The effect of pronuclear morphology on early development and chromosomal abnormalities in cleavage-stage embryos

Human Reproduction

Volumn 18, Issue 11, 2003, Pages 2413-2419

  Gámiz, Pilar ^a   Rubio, Carmen ^a   De Los Santos, M José ^a   Mercader, Amparo ^a   Simón, Carlos ^a,b   Remohí, José ^a,b   Pellicer, Antonio ^a,b  

^a INSTITUTO VALENCIANO DE INFERTILIDAD   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Age; Chromosomal abnormalities; Nucleolar precursor bodies; Pronuclear morphology

Indexed keywords

ADULT; ARTICLE; BLASTOCYST; CELL SIZE; CHROMOSOME ABERRATION; CLASSIFICATION; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO POLARITY; EMBRYO TRANSFER; FEMALE; HUMAN; HUMAN TISSUE; INCIDENCE; INFERTILITY; MATERNAL AGE; MORPHOLOGY; MORULA; PROGNOSIS; PRONUCLEUS; RANDOMIZATION; STATISTICAL ANALYSIS; STRUCTURE ANALYSIS; ZYGOTE;

EID: 0242606874     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/deg458     Document Type: Article

References (37)

1. Alikani, M., Calderón, G., Tomkin, G., Garrisi, J., Kokot, M. and Cohen, J. (2000) Cleavage anomalies in early human embryos and survival after prolonged culture in-vitro. Hum. Reprod., 15, 2634-2643.
2. Balaban, B., Urman, B., Isiklar, Alatas, C., Aksoy, S., Mercan, R., Mumcu, A. and Nuhoglu, A. (2001) The effect of pronuclear morphology on embryo quality parameters and blastocyst transfer outcome. Hum. Reprod., 16, 2357-2361.
3. Demirel, L.C., Evirgen, O., Aydos, K. and Unlu, C. (2001) The impact of the source of spermatozoa used for ICSI on pronuclear morphology. Hum. Reprod., 16, 2327-2332.
4. De Placido, G., Wilding, M., Strina, I., Alviggi, E., Alviggi, C., Mollo, A., Varicchio, M.T., Tolino, A., Schiattarella, C. and Dale, B. (2002) High outcome predictability after IVF using a combined score for zygote and embryo morphology and growth rate. Hum. Reprod., 17, 2402-2409.
5. Fisch, J.D., Rodriguez, H., Ross, R., Overby, G. and Sher, G. (2001) The Graduated Embryo Score (GES) predicts blastocyst formation and pregnancy rate from cleavage-stage embryos. Hum. Reprod., 16, 1970-1975.
6. Gianaroli, L., Magli, M.C., Ferraretti, A.P. and Munne, S. (1999) Preimplantation diagnosis for aneuploidies in patients undergoing in vitro fertilization with a poor prognosis: Identification of the categories for which it should be proposed. Fertil. Steril., 72, 837-844.
7. Hardarson, T., Hanson, C., Sjogren, A. and Lundin, K. (2001) Human embryos with unevenly sized blastomeres have lower pregnancy and implantation rates: Indications for aneuploidy and multinucleation. Hum. Reprod., 16, 313-318.
8. Hassold, T. and Sherman, S. (2000) Down syndrome: Genetic recombination and the origin of the extra chromosome 21. Clin. Genet., 57, 95-100.
9. Jacobs, P.A. and Hassold, T.J. (1995) The origin of numerical chromosome abnormalities. Adv. Genet., 33, 101-133.
10. Kahraman, S., Kumtepe, Y., Setyel, S., Dönmez, E., Benkhalifa, M., Findikli, N. and Vanderzwalmen, P. (2002) Pronuclear morphology scoring and chromosomal status of embryos in severe male infertility. Hum. Reprod., 17, 3193-3200.
11. Kligman, I., Benadiva, C., Alikani, M. and Munne, S. (1996) The presence of multinucleated blastomeres in human embryos is correlated with chromosomal abnormalities. Hum. Reprod., 11, 1492-1498.
12. Ludwig, M., Schopper, B., Al-Hasani, S. and Diedrich, K. (2000) Clinical use of a pronuclear stage score following intracytoplasmic sperm injection: Impact on pregnancy rates under the conditions of the German embryo protection law. Hum. Reprod., 15, 325-329.
13. Magli, M.C., Gianaroli, L., Munne, S. and Ferraretti, A.P. (1998) Incidence of chromosomal abnormalities from a morphologically normal cohort of embryos in poor-prognosis patients. J. Assist. Reprod. Genet., 15, 297-301.
14. Márquez, C., Sandalinas, M., Bahce, M., Alikani, M. and Munné, S. (2000) Chromosome abnormalities in 1255 cleavage stage human embryos. Reprod. Biomed. Online, 1, 17-26.
15. Montag, M. and Van Der Ven, H. (2001) Evaluation of pronuclear morphology as the only selection criterion for further embryo culture and transfer: Results of a prospective multicentre study. Hum. Reprod., 16, 2384-2389.
