Discovery of pyrrolopyridazines as novel DGAT1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 20, 2010, Pages 6030-6033

  Fox, Brian M ^a   Iio, Kiyosei ^b   Li, Kexue ^a   Choi, Rebeka ^a   Inaba, Takashi ^b   Jackson, Simon ^a   Sagawa, Shoichi ^b   Shan, Bei ^a   Tanaka, Masahiro ^b   Yoshida, Atsuhito ^b   Kayser, Frank ^a  

^a AMGEN INC   (United States)

^b JAPAN TOBACCO INC   (Japan)

Author keywords

Acyl CoA:diacylglycerol acyltransferase; DGAT1; DGAT1 inhibitors; Pyrrolopyridazines

Indexed keywords

ACYLTRANSFERASE INHIBITOR; DIACYLGLYCEROL ACYLTRANSFERASE 1; PYRROLOPYRIDAZINE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVITY; HIGH THROUGHPUT SCREENING; HYDROGENATION; HYDROGENOLYSIS; HYDROLYSIS; IC 50; MOLECULAR LIBRARY; OXIDATION; REACTOR OPTIMIZATION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

CELL LINE; DIACYLGLYCEROL O-ACYLTRANSFERASE; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; PYRIDAZINES; PYRROLES; STEROL O-ACYLTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956914790     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.066     Document Type: Article

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