Halothane-induced hepatitis: Paradigm or paradox for drug-induced liver injury

Hepatology

Volumn 60, Issue 5, 2014, Pages 1473-1475

  Kurth, Mark J ^a   Yokoi, Tsuyoshi ^b   Gershwin, M Eric ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; EOTAXIN 2; HALOTHANE; INTERLEUKIN 2; INTERLEUKIN 4; MESSENGER RNA; MICRORNA; STAT3 PROTEIN; THYMIC STROMAL LYMPHOPOIETIN; CYTOKINE; INHALATION ANESTHETIC AGENT;

ANTIGEN PRESENTING CELL; ARTICLE; EOSINOPHIL; GENETIC VARIABILITY; HALOTHANE INDUCED HEPATITIS; HALOTHANE INDUCED LIVER INJURY; HEPATITIS; HUMAN; IMMUNOPATHOLOGY; LIPID PEROXIDATION; LIVER BLOOD FLOW; LIVER FUNCTION TEST; LIVER INJURY; LIVER NECROSIS; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; TOXIC HEPATITIS; ANIMAL; DRUG-INDUCED LIVER INJURY; FEMALE; METABOLISM;

ANESTHETICS, INHALATION; ANIMALS; CYTOKINES; DRUG-INDUCED LIVER INJURY; FEMALE; HALOTHANE; HUMANS; INTERLEUKIN-4;

EID: 84922246363     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27253     Document Type: Article

References (21)

1. Bogdanos DP, Smyk DS, Rigopoulou EI, Mytilinaiou MG, Heneghan MA, Selmi C, Gershwin ME. Twin studies in autoimmune disease: genetics, gender and environment. J Autoimmun 2012;38:J156-J169.
2. Ray DC, Drummond GB. Halothane hepatitis. Br J Anaesth 1991;67:84-99.
3. Bourdi M, Chen W, Peter RM, Martin JL, Buters JT, Nelson SD, Pohl LR. Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis. Chem Res Toxicol 1996;9:1159-1166.
4. Furst SM, Gandolfi AJ. Interaction of lymphocytes with Kupffer cells from halothane-exposed guinea pigs. Int Arch Allergy Immunol 1997;114:46-53.
5. Jenner MA, Plummer JL, Cousins MJ. Halothane reductive metabolism in an adult surgical population. Anaesth Intensive Care 1990;18:395-399.
6. Minoda Y, Kharasch ED. Halothane-dependent lipid peroxidation in human liver microsomes is catalyzed by cytochrome P4502A6 (CYP2A6). Anesthesiology 2001;95:509-514.
7. Kharasch ED, Hankins DC, Fenstamaker K, Cox K. Human halothane metabolism, lipid peroxidation, and cytochromes P(450)2A6 and P(450)3A4. Eur J Clin Pharmacol 2000;55:853-859.
8. Proctor WR, Chakraborty M, Chea LS, Morrison JC, Berkson JD, Semple K, et al. Eosinophils mediate the pathogenesis of halothane-induced liver injury in mice. Hepatology 2013;57:2026-2036.
9. Proctor WR, Chakraborty M, Fullerton AM, Korrapati MC, Ryan PM, Semple K, et al. Thymic stromal lymphopoietin and interleukin-4 mediate the pathogenesis of halothane-induced liver injury in mice. Hepatology 2014;60:1741-1752.
10. Ziegler SF, Roan F, Bell BD, Stoklasek TA, Kitajima M, Han H. The biology of thymic stromal lymphopoietin (TSLP). Adv Pharmacol 2013;66:129-155.
11. Kashyap M, Rochman Y, Spolski R, Samsel L, Leonard WJ. Thymic stromal lymphopoietin is produced by dendritic cells. J Immunol 2011;187:1207-1211.
12. Moon PD, Choi IH, Kim HM. Naringenin suppresses the production of thymic stromal lymphopoietin through the blockade of RIP2 and caspase-1 signal cascade in mast cells. Eur J Pharmacol 2011;671:128-132.
13. Cheng L, You Q, Yin H, Holt MP, Ju C. Involvement of natural killer T cells in halothane-induced liver injury in mice. Biochem Pharmacol 2010;80:255-261.
14. Feng D, Wang Y, Xu Y, Luo Q, Lan B, Xu L. Interleukin 10 deficiency exacerbates halothane induced liver injury by increasing interleukin 8 expression and neutrophil infiltration. Biochem Pharmacol 2009;77:277-284.
15. Kobayashi E, Kobayashi M, Tsuneyama K, Fukami T, Nakajima M, Yokoi T. Halothane-induced liver injury is mediated by interleukin-17 in mice. Toxicol Sci 2009;111:302-310.
16. You Q, Cheng L, Reilly TP, Wegmann D, Ju C. Role of neutrophils in a mouse model of halothane-induced liver injury. Hepatology 2006;44:1421-1431.
17. Endo S, Yano A, Fukami T, Nakajima M, Yokoi T. Involvement of miRNAs in the early phase of halothane-induced liver injury. Toxicology 2014;319:75-84.
18. Bogiatzi SI, Guillot-Delost M, Cappuccio A, Bichet JC, Chouchane-Mlik O, Donnadieu MH, et al. Multiple-checkpoint inhibition of thymic stromal lymphopoietin-induced TH2 response by TH17-related cytokines. J Allergy Clin Immunol 2012;130:233-240.e5.
19. Lin J, Chang W, Dong J, Zhang F, Mohabeer N, Kushwaha KK, et al. Thymic stromal lymphopoietin over-expressed in human atherosclerosis: potential role in Th17 differentiation. Cell Physiol Biochem 2013;31:305-318.
20. Lee HC, Sung SS, Krueger PD, Jo YA, Rosen HR, Ziegler SF, Hahn YS. Hepatitis C virus promotes T-helper (Th)17 responses through thymic stromal lymphopoietin production by infected hepatocytes. Hepatology 2013;57:1314-1324.
21. Siracusa MC, Kim BS, Spergel JM, Artis D. Basophils and allergic inflammation. J Allergy Clin Immunol 2013;132:789-801; quiz, 788.