메뉴 건너뛰기




Volumn 118, Issue 2, 2006, Pages 165-176

Recognition, treatment, and prevention of heparin-induced thrombocytopenia: Review and update

Author keywords

Direct thrombin inhibitor; Heparin induced thrombocytopenia; PF4; Platelets; Unfractionated heparin

Indexed keywords

ANTICOAGULANT AGENT; ARGATROBAN; COUMARIN; DANAPAROID; FONDAPARINUX; HEPARIN; HIRUDIN; HIRULOG; LEPIRUDIN; LOW MOLECULAR WEIGHT HEPARIN; PHENPROCOUMON; THROMBIN INHIBITOR; VITAMIN K GROUP; WARFARIN;

EID: 33645718758     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2005.07.012     Document Type: Review
Times cited : (121)

References (38)
  • 1
    • 0029035681 scopus 로고
    • Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin
    • Warkentin T.E., Levine M.N., Hirsh J., Horsewood P., Roberts R.S., Gent M., et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med 332 (1995) 1330-1335
    • (1995) N Engl J Med , vol.332 , pp. 1330-1335
    • Warkentin, T.E.1    Levine, M.N.2    Hirsh, J.3    Horsewood, P.4    Roberts, R.S.5    Gent, M.6
  • 2
    • 0021262284 scopus 로고
    • Heparin-associated thrombocytopenia
    • King D.J., and Kelton J.G. Heparin-associated thrombocytopenia. Ann Intern Med 100 (1984) 535-540
    • (1984) Ann Intern Med , vol.100 , pp. 535-540
    • King, D.J.1    Kelton, J.G.2
  • 3
    • 0038243178 scopus 로고    scopus 로고
    • The incidence of heparin-induced thrombocytopenia in hospitalized medical patients treated with subcutaneous unfractionated heparin: a prospective cohort study
    • Girolami B., Prandoni P., Stefani P.M., Tanduo C., Sabbion P., Eichler P., et al. The incidence of heparin-induced thrombocytopenia in hospitalized medical patients treated with subcutaneous unfractionated heparin: a prospective cohort study. Blood 101 (2003) 2955-2959
    • (2003) Blood , vol.101 , pp. 2955-2959
    • Girolami, B.1    Prandoni, P.2    Stefani, P.M.3    Tanduo, C.4    Sabbion, P.5    Eichler, P.6
  • 4
    • 0030281338 scopus 로고    scopus 로고
    • A 14-year study of heparin-induced thrombocytopenia
    • Warkentin T.E., and Kelton J.G. A 14-year study of heparin-induced thrombocytopenia. Am J Med 101 (1996) 502-507
    • (1996) Am J Med , vol.101 , pp. 502-507
    • Warkentin, T.E.1    Kelton, J.G.2
  • 5
    • 0036320729 scopus 로고    scopus 로고
    • Current agents for the treatment of patients with heparin-induced thrombocytopenia
    • Warkentin T.E. Current agents for the treatment of patients with heparin-induced thrombocytopenia. Curr Opin Pulm Med 8 (2002) 405-412
    • (2002) Curr Opin Pulm Med , vol.8 , pp. 405-412
    • Warkentin, T.E.1
  • 6
    • 1542604740 scopus 로고    scopus 로고
    • Managing heparin-induced thrombocytopenia: preventing life- and limb-threatening thrombosis. Introduction
    • Spinler S.A. Managing heparin-induced thrombocytopenia: preventing life- and limb-threatening thrombosis. Introduction. Am J Health-Syst Pharm 60 S5 (2003) S2-S4
    • (2003) Am J Health-Syst Pharm , vol.60 , Issue.SUPPL.5
    • Spinler, S.A.1
  • 7
    • 0031795614 scopus 로고    scopus 로고
    • Clinical presentation of heparin-induced thrombocytopenia
    • Warkentin T.E. Clinical presentation of heparin-induced thrombocytopenia. Semin Hematol 35 S5 (1998) 9-16
    • (1998) Semin Hematol , vol.35 , Issue.SUPPL.5 , pp. 9-16
    • Warkentin, T.E.1
  • 8
    • 1242297625 scopus 로고    scopus 로고
    • Treatment of heparin-induced thrombocytopenia: a critical review
    • Hirsh J., Heddle N., and Kelton J.G. Treatment of heparin-induced thrombocytopenia: a critical review. Arch Intern Med 164 (2004) 361-369
    • (2004) Arch Intern Med , vol.164 , pp. 361-369
    • Hirsh, J.1    Heddle, N.2    Kelton, J.G.3
  • 9
    • 0030722915 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: pathogenesis, frequency, avoidance and management
    • Warkentin T.E. Heparin-induced thrombocytopenia: pathogenesis, frequency, avoidance and management. Drug Safety 17 (1997) 325-341