16. Munné, S. and Cohen, J. (1998) Chromosome abnormalities in human embryos. Hum. Reprod. Update, 4, 842-855.
17. Munné, S., Alika, M., Tomkin, G., Grifo, J. and Cohen, J. (1995) Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities. Fertil. Steril., 64, 382-391.
18. Payne, D., Flaherty, S.P., Barry, M.F. and Matthews, C.D. (1997) Preliminary observations on polar body extrusion and pronuclear formation in human oocytes using time-lapse video cinematography. Hum. Reprod., 12, 532-541
19. Pellicer, A., Rubio, C., Vidal, F., Mínguez, Y., Giménez, C., Egozcue, J., Remohí, J. and Simón, C. (1999) In vitro fertilization plus preimplantation genetic diagnosis in patients with recurrent miscarriage: An analysis of chromosome abnormalities in human preimplantation embryos. Fertil. Steril., 71, 1033-1039.
20. Remohí, J., Gartner, B., Gallardo, E., Yalil, S., Simón, C. and Pellicer, A. (1997) Pregnancy and birth rates after oocyte donation. Fertil. Steril., 67, 717-723.
21. Rienzi, L., Ubaldi, F., Iacobelli, M., Ferrero, S., Minasi, M.J., Martínez, F., Tesarik, J. and Greco, E. (2002) Day 3 embryo transfer with combined evaluation at the pronuclear and cleavage stages compares favourably with day 5 blastocyst transfer. Hum. Reprod., 17, 1852-1855.
22. Ron-El, R., Raziel, A., Strassburguer, D., Schachter, M., Kasterstein, E. and Friedler, S. (2000) Outcome of assisted reproductive technology in women over the age of 41. Fertil. Steril., 74, 471-475.
23. Rubio, C., Simón, C., Vidal, F., Rodrigo, L., Pehlivan, T., Remohí, J. and Pellicer, A. (2003) Chromosomal abnormalities and development in preimplantation embryos from recurrent miscarriage couples. Hum. Reprod., 18, 182-188.
24. Sadowy, S., Tomkin, G., Munné, S., Ferrara-Congedo, T. and Cohen, J. (1998) Impaired development of zygotes with uneven pronuclear size. Zygote, 6, 137-141.
25. Sandalinas, M., Sadowy, S., Alikani, M., Calderon, G., Cohen, J. and Munne, S. (2001) Developmental ability of chromosomally abnormal human embryos to develop to the blastocyst stage. Hum. Reprod., 16, 1954-1958.
26. Scott, L. (2003) Pronuclear scoring as a predictor of embryo development. Reprod. Biomed. Online, 6, 201-214.
27. Scott, L.A. and Smith, S. (1998) The successful use of pronuclear embryo transfers the day following oocyte retrieval. Hum. Reprod., 13, 1003-1013.
28. Scott, L., Alvero, R., Leondires, M. and Miller, B. (2000) The morphology of human pronuclear embryos is positively related to blastocyst development and implantation. Hum. Reprod., 15, 2394-2403.
29. Spandorfer, S.D., Chung, P.H., Kligman, I., Liu, H.C., Davis, O.K. and Rosenwal, Z. (2000) An analysis of the effect of age on implantation rates. J. Assist. Reprod. Genet., 17, 303-306.
30. Tarkowski, A.K. (1966) An air drying method for chromosome preparations from mouse eggs. Cytogenetics, 5, 394-400.
31. Tesarik, J. and Greco, E. (1999) The probability of abnormal preimplantation development can be predicted by a single static observation on pronuclear stage morphology. Hum. Reprod., 14, 1318-1323.
32. Tesarik, J. and Kopecny, V. (1989) Development of human male pronucleus: Ultrastructure and timing. Gamete Res., 24, 135-149.
33. Tesarik, J. and Mendoza, C. (1996) Spermatid injection into human oocytes. I. Laboratory techniques and special features of zygote development. Hum. Reprod., 11, 772-779.
34. Tesarik, J., Mendoza, C. and Greco, E. (2002) Paternal effects acting during the first cell cycle of human preimplantation development after ICSI. Hum. Reprod., 17, 184-189.
35. Van Kooij, R.J., Looman, C.W., Habbema, J.D., Dorland, M. and Velde, E.R. (1996) Age-dependent decrease in embryo implantation rate after in vitro fertilization. Fertil. Steril., 66, 769-775.
36. Wittemer, C., Bettahar-Lebugle, K., Ohl, J., Rongieres, C., Nisand, I. and Gerlinger, P. (2000) Zygote evaluation: An efficient tool for embryo selection. Hum. Reprod., 15, 2591-2597.
37. Zollner, U., Zollner, K.P., Hartl, G., Dietl, J. and Steck, T. (2002) The use of a detailed zygote score after IVF/ICSI to obtain good quality blastocysts: The German experience. Hum. Reprod., 17, 1327-1333.