The preventability of ventilator-associated events: The CDC Prevention Epicenters Wake Up and Breathe Collaborative

American Journal of Respiratory and Critical Care Medicine

Volumn 191, Issue 3, 2015, Pages 292-301

  Klompas, Michael ^a,b   Anderson, Deverick ^c   Trick, William ^d   Babcock, Hilary ^e   Kerlin, Meeta Prasad ^f   Li, Lingling ^a   Sinkowitz Cochran, Ronda ^g   Ely, E Wesley ^h,i   Jernigan, John ^g   Magill, Shelley ^g   Lyles, Rosie ^d   O'Neil, Caroline ^e   Kitch, Barrett T ^j   Arrington, Ellen ^j   Balas, Michele C ^k   Kleinman, Ken ^a   Bruce, Christina ^a   Lankiewicz, Julie ^a   Murphy, Michael V ^a   Cox, Christopher E ^c   Lautenbach, Ebbing ^f   Sexton, Daniel ^c   Fraser, Victoria ^e   Weinstein, Robert A ^d   Platt, Richard ^a,b   more..

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Cook County Health and Hospital Systems ^*  (United States)

^e WASHINGTON UNIVERSITY   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

^g NATIONAL CENTER FOR EMERGING AND ZOONOTIC INFECTIOUS DISEASES   (United States)

^h VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

ⁱ Veteran's Affairs Tennessee Valley Healthcare System   (United States)

^j NORTH SHORE MEDICAL CENTER   (United States)

^k OHIO STATE UNIVERSITY   (United States)

more..

Author keywords

Quality improvement; Surveillance; Ventilator associated events

Indexed keywords

ADULT; ARTICLE; ARTIFICIAL VENTILATION; CLINICAL PROTOCOL; COMORBIDITY; DISEASE SURVEILLANCE; ELIXHAUSER COMORBIDITY INDEX; FEMALE; HUMAN; INFECTIOUS COMPLICATION; INTENSIVE CARE; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MEDICAL DEVICE COMPLICATION; MIDDLE AGED; MULTICENTER STUDY; NURSE; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESPIRATORY THERAPIST; RESPIRATORY TRACT INTUBATION; SEDATION; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; TOTAL QUALITY MANAGEMENT; VENTILATED PATIENT; VENTILATOR; VENTILATOR ASSOCIATED EVENT; ADVERSE EFFECTS; CLINICAL TRIAL; DELIRIUM; PNEUMONIA, VENTILATOR-ASSOCIATED; PROCEDURES; PULMONARY ATELECTASIS; PULMONARY EDEMA; RISK ASSESSMENT; RISK FACTOR; STANDARDS; THROMBOEMBOLISM; TIME FACTOR; UNITED STATES; VENTILATOR WEANING;

DELIRIUM; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; PNEUMONIA, VENTILATOR-ASSOCIATED; PROSPECTIVE STUDIES; PULMONARY ATELECTASIS; PULMONARY EDEMA; RESPIRATION, ARTIFICIAL; RISK ASSESSMENT; RISK FACTORS; THROMBOEMBOLISM; TIME FACTORS; UNITED STATES; VENTILATOR WEANING;

EID: 84922326922     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201407-1394OC     Document Type: Article

References (40)

