Effects of age and long-term endurance training on VO2 kinetics

Medicine and Science in Sports and Exercise

Volumn 47, Issue 2, 2015, Pages 289-298

  Grey, Tyler M ^a   Spencer, Matthew D ^a   Belfry, Glen R ^a   Kowalchuk, John M ^a   Paterson, Donald H ^a   Murias, Juan M ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Aging; Exercise; Muscle Deoxygenation; O2 Delivery

Indexed keywords

ADAPTATION; ADULT; AGED; AGING; ENDURANCE; HEART RATE; HUMAN; LUNG GAS EXCHANGE; MALE; MIDDLE AGED; NEAR INFRARED SPECTROSCOPY; OXYGEN CONSUMPTION; PHYSICAL EDUCATION; PHYSIOLOGY; SKELETAL MUSCLE; TIME FACTOR; VASCULARIZATION; YOUNG ADULT;

ADAPTATION, PHYSIOLOGICAL; ADULT; AGED; AGING; HEART RATE; HUMANS; MALE; MIDDLE AGED; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; PHYSICAL EDUCATION AND TRAINING; PHYSICAL ENDURANCE; PULMONARY GAS EXCHANGE; SPECTROSCOPY, NEAR-INFRARED; TIME FACTORS; YOUNG ADULT;

EID: 84922055719     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0000000000000398     Document Type: Article

References (46)

