The role of casein-specific IgA and TGF-β in children with food protein-induced enterocolitis syndrome to milk

Pediatric Allergy and Immunology

Volumn 25, Issue 7, 2014, Pages 651-656

  Konstantinou, George N ^a,b   Bencharitiwong, Ramon ^a   Grishin, Alexander ^a   Caubet, Jean Christoph ^a   Bardina, Luda ^a   Sicherer, Scott H ^a   Sampson, Hugh A ^a   Nowak Wegrzyn, Anna ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b 424 General Army Hospital   (Greece)

Author keywords

Casein; Food challenge; IgA; IgG4; Immunoglobulin A; Milk allergy; PBMCs; Peripheral blood mononuclear cell; TGF ; Transforming growth factor

Indexed keywords

CASEIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G4; TRANSFORMING GROWTH FACTOR BETA; ALLERGEN; BIOLOGICAL MARKER;

ARTICLE; CELL ACTIVATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENTEROCOLITIS; FEMALE; FOOD PROTEIN INDUCED ENTEROCOLITIS SYNDROME; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOGLOBULIN BLOOD LEVEL; MALE; MILK; PATHOPHYSIOLOGY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; T LYMPHOCYTE; ADVERSE EFFECTS; ANIMAL; BLOOD; BOVINE; CELL CULTURE; COMPLICATION; IMMUNIZATION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MILK ALLERGY;

ALLERGENS; ANIMALS; BIOMARKERS; CASEINS; CATTLE; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; ENTEROCOLITIS; FEMALE; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; LYMPHOCYTE ACTIVATION; MALE; MILK; MILK HYPERSENSITIVITY; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

EID: 84922233507     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/pai.12288     Document Type: Article

References (30)

