-
1
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182-6.
-
(1971)
N Engl J Med
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
2
-
-
0030576517
-
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
-
Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996;86:353-64.
-
(1996)
Cell
, vol.86
, pp. 353-364
-
-
Hanahan, D.1
Folkman, J.2
-
3
-
-
77953223359
-
Angiogenesis inhibition in cancer therapy: Platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors: Biological functions and role in malignancy
-
Appelmann I, Liersch R, Kessler T, Mesters RM, Berdel WE. Angiogenesis inhibition in cancer therapy: platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors: biological functions and role in malignancy. Recent Results Cancer Res 2010;180:51-81.
-
(2010)
Recent Results Cancer Res
, vol.180
, pp. 51-81
-
-
Appelmann, I.1
Liersch, R.2
Kessler, T.3
Mesters, R.M.4
Berdel, W.E.5
-
5
-
-
84902986833
-
Randomized, controlled, double-blind, cross-over trial assessing treatment preference for pazopanib versus sunitinib in patients with metastatic renal cell carcinoma: PISCES Study
-
Escudier B, Porta C, Bono P, Powles T, Eisen T, Sternberg CN, et al. Randomized, controlled, double-blind, cross-over trial assessing treatment preference for pazopanib versus sunitinib in patients with metastatic renal cell carcinoma: PISCES Study. J Clin Oncol 2014;32:1412-8.
-
(2014)
J Clin Oncol
, vol.32
, pp. 1412-1418
-
-
Escudier, B.1
Porta, C.2
Bono, P.3
Powles, T.4
Eisen, T.5
Sternberg, C.N.6
-
6
-
-
84878228357
-
Axitinib for the treatment of advanced non-small-cell lung cancer
-
King JW, Lee SM.Axitinib for the treatment of advanced non-small-cell lung cancer. Expert Opin Investig Drugs 2013;22:765-73.
-
(2013)
Expert Opin Investig Drugs
, vol.22
, pp. 765-773
-
-
King, J.W.1
Lee, S.M.2
-
7
-
-
84922341437
-
Tyrosine kinase inhibitors in treatment of unresectable or metastatic gastrointestinal stromal tumors
-
Nishida T, Doi T, Naito Y. Tyrosine kinase inhibitors in treatment of unresectable or metastatic gastrointestinal stromal tumors. Expert Opin Pharmacother 2014;22:1-11.
-
(2014)
Expert Opin Pharmacother
, vol.22
, pp. 1-11
-
-
Nishida, T.1
Doi, T.2
Naito, Y.3
-
8
-
-
84886296148
-
An update on molecularly targeted therapies in second- and third-line treatment in non-small cell lung cancer: Focus on EGFR inhibitors and anti-angiogenic agents
-
Majem M, Pallares C. An update on molecularly targeted therapies in second- and third-line treatment in non-small cell lung cancer: focus on EGFR inhibitors and anti-angiogenic agents. Clin Transl Oncol 2013;15:343-57.
-
(2013)
Clin Transl Oncol
, vol.15
, pp. 343-357
-
-
Majem, M.1
Pallares, C.2
-
9
-
-
79952036599
-
Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: A double-blind randomised phase 3 study
-
Kindler HL, Ioka T, Richel DJ, Bennouna J, Letourneau R, Okusaka T, et al. Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study. Lancet Oncol 2011;12:256-62.
-
(2011)
Lancet Oncol
, vol.12
, pp. 256-262
-
-
Kindler, H.L.1
Ioka, T.2
Richel, D.J.3
Bennouna, J.4
Letourneau, R.5
Okusaka, T.6
-
10
-
-
84876974877
-
Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: Overall survival analysis and updated results from a randomised phase 3 trial
-
Motzer RJ, Escudier B, Tomczak P, Hutson TE, Michaelson MD, Negrier S, et al. Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised phase 3 trial. Lancet Oncol 2013;14:552-62.
