Cholesterol loading reprograms the microRNA-143/145-Myocardin axis to convert aortic smooth muscle cells to a dysfunctional macrophage-like phenotype

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 35, Issue 3, 2015, Pages 535-546

  Vengrenyuk, Yuliya ^a   Nishi, Hitoo ^a   Long, Xiaochun ^b   Ouimet, Mireille ^a   Savji, Nazir ^a   Martinez, Fernando O ^c   Cassella, Courtney P ^a   Moore, Kathryn J ^a   Ramsey, Stephen A ^d   Miano, Joseph M ^e   Fisher, Edward A ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ALBANY MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d OREGON STATE UNIVERSITY   (United States)

^e UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Atherosclerosis; Atherosclerotic; Cholesterol; Macrophages; Plaque

Indexed keywords

APOLIPOPROTEIN A1; BIOLOGICAL MARKER; CALPONIN; CHOLESTEROL; CYCLODEXTRIN; HIGH DENSITY LIPOPROTEIN; MESSENGER RNA; MICRORNA 143; MICRORNA 145; MYOCARDIN; SERUM RESPONSE FACTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTOME; APOLIPOPROTEIN E; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; MICRORNA; MIRN143 MICRORNA, MOUSE; MIRN145 MICRORNA, MOUSE; NUCLEAR PROTEIN; SREBF2 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; AORTIC SMOOTH MUSCLE CELL; ARTICLE; ATHEROSCLEROTIC PLAQUE; BINDING SITE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; EFFEROCYTOSIS; GENE EXPRESSION; HUMAN; HUMAN CELL; MACROPHAGE FUNCTION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PHAGOCYTOSIS; PHENOTYPE; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; ATHEROSCLEROSIS; C57BL MOUSE; CELL LINEAGE; CELL TRANSDIFFERENTIATION; COCULTURE; DEFICIENCY; DISEASE MODEL; DNA MICROARRAY; FOAM CELL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; JURKAT CELL LINE; KNOCKOUT MOUSE; METABOLISM; NECROSIS; PATHOLOGY; PROCEDURES; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CELL; THORACIC AORTA; TIME FACTOR; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA, THORACIC; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BINDING SITES; CELL LINEAGE; CELL TRANSDIFFERENTIATION; CHOLESTEROL; CHOLESTEROL, HDL; COCULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; FOAM CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; JURKAT CELLS; MICE, INBRED C57BL; MICE, KNOCKOUT; MICRORNAS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NECROSIS; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHAGOCYTOSIS; PHENOTYPE; PLAQUE, ATHEROSCLEROTIC; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TIME FACTORS; TRANS-ACTIVATORS; TRANSFECTION;

EID: 84922256949     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.304029     Document Type: Article

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