1. Babcock MA, Paterson DH, Cunningham DA. Effects of aerobic endurance training on gas exchange kinetics of older men. Med Sci Sports Exerc. 1994;26(4):447-52.
2. Babcock MA, Paterson DH, Cunningham DA, Dickinson JR. Exercise on-transient gas exchange kinetics are slowed as a function of age. Med Sci Sports Exerc. 1994;26(4):440-6.
3. Bassett DR, Howley ET. Limiting factors for maximum oxygen uptake and determinants of endurance performance. Med Sci Sports Exerc. 2000;32(1):70-84.
4. Beaver WL, Lamarra N, Wasserman K. Breath-by-breath measurement of true alveolar gas exchange. J Appl Physiol Respir Environ Exerc Physiol. 1981;51(6):1662-75.
5. Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol (1985). 1986; 60(6):2020-7.
6. Behnke BJ, Ramsey MW, Stabley JN, et al. Effects of aging and exercise training on skeletal muscle blood flow and resistance artery morphology. J Appl Physiol (1985). 2012;113(11):1699-708.
7. Bell C, Paterson DH, Kowalchuk JM, et al. Determinants of oxygen uptake kinetics in older humans following single-limb endurance exercise training. Exp Physiol. 2001;86(5):659-65.
8. Berger NJ, Rittweger J, Kwiet A, et al. Pulmonary O2 uptake onkinetics in endurance-and sprint-trained master athletes. Int J Sports Med. 2006;27(12):1005-12.
9. Berger NJ, Tolfrey K, Williams AG, Jones AM. Influence of continuous and interval training on oxygen uptake on-kinetics. Med Sci Sports Exerc. 2006;38(3):504-12.
10. Chilibeck PD, Paterson DH, Petrella RJ, Cunningham DA. The influence of age and cardiorespiratory fitness on kinetics of oxygen uptake. Can J Appl Physiol. 1996;21(3):185-96.
11. Coggan AR, Spina RJ, King DS, et al. Skeletal muscle adaptations to endurance training in 60-to 70-yr-old men and women. J Appl Physiol (1985). 1992;72(5):1780-6.
12. Coggan AR, Spina RJ, Rogers MA, et al. Histochemical and enzymatic characteristics of skeletal muscle in master athletes. J Appl Physiol (1985). 1990;68(5):1896-901.
13. DeLorey DS, Kowalchuk JM, Paterson DH. Effect of age on O2 uptake kinetics and the adaptation of muscle deoxygenation at the onset of moderate-intensity cycling exercise. J Appl Physiol (1985). 2004;97(1):165-72.
14. DeLorey DS, Paterson DH, Kowalchuk JM. Effects of ageing on muscle O2 utilization and muscle oxygenation during the transition to moderate-intensity exercise. Appl Physiol Nutr Metab. 2007; 32(6):1251-62.
15. duManoir GR, DeLorey DS, Kowalchuk JM, Paterson DH. Kinetics ofVO2 limb blood flow and regional muscle deoxygenation in young adults during moderate intensity, knee-extension exercise. Eur J Appl Physiol. 2010;108(3):607-17.
16. Ehsani AA, Ogawa T, Miller TR, Spina RJ, Jilka SM. Exercise training improves left ventricular systolic function in older men. Circulation. 1991;83(1):96-103.
17. Fleg JL, Morrell CH, Bos AG, et al. Accelerated longitudinal decline of aerobic capacity in healthy older adults. Circulation. 2005; 112(5):674-82.
18. Fuchi T, Iwaoka K, Higuchi M, Kobayashi S. Cardiovascular changes associated with decreased aerobic capacity and aging in long-distance runners. Eur J Appl Physiol Occup Physiol. 1989; 58(8):884-9.
19. Fukuoka Y, Grassi B, Conti M, et al. Early effects of exercise training on on-and off-kinetics in 50-year-old subjects. Pflugers Arch. 2002;443(5-6):690-7.
20. Grassi B, Poole DC, Richardson RS, Knight DR, Erickson BK, Wagner PD. Muscle O2 uptake kinetics in humans: implications for metabolic control. J Appl Physiol (1985). 1996;80(3):988-98.
21. Gravelle BM, Murias JM, Spencer MD, Paterson DH, Kowalchuk JM. Adjustments of pulmonary O2 uptake and muscle deoxygenation during ramp incremental exercise and constant-load moderateintensity exercise in young and older adults. J Appl Physiol (1985). 2012;113(9):1466-75.
22. Hagberg JM, Allen WK, Seals DR, Hurley BF, Ehsani AA, Holloszy JO. A hemodynamic comparison of young and older endurance athletes during exercise. J Appl Physiol (1985). 1985;58(6): 2041-6.
23. Jackson AS, Beard EF, Wier LT, Ross RM, Stuteville JE, Blair SN. Changes in aerobic power of men, ages 25-70 yr. Med Sci Sports Exerc. 1995;27(1):113-20.
24. Koppo K, Bouckaert J, Jones AM. Effects of training status and exercise intensity on phase II VO2 kinetics. Med Sci Sports Exerc. 2004;36(2):225-32.
25. Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part II: the aging heart in health: links to heart disease. Circulation. 2003;107(2):346-54.
26. McNarry MA, Kingsley MIC, Lewis MJ. Influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults. Am J Physiol Regul Integr Comp Physiol. 2012; 303(8):R791-8.
27. Murias JM, Dey A, Campos OA, et al. High-intensity endurance training results in faster vessel-specific rate of vasorelaxation in type 1 diabetic rats. PLoS One. 2013;8(3):e59678.
28. Murias JM, Kowalchuk JM, Paterson DH. Speeding ofVO2 kinetics in response to endurance-training in older and young women. Eur J Appl Physiol. 2010;111(2):235-43.
29. Murias JM, Kowalchuk JM, Paterson DH. Speeding of VO2 kinetics with endurance training in old and young men is associated with improved matching of local O2 delivery to muscle O2 utilization. J Appl Physiol (1985). 2010;108(4):913-22.
30. Murias JM, Kowalchuk JM, Paterson DH. Time course and mechanisms of adaptations in cardiorespiratory fitness with endurance training in older and young men. J Appl Physiol (1985). 2010; 108(3):621-7.
31. Murias JM, Kowalchuk JM, Ritchie D, Hepple RT, Doherty TJ, Paterson DH. Adaptations in capillarization and citrate synthase activity in response to endurance training in older and young men. J Gerontol A Biol Sci Med Sci. 2011;66(9):957-64.
32. Murias JM, Spencer MD, Kowalchuk JM, Paterson DH. Influence of phase I duration on phase IIVO2 kinetics parameter estimates in older and young adults. Am J Physiol Regul Integr Comp Physiol. 2011;301(1):R218-24.
33. Murias JM, Spencer MD, Kowalchuk JM, Paterson DH. Muscle deoxygenation to VO2 relationship differs in young subjects with varying TVO2. Eur J Appl Physiol. 2011;111(12):3107-18.
34. Murias JM, Spencer MD, Paterson DH. The critical role of O2 provision in the dynamic adjustment of oxidative phosphorylation. Exerc Sport Sci Rev. 2014;42(1):4-11.
35. Murias JM, Spencer MD, Pogliaghi S, Paterson DH. Noninvasive estimation of microvascular O2 provision during exercise on-transients in healthy young males. Am J Physiol Regul Integr Comp Physiol. 2012;303(8):R815-23.
36. Pimentel AE, Gentile CL, Tanaka H, Seals DR, Gates PE. Greater rate of decline in maximal aerobic capacity with age in endurancetrained than in sedentary men. J Appl Physiol (1985). 2003;94(6): 2406-13.
37. Proctor DN, Newcomer SC, Koch DW, Le KU, MacLean DA, Leuenberger UA. Leg blood flow during submaximal cycle ergometry is not reduced in healthy older normally active men. J Appl Physiol (1985). 2003;94(5):1859-69.
38. Rowell LB. Human cardiovascular adjustments to exercise and thermal stress. Physiol Rev. 1974;54(1):75-159.
39. Seals DR, Hagberg JM, Spina RJ, Rogers MA, Schechtman KB, Ehsani AA. Enhanced left ventricular performance in endurance trained older men. Circulation. 1994;89(1):198-205.
40. Spencer MD, Murias JM, Grey TM, Paterson DH. Regulation of V O2 kinetics by O2 delivery: insights from acute hypoxia and heavyintensity priming exercise in young men. J Appl Physiol (1985). 2012;112(6):1023-32.
41. Spencer MD, Murias JM, Kowalchuk JM, Paterson DH. Pulmonary O2 uptake and muscle deoxygenation kinetics are slowed in the upper compared with lower region of the moderate-intensity exercise domain in older men. Eur J Appl Physiol. 2011;111(9): 2139-48.
42. Spencer MD, Murias JM, Kowalchuk JM, Paterson DH. Effect of moderate-intensity work rate increment on phase II TVO2, functional gain and $[HHb]. Eur J Appl Physiol. 2013;113(3): 545-57.
43. Spier SA, Delp MD, Meininger CJ, Donato AJ, Ramsey MW, Muller-Delp JM. Effects of ageing and exercise training on endothelium-dependent vasodilatation and structure of rat skeletal muscle arterioles. J Physiol. 2004;556(3):947-58.
44. Spier SA, Delp MD, Stallone JN, Dominguez JM 2nd, Muller-Delp JM. Exercise training enhances flow-induced vasodilation in skeletal muscle resistance arteries of aged rats: role of PGI2 and nitric oxide. Am J Physiol Heart Circ Physiol. 2007;292(6): H3119-27.
45. Stathokostas L, Jacob-Johnson S, Petrella RJ, Paterson DH. Longitudinal changes in aerobic power in older men and women. J Appl Physiol (1985). 2004;97(2):781-9.
46. Wilson TM, Tanaka H. Meta-analysis of the age-associated decline in maximal aerobic capacity in men: relation to training status. Am J Physiol. 2000;278(3):H829-34