-
(2013)
Lancet Oncol
, vol.14
, pp. 552-562
-
-
Motzer, R.J.1
Escudier, B.2
Tomczak, P.3
Hutson, T.E.4
Michaelson, M.D.5
Negrier, S.6
-
11
-
-
84882781441
-
Pazopanib versus sunitinib in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Cella D, Reeves J, Hawkins R,Guo J, et al. Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med 2013;369:722-31.
-
(2013)
N Engl J Med
, vol.369
, pp. 722-731
-
-
Motzer, R.J.1
Hutson, T.E.2
Cella, D.3
Reeves, J.4
Hawkins, R.5
Guo, J.6
-
12
-
-
84872287977
-
A Phase I study of pazopanib in combination with gemcitabine in patients with advanced solid tumors
-
Plummer R, Madi A, Jeffels M, Richly H, Nokay B, Rubin S, et al. A Phase I study of pazopanib in combination with gemcitabine in patients with advanced solid tumors. Cancer Chemother Pharmacol 2013;71:93-101.
-
(2013)
Cancer Chemother Pharmacol
, vol.71
, pp. 93-101
-
-
Plummer, R.1
Madi, A.2
Jeffels, M.3
Richly, H.4
Nokay, B.5
Rubin, S.6
-
13
-
-
82755183572
-
Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): A randomised phase 3 trial
-
Rini BI, Escudier B, Tomczak P, Kaprin A, Szczylik C, Hutson TE, et al. Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet 2011;378:1931-9.
-
(2011)
Lancet
, vol.378
, pp. 1931-1939
-
-
Rini, B.I.1
Escudier, B.2
Tomczak, P.3
Kaprin, A.4
Szczylik, C.5
Hutson, T.E.6
-
14
-
-
84866743413
-
Phase I study of axitinib (AG-013736) in combinationwith gemcitabine in patients with advanced pancreatic cancer
-
Spano JP, Moore MJ, Pithavala YK, Ricart AD, Kim S, Rixe O. Phase I study of axitinib (AG-013736) in combinationwith gemcitabine in patients with advanced pancreatic cancer. Invest New Drugs 2012;30:1531-9.
-
(2012)
Invest New Drugs
, vol.30
, pp. 1531-1539
-
-
Spano, J.P.1
Moore, M.J.2
Pithavala, Y.K.3
Ricart, A.D.4
Kim, S.5
Rixe, O.6
-
15
-
-
77949890945
-
Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
-
Sternberg CN, Davis ID, Mardiak J, Szczylik C, Lee E, Wagstaff J, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol 2010;28:1061-8.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1061-1068
-
-
Sternberg, C.N.1
Davis, I.D.2
Mardiak, J.3
Szczylik, C.4
Lee, E.5
Wagstaff, J.6
-
16
-
-
84861098484
-
Pazopanib for metastatic soft-tissue sarcoma (PALETTE): A randomised, double-blind, placebo-controlled phase 3 trial
-
van der Graaf WT, Blay JY, Chawla SP, Kim DW, Bui-Nguyen B, Casali PG, et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 2012;379:1879-86.
-
(2012)
Lancet
, vol.379
, pp. 1879-1886
-
-
Van Der Graaf, W.T.1
Blay, J.Y.2
Chawla, S.P.3
Kim, D.W.4
Bui-Nguyen, B.5
Casali, P.G.6
-
17
-
-
77955123488
-
A phase I study of Vandetanib in combination with vinorelbine/cisplatin or gemcitabine/cisplatin as first-line treatment for advanced non-small cell lung cancer
-
Blackhall FH, O'Brien M, Schmid P, Nicolson M, Taylor P, Milenkova T, et al. A phase I study of Vandetanib in combination with vinorelbine/cisplatin or gemcitabine/cisplatin as first-line treatment for advanced non-small cell lung cancer. J Thorac Oncol 2010;5:1285-8.