1. Boyce JA, Assa'ad A, Burks AW, et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol 2010: 126: S1-58.
2. Leonard SA, Nowak-Wegrzyn A. Clinical diagnosis and management of food protein-induced enterocolitis syndrome. Curr Opin Pediatr 2012: 24: 739-45.
3. Mehr S, Kakakios A, Frith K, Kemp AS. Food protein-induced enterocolitis syndrome: 16-year experience. Pediatrics 2009: 123: e459-64.
4. Caubet JC, Nowak-Wegrzyn A. Current understanding of the immune mechanisms of food protein-induced enterocolitis syndrome. Expert Rev Clin Immunol 2011: 7: 317-27.
5. Nowak-Wegrzyn A, Assa'ad AH, Bahna SL, Bock SA, Sicherer SH, Teuber SS. Work Group report: oral food challenge testing. J Allergy Clin Immunol 2009: 123: S365-83.
6. Monti G, Castagno E, Liguori SA, et al. Food protein-induced enterocolitis syndrome by cow's milk proteins passed through breast milk. J Allergy Clin Immunol 2011: 127: 679-80.
7. Lake AM. Food-induced eosinophilic proctocolitis. J Pediatr Gastroenterol Nutr 2000: 30(Suppl): S58-60.
8. Kim PH, Kagnoff MF. Transforming growth factor beta 1 increases IgA isotype switching at the clonal level. J Immunol 1990: 145: 3773-8.
9. Kim PH, Kagnoff MF. Transforming growth factor-beta 1 is a costimulator for IgA production. J Immunol 1990: 144: 3411-6.
10. Nowak-Wegrzyn A. Food Protein-Induced Enterocolitis and Enteropathies. In: Metcalfe DD, Sampson HA, Simon RA, eds. Food Allergy: Adverse Reactions to Foods and Food Additives, 4th edn. Blackwell Publishing: Malden MA, 2008: 195-210.
11. Konstantinou GN, Nowak-Wegrzyn A, Bencharitiwong R, Bardina L, Sicherer SH, Sampson HA. Egg-white-specific IgA and IgA2 antibodies in egg-allergic children: is there a role in tolerance induction? Pediatr Allergy Immunol 2014: 25: 64-70.
12. Tesseur I, Zou K, Berber E, Zhang H, Wyss-Coray T. Highly sensitive and specific bioassay for measuring bioactive TGF-beta. BMC Cell Biol 2006: 7: 15.
13. Shek LP, Bardina L, Castro R, Sampson HA, Beyer K. Humoral and cellular responses to cow milk proteins in patients with milk-induced IgE-mediated and non-IgE-mediated disorders. Allergy 2005: 60: 912-9.
14. McDonald PJ, Goldblum RM, Van Sickle GJ, Powell GK. Food protein-induced enterocolitis: altered antibody response to ingested antigen. Pediatr Res 1984: 18: 751-5.
15. Stapel SO, Asero R, Ballmer-Weber BK, et al. Testing for IgG4 against foods is not recommended as a diagnostic tool: EAACI Task Force Report. Allergy 2008: 63: 793-6.
16. Lemon-Mule H, Sampson HA, Sicherer SH, Shreffler WG, Noone S, Nowak-Wegrzyn A. Immunologic changes in children with egg allergy ingesting extensively heated egg. J Allergy Clin Immunol 2008: 122: 977-83.e1.
17. Kim JS, Nowak-Wegrzyn A, Sicherer SH, Noone S, Moshier EL, Sampson HA. Dietary baked milk accelerates the resolution of cow's milk allergy in children. J Allergy Clin Immunol 2011: 128: 125-31.e2.
18. Nowak-Wegrzyn A, Bloom KA, Sicherer SH, et al. Tolerance to extensively heated milk in children with cow's milk allergy. J Allergy Clin Immunol 2008: 122: 342-7, 47.e1-2.
19. Nouri-Aria KT, Wachholz PA, Francis JN, et al. Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity. J Immunol 2004: 172: 3252-9.
20. Philips JR, Brouwer W, Edwards M, Mahler S, Ruhno J, Collins AM. The effectiveness of different rat IgG subclasses as IgE-blocking antibodies in the rat basophil leukaemia cell model. Immunol Cell Biol 1999: 77: 121-6.
21. Francis JN, James LK, Paraskevopoulos G, et al. Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity. J Allergy Clin Immunol 2008: 121: 1120-25.e2.
22. Mothes N, Heinzkill M, Drachenberg KJ, et al. Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies. Clin Exp Allergy 2003: 33: 1198-208.
23. Strait RT, Mahler A, Hogan S, Khodoun M, Shibuya A, Finkelman FD. Ingested allergens must be absorbed systemically to induce systemic anaphylaxis. J Allergy Clin Immunol 2011: 127: 982-9.e1.
24. Schwarze J, Cieslewicz G, Joetham A, et al. Antigen-specific immunoglobulin-A prevents increased airway responsiveness and lung eosinophilia after airway challenge in sensitized mice. Am J Respir Crit Care Med 1998: 158: 519-25.
25. Annes JP, Munger JS, Rifkin DB. Making sense of latent TGFbeta activation. J Cell Sci 2003: 116: 217-24.
26. Cazac BB, Roes J. TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo. Immunity 2000: 13: 443-51.
27. Pascal M, Konstantinou GN, Masilamani M, Lieberman J, Sampson HA. In silico prediction of Ara h 2 T cell epitopes in peanut-allergic children. Clin Exp Allergy 2013: 43: 116-27.
28. Chung HL, Hwang JB, Park JJ, Kim SG. Expression of transforming growth factor beta1, transforming growth factor type I and II receptors, and TNF-alpha in the mucosa of the small intestine in infants with food protein-induced enterocolitis syndrome. J Allergy Clin Immunol 2002: 109: 150-4.
29. Planchon SM, Martins CA, Guerrant RL, Roche JK. Regulation of intestinal epithelial barrier function by TGF-beta 1. Evidence for its role in abrogating the effect of a T cell cytokine. J Immunol 1994: 153: 5730-9.
30. Suenaert P, Maerten P, Van Assche G, et al. Effects of T cell-induced colonic inflammation on epithelial barrier function. Inflamm Bowel Dis 2010: 16: 1322-31.