Identification of microRNAs 758 and 33b as potential modulators ofABCA1 expression in human atherosclerotic plaques

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 25, Issue 2, 2015, Pages 202-209

  Mandolini, C ^a,c   Santovito, D ^a,b,d   Marcantonio, P ^a,b   Buttitta, F ^b   Bucci, M ^a,b   Ucchino, S ^c   Mezzetti, A ^a,b   Cipollone, F ^a,b  

^a European Center of Excellence on Atherosclerosis   (Italy)

^b Center of Excellence on Aging (CeSI)   (Italy)

^c UNIVERSITY OF CHIETI   (Italy)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

ABC transporter; Atherosclerosis; Carotid endarterectomy; Cholesterol efflux; MicroRNA

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G1; CD68 ANTIGEN; MICRORNA; MICRORNA 33B; MICRORNA 758; UNCLASSIFIED DRUG; ABC TRANSPORTER; ABCA1 PROTEIN, HUMAN; ABCG1 PROTEIN, HUMAN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; MIRN33 MICRORNA, HUMAN; MIRN758 MICRORNA, HUMAN;

AGED; ARTICLE; CAROTID ATHEROSCLEROSIS; CAROTID ENDARTERECTOMY; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HYPERCHOLESTEROLEMIA; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA PROCESSING; STENOSIS; UPREGULATION; WESTERN BLOTTING; ATHEROSCLEROTIC PLAQUE; BLOOD; GENETICS; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ATP BINDING CASSETTE TRANSPORTER 1; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CHOLESTEROL, HDL; CHOLESTEROL, LDL; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; MALE; MICRORNAS; PLAQUE, ATHEROSCLEROTIC; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; UP-REGULATION;

EID: 84922021706     PISSN: 09394753     EISSN: 15903729     Source Type: Journal    
DOI: 10.1016/j.numecd.2014.09.005     Document Type: Article

References (30)

