Microemulsion for simultaneous transdermal delivery of benzocaine and indomethacin: In vitro and in vivo evaluation

Drug Development and Industrial Pharmacy

Volumn 40, Issue 12, 2014, Pages 1637-1644

  El Maghraby, Gamal M ^a   Arafa, Mona F ^a   Osman, Mohamed A ^a  

^a TANTA UNIVERSITY   (Egypt)

Author keywords

Benzocaine microemulsion; Eucalyptus oil; Indomethacin transdermal; Pinprick assay; Topical analgesia

Indexed keywords

BENZOCAINE; INDOMETACIN; EMULSION;

ADULT; ANALGESIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; LIMIT OF QUANTITATION; MALE; MICROEMULSION; NORMAL HUMAN; SINGLE DRUG DOSE; SURFACE TENSION; TRANSDERMAL DRUG DELIVERY SYSTEM; ADMINISTRATION AND DOSAGE; ANIMAL; DRUG DELIVERY SYSTEM; DRUG EFFECTS; DRUG SCREENING; EMULSION; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; PROCEDURES; RABBIT; SKIN ABSORPTION;

ADMINISTRATION, CUTANEOUS; ANIMALS; BENZOCAINE; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; EMULSIONS; HUMANS; INDOMETHACIN; ORGAN CULTURE TECHNIQUES; RABBITS; SKIN ABSORPTION;

EID: 84922231393     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2013.841186     Document Type: Article

References (37)