    • (1997) Drug Safety , vol.17 , pp. 325-341
    • Warkentin, T.E.1
  • 10
    • 0037236532 scopus 로고    scopus 로고
    • Comparison of bovine and porcine heparin in heparin antibody formation after cardiac surgery
    • Francis J.L., Palmer III G.J., Moroose R., and Drexler A. Comparison of bovine and porcine heparin in heparin antibody formation after cardiac surgery. Ann Thorac Surg 75 (2003) 17-22
    • (2003) Ann Thorac Surg , vol.75 , pp. 17-22
    • Francis, J.L.1    Palmer III, G.J.2    Moroose, R.3    Drexler, A.4
  • 11
    • 4644242157 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: recognition, treatment, and prevention: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy [review]
    • Warkentin T.E., and Greinacher A. Heparin-induced thrombocytopenia: recognition, treatment, and prevention: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy [review]. Chest 126 (2004) 311S-337S
    • (2004) Chest , vol.126
    • Warkentin, T.E.1    Greinacher, A.2
  • 12
    • 4644371113 scopus 로고    scopus 로고
    • Applying the grades of recommendation for antithrombotic and thrombolytic therapy: the seventh ACCP conference on antithrombotic and thrombolytic therapy
    • Guyatt G., Schünemann H.J., Cook D., Jaeschke R., and Pauker S. Applying the grades of recommendation for antithrombotic and thrombolytic therapy: the seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest 126(S) (2004) 179S-187S
    • (2004) Chest , vol.126 S
    • Guyatt, G.1    Schünemann, H.J.2    Cook, D.3    Jaeschke, R.4    Pauker, S.5
  • 13
    • 0029062152 scopus 로고
    • Heparin-induced thrombocytopenia and thrombosis
    • Aster R.H. Heparin-induced thrombocytopenia and thrombosis. N Engl J Med 332 (1995) 1374-1376
    • (1995) N Engl J Med , vol.332 , pp. 1374-1376
    • Aster, R.H.1
  • 14
    • 1542395062 scopus 로고    scopus 로고
    • Overview of heparin-induced thrombocytopenia
    • Spinler S.A., and Dager W. Overview of heparin-induced thrombocytopenia. Am J Health-Syst Pharm 60 S5 (2003) S5-S11
    • (2003) Am J Health-Syst Pharm , vol.60 , Issue.SUPPL.5
    • Spinler, S.A.1    Dager, W.2
  • 15
    • 0035953702 scopus 로고    scopus 로고
    • Temporal aspects of heparin-induced thrombocytopenia
    • Warkentin T.E., and Kelton J.G. Temporal aspects of heparin-induced thrombocytopenia. N Engl J Med 344 (2001) 1286-1292
    • (2001) N Engl J Med , vol.344 , pp. 1286-1292
    • Warkentin, T.E.1    Kelton, J.G.2
  • 16
    • 0035797925 scopus 로고    scopus 로고
    • Delayed-onset heparin-induced thrombocytopenia and thrombosis
    • Warkentin T.E., and Kelton J.G. Delayed-onset heparin-induced thrombocytopenia and thrombosis. Ann Intern Med 135 (2001) 502-506
    • (2001) Ann Intern Med , vol.135 , pp. 502-506
    • Warkentin, T.E.1    Kelton, J.G.2
  • 17
    • 33744549258 scopus 로고    scopus 로고
    • Greinacher A, Farner B, Kroll H, Kohlmann T, Warkentin TE, Eichler P. Clinical features of heparin-induced thrombocytopenia including risk factors for thrombosis: a retrospective analysis of 408 patients. Thromb Haemost in press.
  • 18
    • 33744518619 scopus 로고    scopus 로고
    • Greinacher A, Eichler P, Lietz T, Warkentin TE. Replacement of unfractioned heparin by low-molecular-weight heparin for postorthopedic surgery antithrombotic prophylaxis lowers the overall risk of symptomatic thrombosis because of a lower frequency of heparin-induced thrombocytopenia. Blood in press.
  • 19
    • 13544251729 scopus 로고    scopus 로고
    • New approaches to the diagnosis of heparin-induced thrombocytopenia
    • Warkentin T.E. New approaches to the diagnosis of heparin-induced thrombocytopenia. Chest 127 S2 (2005) 35S-45S
    • (2005) Chest , vol.127 , Issue.SUPPL.2
    • Warkentin, T.E.1
  • 20
    • 0028335456 scopus 로고
    • Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced platelet activation test, and platelet factor 4/heparin enzyme-linked immunosorbent assay