-
(2010)
J Thorac Oncol
, vol.5
, pp. 1285-1288
-
-
Blackhall, F.H.1
O'Brien, M.2
Schmid, P.3
Nicolson, M.4
Taylor, P.5
Milenkova, T.6
-
18
-
-
53949121341
-
Gemcitabine combined with gefitinib in patients with inoperable or metastatic pancreatic cancer: A phase II Study of the Hellenic Cooperative Oncology Group with biomarker evaluation
-
Fountzilas G, Bobos M, Kalogera-Fountzila A, Xiros N, Murray S, Linardou H, et al. Gemcitabine combined with gefitinib in patients with inoperable or metastatic pancreatic cancer: a phase II Study of theHellenic Cooperative Oncology Group with biomarker evaluation. Cancer Invest 2008;26:784-93.
-
(2008)
Cancer Invest
, vol.26
, pp. 784-793
-
-
Fountzilas, G.1
Bobos, M.2
Kalogera-Fountzila, A.3
Xiros, N.4
Murray, S.5
Linardou, H.6
-
19
-
-
1542503746
-
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial-INTACT 1
-
Giaccone G, Herbst RS, Manegold C, Scagliotti G, Rosell R, Miller V, et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 1. J Clin Oncol 2004;22:777-84.
-
(2004)
J Clin Oncol
, vol.22
, pp. 777-784
-
-
Giaccone, G.1
Herbst, R.S.2
Manegold, C.3
Scagliotti, G.4
Rosell, R.5
Miller, V.6
-
20
-
-
36849022660
-
A phase II trial of cisplatin, fixed dose-rate gemcitabine and gefitinib for advanced urothelial tract carcinoma: Results of the Cancer and Leukaemia Group B 90102
-
Philips GK, Halabi S, Sanford BL, Bajorin D, Small EJ. A phase II trial of cisplatin, fixed dose-rate gemcitabine and gefitinib for advanced urothelial tract carcinoma: results of the Cancer and Leukaemia Group B 90102. BJU Int 2008;101:20-5.
-
(2008)
BJU Int
, vol.101
, pp. 20-25
-
-
Philips, G.K.1
Halabi, S.2
Sanford, B.L.3
Bajorin, D.4
Small, E.J.5
-
21
-
-
66149084012
-
A phase II trial of cisplatin (C), gemcitabine (G) and gefitinib for advanced urothelial tract carcinoma: Results of Cancer and Leukemia Group B (CALGB) 90102
-
Philips GK, Halabi S, Sanford BL, Bajorin D, Small EJ. A phase II trial of cisplatin (C), gemcitabine (G) and gefitinib for advanced urothelial tract carcinoma: results of Cancer and Leukemia Group B (CALGB) 90102. Ann Oncol 2009;20:1074-9.
-
(2009)
Ann Oncol
, vol.20
, pp. 1074-1079
-
-
Philips, G.K.1
Halabi, S.2
Sanford, B.L.3
Bajorin, D.4
Small, E.J.5
-
22
-
-
80051913597
-
Antitumour activity of sunitinib in combination with gemcitabine in experimental pancreatic cancer
-
Awasthi N, Schwarz MA, Schwarz RE. Antitumour activity of sunitinib in combination with gemcitabine in experimental pancreatic cancer. HPB 2011;13:597-604.
-
(2011)
HPB
, vol.13
, pp. 597-604
-
-
Awasthi, N.1
Schwarz, M.A.2
Schwarz, R.E.3
-
23
-
-
84922372124
-
Prospective randomized phase II trial with gemictabine versus gemcitabine plus sunitinib in advanced pancreatic cancer
-
Richly H, Maute L,Heil G, Russel J, Jager E. Prospective randomized phase II trial with gemictabine versus gemcitabine plus sunitinib in advanced pancreatic cancer. J Clin Oncol 31, 2013 (suppl; abstr 4035).
