Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 35, 2014, Pages 12907-12912

  Maeda, Reo ^a   Kindt, Katie S ^a,b   Mo, Weike ^a   Morgan, Clive P ^a   Erickson, Timothy ^a   Zhao, Hongyu ^a   Clemens Grisham, Rachel ^a   Barr Gillespie, Peter G ^a   Nicolson, Teresa ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CADHERINS; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HAIR CELLS, AUDITORY; HAIR CELLS, VESTIBULAR; HEK293 CELLS; HUMANS; MECHANOTRANSDUCTION, CELLULAR; MEMBRANE PROTEINS; MICE; PHYLOGENY; PROTEIN PRECURSORS; TWO-HYBRID SYSTEM TECHNIQUES; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84907228023     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1402152111     Document Type: Article

References (31)

1. Sakaguchi H, Tokita J, Müller U, Kachar B (2009) Tip links in hair cells: Molecular composition and role in hearing loss. Curr Opin Otolaryngol Head Neck Surg 17(5):388-393.
2. Ahmed ZM, et al. (2001) Mutations of the protocadherin gene PCDH15 cause Usher syndrome type 1F. Am J Hum Genet 69(1):25-34.
3. Alagramam KN, et al. (2001) Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F. Hum Mol Genet 10(16):1709-1718.
4. Alagramam KN, et al. (2001) The mouse Ames waltzer hearing-loss mutant is caused by mutation of Pcdh15, a novel protocadherin gene. Nat Genet 27(1):99-102.
5. Seiler C, et al. (2005) Duplicated genes with split functions: Independent roles of protocadherin15 orthologues in zebrafish hearing and vision. Development 132(3):615-623.
6. Kazmierczak P, et al. (2007) Cadherin 23 and protocadherin 15 interact to form tiplink filaments in sensory hair cells. Nature 449(7158):87-91.
7. Alagramam KN, et al. (2011) Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells. PLoS One 6(4):e19183.
8. Beurg M, Fettiplace R, Nam J-H, Ricci AJ (2009) Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging. Nat Neurosci 12(5):553-558.
9. Goodyear RJ, Forge A, Legan PK, Richardson GP (2010) Asymmetric distribution of cadherin 23 and protocadherin 15 in the kinocilial links of avian sensory hair cells. J Comp Neurol 518(21):4288-4297.
10. Pan B, et al. (2013) TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear. Neuron 79(3):504-515.
11. Keresztes G, Mutai H, Heller S (2003) TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. BMC Genomics 4(1):24.
12. Labay V, Weichert RM, Makishima T, Griffith AJ (2010) Topology of transmembrane channel-like gene 1 protein. Biochemistry 49(39):8592-8598.
13. Chatzigeorgiou M, Bang S, Hwang SW, Schafer WR (2013) tmc-1 encodes a sodiumsensitive channel required for salt chemosensation in C. elegans. Nature 494(7435):95-99.
14. Kurima K, et al. (2002) Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function. Nat Genet 30(3):277-284.
15. Vreugde S, et al. (2002) Beethoven, a mouse model for dominant, progressive hearing loss DFNA36. Nat Genet 30(3):257-258.
16. Duman D, Tekin M (2012) Autosomal recessive nonsyndromic deafness genes: A review. Front Biosci (Landmark Ed) 17:2213-2236.
17. Kawashima Y, et al. (2011) Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes. J Clin Invest 121(12):4796-4809.
18. Kim KX, Fettiplace R (2013) Developmental changes in the cochlear hair cell mechanotransducer channel and their regulation by transmembrane channel-like proteins. J Gen Physiol 141(1):141-148.
19. Kim KX, et al. (2013) The role of transmembrane channel-like proteins in the operation of hair cell mechanotransducer channels. J Gen Physiol 142(5):493-505.
20. Marcotti W, et al. (2014) Transduction without tip links in cochlear hair cells is mediated by ion channels with permeation properties distinct from those of the mechanoelectrical transducer channel. J Neurosci 34(16):5505-5514.
21. Snider J, et al. (2010) Detecting interactions with membrane proteins using a membrane two-hybrid assay in yeast. Nat Protoc 5(7):1281-1293.
22. Ahmed ZM, et al. (2006) The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15. J Neurosci 26(26):7022-7034.
23. Alagramam KN, et al. (2007) Promoter, alternative splice forms, and genomic structure of protocadherin 15. Genomics 90(4):482-492.
24. Lupas A, Van Dyke M, Stock J (1991) Predicting coiled coils from protein sequences. Science 252(5009):1162-1164.
25. 2+ and diacylglycerol signaling in living cells. PLoS One 7(8):e42791.
26. Kindt KS, Finch G, Nicolson T (2012) Kinocilia mediate mechanosensitivity in developing zebrafish hair cells. Dev Cell 23(2):329-341.
27. Brown SDM, Hardisty-Hughes RE, Mburu P (2008) Quiet as a mouse: Dissecting the molecular and genetic basis of hearing. Nat Rev Genet 9(4):277-290.
28. Xiong W, et al. (2012) TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells. Cell 151(6):1283-1295.
29. Webb SW, et al. (2011) Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain. Development 138(8):1607-1617.
30. Thisse C, Thisse B (2008) High-resolution in situ hybridization to whole-mount zebrafish embryos. Nat Protoc 3(1):59-69.
31. Obholzer N, et al. (2008) Vesicular glutamate transporter 3 is required for synaptic transmission in zebrafish hair cells. J Neurosci 28(9):2110-2118.