Attributable mortality of ventilator-associated pneumonia: A meta-analysis of individual patient data from randomised prevention studies

The Lancet Infectious Diseases

Volumn 13, Issue 8, 2013, Pages 665-671

  Melsen, Wilhelmina G ^a   Rovers, Maroeska M ^a,b   Groenwold, Rolf HH ^a   Bergmans, Dennis CJJ ^c   Camus, Christophe ^d   Bauer, Torsten T ^e   Hanisch, Ernst W ^f   Klarin, Bengt ^g   Koeman, Mirelle ^h   Krueger, Wolfgang A ^a   Lacherade, Jean Claude ⁱ   Lorente, Leonardo ^j   Memish, Ziad A ^k   Morrow, Lee E ^l   Nardi, Giuseppe ^m   van Nieuwenhoven, Christianne A ⁿ   O'Keefe, Grant E ^o   Nakos, George ^p   Scannapieco, Frank A ^q,v   Seguin, Philippe ^r,w   Staudinger, Thomas ^c,x   Topeli, Arzu ^s,y   Ferrer, Miquel ^t,z   Bonten, Marc JM ^a,u   more..

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^d HÔpital de Pontchaillou   (France)

^e UNIVERSITY OF BARCELONA   (Spain)

^f HELIOS KLINIKUM EMIL VON BEHRING   (Germany)

^g GOETHE UNIVERSITY   (Germany)

^h LUND UNIVERSITY HOSPITAL   (Sweden)

ⁱ HAGA HOSPITAL   (Netherlands)

^j UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^k KLINIKUM KONSTANZ   (Germany)

^l Service de Réanimation Polyvalente   (France)

^m HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

ⁿ KING FAHAD NATIONAL GUARD HOSPITAL   (Saudi Arabia)

^o MINISTRY OF HEALTH   (Saudi Arabia)

^p CREIGHTON UNIVERSITY MEDICAL CENTER   (United States)

^q SANTA MARIA DELLA MISERICORDIA UNIVERSITY HOSPITAL   (Italy)

^r SAN CAMILLO FORLANINI HOSPITAL   (Italy)

^s ERASMUS MEDICAL CENTER   (Netherlands)

^t UNIVERSITY OF WASHINGTON   (United States)

^u UNIVERSITY HOSPITAL OF IOANNINA   (Greece)

^v UNIVERSITY AT BUFFALO   (United States)

^w PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^x MEDICAL UNIVERSITY OF VIENNA   (Austria)

^y HACETTEPE UNIVERSITY   (Turkey)

^z INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

more..

Author keywords

[No Author keywords available]

Indexed keywords

APACHE; ARTICLE; ARTIFICIAL VENTILATION; DISEASE SEVERITY; DYING; HUMAN; INJURY; INTENSIVE CARE UNIT; LENGTH OF STAY; META ANALYSIS; MORTALITY; PRIORITY JOURNAL; RISK FACTOR; RISK REDUCTION; SIMPLIFIED ACUTE PHYSIOLOGY SCORE; SURGICAL PATIENT; VENTILATOR ASSOCIATED PNEUMONIA;

APACHE; CONFIDENCE INTERVALS; HUMANS; INTENSIVE CARE; LENGTH OF STAY; PNEUMONIA, VENTILATOR-ASSOCIATED; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SURGICAL PROCEDURES, OPERATIVE;

EID: 84880702331     PISSN: 14733099     EISSN: 14744457     Source Type: Journal    
DOI: 10.1016/S1473-3099(13)70081-1     Document Type: Article

References (32)

