Reduced neonatal regulatory T cell response to microbial stimuli associates with subsequent eczema in high-risk infants

Pediatric Allergy and Immunology

Volumn 25, Issue 7, 2014, Pages 674-684

  Ismail, Intan H ^a,b,c   Boyle, Robert J ^a,b,d   Mah, Li Jeen ^a   Licciardi, Paul V ^a,b   Tang, Mimi L K ^a,b,e  

^a MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

Atopic sensitization; Cord blood; Cytokines; Eczema; Infants; Microbial stimuli; Neonates; Regulatory T cell; Toll like receptor

Indexed keywords

CD3 ANTIBODY; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; LIPOTEICHOIC ACID; OVALBUMIN; TRANSCRIPTION FACTOR FOXP3; BACTERIAL ANTIGEN; CYTOKINE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IL2RA PROTEIN, HUMAN; INTERLEUKIN 2 RECEPTOR ALPHA; TEICHOIC ACID; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ALLERGIC DISEASE; ARTICLE; ATOPIC DERMATITIS; CD25+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; ECZEMA; FEMALE; HIGH RISK INFANT; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFANT; INFANT DISEASE; INNATE IMMUNITY; LACTOBACILLUS RHAMNOSUS; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; NEWBORN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SKIN SENSITIZATION; UMBILICAL CORD BLOOD; CELL CULTURE; FETUS BLOOD; FOLLOW UP; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METABOLISM; RISK;

ANTIGENS, BACTERIAL; CELLS, CULTURED; CYTOKINES; ECZEMA; FEMALE; FETAL BLOOD; FOLLOW-UP STUDIES; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNE TOLERANCE; INFANT; INFANT, NEWBORN; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LACTOBACILLUS RHAMNOSUS; LIPOPOLYSACCHARIDES; MALE; RISK; T-LYMPHOCYTES, REGULATORY; TEICHOIC ACIDS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84922216479     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/pai.12303     Document Type: Article

References (33)

