메뉴 건너뛰기




Volumn 17, Issue 24, 2011, Pages 7634-7644

Pharmacodynamic study using FLT PET/CT in patients with renal cell cancer and other solid malignancies treated with sunitinib malate

Author keywords

[No Author keywords available]

Indexed keywords

3' FLUOROTHYMIDINE F 18; INTERLEUKIN 2; SUNITINIB; VASCULOTROPIN;

EID: 84055222066     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-11-1677     Document Type: Article
Times cited : (58)

References (45)
  • 1
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182-6.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 5
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • DOI 10.1200/JCO.2006.09.6305
    • Giantonio BJ, Catalano PJ, Meropol NJ, O'Dwyer PJ, Mitchell EP, Alberts SR, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 2007;25:1539-44. (Pubitemid 46733080)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3    O'Dwyer, P.J.4    Mitchell, E.P.5    Alberts, S.R.6    Schwartz, M.A.7    Benson III, A.B.8
  • 9
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
    • Sternberg CN, Davis ID, Mardiak J, Szczylik C, Lee E, Wagstaff J, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol 2010; 28:1061-8.
    • (2010) J Clin Oncol , vol.28 , pp. 1061-1068
    • Sternberg, C.N.1    Davis, I.D.2    Mardiak, J.3    Szczylik, C.4    Lee, E.5    Wagstaff, J.6
  • 10
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S, et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 2009;27:3584-90.
    • (2009) J Clin Oncol , vol.27 , pp. 3584-3590
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3    Michaelson, M.D.4    Bukowski, R.M.5    Oudard, S.6
  • 11
    • 70249097380 scopus 로고    scopus 로고
    • Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
    • Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Staehler M, et al. Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol 2009;27:3312-8.
    • (2009) J Clin Oncol , vol.27 , pp. 3312-3318
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3    Szczylik, C.4    Oudard, S.5    Staehler, M.6
  • 13
    • 76249126867 scopus 로고    scopus 로고
    • Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma
    • Huang D, Ding Y, Li Y, Luo WM, Zhang ZF, Snider J, et al. Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma. Cancer Res 2010;70:1053-62.
    • (2010) Cancer Res , vol.70 , pp. 1053-1062
    • Huang, D.1    Ding, Y.2    Li, Y.3    Luo, W.M.4    Zhang, Z.F.5    Snider, J.6
  • 14
    • 37249072373 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of sunitinib administered daily for 2 weeks, followed by a 1-week off period
    • DOI 10.1007/s00280-007-0498-4
    • Britten CD, Kabbinavar F, Hecht JR, Bello CL, Li J, Baum C, et al. A phase I and pharmacokinetic study of sunitinib administered daily for 2 weeks, followed by a 1-week off period. Cancer Chemother Pharmacol 2008;61:515-24. (Pubitemid 350275988)
    • (2008) Cancer Chemotherapy and Pharmacology , vol.61 , Issue.3 , pp. 515-524
    • Britten, C.D.1    Kabbinavar, F.2    Randolph, H.J.3    Bello, C.L.4    Li, J.5    Baum, C.6    Slamon, D.7
  • 15
    • 38949107601 scopus 로고    scopus 로고
    • Prolonged complete responses and near-complete responses to sunitinib in metastatic renal cell carcinoma
    • DOI 10.3816/CGC.2007.n.033
    • Heng DY, Rini BI, Garcia J, Wood L, Bukowski RM. Prolonged complete responses and near-complete responses to sunitinib in metastatic renal cell carcinoma. Clin Genitourin Cancer 2007;5: 446-51. (Pubitemid 351219698)
    • (2007) Clinical Genitourinary Cancer , vol.5 , Issue.7 , pp. 446-451
    • Heng, D.Y.C.1    Rini, B.I.2    Garcia, J.3    Wood, L.4    Bukowski, R.M.5
  • 17
    • 76449101994 scopus 로고    scopus 로고
    • Renal cell carcinoma: Complete pathological response in a patient with gastric metastasis of renal cell carcinoma
    • Garcia-Campelo R, Quindos M, Vazquez DD, Lopez MR, Carral A, Calvo OF, et al. Renal cell carcinoma: complete pathological response in a patient with gastric metastasis of renal cell carcinoma. Anticancer Drugs 2010;21 Suppl 1:S13-5.
    • (2010) Anticancer Drugs , vol.21 , Issue.SUPPL. 1
    • Garcia-Campelo, R.1    Quindos, M.2    Vazquez, D.D.3    Lopez, M.R.4    Carral, A.5    Calvo, O.F.6
  • 20
  • 21
    • 24944453855 scopus 로고    scopus 로고
    • Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: Pharmacokinetic and clinical results
