Associative fear learning and perceptual discrimination: A perceptual pathway in the development of chronic pain

Neuroscience and Biobehavioral Reviews

Volumn 51, Issue , 2015, Pages 118-125

  Zaman, Jonas ^a   Vlaeyen, Johan W S ^a,b   Van Oudenhove, Lukas ^c,d   Wiech, Katja ^a,e   Van Diest, Ilse ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Associative fear learning; Chronic pain; Pain perception; Perceptual discrimination

Indexed keywords

ABDOMINAL PAIN; AMYGDALOID NUCLEUS; ANXIETY; ASSOCIATION; ASSOCIATIVE FEAR LEARNING; AUDITORY CORTEX; AUDITORY DISCRIMINATION; AVOIDANCE BEHAVIOR; BACKACHE; BURNING SENSATION; CHRONIC PAIN; COMPLEX REGIONAL PAIN SYNDROME; CONDITIONING; DEFENSIVE BEHAVIOR; FEAR; HUMAN; INTEROCEPTION; IRRITABLE COLON; LIMBIC SYSTEM; LONG TERM MEMORY; MUSCULOSKELETAL PAIN; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; OLFACTORY DISCRIMINATION; PERCEPTIVE DISCRIMINATION; REVIEW; SOMATOSENSORY SYSTEM; STATE DEPENDENT LEARNING; TACTILE DISCRIMINATION; THEORETICAL MODEL; TRANSCRANIAL MAGNETIC STIMULATION; VISCERAL PAIN; ANIMAL; BRAIN; DISCRIMINATION LEARNING; LEARNING; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGICAL MODEL; PSYCHOLOGY;

ANIMALS; ASSOCIATION LEARNING; BRAIN; CHRONIC PAIN; DISCRIMINATION (PSYCHOLOGY); DISCRIMINATION LEARNING; FEAR; HUMANS; MODELS, PSYCHOLOGICAL;

EID: 84921992911     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2015.01.009     Document Type: Review

References (99)

