Repeated early hemofiltration filters clotting and heparin-induced thrombocytopenia in ICU

Journal of Clinical Monitoring and Computing

Volumn 29, Issue 1, 2015, Pages 25-28

  Perbet, Sébastien ^a,b   Godet, Thomas ^a   Lebreton, Aurélien ^a   Sapin, Anne Françoise ^a   Constantin, Jean Michel ^a,b  

^a UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

^b INSERM   (France)

Author keywords

4T s score; Anti PF4; Diagnosis; Hemofiltration; Heparin induced thrombocytopenia

Indexed keywords

DIAGNOSIS; POLYSACCHARIDES; PROBABILITY;

ANTI-PF4; CLINICAL SITUATIONS; FUNCTIONAL TEST; HEMOFILTRATION; LOW PROBABILITY; PLATELET ACTIVATION; PROBABILITY TESTS; THROMBOCYTOPENIA;

PASSIVE FILTERS;

HEPARIN; IMMUNOGLOBULIN G; SEROTONIN;

BLOOD CLOTTING; CASE REPORT; CHEMICALLY INDUCED; CHEMISTRY; COMPLICATION; HEMODYNAMICS; HEMOFILTRATION; HUMAN; INTENSIVE CARE; INTENSIVE CARE UNIT; MALE; METABOLISM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PATHOPHYSIOLOGY; PROCEDURES; RECURRENT DISEASE; SEVERITY OF ILLNESS INDEX; STAPHYLOCOCCUS INFECTION; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT; THROMBOCYTOPENIA; THROMBOSIS; TIME; VERY ELDERLY;

AGED, 80 AND OVER; BLOOD COAGULATION; HEMODYNAMICS; HEMOFILTRATION; HEPARIN; HUMANS; IMMUNOGLOBULIN G; INTENSIVE CARE; INTENSIVE CARE UNITS; MALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PLATELET ACTIVATION; PLATELET COUNT; RECURRENCE; SEROTONIN; SEVERITY OF ILLNESS INDEX; STAPHYLOCOCCAL INFECTIONS; THROMBOCYTOPENIA; THROMBOSIS; TIME FACTORS;

EID: 84922337895     PISSN: 13871307     EISSN: 15732614     Source Type: Journal    
DOI: 10.1007/s10877-014-9589-z     Document Type: Article

References (18)

1. Arepally GM, Ortel TL. Clinical practice. Heparin-induced thrombocytopenia. New Engl J Med. 2006;355:809–17.
2. Greinacher A, Warkentin TE. Recognition, treatment, and prevention of heparin-induced thrombocytopenia: review and update. Thromb Res. 2006;118:165–76.
3. Warkentin TE, Linkins LA. Non-necrotizing heparin-induced skin lesions and the 4T’s score. J Thromb Haemost JTH. 2010;8:1483–5.
4. Davies JO, Patel P, Zoumot Z. Diagnosing heparin induced thrombocytopenia in critically ill patients. Intensive Care Med. 2010;36:1447–8.
5. Williamson DR, Albert M, Heels-Ansdell D, et al. Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors, and outcomes. Chest. 2013;144:1207–15.
6. Lo GK, Juhl D, Warkentin TE, Sigouin CS, Eichler P, Greinacher A. Evaluation of pretest clinical score (4 T’s) for the diagnosis of heparin-induced thrombocytopenia in two clinical settings. J Thromb Haemost JTH. 2006;4:759–65.
7. Warkentin TE, Sheppard JA, Moore JC, Moore KM, Sigouin CS, Kelton JG. Laboratory testing for the antibodies that cause heparin-induced thrombocytopenia: how much class do we need? J Lab Clin Med. 2005;146:341–6.
8. Selleng S, Malowsky B, Strobel U, et al. Early-onset and persisting thrombocytopenia in post-cardiac surgery patients is rarely due to heparin-induced thrombocytopenia, even when antibody tests are positive. J Thromb Haemost JTH. 2010;8:30–6.
9. Zhao D, Sun X, Yao L, et al. The clinical significance and risk factors of anti-platelet factor 4/heparin antibody on maintenance hemodialysis patients: a two-year prospective follow-up. PLoS ONE. 2013;8:e62239.
10. Warkentin TE, Greinacher A, Gruel Y, et al. Laboratory testing for heparin-induced thrombocytopenia: a conceptual framework and implications for diagnosis. J Thromb Haemost JTH. 2011;9:2498–500.
11. Greinacher A, Amiral J, Dummel V, Vissac A, Kiefel V, Mueller-Eckhardt C. Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced platelet activation test, and platelet factor 4/heparin enzyme-linked immunosorbent assay. Transfusion. 1994;34:381–5.
12. Warkentin TE, Hayward CP, Smith CA, Kelly PM, Kelton JG. Determinants of donor platelet variability when testing for heparin-induced thrombocytopenia. J Lab Clin Med. 1992;120:371–9.
13. Lasocki S, Piednoir P, Ajzenberg N, Geffroy A, Benbara A, Montravers P. Anti-PF4/heparin antibodies associated with repeated hemofiltration-filter clotting: a retrospective study. Crit Care. 2008;12:R84.
14. Crowther MA, Cook DJ, Albert M, et al. The 4Ts scoring system for heparin-induced thrombocytopenia in medical-surgical intensive care unit patients. J Crit Care. 2010;25:287–93.
15. Bertrand PM, Perbet S, Sapin AF, et al. Heparin-induced skin necrosis: HIT-2 without thrombocytopenia. Intensive Care Med. 2011;37:172–3.
16. Godet T, Perbet S, Lebreton A, et al. Low Molecular Weight Heparin Induced Skin Necrosis without Platelet Fall Revealing Immunoallergic Heparin Induced Thrombocytopenia. Case Reports in Hematology 2013;Article ID 849168:doi:10.1155/2013/849168.
17. Lasocki S, Ajzenberg N, Quintard H, Plantefeve G, Desmonts JM, Montravers P. Heparin-induced thrombocytopenia suspected because of repeated hemofiltration filter clotting. Intensive Care Med. 2007;33:1305–7.
18. Syed S, Reilly RF. Heparin-induced thrombocytopenia: a renal perspective. Nat Rev Nephrol. 2009;5:501–11.