    • Greinacher A., Amiral J., Dummel V., Vissac A., Kiefel V., and Mueller-Eckhardt C. Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced platelet activation test, and platelet factor 4/heparin enzyme-linked immunosorbent assay. Transfusion 34 (1994) 381-385
    • (1994) Transfusion , vol.34 , pp. 381-385
    • Greinacher, A.1    Amiral, J.2    Dummel, V.3    Vissac, A.4    Kiefel, V.5    Mueller-Eckhardt, C.6
  • 21
    • 0033029056 scopus 로고    scopus 로고
    • Failure of early heparin cessation as treatment for heparin-induced thrombocytopenia
    • Wallis D.E., Workman D.L., Lewis B.E., Steen L., Pifarre R., and Moran J.F. Failure of early heparin cessation as treatment for heparin-induced thrombocytopenia. Am J Med 106 (1999) 629-635
    • (1999) Am J Med , vol.106 , pp. 629-635
    • Wallis, D.E.1    Workman, D.L.2    Lewis, B.E.3    Steen, L.4    Pifarre, R.5    Moran, J.F.6
  • 22
    • 0030764112 scopus 로고    scopus 로고
    • Heparin-associated thrombocytopenia and thrombosis: implications for perioperative management
    • Slaughter T.F., and Greenberg C.S. Heparin-associated thrombocytopenia and thrombosis: implications for perioperative management. Anesthesiology 87 (1997) 667-675
    • (1997) Anesthesiology , vol.87 , pp. 667-675
    • Slaughter, T.F.1    Greenberg, C.S.2
  • 23
    • 0032854536 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia (HIT) due to heparin flushes: a report of three cases
    • Kadidal V.V., Mayo D.J., and Horne M.K. Heparin-induced thrombocytopenia (HIT) due to heparin flushes: a report of three cases. J Intern Med 246 (1999) 325-329
    • (1999) J Intern Med , vol.246 , pp. 325-329
    • Kadidal, V.V.1    Mayo, D.J.2    Horne, M.K.3
  • 24
    • 0034254793 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia with thromboembolic complications: meta-analysis of 2 prospective trials to assess the value of parenteral treatment with lepirudin and its therapeutic aPTT range
    • Greinacher A., Eichler P., Lubenow N., Kwasny H., and Luz M. Heparin-induced thrombocytopenia with thromboembolic complications: meta-analysis of 2 prospective trials to assess the value of parenteral treatment with lepirudin and its therapeutic aPTT range. Blood 96 (2000) 846-851
    • (2000) Blood , vol.96 , pp. 846-851
    • Greinacher, A.1    Eichler, P.2    Lubenow, N.3    Kwasny, H.4    Luz, M.5
  • 25
    • 0035853125 scopus 로고    scopus 로고
    • Recombinant hirudin in clinical practice: focus on lepirudin
    • Greinacher A., and Lubenow N. Recombinant hirudin in clinical practice: focus on lepirudin. Circulation 103 (2001) 1479-1484
    • (2001) Circulation , vol.103 , pp. 1479-1484
    • Greinacher, A.1    Lubenow, N.2
  • 26
    • 33744525932 scopus 로고    scopus 로고
    • Refludan [package insert]. Wayne, NJ: Berlex Laboratories; 2002.
  • 27
    • 33744535956 scopus 로고    scopus 로고
    • Argatroban [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2003.
  • 28
    • 2542466025 scopus 로고    scopus 로고
    • Lepirudin: a bivalent direct thrombin inhibitor for anticoagulation therapy
    • Greinacher A. Lepirudin: a bivalent direct thrombin inhibitor for anticoagulation therapy. Exp Rev Cardiovasc Ther 2 (2004) 89-106
    • (2004) Exp Rev Cardiovasc Ther , vol.2 , pp. 89-106
    • Greinacher, A.1
  • 29
    • 0035836541 scopus 로고    scopus 로고
    • Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia
    • for the ARG-911 Study Investigators
    • Lewis B.E., et al., for the ARG-911 Study Investigators. Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia. Circulation 103 (2001) 1838-1843
    • (2001) Circulation , vol.103 , pp. 1838-1843
    • Lewis, B.E.1
  • 30
    • 0038285887 scopus 로고    scopus 로고
    • Argatroban anticoagulation in patients with heparin-induced thrombocytopenia
    • for The Argatroban-915 Investigators
    • Lewis B.E., Wallis D.E., Leya F., Hursting M.J., Kelton J.G., and for The Argatroban-915 Investigators. Argatroban anticoagulation in patients with heparin-induced thrombocytopenia. Arch Intern Med 163 (2003) 1849-1856
