrafish embryos/larvae to tris(1,3-dichloro-2-propyl) phosphate (tdcpp) reveal possible molecular mechanisms of developmental toxicity. Environ. Sci. Technol. 2013, 47:10574-10582.
17. Kim Y.S., Nirenberg M. Drosophila nk-homeobox genes - (nk-1, nk-2, nk-3, and nk-4 dna clones chromosome locations of genes). Proc. Natl. Acad. Sci. U. S. A. 1989, 86:7716-7720.
18. Kimmel C.B., Ballard W.W., Kimmel S.R., Ullmann B., Schilling T.F. Stages of embryonic-development of the zebrafish. Dev. Dyn. 1995, 203:253-310.
19. Liu C., Yu L., Deng J., Lam P.K., Wu R.S., Zhou B. Waterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic-pituitary-gonadal (HPG) axis of zebrafish. Aquat. Toxicol. 2009, 93:131-137.
20. Lu W., Chen Y., Liu M., Chen X., Hu Z. QSPR prediction of n-octanol/water partition coefficient for polychlorinated biphenyls. Chemosphere 2007, 69:469-478.
21. Lyons I., Parsons L.M., Hartley L., Li R., Andrews J.E., Robb L., Harvey R.P. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev. 1995, 9:1654-1666.
22. Martinez-Carballo E., Gonzalez-Barreiro C., Sitka A., Scharf S., Gans O. Determination of selected organophosphate esters in the aquatic environment of Austria. Sci. Total Environ. 2007, 388:290-299.
23. McGee S.P., Cooper E.M., Stapleton H.M., Volz D.C. Early zebrafish embryogenesis is susceptible to developmental TDCPP exposure. Environ. Health Persp. 2012, 120:1585-1591.
24. McGee S.P., Konstantinov A., Stapleton H.M., Volz D.C. Aryl phosphate esters within a major PentaBDE replacement product induce cardiotoxicity in developing zebrafish embryos: potential role of the aryl hydrocarbon receptor. Toxicol. Sci. 2013, 133:144-156.
25. Meeker J.D., Stapleton H.M. House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters. Environ. Health Perspect. 2010, 118:318-323.
26. Moskowitz I.P., Kim J.B., Moore M.L., Wolf C.M., Peterson M.A., Shendure J., Nobrega M.A., Yokota Y., Berul C., Izumo S., Seidman J.G., Seidman C.E. A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development. Cell 2007, 129:1365-1376.
27. OECD. (2013). Fish Embryo Acute Toxicity (FET) Test. Test Guideline No. 236. Guidelines for the Testing of Chemicals, OECD, Paris.
28. Olson E.N. Gene regulatory networks in the evolution and development of the heart. Science 2006, 313:1922-1927.
29. Qin X., Xing Q., Ma L., Meng H., Liu Y., Pang S., Yan B. Genetic analysis of an enhancer of the NKX2-5 gene in ventricular septal defects. Gene 2012, 508:106-109.
30. Santoriello C., Zon L.I. Hooked! Modeling human disease in zebrafish. J. Clin. Invest. 2012, 122:2337-2343.
31. Shiojima I., Komuro I. Cardiac developmental biology: from flies to humans. Jpn. J. Physiol. 2005, 55:245-254.
32. Sorrentino R.P., Gajewski K.M., Schulz R.A. GATA factors in Drosophila heart and blood cell development. Semin. Cell Dev. Bio. 2005, 16:107-116.
33. Stapleton H.M., Allen J.G., Kelly S.M., Konstantinov A., Klosterhaus S., Watkins D., McClean M.D., Webster T.F. Alternate and new brominated flame retardants detected in US house dust. Environ. Sci. Technol. 2008, 42:6910-6916.
34. Stapleton H.M., Klosterhaus S., Eagle S., Fuh J., Meeker J.D., Blum A., Webster T.F. Detection of organophosphate flame retardants in furniture foam and US house dust. Environ. Sci. Technol. 2009, 43:7490-7495.
35. Stapleton H.M., Klosterhaus S., Keller A., Ferguson P.L., van Bergen S., Cooper E., Webster T.F., Blum A. Identification of flame retardants in polyurethane foam collected from baby products. Environ. Sci. Technol. 2011, 45:5323-5331.
36. Thomas P.S., Kasahara H., Edmonson A.M., Izumo S., Yacoub M.H., Barton P.J.R., Gourdie R.G. Elevated expression of Nkx-2.5 in developing myocardial conduction cells. Anat. Rec. 2001, 263:307-313.
37. USEPA, 2005. Furniture flame retardancy partnership: Environmental profiles of chemical flame-retardant alternatives for low-density polyurethane foam. USEPA, Washington, DC Available at: http://www.epa.gov/dfe/pubs/flameret/ffr-alt.htm.
38. USEPA, 2007. Report on Alternatives to the Flame Retardant DecaBDE: Evaluation of Toxicity, Availability, Affordability and Fire Safety Issues Report to the Governor and the General Assembly, Illinois.
39. Washington State, 2006. Polybrominated Diphenyl Ether (PBDE) Chemical Action Plan: Department of Ecology Publication No. 05-07-048, Department of Health, Publication No. 334-079 (January).
40. Wu M., Zuo Z., Li B., Huang L., Chen M., Wang C. Effects of low-level hexabromocyclododecane (HBCD) exposure on cardiac development in zebrafish embryos. Ecotoxicology 2013, 22:1200-1207.
41. Zhang Y., Wang C., Huang L., Chen R., Chen Y., Zuo Z. Low-level pyrene exposure causes cardiac toxicity in zebrafish (Danio rerio) embryos. Aquat. Toxicol. 2012, 114-115:119-124.