-
J Clin Oncol
, vol.31
, pp. 2013
-
-
Richly, H.1
Maute, L.2
Heil, G.3
Russel, J.4
Jager, E.5
-
24
-
-
45449090215
-
Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: An open-label randomised phase II study
-
Spano JP, Chodkiewicz C, Maurel J, Wong R, Wasan H, Barone C, et al. Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: an open-label randomised phase II study. Lancet 2008;371:2101-8.
-
(2008)
Lancet
, vol.371
, pp. 2101-2108
-
-
Spano, J.P.1
Chodkiewicz, C.2
Maurel, J.3
Wong, R.4
Wasan, H.5
Barone, C.6
-
25
-
-
84875191343
-
The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29
-
Young JD, Yao SY, Baldwin JM, Cass CE, Baldwin SA. The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol Aspects Med 2013;34:529-47.
-
(2013)
Mol Aspects Med
, vol.34
, pp. 529-547
-
-
Young, J.D.1
Yao, S.Y.2
Baldwin, J.M.3
Cass, C.E.4
Baldwin, S.A.5
-
26
-
-
75749088520
-
Human nucleoside transporters: Biomarkers for response to nucleoside drugs
-
Damaraju VL, Sawyer MB, Mackey JR, Young JD, Cass CE. Human nucleoside transporters: biomarkers for response to nucleoside drugs. Nucleosides Nucleotides Nucleic Acids 2009;28:450-63.
-
(2009)
Nucleosides Nucleotides Nucleic Acids
, vol.28
, pp. 450-463
-
-
Damaraju, V.L.1
Sawyer, M.B.2
Mackey, J.R.3
Young, J.D.4
Cass, C.E.5
-
27
-
-
33947430594
-
The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs
-
Zhang J, Visser F, King KM, Baldwin SA, Young JD, Cass CE. The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs. Cancer Metastasis Rev 2007;26:85-110.
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 85-110
-
-
Zhang, J.1
Visser, F.2
King, K.M.3
Baldwin, S.A.4
Young, J.D.5
Cass, C.E.6
-
28
-
-
0037309360
-
Inhibition of nucleoside transport by protein kinase inhibitors
-
Huang M, Wang Y, Cogut SB, Mitchell BS, Graves LM. Inhibition of nucleoside transport by protein kinase inhibitors. J Pharmacol Exp Ther 2003;304:753-60.
-
(2003)
J Pharmacol Exp Ther
, vol.304
, pp. 753-760
-
-
Huang, M.1
Wang, Y.2
Cogut, S.B.3
Mitchell, B.S.4
Graves, L.M.5
-
29
-
-
0037047304
-
Inhibition of nucleoside transport by p38 MAPK inhibitors
-
Huang M,Wang Y, Collins M, Gu JJ, Mitchell BS, Graves LM. Inhibition of nucleoside transport by p38 MAPK inhibitors. J Biol Chem 2002;277:28364-7.
-
(2002)
J Biol Chem
, vol.277
, pp. 28364-28367
-
-
Huang, M.1
Wang, Y.2
Collins, M.3
Gu, J.J.4
Mitchell, B.S.5
Graves, L.M.6
-
30
-
-
46749155824
-
Imatinib-resistant CML cells have low ENT activity but maintain sensitivity to gemcitabine
-
Leisewitz AV, Zimmerman EI, Jones SZ, Yang J, Graves LM. Imatinib-resistant CML cells have low ENT activity but maintain sensitivity to gemcitabine. Nucleosides Nucleotides Nucleic Acids 2008;27:779-86.
-
(2008)
Nucleosides Nucleotides Nucleic Acids
, vol.27
, pp. 779-786
-
-
Leisewitz, A.V.1
Zimmerman, E.I.2
Jones, S.Z.3
Yang, J.4
Graves, L.M.5
-
31
-
-
47549111536
-
Imatinib inhibition of fludarabine uptake in T-lymphocytes
-
Woodahl EL, Wang J, Heimfeld S, Ren AG, McCune JS. Imatinib inhibition of fludarabine uptake in T-lymphocytes. Cancer Chemother Pharmacol 2008;62:735-9.