1. Lien E, Sellati TJ, Yoshimura A, et al. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem 1999: 274: 33419-25.
2. Boyle RJ, Morley R, Mah LJ, Kivivuori S, Tang MLK. Reduced membrane bound CD14 expression in the cord blood of infants with a family history of allergic disease. Clin Exp Allergy 2009: 39: 982-90.
3. Tang M, Kemp A. Production and secretion of interferon-gamma (IFN-gamma) in children with atopic dermatitis. Clin Exp Immunol 1994: 95: 66-72.
4. Prescott SL, Noakes P, Chow BWY, et al. Presymptomatic differences in Toll-like receptor function in infants who have allergy. J Allergy Clin Immunol 2008: 122: 391-99.e5.
5. Tulic MK, Hodder M, Forsberg A, et al. Differences in innate immune function between allergic and nonallergic children: new insights into immune ontogeny. J Allergy Clin Immunol 2011: 127: 470-78.e1.
6. Ou LS, Goleva E, Hall C, Leung DY. T regulatory cells in atopic dermatitis and subversion of their activity by superantigens. J Allergy Clin Immunol 2004: 113: 756-63.
7. Ito Y, Adachi Y, Makino T, et al. Expansion of FOXP3-positive CD4+CD25+ T cells associated with disease activity in atopic dermatitis. Ann Allergy Asthma Immunol 2009: 103: 160-5.
8. Taylor AL, Hale J, Hales BJ, Dunstan JA, Thomas WR, Prescott SL. FOXP3 mRNA expression at 6 months of age is higher in infants who develop atopic dermatitis, but is not affected by giving probiotics from birth. Pediatr Allergy Immunol 2007: 18: 10-9.
9. Lee JH, Yu HH, Wang LC, Yang YH, Lin YT, Chiang BL. The levels of CD4+CD25+ regulatory T cells in paediatric patients with allergic rhinitis and bronchial asthma. Clin Exp Immunol 2007: 148: 53-63.
10. Shreffler WG, Wanich N, Moloney M, Nowak-Wegrzyn A, Sampson HA. Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein. J Allergy Clin Immunol 2009: 123:43-52.e7.
11. Bellinghausen I, Klostermann B, Knop J, Saloga J. Human CD4+CD25+ T cells derived from the majority of atopic donors are able to suppress TH1 and TH2 cytokine production. J Allergy Clin Immunol 2003: 111: 862-8.
12. Vukmanovic-Stejic M, McQuaid A, Birch KE, et al. Relative impact of CD4+CD25+ regulatory T cells and tacrolimus on inhibition of T-cell proliferation in patients with atopic dermatitis. Br J Dermatol 2005: 153: 750-7.
13. Smith M, Tourigny MR, Noakes P, Thornton CA, Tulic MK, Prescott SL. Children with egg allergy have evidence of reduced neonatal CD4+CD25+CD127lo/- regulatory T cell function. J Allergy Clin Immunol 2008: 121: 1460-66.e7.
14. Schaub B, Liu J, Hoppler S, et al. Impairment of T-regulatory cells in cord blood of atopic mothers. J Allergy Clin Immunol 2008: 121: 1491-9, 99 e1-13.
15. Haddeland U, Karstensen AB, Farkas L, et al. Putative regulatory T cells are impaired in cord blood from neonates with hereditary allergy risk. Pediatr Allergy Immunol 2005: 16: 104-12.
16. Rindsjo E, Joerink M, Johansson C, Bremme K, Malmstrom V, Scheynius A. Maternal allergic disease does not affect the phenotype of T and B cells or the immune response to allergens in neonates. Allergy 2010: 65: 822-30.
17. Leung TF, Tang NL, Wong GW, Fok TF. CD14 and toll-like receptors: potential contribution of genetic factors and mechanisms to inflammation and allergy. Curr Drug Targets Inflamm Allergy 2005: 4: 169-75.
18. Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004: 22: 531-62.
19. Boyle RJ, Ismail IH, Kivivuori S, et al. Lactobacillus GG treatment during pregnancy for the prevention of eczema: a randomized controlled trial. Allergy 2011: 66: 509-16.
20. Boyle RJ, Mah LJ, Chen A, Kivivuori S, Robins-Browne RM, Tang ML. Effects of Lactobacillus GG treatment during pregnancy on the development of fetal antigen-specific immune responses. Clin Exp Allergy 2008: 38: 1882-90.
21. Williams HC, Burney PG, Pembroke AC, Hay RJ. The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. III. Independent hospital validation. Br J Dermatol 1994: 131: 406-16.
22. Pillai V, Ortega SB, Wang CK, Karandikar NJ. Transient regulatory T-cells: a state attained by all activated human T-cells. Clin Immunol 2007: 123: 18-29.
23. Noverr MC, Huffnagle GB. The microflora hypothesis of allergic diseases. Clin Exp Allergy 2005: 35: 1511-20.
24. Salminen S, Tang M. Gut microbiota in infants. In: Koletzko B, ed. Paediatric Nutrition in Practice. Munich: Karger, 2008: 80-4.
25. Kosiewicz MM, Zirnheld AL, Alard P. Gut microbiota, immunity, and disease: a complex relationship. Front Microbiol 2011: 2: 180.
26. Round JL, Mazmanian SK. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci USA 2010: 107: 12204-9.
27. Liu G, Zhao Y. Toll-like receptors and immune regulation: their direct and indirect modulation on regulatory CD4+ CD25+ T cells. Immunology 2007: 122: 149-56.
28. Matsuguchi T, Takagi A, Matsuzaki T, et al. Lipoteichoic acids from Lactobacillus strains elicit strong tumor necrosis factor alpha-inducing activities in macrophages through Toll-like receptor 2. Clin Diagn Lab Immunol 2003: 10: 259-66.
29. Caramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, Demengeot J. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med 2003: 197: 403-11.
30. Josefowicz SZ, Niec RE, Kim HY, et al. Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature 2012: 482: 395-9.
31. Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol 2010: 10: 490-500.
32. Schaub B, Campo M, He H, et al. Neonatal immune responses to TLR2 stimulation: influence of maternal atopy on Foxp3 and IL-10 expression. Respir Res 2006: 7: 40.
33. Wang J, Ioan-Facsinay A, vanderVoort EIH, Huizinga TWJ, Toes REM. Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells. Eur J Immunol 2007: 37: 129-38.