1. Vincent JL, Rello J, Marshall J, et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA 2009, 302:2323-2329.
2. Melsen WG, Rovers MM, Bonten MJ Ventilator-associated pneumonia and mortality: a systematic review of observational studies. Crit Care Med 2009, 37:2709-2718.
3. Nguile-Makao M, Zahar JR, Francais A, et al. Attributable mortality of ventilator-associated pneumonia: respective impact of main characteristics at ICU admission and VAP onset using conditional logistic regression and multi-state models. Intensive Care Med 2010, 36:781-789.
4. Schumacher M, Wangler M, Wolkewitz M, Beyersmann J Attributable mortality due to nosocomial infections. A simple and useful application of multistate models. Methods Inf Med 2007, 46:595-600.
5. Melsen WG, Rovers MM, Koeman M, Bonten MJ Estimating the attributable mortality of ventilator-associated pneumonia from randomized prevention studies. Crit Care Med 2011, 39:2736-2742.
6. Krueger WA, Lenhart FP, Neeser G, et al. Influence of combined intravenous and topical antibiotic prophylaxis on the incidence of infections, organ dysfunctions, and mortality in critically ill surgical patients: a prospective, stratified, randomized, double-blind, placebo-controlled clinical trial. Am J Respir Crit Care Med 2002, 166:1029-1037.
7. Bergmans DC, Bonten MJ, Gaillard CA, et al. Prevention of ventilator-associated pneumonia by oral decontamination: a prospective, randomized, double-blind, placebo-controlled study. Am J Respir Crit Care Med 2001, 164:382-388.
8. Camus C, Bellissant E, Sebille V, et al. Prevention of acquired infections in intubated patients with the combination of two decontamination regimens. Crit Care Med 2005, 33:307-314.
9. Cook D, Guyatt G, Marshall J, et al. A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. New Engl J Med 1998, 338:791-797.
10. Drakulovic MB, Torres A, Bauer TT, Nicolas JM, Nogue S, Ferrer M Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet 1999, 354:1851-1858.
11. Hanisch EW, Encke A, Naujoks F, Windolf J A randomized, double-blind trial for stress ulcer prophylaxis shows no evidence of increased pneumonia. Am J Surg 1998, 176:453-457.
12. Klarin B, Molin G, Jeppsson B, Larsson A Use of the probiotic Lactobacillus plantarum 299 to reduce pathogenic bacteria in the oropharynx of intubated patients: a randomised controlled open pilot study. Crit Care 2008, 12:R136.
13. Koeman M, van der Ven AJ, Hak E, et al. Oral decontamination with chlorhexidine reduces the incidence of ventilator-associated pneumonia. Am J Respir Crit Care Med 2006, 173:1348-1355.
14. Lacherade JC, Auburtin M, Cerf C, et al. Impact of humidification systems on ventilator-associated pneumonia: a randomized multicenter trial. Am J Respir Crit Care Med 2005, 172:1276-1282.
15. Lacherade JC, De Jonghe B, Guezennec P, et al. Intermittent subglottic secretion drainage and ventilator-associated pneumonia: a multicenter trial. Am J Respir Crit Care Med 2010, 182:910-917.
16. Lorente L, Lecuona M, Martin MM, Garcia C, Mora ML, Sierra A Ventilator-associated pneumonia using a closed versus an open tracheal suction system. Crit Care Med 2005, 33:115-119.
17. Lorente L, Lecuona M, Jimenez A, Mora ML, Sierra A Ventilator-associated pneumonia using a heated humidifier or a heat and moisture exchanger: a randomized controlled trial [ISRCTN88724583]. Crit Care 2006, 10:R116.
18. Lorente L, Lecuona M, Jimenez A, Mora ML, Sierra A Influence of an endotracheal tube with polyurethane cuff and subglottic secretion drainage on pneumonia. Am J Respir Crit Care Med 2007, 176:1079-1083.
19. Memish ZA, Oni GA, Djazmati W, Cunningham G, Mah MW A randomized clinical trial to compare the effects of a heat and moisture exchanger with a heated humidifying system on the occurrence rate of ventilator-associated pneumonia. Am J Infect Control 2001, 29:301-305.
20. Morrow LE, Kollef MH, Casale TB Probiotic prophylaxis of ventilator-associated pneumonia: a blinded, randomized, controlled trial. Am J Respir Crit Care Med 2010, 182:1058-1064.
21. Nardi G, Di Silvestre AD, De Monte A, et al. Reduction in Gram-positive pneumonia and antibiotic consumption following the use of a SDD protocol including nasal and oral mupirocin. Eur J Emerg Med 2001, 8:203-214.
22. O'Keefe GE, Gentilello LM, Maier RV Incidence of infectious complications associated with the use of histamine2-receptor antagonists in critically ill trauma patients. Ann Surg 1998, 227:120-125.
23. Pneumatikos I, Koulouras V, Nathanail C, Goe D, Nakos G Selective decontamination of subglottic area in mechanically ventilated patients with multiple trauma. Intensive Care Med 2002, 28:432-437.
24. Scannapieco FA, Yu J, Raghavendran K, et al. A randomized trial of chlorhexidine gluconate on oral bacterial pathogens in mechanically ventilated patients. Crit Care 2009, 13:R117.
25. Seguin P, Tanguy M, Laviolle B, Tirel O, Mallédant Y Effect of oropharyngeal decontamination by povidone-iodine on ventilator-associated pneumonia in patients with head trauma. Crit Care Med 2006, 34:1514-1519.
26. Staudinger T, Bojic A, Holzinger U, et al. Continuous lateral rotation therapy to prevent ventilator-associated pneumonia. Crit Care Med 2010, 38:486-490.
27. Topeli A, Harmanci A, Cetinkaya Y, Akdeniz S, Unal S Comparison of the effect of closed versus open endotracheal suction systems on the development of ventilator-associated pneumonia. J Hosp Infect 2004, 58:14-19.
28. Valencia M, Ferrer M, Farre R, et al. Automatic control of tracheal tube cuff pressure in ventilated patients in semirecumbent position. A randomized trial. Crit Care Med 2007, 35:1543-1549.
29. Van Nieuwenhoven CA, Vandenbroucke-Grauls C, Van Tiel FH, et al. Feasibility and effects of the semirecumbent position to prevent ventilator-associated pneumonia: a randomized study. Crit Care Med 2006, 34:396-402.
30. Magret M, Maya-Villar R, Garnacho J, et al. Ventilator-associated pneumonia in trauma patients is associated with lower mortality: results from EU-VAP study. J Trauma 2010, 69:849-854.
31. Bonten MJ Prevention of ventilator-associated pneumonia: bugs or drugs?. Am J Respir Crit Care Med 2010, 182:993-994.
32. Klompas M Ventilator-associated pneumonia: is zero possible?. Clin Infect Dis 2010, 51:1123-1126.