1. Åhs F., Miller S.S., Gordon A.R., Lundström J.N. Aversive learning increases sensory detection sensitivity. Biol. Psychol. 2013, 92:135-141. 10.1016/j.biopsycho.2012.11.004.
2. Aizenberg M., Geffen M.N. Bidirectional effects of aversive learning on perceptual acuity are mediated by the sensory cortex. Nat. Neurosci. 2013, 16:994-996. 10.1038/nn.3443.
3. Amaral D., Behniea H., Kelly J. Topographic organization of projections from the amygdala to the visual cortex in the macaque monkey. Neuroscience 2003, 118:1099-1120. 10.1016/S0306-4522(02)01001-1.
4. Apkarian V.A., Baliki M.N., Geha P.Y. Towards a theory of chronic pain. Prog. Neurobiol. 2009, 87:81-97. 10.1016/j.pneurobio.2008.09.018.
5. Apkarian V.A., Hashmi J.A., Baliki M.N. Pain and the brain: specificity and plasticity of the brain in clinical chronic pain. Pain 2011, 152:S49-S64. 10.1016/j.pain.2010.11.010.
6. Armony J.L., Dolan R.J. Modulation of spatial attention by fear-conditioned stimuli: an event-related fMRI study. Neuropsychologia 2002, 40:817-826.
7. Asutay E., Västfjäll D. Perception of loudness is influenced by emotion. PLoS ONE 2012, 7:e38660. 10.1371/journal.pone.0038660.
8. Bardoni R., Torsney C., Tong C.-K., Prandini M., MacDermott A.B. Presynaptic NMDA receptors modulate glutamate release from primary sensory neurons in rat spinal cord dorsal horn. J. Neurosci. 2004, 24:2774-2781. 10.1523/JNEUROSCI.4637-03.2004.
9. Benson S., Kattoor J., Kullmann J.S., Hofmann S., Engler H., Forsting M., Gizewski E.R., Elsenbruch S. Towards understanding sex differences in visceral pain: Enhanced reactivation of classically-conditioned fear in healthy women. Neurobiol. Learn. Mem. 2014, 109:113-121. 10.1016/j.nlm.2013.12.014.
10. Boersma K., Linton S., Overmeer T., Jansson M., Vlaeyen J., de Jong J. Lowering fear-avoidance and enhancing function through exposure in vivo. A multiple baseline study across six patients with back pain. Pain 2004, 108:8-16. 10.1016/j.pain.2003.03.001.
11. Bouton M.E., Mineka S., Barlow D.H. A modern learning theory perspective on the etiology of panic disorder. Psychol. Rev. 2001, 108:4-32. 10.1037//0033-295X.108.1.4.
12. Catani M., Jones D.K., Donato R., Ffytche D.H. Occipito-temporal connections in the human brain. Brain 2003, 126:2093-2107. 10.1093/brain/awg203.
13. Chen C.-F.F., Barnes D.C., Wilson D.A. Generalized vs. stimulus-specific learned fear differentially modifies stimulus encoding in primary sensory cortex of awake rats. J. Neurophysiol. 2011, 106:3136-3144. 10.1152/jn.00721.2011.
14. Cohen M.J., Naliboff B.D., Schandler S.L., Heinrich R.L. Signal detection and threshold measures to loud tones and radiant heat in chronic low back pain patients and cohort controls. Pain 1983, 16:245-252. 10.1016/0304-3959(83)90112-4.
15. Craske M.G., Wolitzky-Taylor K.B., Labus J., Wu S., Frese M., Mayer E.A., Naliboff B.D. A cognitive-behavioral treatment for irritable bowel syndrome using interoceptive exposure to visceral sensations. Behav. Res. Ther. 2011, 49:413-421. 10.1016/j.brat.2011.04.001.
16. Crombez G., Van Damme S., Eccleston C. Hypervigilance to pain: an experimental and clinical analysis. Pain 2005, 116:4-7. 10.1016/j.pain.2005.03.035.
17. De Houwer J. A conceptual and theoretical analysis of evaluative conditioning. Span. J. Psychol. 2007, 10:230-241.
18. De Jong J.R., Vlaeyen J.W.S., Onghena P., Cuypers C., den Hollander M., Ruijgrok J. Reduction of pain-related fear in complex regional pain syndrome type I: the application of graded exposure in vivo. Pain 2005, 116:264-275. 10.1016/j.pain.2005.04.019.
19. De Peuter S., Van Diest I., Vansteenwegen D., Van den Bergh O., Vlaeyen J.W.S. Understanding fear of pain in chronic pain: interoceptive fear conditioning as a novel approach. Eur. J. Pain 2011, 15:889-894. 10.1016/j.ejpain.2011.03.002.
20. De Ridder D., Elgoyhen A.B., Romo R., Langguth B. Phantom percepts: tinnitus and pain as persisting aversive memory networks. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:8075-8080. 10.1073/pnas.1018466108.
21. Dickhaus B., Mayer E.A., Firooz N., Stains J., Conde F., Olivas T.I., Fass R., Chang L., Mayer M., Naliboff B.D. Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stress. Am. J. Gastroenterol. 2003, 98:135-143. 10.1111/j. 1572-0241.2003.07156.x.
22. Diesch E., Flor H. Alteration in the response properties of primary somatosensory cortex related to differential aversive Pavlovian conditioning. Pain 2007, 131:171-180. 10.1016/j.pain.2007.01.016.