1. Klein Klouwenberg PM, Ong DS, Bos LD, de Beer FM, van Hooijdonk RT, Huson MA, Straat M, van Vught LA, Wieske L, Horn J, et al. Interobserver agreement of Centers for Disease Control and Prevention criteria for classifying infections in critically ill patients. Crit Care Med 2013;41:2373-2378.
2. Stevens JP, Kachniarz B, Wright SB, Gillis J, Talmor D, Clardy P, Howell MD. When policy gets it right: variability in U.S. Hospitals' diagnosis of ventilator-associated pneumonia. Crit Care Med 2014;42:497-503.
3. Melsen WG, Rovers MM, Groenwold RH, Bergmans DC, Camus C, Bauer TT, Hanisch EW, Klarin B, Koeman M, Krueger WA, et al. Attributable mortality of ventilator-associated pneumonia: a meta-analysis of individual patient data from randomised prevention studies. Lancet Infect Dis 2013;13:665-671.
4. Magill SS, Klompas M, Balk R, Burns SM, Deutschman CS, Diekema D, Fridkin S, Greene L, Guh A, Gutterman D, et al. Developing a new, national approach to surveillance for ventilator-associated events. Crit Care Med 2013;41:2467-2475.
5. Klompas M. Complications of mechanical ventilation - the CDC's new surveillance paradigm. N Engl J Med 2013;368:1472-1475.
6. Shorr AF, Zilberberg MD. Nature (and the ICU) abhors a VACuum. Chest 2012;142:1365-1366.
7. Lilly CM, Ellison RT III. Quality measures for critically ill patients: where does ventilator-associated condition fit in? Chest 2013;144:1429-1430.
8. Girard TD, Kress JP, Fuchs BD, Thomason JW, Schweickert WD, Pun BT, Taichman DB, Dunn JG, Pohlman AS, Kinniry PA, et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet 2008;371:126-134.
9. Strøm T, Martinussen T, Toft P. A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial. Lancet 2010;375:475-480.
10. Jackson DL, Proudfoot CW, Cann KF, Walsh T. A systematic review of the impact of sedation practice in the ICU on resource use, costs and patient safety. Crit Care 2010;14:R59.
11. Nseir S, Makris D, Mathieu D, Durocher A, Marquette CH. Intensive care unit-acquired infection as a side effect of sedation. Crit Care 2010;14:R30.
12. Klompas M, Andersen DJ, Trick W, Babcock H, Sinkowitz-Cochran RL, Ely EW, Jernigan JA, Magill S, Lyles RD, O'Neill C, et al. The preventability of ventilator-associated events: the CDC Prevention Epicenters' Wake Up and Breathe Collaborative. Presented at ID Week 2014, October 8-12, 2014, Philadelphia, PA. Abstract 46339.
13. Institute for Healthcare Improvement. The Breathrough Series: IHI's collaborative model for achieving breakthrough improvement. Diabetes Spectrum 2004;17:97-101.
14. Elixhauser A, Steiner C, Harris DR, Coffey RM. Comorbidity measures for use with administrative data. Med Care 1998;36:8-27.
15. van Walraven C, Austin PC, Jennings A, Quan H, Forster AJ. A modification of the Elixhauser comorbidity measures into a point system for hospital death using administrative data. Med Care 2009;47:626-633.
16. Centers for Disease Control and Prevention. Ventilator-associated event protocol. 2014 [accessed 2014 March 25]. Available from: http://www.cdc.gov/nhsn/acute-care-hospital/vae/index.html
17. van Buuren S, Boshuizen HC, Knook DL. Multiple imputation of missing blood pressure covariates in survival analysis. Stat Med 1999;18:681-694.
18. Raghunathan TE, Lepkowski JM, van Hoewyk J, Solenberger P. A multivariate technique for multiply imputing missing values using a sequence of regression models. Surv Methodol 2001;27:85-95.
19. Klompas M, Khan Y, Kleinman K, Evans RS, Lloyd JF, Stevenson K, Samore M, Platt R; CDC Prevention Epicenters Program. Multicenter evaluation of a novel surveillance paradigm for complications of mechanical ventilation. PLoS One 2011;6:e18062.
20. Klompas M, Magill S, Robicsek A, Strymish JM, Kleinman K, Evans RS, Lloyd JF, Khan Y, Yokoe DS, Stevenson K, et al.; CDC Prevention Epicenters Program. Objective surveillance de finitions for ventilator-associated pneumonia. Crit Care Med 2012;40:3154-3161.
21. Hayashi Y, Morisawa K, Klompas M, Jones M, Bandeshe H, Boots R, Lipman J, Paterson DL. Toward improved surveillance: the impact of ventilator-associated complications on length of stay and antibiotic use in patients in intensive care units. Clin Infect Dis 2013;56:471-477.
22. Muscedere J, Sinuff T, Heyland D, Dodek P, Keenan S, Wood G, Jiang X, Day A, Laporta D. The clinical impact and preventability of ventilator-associated conditions in critically ill mechanically ventilated patients. Chest 2013;144:1453-1460.