-
(2008)
Cancer Chemother Pharmacol
, vol.62
, pp. 735-739
-
-
Woodahl, E.L.1
Wang, J.2
Heimfeld, S.3
Ren, A.G.4
McCune, J.S.5
-
32
-
-
84892152853
-
Erlotinib, gefitinib, and vandetanib inhibit human nucleoside transporters and protect cancer cells from gemcitabine cytotoxicity
-
Damaraju VL, Scriver T, Mowles D, Kuzma M, Ryan AJ, Cass CE, et al. Erlotinib, gefitinib, and vandetanib inhibit human nucleoside transporters and protect cancer cells from gemcitabine cytotoxicity. Clin Cancer Res 2014;20:176-86.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 176-186
-
-
Damaraju, V.L.1
Scriver, T.2
Mowles, D.3
Kuzma, M.4
Ryan, A.J.5
Cass, C.E.6
-
33
-
-
0347997273
-
Comparison of the interaction of uridine, cytidine, and other pyrimidine nucleoside analogues with recombinant human equilibrative nucleoside transporter 2 (hENT2) produced in Saccharomyces cerevisiae
-
Vickers MF, Kumar R, Visser F, Zhang J, Charania J, Raborn RT, et al. Comparison of the interaction of uridine, cytidine, and other pyrimidine nucleoside analogues with recombinant human equilibrative nucleoside transporter 2 (hENT2) produced in Saccharomyces cerevisiae. Biochem Cell Biol 2002;80:639-44.
-
(2002)
Biochem Cell Biol
, vol.80
, pp. 639-644
-
-
Vickers, M.F.1
Kumar, R.2
Visser, F.3
Zhang, J.4
Charania, J.5
Raborn, R.T.6
-
34
-
-
10744233849
-
Uridine binding motifs of human concentrative nucleoside transporters 1 and 3 produced in Saccharomyces cerevisiae
-
Zhang J, Visser F, Vickers MF, Lang T, Robins MJ, Nielsen LP, et al. Uridine binding motifs of human concentrative nucleoside transporters 1 and 3 produced in Saccharomyces cerevisiae. Mol Pharmacol 2003;64:1512-20.
-
(2003)
Mol Pharmacol
, vol.64
, pp. 1512-1520
-
-
Zhang, J.1
Visser, F.2
Vickers, M.F.3
Lang, T.4
Robins, M.J.5
Nielsen, L.P.6
-
35
-
-
12144287868
-
Uridine recognition motifs of human equilibrative nucleoside transporters 1 and 2 produced in Saccharomyces cerevisiae
-
Vickers MF, Zhang J, Visser F, Tackaberry T, Robins MJ, Nielsen LP, et al. Uridine recognition motifs of human equilibrative nucleoside transporters 1 and 2 produced in Saccharomyces cerevisiae. Nucleosides Nucleotides Nucleic Acids 2004;23:361-73.
-
(2004)
Nucleosides Nucleotides Nucleic Acids
, vol.23
, pp. 361-373
-
-
Vickers, M.F.1
Zhang, J.2
Visser, F.3
Tackaberry, T.4
Robins, M.J.5
Nielsen, L.P.6
-
36
-
-
0037016739
-
Mutation of residue 33 of human equilibrative nucleoside transporters 1 and 2 alters sensitivity to inhibition of transport by dilazep and dipyridamole
-
Visser F, Vickers MF, Ng AM, Baldwin SA, Young JD, Cass CE. Mutation of residue 33 of human equilibrative nucleoside transporters 1 and 2 alters sensitivity to inhibition of transport by dilazep and dipyridamole. J Biol Chem 2002;277:395-401.