23. Dorn S.D., Palsson O.S., Thiwan S.I.M., Kanazawa M., Clark W.C., van Tilburg M.A.L., Drossman D.A., Scarlett Y., Levy R.L., Ringel Y., Crowell M.D., Olden K.W., Whitehead W.E. Increased colonic pain sensitivity in irritable bowel syndrome is the result of an increased tendency to report pain rather than increased neurosensory sensitivity. Gut 2007, 56:1202-1209. 10.1136/gut.2006.117390.
24. Ethofer T., Bretscher J., Gschwind M., Kreifelts B., Wildgruber D., Vuilleumier P. Emotional voice areas: anatomic location, functional properties, and structural connections revealed by combined fMRI/DTI. Cereb. Cortex 2012, 22:191-200. 10.1093/cercor/bhr113.
25. Flor H., Fürst M., Birbaumer N. Deficient discrimination of EMG levels and overestimation of perceived tension in chronic pain patients. Appl. Psychophysiol. Biofeedback 1999, 24:55-66. 10.1023/A:1022847131149.
26. Flor H., Knost B., Birbaumer N. The role of operant conditioning in chronic pain: an experimental investigation. Pain 2002, 95:111-118.
27. Flor H., Schugens M.M., Birbaumer N. Discrimination of muscle tension in chronic pain patients and healthy controls. Biofeedback Self. Regul. 1992, 17:165-177. 10.1007/BF01000401.
28. Jänig W., Zimmermann M. Presynaptic depolarization of myelinated afferent fibres evoked by stimulation of cutaneous C fibres. J. Physiol. 1971, 214:29-50.
29. Jenewein J., Moergeli H., Sprott H., Honegger D., Brunner L., Ettlin D., Grillon C., Bloch K., Brügger M., Schwegler K., Schumacher S., Hasler G. Fear-learning deficits in subjects with fibromyalgia syndrome?. Eur. J. Pain 2013, 17:1374-1384. 10.1002/j. 1532-2149.2013.00300.x.
30. Kattoor J., Gizewski E.R., Kotsis V., Benson S., Gramsch C., Theysohn N., Maderwald S., Forsting M., Schedlowski M., Elsenbruch S. Fear conditioning in an abdominal pain model: neural responses during associative learning and extinction in healthy subjects. PLoS ONE 2013, 8:e51149. 10.1371/journal.pone.0051149.
31. Klosterhalfen S., Rüttgers A., Krumrey E., Otto B., Stockhorst U., Riepl R.L., Probst T., Enck P. Pavlovian conditioning of taste aversion using a motion sickness paradigm. Psychosom. Med. 2000, 62:671-677.
32. Labus J.S., Bolus R., Chang L., Wiklund I., Naesdal J., Mayer E.A., Naliboff B.D. The Visceral Sensitivity Index: development and validation of a gastrointestinal symptom-specific anxiety scale. Aliment. Pharmacol. Ther. 2004, 20:89-97. 10.1111/j.1365-2036.2004.02007.x.
33. Labus J.S., Hubbard C.S., Bueller J., Ebrat B., Tillisch K., Chen M., Stains J., Dukes G.E., Kelleher D.L., Naliboff B.D., Fanselow M., Mayer E.A. Impaired emotional learning and involvement of the corticotropin-releasing factor signaling system in patients with irritable bowel syndrome. Gastroenterology 2013, 145:1253-1261. e1-e3. 10.1053/j.gastro.2013.08.016.
34. Labus J.S., Mayer E.A., Chang L., Bolus R., Naliboff B.D. The central role of gastrointestinal-specific anxiety in irritable bowel syndrome: further validation of the visceral sensitivity index. Psychosom. Med. 2007, 69:89-98. 10.1097/PSY.0b013e31802e2f24.
35. Laufer O., Paz R. Monetary loss alters perceptual thresholds and compromises future decisions via amygdala and prefrontal networks. J. Neurosci. 2012, 32:6304-6311. 10.1523/JNEUROSCI.6281-11.2012.
36. Leeuw M., Goossens M.E.J.B., Linton S.J., Crombez G., Boersma K., Vlaeyen J.W.S. The fear-avoidance model of musculoskeletal pain: current state of scientific evidence. J. Behav. Med. 2007, 30:77-94. 10.1007/s10865-006-9085-0.
37. Li W., Howard J.D., Parrish T.B., Gottfried J.A. Aversive learning enhances perceptual and cortical discrimination of indiscriminable odor cues. Science 2008, 319:1842-1845. 10.1126/science.1152837.
38. Lissek S., Powers A.S., McClure E.B., Phelps E.A., Woldehawariat G., Grillon C., Pine D.S. Classical fear conditioning in the anxiety disorders: a meta-analysis. Behav. Res. Ther. 2005, 43:1391-1424. 10.1016/j.brat.2004.10.007.
39. Lissek S., Wilimzig C., Stude P., Pleger B., Kalisch T., Maier C., Peters S.A., Nicolas V., Tegenthoff M., Dinse H.R. Immobilization impairs tactile perception and shrinks somatosensory cortical maps. Curr. Biol. 2009, 19:837-842. 10.1016/j.cub.2009.03.065.
40. Ljótsson B., Hedman E., Lindfors P., Hursti T., Lindefors N., Andersson G., Rück C. Long-term follow-up of internet-delivered exposure and mindfulness based treatment for irritable bowel syndrome. Behav. Res. Ther. 2011, 49:58-61. 10.1016/j.brat.2010.10.006.
41. Ljótsson B., Hesser H., Andersson E., Lackner J.M., El Alaoui S., Falk L., Aspvall K., Fransson J., Hammarlund K., Löfström A., Nowinski S., Lindfors P., Hedman E. Provoking symptoms to relieve symptoms: a randomized controlled dismantling study of exposure therapy in irritable bowel syndrome. Behav. Res. Ther. 2014, 55:27-39. 10.1016/j.brat.2014.01.007.