23. Klompas M, Kleinman K, Murphy MV. Descriptive epidemiology and attributable morbidity of ventilator-associated events. Infect Control Hosp Epidemiol 2014;35:502-510.
24. Prospero E, Illuminati D, Marigliano A, Pelaia P, Munch C, Barbadoro P, D'Errico MM. Learning from Galileo: ventilator-associated pneumonia surveillance. Am J Respir Crit Care Med 2012;186:1308-1309.
25. Klein Klouwenberg PM, van Mourik MS, Ong DS, Horn J, Schultz MJ, Cremer OL, Bonten MJ; MARS Consortium. Electronic implementation of a novel surveillance paradigm for ventilator-associated events. Feasibility and validation. Am J Respir Crit Care Med 2014;189:947-955.
26. Lilly CM, Landry KE, Sood RN, Dunnington CH, Ellison RT III, Bagley PH, Baker SP, Cody S, Irwin RS; UMass Memorial Critical Care Operations Group; UMass Memorial Critical Care Operations Group. Prevalence and test characteristics of national health safety network ventilator-associated events. Crit Care Med 2014;42:2019-2028.
27. Barr J, Fraser GL, Puntillo K, Ely EW, Gélinas C, Dasta JF, Davidson JE, Devlin JW, Kress JP, Joffe AM, et al.; American College of Critical Care Medicine. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med 2013;41:263-306.
28. Mehta S, Burry L, Fischer S, Martinez-Motta JC, Hallett D, Bowman D, Wong C, Meade MO, Stewart TE, Cook DJ; Canadian Critical Care Trials Group. Canadian survey of the use of sedatives, analgesics, and neuromuscular blocking agents in critically ill patients. Crit Care Med 2006;34:374-380.
29. Miller MA, Krein SL, George CT, Watson SR, Hyzy RC, Iwashyna TJ. Diverse attitudes to and understandings of spontaneous awakening trials: results from a statewide quality improvement collaborative. Crit Care Med 2013;41:1976-1982.
30. Patel RP, Gambrell M, Speroff T, Scott TA, Pun BT, Okahashi J, Strength C, Pandharipande P, Girard TD, Burgess H, et al. Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionals. Crit Care Med 2009;37:825-832.
31. Leone M, Ragonnet B, Alonso S, Allaouchiche B, Constantin JM, Jaber S, Martin C, Fabbro-Peray P, Lefrant JY; AzuRéa Group. Variable compliance with clinical practice guidelines identified in a 1-day audit at 66 French adult intensive care units. Crit Care Med 2012;40:3189-3195.
32. Mehta S, Burry L, Cook D, Fergusson D, Steinberg M, Granton J, Herridge M, Ferguson N, Devlin J, Tanios M, et al.; SLEAP Investigators; Canadian Critical Care Trials Group. Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA 2012;308:1985-1992.
33. Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, Spears L, Miller M, Franczyk M, Deprizio D, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 2009;373:1874-1882.
34. Mekontso Dessap A, Roche-Campo F, Kouatchet A, Tomicic V, Beduneau G, Sonneville R, Cabello B, Jaber S, Azoulay E, Castanares-Zapatero D, et al. Natriuretic peptide-driven fluid management during ventilator weaning: a randomized controlled trial. Am J Respir Crit Care Med 2012;186:1256-1263.
35. Lellouche F, Mancebo J, Jolliet P, Roeseler J, Schortgen F, Dojat M, Cabello B, Bouadma L, Rodriguez P, Maggiore S, et al. A multicenter randomized trial of computer-driven protocolized weaning from mechanical ventilation. Am J Respir Crit Care Med 2006;174:894-900.
36. Mekontso Dessap A, Katsahian S, Roche-Campo F, Varet H, Kouatchet A, Tomicic V, Beduneau G, Sonneville R, Jaber S, Darmon M, et al. Ventilator-associated pneumonia during weaning from mechanical ventilation: role of fluid management. Chest 2014:146:58-65.
37. Wright MO, Kharasch M, Beaumont JL, Peterson LR, Robicsek A. Reporting catheter-associated urinary tract infections: denominator matters. Infect Control Hosp Epidemiol 2011;32:635-640.
38. Serpa Neto A, Cardoso SO, Manetta JA, Pereira VG, Espósito DC, Pasqualucci Mde.O, Damasceno MC, Schultz MJ. Association between use of lung-protective ventilation with lower tidal volumes and clinical outcomes among patients without acute respiratory distress syndrome: a meta-analysis. JAMA 2012;308:1651-1659.
39. Hébert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999;340:409-417.
40. Muscedere J, Rewa O, McKechnie K, Jiang X, Laporta D, Heyland DK. Subglottic secretion drainage for the prevention of ventilator-associated pneumonia: a systematic review and meta-analysis. Crit Care Med 2011;39:1985-1991.