How many proteins does it take to gate hair cell mechanotransduction?

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 5, 2015, Pages 1254-1255

  Fuchs, Paul Albert ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN;

ACTIN FILAMENT; ANTIBODY LABELING; CONDUCTANCE; HAIR CELL; HUMAN; MECHANOTRANSDUCTION; NONHUMAN; NOTE; PRIORITY JOURNAL; STEREOCILIUM; STIMULUS; ANIMAL; FEMALE; MALE; PHYSIOLOGY;

ANIMALS; FEMALE; HAIR CELLS, AUDITORY; MALE; MECHANOTRANSDUCTION, CELLULAR;

EID: 84922324317     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1424987112     Document Type: Note

References (18)

1. Sukharev S, Sachs F (2012) Molecular force transduction by ion channels: Diversity and unifying principles. J Cell Sci 125(Pt 13): 3075-3083.
2. Beurg M, Fettiplace R, Nam JH, Ricci AJ (2009) Localization of inner hair cell mechanotransducer channels using highspeed calcium imaging. Nat Neurosci 12(5):553-558.
3. Jaramillo F, Hudspeth AJ (1991) Localization of the hair cell ' s transduction channels at the hair bundle ' s top by iontophoretic application of a channel blocker. Neuron 7(3): 409-420.
4. Hudspeth AJ, Corey DP (1977) Sensitivity, polarity, and conductance change in the response of vertebrate hair cells to controlled mechanical stimuli. Proc Natl Acad Sci USA 74(6): 2407-2411.
5. Kazmierczak P, et al. (2007) Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells. Nature 449(7158):87-91.
6. Kachar B, Parakkal M, Kurc M, Zhao Y, Gillespie PG (2000) Highresolution structure of hair-cell tip links. Proc Natl Acad Sci USA 97(24):13336-13341.
7. Zhao Y, Yamoah EN, Gillespie PG (1996) Regeneration of broken tip links and restoration of mechanical transduction in hair cells. Proc Natl Acad Sci USA 93(26):15469-15474.
8. Pickles JO, Comis SD, Osborne MP (1984) Cross-links between stereocilia in the guinea pig organ of Corti, and their possible relation to sensory transduction. Hear Res 15(2): 103-112.
9. Kurima K, et al. (2002) Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function. Nat Genet 30(3):277-284.
10. Maeda R, et al. (2014) Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2. Proc Natl Acad Sci USA 111(35):12907-12912.
11. Pan B, et al. (2013) TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear. Neuron 79(3):504-515.
12. Beurg M, Evans MG, Hackney CM, Fettiplace R (2006) A largeconductance calcium-selective mechanotransducer channel in mammalian cochlear hair cells. J Neurosci 26(43):10992-11000.
13. Beurg M, Xiong W, Zhao B, Müller U, Fettiplace R (2015) Subunit determination of the conductance of hair-cell mechanotransducer channels. Proc Natl Acad Sci USA 112:1589-1594.
14. Kim KX, et al. (2013) The role of transmembrane channel-like proteins in the operation of hair cell mechanotransducer channels. J Gen Physiol 142(5):493-505.
15. Marcotti W, et al. (2014) Transduction without tip links in cochlear hair cells is mediated by ion channels with permeation properties distinct from those of the mechano-electrical transducer channel. J Neurosci 34(16):5505-5514.
16. Beurg M, Kim KX, Fettiplace R (2014) Conductance and block of hair-cell mechanotransducer channels in transmembrane channel-like protein mutants. J Gen Physiol 144(1):55-69.
17. Nayak GD, Ratnayaka HS, Goodyear RJ, Richardson GP (2007) Development of the hair bundle and mechanotransduction. Int J Dev Biol 51(6-7):597-608.
18. Deans MR (2013) A balance of form and function: planar polarity and development of the vestibular maculae. Semin Cell Dev Biol 24(5):490-498.