1. Roger V.L., Go A.S., Lloyd-Jones D.M., Benjamin E.J., Berry J.D., Borden W.B., et al. Heart disease and stroke statistics-2012 update: a report from the American heart association. Circulation 2012, 125:e2-e220. 10.1161/CIR.0b013e31823ac046.
2. Nakashima Y., Fujii H., Sumiyoshi S., Wight T.N., Sueishi K. Early human atherosclerosis: accumulation of lipid and proteoglycans in intimal thickenings followed by macrophage infiltration. Arterioscler Thromb Vasc Biol 2007, 27:1159-1165. 10.1161/ATVBAHA.106.134080.
3. Nishi K., Itabe H., Uno M., Kitazato K.T., Horiguchi H., Shinno K., et al. Oxidized LDL in carotid plaques and plasma associates with plaque instability. Arterioscler Thromb Vasc Biol 2002, 22:1649-1654. 10.1161/01.ATV.0000033829.14012.18.
4. Navab M., Reddy S.T., Van Lenten B.J., Fogelman A.M. HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms. Nat Rev Cardiol 2011, 8:222-232. 10.1038/nrcardio.2010.222.
5. Liao H., Langmann T., Schmitz G., Zhu Y. Native LDL upregulation of ATP-binding cassette transporter-1 in human vascular endothelial cells. Arterioscler Thromb Vasc Biol 2002, 22:127-132. 10.1161/hq1201.101772.
6. Venkateswaran A., Laffitte B.A., Joseph S.B., Mak P.A., Wilpitz D.C., Edwards P.A., et al. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proc Natl Acad Sci U S A 2000, 97:12097-12102. 10.1073/pnas.200367697.
7. Chinetti G., Lestavel S., Bocher V., Remaley A.T., Neve B., Torra I.P., et al. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat Med 2001, 7:53-58. 10.1038/83348.
8. Yvan-Charvet L., Ranalletta M., Wang N., Han S., Terasaka N., Li R., et al. Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice. J Clin Invest 2007, 117:3900-3908. 10.1172/JCI33372.
9. Albrecht C., Soumian S., Amey J.S., Sardini A., Higgins C.F., Davies A.H., et al. ABCA1 expression in carotid atherosclerotic plaques. Stroke 2004, 35:2801-2806. 10.1161/01.STR.0000147036.07307.93.
10. Liu H.F., Cui K.F., Wang J.P., Zhang M., Guo Y.P., Li X.Y., et al. Significance of ABCA1 in human carotid atherosclerotic plaques. Exp Ther Med 2012, 4:297-302. 10.3892/etm.2012.576.
11. Bartel D.P. MicroRNAs: target recognition and regulatory functions. Cell 2009, 136:215-233. 10.1016/j.cell.2009.01.002.
12. Nana-Sinkam S.P., Croce C.M. MicroRNAs as therapeutic targets in cancer. Transl Res 2011, 157:216-225. 10.1016/j.trsl.2011.01.013.
13. Dai R., Ahmed S.A. MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases. Transl Res 2011, 157:163-179. 10.1016/j.trsl.2011.01.007.
14. Santovito D., Mezzetti A., Cipollone F. MicroRNAs and atherosclerosis: new actors for an old movie. Nutr Metab Cardiovasc Dis 2012, 22:937-943. 10.1016/j.numecd.2012.03.007.
15. Santovito D., De Nardis V., Marcantonio P., Mandolini C., Paganelli C., Vitale E., et al. Plasma exosome microRNA profiling unravels a new potential modulator of adiponectin pathway in diabetes: effect of glycemic control. J Clin Endocrinol Metab 2014, 99:E1681-E1685. jc20133843. 10.1210/jc.2013-3843.
16. Rayner K.J., Suarez Y., Davalos A., Parathath S., Fitzgerald M.L., Tamehiro N., et al. MiR-33 contributes to the regulation of cholesterol homeostasis. Science 2010, 328:1570-1573. 10.1126/science.1189862.
17. Najafi-Shoushtari S.H., Kristo F., Li Y., Shioda T., Cohen D.E., Gerszten R.E., et al. MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science 2010, 328:1566-1569. 10.1126/science.1189123.
18. Rayner K.J., Sheedy F.J., Esau C.C., Hussain F.N., Temel R.E., Parathath S., et al. Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis. J Clin Invest 2011, 121:2921-2931. 10.1172/JCI57275.
19. Rayner K.J., Esau C.C., Hussain F.N., McDaniel A.L., Marshall S.M., van Gils J.M., et al. Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Nature 2011, 478:404-407. 10.1038/nature10486.
20. Ramirez C.M., Davalos A., Goedeke L., Salerno A.G., Warrier N., Cirera-Salinas D., et al. MicroRNA-758 regulates cholesterol efflux through posttranscriptional repression of ATP-binding cassette transporter A1. Arterioscler Thromb Vasc Biol 2011, 31:2707-2714. 10.1161/ATVBAHA.111.232066.
21. Cipollone F., Felicioni L., Sarzani R., Ucchino S., Spigonardo F., Mandolini C., et al. A unique microRNA signature associated with plaque instability in humans. Stroke 2011, 42:2556-2563. 10.1161/STROKEAHA.110.597575.
22. Santovito D., Mandolini C., Marcantonio P., De Nardis V., Bucci M., Paganelli C., et al. Overexpression of microRNA-145 in atherosclerotic plaques from hypertensive patients. Expert Opin Ther Targets 2013, 17:217-223. 10.1517/14728222.2013.745512.
23. Wang X., Collins H.L., Ranalletta M., Fuki I.V., Billheimer J.T., Rothblat G.H., et al. Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport invivo. J Clin Invest 2007, 117:2216-2224. 10.1172/JCI32057.
24. Civelek M., Grant G.R., Irolla C.R., Shi C., Riley R.J., Chiesa O.A., et al. Prelesional arterial endothelial phenotypes in hypercholesterolemia: universal ABCA1 upregulation contrasts with region-specific gene expression invivo. Am J Physiol Heart Circ Physiol 2010, 298:H163-H170. 10.1152/ajpheart.00652.2009.
25. Chinetti-Gbaguidi G., Baron M., Bouhlel M.A., Vanhoutte J., Copin C., Sebti Y., et al. Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARgamma and LXRalpha pathways. Circ Res 2011, 108:985-995. 10.1161/CIRCRESAHA.110.233775.
26. Betel D., Koppal A., Agius P., Sander C., Leslie C. Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biol 2010, 11. R90. 10.1186/gb-2010-11-8-r90.
27. Kim J., Yoon H., Ramirez C.M., Lee S.M., Hoe H.S., Fernandez-Hernando C., et al. MiR-106b impairs cholesterol efflux and increases abeta levels by repressing ABCA1 expression. Exp Neurol 2012, 235:476-483. 10.1016/j.expneurol.2011.11.010.
28. Bidzhekov K., Gan L., Denecke B., Rostalsky A., Hristov M., Koeppel T.A., et al. microRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans. Thromb Haemost 2012, 107:619-625. 10.1160/TH11-09-0607.
29. Raitoharju E., Lyytikainen L.P., Levula M., Oksala N., Mennander A., Tarkka M., et al. miR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques in the tamperevascular study. Atherosclerosis 2011, 219:211-217. 10.1016/j.atherosclerosis.2011.07.020.
30. Janssen H.L., Reesink H.W., Lawitz E.J., Zeuzem S., Rodriguez-Torres M., Patel K., et al. Treatment of HCV infection by targeting microRNA. N. Engl J Med 2013, 368:1685-1694. 10.1056/NEJMoa1209026.