1. Barry BW. Dermatological formulations: percutaneous absorption. New York/Basel: Marcel Dekker; 1983.
2. Goodman M, Barry BW. Action of penetration enhancers on human skin as assessed by permeation of model drugs 5-fluorouracil and estradiol. I. Infinite dose technique. J Invest Dermatol 1988;91: 323-7.
3. El Maghraby GM, Alanazi FK, Alsarra IA. Transdermal delivery of tadalafil. I. Effect of vehicles on skin permeation. Drug Dev Ind Pharm 2009;35:329-36.
4. Megrab NA, Williams AC, Barry BW. Oestradiol permeation across human skin and silastic membranes: effects of propylene glycol and supersaturation. J Control Release 1995;36:277-94.
5. Miller LL, Kolaskie CJ, Smith GA, Rivier J. Transdermal Iontophoresis of gonadotropin releasing hormone and two analogues. J Pharm Sci 1990;79:490-3.
6. Kost J, Pliquett U, Mitragotri S, et al. Synergistic effect of electric field and ultrasound on transdermal transport. Pharm Res 1996;13: 633-8.
7. Banga AK, Bose S, Ghosh TK. Iontophoresis and electroporation: comparisons and contrasts. Int J Pharm 1999;179:1-19.
8. Manosroi A, Jantrawut P, Manosroi J. Anti-inflammatory activity of gel containing novel elastic niosomes entrapped with diclofenac diethylammonium. Int J Pharm 2008;360:156-63.
9. El Maghraby GM, Williams AC. Vesicular systems for delivering conventional small organic molecules and larger macromolecules to and through human skin. Expert Opin Drug Deliv 2009;6:149-63.
10. El Maghraby GM. Microemulsions as transdermal drug delivery systems. Curr Nanosci 2012;8:504-11.
11. El Maghraby GM. Self microemulsifying and microemulsion systems for transdermal delivery of indomethacin: effect of phase transition. Colloids Surf B Biointerfaces 2010;75:595-600.
12. Mura P, Maestrelli F, Rodriguez LG, et al. Development, characterization and in vivo evaluation of benzocaine-loaded liposomes. Eur J Pharm 2007;67:86-95.
13. Biruss B, Kahlig H, Valenta C. Evaluation of an eucalyptus oil containing topical drug delivery system for steroid hormones. Int J Pharm 2007;328:142-51.
14. El Maghraby GM. Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion: effects of cosurfactant. Int J Pharm 2008;355:285-92.
15. Chen H, Chang X, Weng T, et al. A study of microemulsion systems for transdermal delivery of triptolide. J Control Release 2004;98: 427-36.
16. Fang JY, Fang CL, Hong CT, et al. Capsaicin and nonivamide as novel skin permeation enhancers for indomethacin. Eur J Pharm Sci 2001;12:195-203.
17. Corbo M, Liu JC, Chien YW. Bioavailability of propranolol following oral and transdermal administration in rabbits. J Pharm Sci 1990;79:584-7.
18. Touitou E, Dayan N, Bergelson L, et al. Ethosomes-novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J Control Release 2000;65:403-18.
19. Lubens HM, Ausdenmoore RW, Sharfer AD, Reece RM. Anesthetic patch for painful procedures such as minor operations. Am J Dis Child 1974;4:128-92.
20. Gesztes A, Mezei M. Topical anesthesia of the skin by liposomeencapsulated tetracaine. Anesth Analg 1988;67:1079-81.
21. Fisher R, Hung O, Mezei M, Stewart R. Topical anaesthesia of intact skin: liposome-encapsulated tetracaine vs EMLA. Br J Anaesth 1998;81:972-3.
22. Lawrence J. Surfactant systems: microemulsions and vesicles as vehicles for drug delivery. Eur J Drug Metab Pharmacokin 1994;3: 257-69.
23. Stilbs P, Lindman B, Rapacki K. Effect of alcohol cosurfactant length on microemulsion structure. J Colloid Interf Sci 1983;95: 583-5.
24. Aboofazeli R, Lawrence MJ. Investigations into the formation of and characterization of phospholipids microemulsion. II Pseudo-Ternary phase diagrams of systems containing water-lecithin-isopropylmyristate and alcohol: influence of purity of lecithin. Int J Pharm 1994; 106:51-61.
25. Kreilgaard M. Influence of microemulsions on cutaneous drug delivery. Adv Drug Deliv Rev 2002;54:S77-98.
26. Peña AM, Bustamantea P, Escalera B, et al. Solubility and phase separation of benzocaine and salicylic acid in 1, 4-dioxane-water mixtures at several temperatures. J Pharm Biomed Anal 2004;36: 571-8.
27. Yadav VB, Yadav AV. Recrystallized agglomerates of indomethacin by emulsion solvent diffusion (ESD) technique. Int J Pharm Biol Sci 2010;1:1-13.
28. Mo C, Zhong M, Zhong Q. Investigation of structure and structural transition in microemulsion systems of sodium dodecyl sulfonatepn-heptanepn-butanolpwater by cyclic voltammetric and electrical conductivity measurements. J Electroanal Chem 2000; 493:100-7.
29. Alany RG, Tucker IG, Davies NM, Rades T. Characterizing colloidal structures of pseudoternary phase diagrams formed by oil/water/amphiphile systems. Drug Dev Ind Pharm 2001;27:31-8.
30. Zhang JI, Kohn BM. Investigation of microemulsion microstructures and their relationship to transdermal permeation of model drugs: ketoprofen, lidocaine, and caffeine. Int J Pharm 2011;421:34-44.
31. El Maghraby GM. Occlusive and non-occlusive application of microemulsion for transdermal delivery of progesterone: mechanistic studies. Sci Pharm 2012;80:765-78.
32. Shin SC, Lee JW, Yang KH, Lee CH. Preparation and evaluation of bioadhesive benzocaine gels for enhanced local anesthetic effects. Int J Pharm 2003;260:77-81.
33. Araujo DR, Padula C, Cereda CMS, et al. Bioadhesive films containing benzocaine: correlation between in vitro permeation and in vivo local anesthetic effect. Pharm Res 2010;8:1677-86.
34. Puglia C, Sarpietro MG, Bonina F, et al. Development, characterization, and in vitro and in vivo evaluation of benzocaine-And lidocaine-loaded nanostructrured lipid carriers. J Pharm Sci 2010; 100:1892-9.
35. Peltola S, Saarinen-Savolainen P, Kiesvaara J, et al. Microemulsions for topical delivery of estradiol. Int J Pharm 2003;254:99-107.
36. Kemken J, Ziegler A, Müller BW. Influence of supersaturation on the pharmacodynamic effect of bupranolol after dermal administration using microemulsions as vehicle. Pharm Res 1992;9:554-8.
37. Planas ME, Gonzalez P, Rodriguez L, et al. Noninvasive percutaneous induction of topical analgesia by a new type of drug carrier, and prolongation of local pain insensitivity by anesthetic liposomes. Anesth Analg 1992;75:615-21.