Laboratory testing for the antibodies that cause heparin-induced thrombocytopenia: How much class do we need?

Journal of Laboratory and Clinical Medicine

Volumn 146, Issue 6, 2005, Pages 341-346

  Warkentin, Theodore E ^a,b   Sheppard, Jo Ann I ^a   Moore, Jane C ^a   Moore, Kathleen M ^a   Sigouin, Christopher S ^a   Kelton, John G ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b HAMILTON REGIONAL LABORATORY MEDICINE PROGRAM   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LOW MOLECULAR WEIGHT HEPARIN;

ANTIBODY PRODUCTION; ARTICLE; COMPARATIVE STUDY; ELECTROIMMUNOASSAY; IMMUNE RESPONSE; IMMUNOASSAY; LABORATORY TEST; MONITORING; SENSITIVITY AND SPECIFICITY; SEROLOGY; SEROTONIN RELEASE; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

CLINICAL MEDICINE; HEPARIN; HUMANS; IMMUNOGLOBULIN ISOTYPES; PROSPECTIVE STUDIES; ROC CURVE; THROMBOCYTOPENIA;

EID: 28244476376     PISSN: 00222143     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lab.2005.08.003     Document Type: Article

References (22)

1. R.H. Aster Heparin-induced thrombocytopenia and thrombosis N Engl J Med 332 1995 1374 1376
2. T.E. Warkentin Heparin-induced thrombocytopenia pathogenesis and management Br J Haematol 121 2003 535 555
3. T.E. Warkentin, J.G. Kelton A 14-year study of heparin-induced thrombocytopenia Am J Med 101 1996 502 507
4. J. Amiral, F. Bridey, M. Dreyfus, A.M. Vissoc, E. Fressinaud, M. Wolf Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia Thromb Haemost 68 1992 95 96
5. G.P. Visentin, S.E. Ford, J.P. Scott, R.H. Aster Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells J Clin Invest 93 1994 81 88
6. A. Greinacher, B. Poetzsch, J. Amiral, V. Dummel, A. Eichner, C. Mueller-Eckhardt Heparin-associated thrombocytopenia isolation of the antibody and characterization of a multimolecular PF4-heparin complex as the major antigen Thromb Haemost 71 1994 247 251
7. J.G. Kelton, J.W. Smith, T.E. Warkentin, C.P.M. Hayward, G.A. Denomme, P. Horsewood Immunoglobulin G from patients with heparin-induced thrombocytopenia binds to a complex of heparin and platelet factor 4 Blood 83 1994 3232 3239
8. E. Lindhoff-Last, F. Gerdsen, H. Ackermann, R. Bauersachs Determination of heparin-platelet factor 4-IgG antibodies improves diagnosis of heparin-induced thrombocytopenia Br J Haematol 113 2001 886 890
9. T.E. Warkentin, B.H. Chong, A. Greinacher Heparin-induced thrombocytopenia towards consensus Thromb Haemost 79 1998 1 7
10. T.E. Warkentin, J.G. Kelton Temporal aspects of heparin-induced thrombocytopenia N Engl J Med 344 2001 1286 1292 2001
11. N. Lubenow, R. Kempf, A. Eichner, P. Eichler, L.E. Carlsson, A. Greinacher Heparin-induced thrombocytopenia temporal pattern of thrombocytopenia in relation to initial use or reexposure to heparin Chest 122 2002 37 42
12. T.E. Warkentin Laboratory testing for heparin-induced thrombocytopenia J Thromb Thrombolysis 10 2000 35 45
13. D.B. Cines, J.B. Bussel, R.B. McMillan, J.L. Zehnder Congenital and acquired thrombocytopenia Hematology (Am Soc Hematol Educ Program) 2004 390 406
14. J. Amiral, M. Wolf, A. Fischer, C. Boyer-Neumann, A. Vissac, D. Meyer Pathogenicity of IgA and/or IgM antibodies to heparin-PF4 complexes in patients with heparin-induced thrombocytopenia Br J Haematol 92 1996 954 959
15. T.E. Warkentin, M.N. Levine, J. Hirsh, P. Horsewood, R.S. Roberts, M. Gent Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin N Engl J Med 332 1995 1330 1335
16. T.E. Warkentin, R.S. Roberts, J. Hirsh, J.G. Kelton An improved definition of immune heparin-induced thrombocytopenia in postoperative orthopedic patients Arch Intern Med 163 2003 2518 2524
17. T.E. Warkentin, J.I. Sheppard, P. Horsewood, P.J. Simpson, J.C. Moore, J.G. Kelton Impact of the patient population on the risk for heparin-induced thrombocytopenia Blood 96 2000 1703 1708
18. D. Sheridan, C. Carter, J.G. Kelton A diagnostic test for heparin-induced thrombocytopenia Blood 67 1986 27 30
19. T.E. Warkentin, C.P.M. Hayward, C.A. Smith, P.M. Kelly, J.G. Kelton Determinants of donor platelet variability when testing for heparin-induced thrombocytopenia J Lab Clin Med 120 1992 371 379
20. P. Horsewood, T.E. Warkentin, C.P.M. Hayward, J.G. Kelton The epitope specificity of heparin-induced thrombocytopenia Br J Haematol 95 1996 161 167
21. C.F. Metz Basic principles of ROC analysis Semin Nucl Med 8 1978 283 298
22. J.I. Zwicker, L. Uhl, W.Y. Huang, B.H. Shaz, K.A. Bauer Thrombosis and ELISA optical density values in hospitalized patients with heparin-induced thrombocytopenia J Thromb Haemost 2 2004 2133 2137