Bioadhesive films containing benzocaine: Correlation between in vitro permeation and in vivo local anesthetic effect

Pharmaceutical Research

Volumn 27, Issue 8, 2010, Pages 1677-1686

  De Araujo, Daniele Ribeiro ^a,b   Padula, Cristina ^e   Cereda, Cíntia Maria Saia ^b   Tófoli, Giovana Radomille ^c   Brito Jr , Rui Barbosa ^d   De Paula, Eneida ^b   Nicoli, Sara ^e   Santi, Patrizia ^e  

^a UNIVERSIDADE FEDERAL DO ABC   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c UNIVERSIDADE SÃO FRANCISCO   (Brazil)

^d Faculty of Dentistry   (Brazil)

^e UNIVERSITY OF PARMA   (Italy)

Author keywords

benzocaine; in vitro in vivo correlation; local anestetic; patch; transdermal

Indexed keywords

BENZOCAINE; DIETHYLENE GLYCOL MONOETHYL ETHER; FOILLE; LABOCAINA; MYRISTIC ACID ISOPROPYL ESTER; PLACEBO; PROPYLENE GLYCOL; UNCLASSIFIED DRUG; LOCAL ANESTHETIC AGENT;

ADULT ANIMAL; ANALGESIA; ANALYTIC METHOD; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOFILM; CELL INFILTRATION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; DRUG PENETRATION; EAR; HISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; MALE; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN PENETRATION; SWINE; TAIL FLICK TEST; TOXICITY TESTING; ANIMAL; CELL CULTURE; DRUG EFFECTS; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; SKIN; SKIN ABSORPTION; WISTAR RAT;

ADMINISTRATION, CUTANEOUS; ANESTHETICS, LOCAL; ANIMALS; BENZOCAINE; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; MALE; RATS; RATS, WISTAR; SKIN; SKIN ABSORPTION; SWINE;

EID: 77955437797     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0151-5     Document Type: Article

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