-
(2002)
J Biol Chem
, vol.277
, pp. 395-401
-
-
Visser, F.1
Vickers, M.F.2
Ng, A.M.3
Baldwin, S.A.4
Young, J.D.5
Cass, C.E.6
-
37
-
-
0021118703
-
Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
-
Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984;22:27-55.
-
(1984)
Adv Enzyme Regul
, vol.22
, pp. 27-55
-
-
Chou, T.C.1
Talalay, P.2
-
38
-
-
0003518480
-
-
New York, NY: John Wiley and Sons
-
Segel IH. Enzyme Kinetics. New York, NY: John Wiley and Sons; 1975.
-
(1975)
Enzyme Kinetics
-
-
Segel, I.H.1
-
39
-
-
79953779522
-
Long-term response and postsurgical complete remissions after treatment with sunitinib malate, an oral multitargeted receptor tyrosine kinase inhibitor, in patients with metastatic renal cell carcinoma
-
Ayllon J, Beuselinck B, Morel A, Barrascout E, Medioni J, Scotte F, et al. Long-term response and postsurgical complete remissions after treatment with sunitinib malate, an oral multitargeted receptor tyrosine kinase inhibitor, in patients with metastatic renal cell carcinoma. Cancer Invest 2011;29:282-5.
-
(2011)
Cancer Invest
, vol.29
, pp. 282-285
-
-
Ayllon, J.1
Beuselinck, B.2
Morel, A.3
Barrascout, E.4
Medioni, J.5
Scotte, F.6
-
40
-
-
84892677470
-
Small molecule targeted therapies for the second-line treatment for metastatic renal cell carcinoma: A systematic review and indirect comparison of safety and efficacy
-
Dranitsaris G, Schmitz S, Broom RJ. Small molecule targeted therapies for the second-line treatment for metastatic renal cell carcinoma: a systematic review and indirect comparison of safety and efficacy. J Cancer Res Clin Oncol 2013;139:1917-26.
-
(2013)
J Cancer Res Clin Oncol
, vol.139
, pp. 1917-1926
-
-
Dranitsaris, G.1
Schmitz, S.2
Broom, R.J.3
-
41
-
-
56749169190
-
An update on themedical therapy of advanced metastatic renal cell carcinoma
-
Kruck S, Merseburger AS, Gakis G, Kramer MW, Stenzl A, Kuczyk MA. An update on themedical therapy of advanced metastatic renal cell carcinoma. Scand J Urol Nephrol 2008;42:501-6.
-
(2008)
Scand J Urol Nephrol
, vol.42
, pp. 501-506
-
-
Kruck, S.1
Merseburger, A.S.2
Gakis, G.3
Kramer, M.W.4
Stenzl, A.5
Kuczyk, M.A.6
-
42
-
-
84875157974
-
Sunitinib malate for the treatment of pancreas malignancies-where does it fit?
-
Mankal P, O'Reilly E. Sunitinib malate for the treatment of pancreas malignancies-where does it fit? Expert Opin Pharmacother 2013;14:783-92.
-
(2013)
Expert Opin Pharmacother
, vol.14
, pp. 783-792
-
-
Mankal, P.1
O'Reilly, E.2
-
43
-
-
7244232706
-
Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump
-
Burger H, van Tol H, Boersma AW, Brok M, Wiemer EA, Stoter G, et al. Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood 2004;104:2940-2.
-
(2004)
Blood
, vol.104
, pp. 2940-2942
-
-
Burger, H.1
Van Tol, H.2
Boersma, A.W.3
Brok, M.4
Wiemer, E.A.5
Stoter, G.6
-
44
-
-
20144389530
-
Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal growth factor receptor inhibitor Iressa (ZD1839, Gefitinib)
-
Elkind NB, Szentpetery Z, Apati A, Ozvegy-Laczka C, Varady G, Ujhelly O, et al. Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal growth factor receptor inhibitor Iressa (ZD1839, Gefitinib). Cancer Res 2005;65:1770-7.
