Enhanced production of Chikungunya virus-like particles using a high-pH adapted Spodoptera frugiperda insect cell line

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Wagner, James M ^a   Pajerowski, J David ^a   Daniels, Christopher L ^a   McHugh, Patrick M ^a   Flynn, Jessica A ^a   Balliet, John W ^a   Casimiro, Danilo R ^a   Subramanian, Shyamsundar ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; VIRUS PROTEIN; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACULOVIRUS; BACULOVIRUS EXPRESSION SYSTEM; CELL GROWTH; CELL LINE; CHIKUNGUNYA ALPHAVIRUS; CHROMATOGRAPHY; CONTROLLED STUDY; CULTURE MEDIUM; GENE EXPRESSION; GUINEA PIG; HEK293 CELL LINE; HUMAN; HUMAN CELL; INSECT CELL CULTURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; SPODOPTERA FRUGIPERDA; STIRRED REACTOR; VIRUS ASSEMBLY; VIRUS CAPSID; VIRUS INFECTION; VIRUS LIKE AGENT; VIRUS MORPHOLOGY; VIRUS NEUTRALIZATION; VIRUS PARTICLE; VIRUS PURIFICATION; VIRUS RECOMBINANT; VIRUS STRAIN; ANIMAL; CULTURE TECHNIQUE; GENETICS; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; SPODOPTERA; ULTRASTRUCTURE; VIRION; VIRUS REPLICATION;

ANIMALS; CAPSID; CELL CULTURE TECHNIQUES; CELL LINE; CHIKUNGUNYA VIRUS; GENE EXPRESSION; GUINEA PIGS; HUMANS; HYDROGEN-ION CONCENTRATION; RECOMBINANT PROTEINS; SPODOPTERA; VIRAL STRUCTURAL PROTEINS; VIRION; VIRUS REPLICATION;

EID: 84899416287     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094401     Document Type: Article

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