    • (2003) Arch Intern Med , vol.163 , pp. 1849-1856
    • Lewis, B.E.1    Wallis, D.E.2    Leya, F.3    Hursting, M.J.4    Kelton, J.G.5
  • 31
    • 8644253626 scopus 로고    scopus 로고
    • Lepirudin for prophylaxis of thrombosis in patients with acute isolated heparin-induced thrombocytopenia: an analysis of 3 prospective studies
    • Lubenow N., Eichler P., Lietz T., Farner B., and Greinacher A. Lepirudin for prophylaxis of thrombosis in patients with acute isolated heparin-induced thrombocytopenia: an analysis of 3 prospective studies. Blood 104 (2004) 3072-3077
    • (2004) Blood , vol.104 , pp. 3072-3077
    • Lubenow, N.1    Eichler, P.2    Lietz, T.3    Farner, B.4    Greinacher, A.5
  • 32
    • 0008664440 scopus 로고    scopus 로고
    • Warkentin T.E., and Greinacher A. (Eds), Marcel Dekker, Inc., New York, NY
    • In: Warkentin T.E., and Greinacher A. (Eds). Heparin-induced thrombocytopenia. 2nd ed. (2001), Marcel Dekker, Inc., New York, NY
    • (2001) Heparin-induced thrombocytopenia. 2nd ed.
  • 33
    • 33744515847 scopus 로고    scopus 로고
    • Lubenow N, Eichler P, Greinacher A. Results of a large drug-monitoring program confirms the safety and efficacy of Refludan (lepirudin) in patients with immune-mediated heparin-induced thrombocytopenia (HIT) [abstract]. Blood 2002;100(pt 1):502a [Abstract 1955].
  • 34
    • 4143113354 scopus 로고    scopus 로고
    • Comparing direct thrombin inhibitors using aPTT, ecarin clotting times, and thrombin inhibitor management testing
    • Gosselin R.C., King J.H., Janatpour K.A., Dager W.E., Larkin E.C., and Owings J.T. Comparing direct thrombin inhibitors using aPTT, ecarin clotting times, and thrombin inhibitor management testing. Ann Pharmacother 38 (2004) 1383-1388
    • (2004) Ann Pharmacother , vol.38 , pp. 1383-1388
    • Gosselin, R.C.1    King, J.H.2    Janatpour, K.A.3    Dager, W.E.4    Larkin, E.C.5    Owings, J.T.6
  • 35
    • 0036800879 scopus 로고    scopus 로고
    • Methods for the monitoring of direct thrombin inhibitors
    • Hafner G., Roser M., and Nauck M. Methods for the monitoring of direct thrombin inhibitors. Semin Thromb Hemost 28 (2002) 425-430
    • (2002) Semin Thromb Hemost , vol.28 , pp. 425-430
    • Hafner, G.1    Roser, M.2    Nauck, M.3
  • 36
    • 0242381320 scopus 로고    scopus 로고
    • Anaphylactic and anaphylactoid reactions associated with lepirudin in patients with heparin-induced thrombocytopenia
    • Greinacher A., Lubenow N., and Eichler P. Anaphylactic and anaphylactoid reactions associated with lepirudin in patients with heparin-induced thrombocytopenia. Circulation 108 (2003) 2062-2065
    • (2003) Circulation , vol.108 , pp. 2062-2065
    • Greinacher, A.1    Lubenow, N.2    Eichler, P.3
  • 37
    • 0033543081 scopus 로고    scopus 로고
    • Lepirudin (recombinant hirudin) for parenteral anticoagulation in patients with heparin-induced thrombocytopenia
    • and for the Heparin-Associated Thrombocytopenia Study (HAT) Investigators
    • Greinacher A., et al., and for the Heparin-Associated Thrombocytopenia Study (HAT) Investigators. Lepirudin (recombinant hirudin) for parenteral anticoagulation in patients with heparin-induced thrombocytopenia. Circulation 100 (1999) 587-593
    • (1999) Circulation , vol.100 , pp. 587-593
    • Greinacher, A.1
  • 38
    • 1642317572 scopus 로고    scopus 로고
    • Effect of direct thrombin inhibitors, bivalirudin, lepirudin, and argatroban, on prothrombin time and INR values
    • Gosselin R.C., Dager W.E., King J.H., Janatpour K.A., Mahackian K.A., Larkin E.C., et al. Effect of direct thrombin inhibitors, bivalirudin, lepirudin, and argatroban, on prothrombin time and INR values. Am J Clin Pathol 121 (2004) 593-599
    • (2004) Am J Clin Pathol , vol.121 , pp. 593-599
    • Gosselin, R.C.1    Dager, W.E.2    King, J.H.3    Janatpour, K.A.4    Mahackian, K.A.5    Larkin, E.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.