-
(2005)
Cancer Res
, vol.65
, pp. 1770-1777
-
-
Elkind, N.B.1
Szentpetery, Z.2
Apati, A.3
Ozvegy-Laczka, C.4
Varady, G.5
Ujhelly, O.6
-
45
-
-
0035863314
-
The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux
-
Erlichman C, Boerner SA, Hallgren CG, Spieker R, Wang XY, James CD, et al. The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux. Cancer Res 2001;61:739-48.
-
(2001)
Cancer Res
, vol.61
, pp. 739-748
-
-
Erlichman, C.1
Boerner, S.A.2
Hallgren, C.G.3
Spieker, R.4
Wang, X.Y.5
James, C.D.6
-
46
-
-
34948887693
-
ZD6474 reverses multidrug resistance by directly inhibiting the function of P-glycoprotein
-
Mi Y, Lou L. ZD6474 reverses multidrug resistance by directly inhibiting the function of P-glycoprotein. Br J Cancer 2007;97:934-40.
-
(2007)
Br J Cancer
, vol.97
, pp. 934-940
-
-
Mi, Y.1
Lou, L.2
-
47
-
-
54249157033
-
Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2
-
Dai CL, Tiwari AK, Wu CP, Su XD, Wang SR, Liu DG, et al. Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2. Cancer Res 2008;68:7905-14.
-
(2008)
Cancer Res
, vol.68
, pp. 7905-7914
-
-
Dai, C.L.1
Tiwari, A.K.2
Wu, C.P.3
Su, X.D.4
Wang, S.R.5
Liu, D.G.6
-
48
-
-
36348967305
-
Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance
-
Shi Z, Peng XX, Kim IW, Shukla S, Si QS, RobeyRW, et al. Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance. Cancer Res 2007;67:11012-20.
-
(2007)
Cancer Res
, vol.67
, pp. 11012-11020
-
-
Shi, Z.1
Peng, X.X.2
Kim, I.W.3
Shukla, S.4
Si, Q.S.5
Robey, R.W.6
-
49
-
-
67449164582
-
Phase I trial of pazopanib in patients with advanced cancer
-
Hurwitz HI, Dowlati A, Saini S, Savage S, Suttle AB, Gibson DM, et al. Phase I trial of pazopanib in patients with advanced cancer. Clin Cancer Res 2009;15:4220-7.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4220-4227
-
-
Hurwitz, H.I.1
Dowlati, A.2
Saini, S.3
Savage, S.4
Suttle, A.B.5
Gibson, D.M.6
-
50
-
-
18044389786
-
Tumor penetration of gefitinib (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor
-
McKillop D, Partridge EA, Kemp JV, Spence MP, Kendrew J, Barnett S, et al. Tumor penetration of gefitinib (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor. Mol Cancer Ther 2005;4:641-9.
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 641-649
-
-
McKillop, D.1
Partridge, E.A.2
Kemp, J.V.3
Spence, M.P.4
Kendrew, J.5
Barnett, S.6
-
51
-
-
78149469826
-
A pilot study of preoperative gefitinib for early-stage lung cancer to assess intratumor drug concentration and pathways mediating primary resistance
-
Haura EB, Sommers E, Song L, Chiappori A, Becker A. A pilot study of preoperative gefitinib for early-stage lung cancer to assess intratumor drug concentration and pathways mediating primary resistance. J Thorac Oncol 2010;5:1806-14.
-
(2010)
J Thorac Oncol
, vol.5
, pp. 1806-1814
-
-
Haura, E.B.1
Sommers, E.2
Song, L.3
Chiappori, A.4
Becker, A.5
-
52
-
-
82555189379
-
Lysosomal sequestration of sunitinib: A novel mechanism of drug resistance
-
Gotink KJ, Broxterman HJ, Labots M, deHaas RR, Dekker H, Honeywell RJ, et al. Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance. Clin Cancer Res 2011;17:7337-46.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 7337-7346
-
-
Gotink, K.J.1
Broxterman, H.J.2
Labots, M.3
DeHaas, R.R.4
Dekker, H.5
Honeywell, R.J.6
-
53
-
-
84883139057
-
Clinical pharmacology of axitinib
-
Chen Y, Tortorici MA, Garrett M, Hee B, Klamerus KJ, Pithavala YK. Clinical pharmacology of axitinib. Clin Pharmacokinet 2013;52:713-25.