    • Rugo HS, Herbst RS, Liu G, Park JW, Kies MS, Steinfeldt HM, et al. Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results. J Clin Oncol 2005;23:5474-83.
    • (2005) J Clin Oncol , vol.23 , pp. 5474-5483
    • Rugo, H.S.1    Herbst, R.S.2    Liu, G.3    Park, J.W.4    Kies, M.S.5    Steinfeldt, H.M.6
  • 22
    • 0036205096 scopus 로고    scopus 로고
    • 3H]arabinothymidine, and cell-analysis in 22 asynchronously growing tumor cell lines
    • DOI 10.1016/S0969-8051(02)00286-X, PII S096980510200286X
    • Toyohara J, Waki A, Takamatsu S, Yonekura Y, Magata Y, Fujibayashi Y. Basis of FLT as a cell proliferation marker: comparative uptake studies with [3H]thymidine and [3H]arabinothymidine, and cell-analysis in 22 asynchronously growing tumor cell lines. Nucl Med Biol 2002;29:281-7. (Pubitemid 34258548)
    • (2002) Nuclear Medicine and Biology , vol.29 , Issue.3 , pp. 281-287
    • Toyohara, J.1    Waki, A.2    Takamatsu, S.3    Yonekura, Y.4    Magata, Y.5    Fujibayashi, Y.6
  • 23
  • 26
    • 1542681635 scopus 로고    scopus 로고
    • Monitoring tumor cell proliferation by targeting DNA synthetic processes with thymidine and thymidine analogs
    • Schwartz JL, Tamura Y, Jordan R, Grierson JR, Krohn KA. Monitoring tumor cell proliferation by targeting DNA synthetic processes with thymidine and thymidine analogs. J Nucl Med 2003;44: 2027-32. (Pubitemid 40022149)
    • (2003) Journal of Nuclear Medicine , vol.44 , Issue.12 , pp. 2027-2032
    • Schwartz, J.L.1    Tamura, Y.2    Jordan, R.3    Grierson, J.R.4    Krohn, K.A.5
  • 27
    • 0036847428 scopus 로고    scopus 로고
    • 18F]FLT uptake by positron emission tomography with Ki-67 immunohistochemistry and flow cytometry in human lung tumors
    • Vesselle H, Grierson J, Muzi M, Pugsley JM, Schmidt RA, Rabinowitz P, et al. In vivo validation of 30deoxy-30-[(18)F]fluorothymidine ([(18) F]FLT) as a proliferation imaging tracer in humans: correlation of [(18) F]FLT uptake by positron emission tomography with Ki-67 immunohistochemistry and flow cytometry in human lung tumors. Clin Cancer Res 2002;8:3315-23. (Pubitemid 35340704)
    • (2002) Clinical Cancer Research , vol.8 , Issue.11 , pp. 3315-3323
    • Vesselle, H.1    Grierson, J.2    Muzi, M.3    Pugsley, J.M.4    Schmidt, R.A.5    Rabinowitz, P.6    Peterson, L.M.7    Vallieres, E.8    Wood, D.E.9
  • 31
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000;92: 205-16.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3    Wanders, J.4    Kaplan, R.S.5    Rubinstein, L.6
  • 32
    • 72149128890 scopus 로고    scopus 로고
    • Bioanalytical method for the quantification of sunitinib and its n-desethyl metabolite SU12662 in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry
    • de Bruijn P, Sleijfer S, Lam MH, Mathijssen RH, Wiemer EA, Loos WJ. Bioanalytical method for the quantification of sunitinib and its n-desethyl metabolite SU12662 in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry. J Pharm Biomed Anal 2010;51:934-41.
    • (2010) J Pharm Biomed Anal , vol.51 , pp. 934-941
    • De Bruijn, P.1    Sleijfer, S.2    Lam, M.H.3    Mathijssen, R.H.4    Wiemer, E.A.5    Loos, W.J.6
  • 33
    • 0033781697 scopus 로고    scopus 로고
    • The diagnostic utility of the lognormal behavior of PET standardized uptake values in tumors
    • Thie JA, Hubner KF, Smith GT. The diagnostic utility of the lognormal behavior of PET standardized uptake values in tumors. J Nucl Med 2000;41:1664-72.
    • (2000) J Nucl Med , vol.41 , pp. 1664-1672
    • Thie, J.A.1    Hubner, K.F.2    Smith, G.T.3
  • 34
    • 67649909568 scopus 로고    scopus 로고
    • Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma
    • Hauschild A, Agarwala SS, Trefzer U, Hogg D, Robert C, Hersey P, et al. Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma. J Clin Oncol 2009;27:2823-30.
    • (2009) J Clin Oncol , vol.27 , pp. 2823-2830
    • Hauschild, A.1    Agarwala, S.S.2    Trefzer, U.3    Hogg, D.4    Robert, C.5    Hersey, P.6
  • 35
    • 77951639655 scopus 로고    scopus 로고
    • Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer
    • Scagliotti G, Novello S, von Pawel J, Reck M, Pereira JR, Thomas M, et al. Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer. J Clin Oncol 2010; 28:1835-42.
    • (2010) J Clin Oncol , vol.28 , pp. 1835-1842
    • Scagliotti, G.1    Novello, S.2    Von Pawel, J.3    Reck, M.4    Pereira, J.R.5    Thomas, M.6
  • 36
    • 79952036599 scopus 로고    scopus 로고
    • Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: A double-blind randomised phase 3 study
    • Kindler HL, Ioka T, Richel DJ, Bennouna J, Letourneau R, Okusaka T, et al. Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study. Lancet Oncol 2011;12: 256-62.
    • (2011) Lancet Oncol , vol.12 , pp. 256-262
    • Kindler, H.L.1    Ioka, T.2    Richel, D.J.3    Bennouna, J.4    Letourneau, R.5    Okusaka, T.6
  • 37
    • 84055169700 scopus 로고    scopus 로고
    • Final results from a multicenter, randomized, double-blind, phase 3 study of sunitinib in metastatic colorectal cancer patients receiving irinotecan, 5-fluorouracil and leucovorin (FOLFIRI) as first line treatment
    • Barcelona, Spain: European Society of Medical Oncology, Abstract nr O-0026
    • Carrato A, Swieboda-Sadlej A, Staszewska-Skurczynska M, et al. Final results from a multicenter, randomized, double-blind, phase 3 study of sunitinib in metastatic colorectal cancer patients receiving irinotecan, 5-fluorouracil and leucovorin (FOLFIRI) as first line treatment. 12th World Congress on Gastrointestinal Cancer. Barcelona, Spain: European Society of Medical Oncology, 2010. Abstract nr O-0026.
    • (2010) 12th World Congress on Gastrointestinal Cancer
    • Carrato, A.1    Swieboda-Sadlej, A.2    Staszewska-Skurczynska, M.3
  • 38
    • 0030018743 scopus 로고    scopus 로고
    • A systems approach to cancer therapy. (Antioncogenics+ standard cytotoxics->mechanism(s) of interaction)
    • Teicher BA. A systems approach to cancer therapy. (Antioncogenics+ standard cytotoxics->mechanism(s) of interaction). Cancer Metastasis Rev 1996;15:247-72.
    • (1996) Cancer Metastasis Rev , vol.15 , pp. 247-272
    • Teicher, B.A.1
  • 39
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • DOI 10.1038/nm0901-987
    • Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 2001;7:987-9. (Pubitemid 32937367)
    • (2001) Nature Medicine , vol.7 , Issue.9 , pp. 987-989
    • Jain, R.K.1
  • 40
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • DOI 10.1126/science.1104819
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005;307:58-62. (Pubitemid 40093472)
    • (2005) Science , vol.307 , Issue.5706 , pp. 58-62
    • Jain, R.K.1
  • 41
    • 78449251493 scopus 로고    scopus 로고
    • Dynamic contrast-enhanced magnetic resonance imaging of sunitinib-induced vascular changes to schedule chemotherapy in renal cell carcinoma xenograft tumors
    • Hillman GG, Singh-Gupta V, Al-Bashir AK, Zhang H, Yunker CK, Patel AD, et al. Dynamic contrast-enhanced magnetic resonance imaging of sunitinib-induced vascular changes to schedule chemotherapy in renal cell carcinoma xenograft tumors. Transl Oncol 2010;3:293-306.
    • (2010) Transl Oncol , vol.3 , pp. 293-306
    • Hillman, G.G.1    Singh-Gupta, V.2    Al-Bashir, A.K.3    Zhang, H.4    Yunker, C.K.5    Patel, A.D.6
  • 42
    • 34547779489 scopus 로고    scopus 로고
    • Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: Modulation of VEGF and VEGF-related proteins
    • Deprimo SE, Bello CL, Smeraglia J, Baum CM, Spinella D, Rini BI, et al. Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins. J Transl Med 2007; 5:32.
    • (2007) J Transl Med , vol.5 , pp. 32
    • Deprimo, S.E.1    Bello, C.L.2    Smeraglia, J.3    Baum, C.M.4    Spinella, D.5    Rini, B.I.6
  • 43
    • 63049093371 scopus 로고    scopus 로고
    • Phase I trial of bevacizumab plus escalated doses of sunitinib in patients with metastatic renal cell carcinoma
    • Feldman DR, Baum MS, Ginsberg MS, Hassoun H, Flombaum CD, Velasco S, et al. Phase I trial of bevacizumab plus escalated doses of sunitinib in patients with metastatic renal cell carcinoma. J Clin Oncol 2009;27:1432-9.
    • (2009) J Clin Oncol , vol.27 , pp. 1432-1439
    • Feldman, D.R.1    Baum, M.S.2    Ginsberg, M.S.3    Hassoun, H.4    Flombaum, C.D.5    Velasco, S.6
  • 45
    • 84055175977 scopus 로고    scopus 로고
    • Concurrent assessment of vasculature and proliferative pharmacodynamics in patients treated with VEGFR TKI
    • abstr 3050
    • Jeraj R, Liu G, Simoncic U, Vanderhoek M, Perlman SB, Alberti D, et al. Concurrent assessment of vasculature and proliferative pharmacodynamics in patients treated with VEGFR TKI. J Clin Oncol 2010;28:abstr 3050.
    • (2010) J Clin Oncol , vol.28
    • Jeraj, R.1    Liu, G.2    Simoncic, U.3    Vanderhoek, M.4    Perlman, S.B.5    Alberti, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.