-
(2013)
Clin Pharmacokinet
, vol.52
, pp. 713-725
-
-
Chen, Y.1
Tortorici, M.A.2
Garrett, M.3
Hee, B.4
Klamerus, K.J.5
Pithavala, Y.K.6
-
54
-
-
84880654833
-
In vitro characterization of axitinib interactions with human efflux and hepatic uptake transporters: Implications for disposition and drug interactions
-
Reyner EL, Sevidal S, West MA, Clouser-Roche A, Freiwald S, Fenner K, et al. In vitro characterization of axitinib interactions with human efflux and hepatic uptake transporters: implications for disposition and drug interactions. Drug Metab Dispos 2013;41:1575-83.
-
(2013)
Drug Metab Dispos
, vol.41
, pp. 1575-1583
-
-
Reyner, E.L.1
Sevidal, S.2
West, M.A.3
Clouser-Roche, A.4
Freiwald, S.5
Fenner, K.6
-
55
-
-
54349124554
-
The role of human nucleoside transporters in uptake of 3′-deoxy-3′-fluorothymidine
-
Paproski RJ, Ng AM, Yao SY, Graham K, Young JD, Cass CE. The role of human nucleoside transporters in uptake of 3′-deoxy-3′-fluorothymidine. Mol Pharmacol 2008;74:1372-80.
-
(2008)
Mol Pharmacol
, vol.74
, pp. 1372-1380
-
-
Paproski, R.J.1
Ng, A.M.2
Yao, S.Y.3
Graham, K.4
Young, J.D.5
Cass, C.E.6
-
56
-
-
0037742189
-
3′-deoxy-3′-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography
-
Barthel H, Cleij MC, Collingridge DR, Hutchinson OC, Osman S, He Q, et al. 3′-deoxy-3′-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography. Cancer Res 2003;63:3791-8.
-
(2003)
Cancer Res
, vol.63
, pp. 3791-3798
-
-
Barthel, H.1
Cleij, M.C.2
Collingridge, D.R.3
Hutchinson, O.C.4
Osman, S.5
He, Q.6
-
57
-
-
84055222066
-
Pharmacodynamic study using FLT PET/CT in patients with renal cell cancer and other solid malignancies treated with sunitinib malate
-
Liu G, Jeraj R, Vanderhoek M, Perlman S, Kolesar J, Harrison M, et al. Pharmacodynamic study using FLT PET/CT in patients with renal cell cancer and other solid malignancies treated with sunitinib malate. Clin Cancer Res 2012;17:7634-44.
-
(2012)
Clin Cancer Res
, vol.17
, pp. 7634-7644
-
-
Liu, G.1
Jeraj, R.2
Vanderhoek, M.3
Perlman, S.4
Kolesar, J.5
Harrison, M.6
-
58
-
-
84887027989
-
Assessment of early changes in 3H-fluorothymidine uptake after treatment with gefitinib in human tumor xenograft in comparison with Ki-67 and phospho-EGFR expression
-
Zhao S, Kuge Y, Zhao Y, Takeuchi S, Hirata K, Takei T, et al. Assessment of early changes in 3H-fluorothymidine uptake after treatment with gefitinib in human tumor xenograft in comparison with Ki-67 and phospho-EGFR expression. BMC Cancer 2013;13:525.
-
(2013)
BMC Cancer
, vol.13
, pp. 525
-
-
Zhao, S.1
Kuge, Y.2
Zhao, Y.3
Takeuchi, S.4
Hirata, K.5
Takei, T.6
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