42. Ljótsson B., Hesser H., Andersson E., Lindfors P., Hursti T., Rück C., Lindefors N., Andersson G., Hedman E. Mechanisms of change in an exposure-based treatment for irritable bowel syndrome. J. Consult. Clin. Psychol. 2013, 81:1113-1126. 10.1037/a0033439.
43. Luo Q., Holroyd T., Majestic C., Cheng X., Schechter J., Blair R.J. Emotional automaticity is a matter of timing. J. Neurosci. 2010, 30:5825-5829. 10.1523/JNEUROSCI.BC-5668-09.2010.
44. Maihöfner C., DeCol R. Decreased perceptual learning ability in complex regional pain syndrome. Eur. J. Pain 2007, 11:903-909. 10.1016/j.ejpain.2007.03.006.
45. Maihöfner C., Neundörfer B., Birklein F., Handwerker H.O. Mislocalization of tactile stimulation in patients with complex regional pain syndrome. J. Neurol. 2006, 253:772-779. 10.1007/s00415-006-0117-z.
46. McLaren I.P.L., Mackintosh N.J. An elemental model of associative learning. I. Latent inhibition and perceptual learning. Anim. Learn. Behav. 2000, 28:211-246. 10.3758/BF03200258.
47. Meulders A., Jans A., Vlaeyen J.W.S. Differences in pain-related fear acquisition and generalization: an experimental study comparing fibromyalgia patients and healthy controls. Pain 2015, 156:108-122.
48. Meulders A., Vandebroek N., Vervliet B., Vlaeyen J.W.S. Generalization gradients in cued and contextual pain-related fear: an experimental study in healthy participants. Front. Hum. Neurosci. 2013, 7:345. 10.3389/fnhum.2013.00345.
49. Meulders A., Vansteenwegen D., Vlaeyen J.W.S. The acquisition of fear of movement-related pain and associative learning: a novel pain-relevant human fear conditioning paradigm. Pain 2011, 152:2460-2469. 10.1016/j.pain.2011.05.015.
50. Meulders A., Vansteenwegen D., Vlaeyen J.W.S. Women, but not men, report increasingly more pain during repeated (un)predictable painful electrocutaneous stimulation: evidence for mediation by fear of pain. Pain 2012, 153:1030-1041. 10.1016/j.pain.2012.02.005.
51. Mineka S., Oehlberg K. The relevance of recent developments in classical conditioning to understanding the etiology and maintenance of anxiety disorders. Acta Psychol. (Amst.) 2008, 127:567-580. 10.1016/j.actpsy.2007.11.007.
52. Moseley G.L. I can't find it! Distorted body image and tactile dysfunction in patients with chronic back pain. Pain 2008, 140:239-243. 10.1016/j.pain.2008.08.001.
53. Moseley G.L., Wiech K. The effect of tactile discrimination training is enhanced when patients watch the reflected image of their unaffected limb during training. Pain 2009, 144:314-319. 10.1016/j.pain.2009.04.030.
54. Moseley G.L., Zalucki N.M., Wiech K. Tactile discrimination, but not tactile stimulation alone, reduces chronic limb pain. Pain 2008, 137:600-608. 10.1016/j.pain.2007.10.021.
55. Naliboff B.D., Munakata J., Fullerton S., Gracely R.H., Kodner A., Harraf F., Mayer E.A. Evidence for two distinct perceptual alterations in irritable bowel syndrome. Gut 1997, 41:505-512.
56. Padmala S., Pessoa L. Affective learning enhances visual detection and responses in primary visual cortex. J. Neurosci. 2008, 28:6202-6210. 10.1523/JNEUROSCI. 1233-08.2008.
57. Pappens M., Smets E., Vansteenwegen D., Van Den Bergh O., Van Diest I. Learning to fear suffocation: a new paradigm for interoceptive fear conditioning. Psychophysiology 2012, 49:821-828. 10.1111/j.1469-8986.2012.01357.x.
58. Pappens M., Van den Bergh O., Vansteenwegen D., Ceunen E., De Peuter S., Van Diest I. Learning to fear obstructed breathing: comparing interoceptive and exteroceptive cues. Biol. Psychol. 2013, 92:36-42. 10.1016/j.biopsycho.2011.05.004.
59. Pavlov I.P. Conditioned Reflexes: An Investigation of the Physiological Activity of the Cerebral Cortex 1927, Oxford University Press, Oxford, England.
60. Peters M.L., Schmidt A.J.M. A comparison of two-point discrimination threshold of tactual, non-painful stimuli between chronic low back pain patients and controls. Pain 1991, 44:57-60.
61. Peters M.L., Schmidt A.J.M. Differences in pain perception and sensory discrimination between chronic low back pain patients and healthy controls. J. Psychosom. Res. 1992, 36:47-53.
62. Pleger B., Foerster A.F., Ragert P., Dinse H.R., Schwenkreis P., Malin J.P., Nicolas V., Tegenthoff M. Functional imaging of perceptual learning in human primary and secondary somatosensory cortex. Neuron 2003, 40:643-653.
63. Pleger B., Ragert P., Schwenkreis P., Förster A.-F., Wilimzig C., Dinse H., Nicolas V., Maier C., Tegenthoff M. Patterns of cortical reorganization parallel impaired tactile discrimination and pain intensity in complex regional pain syndrome. Neuroimage 2006, 32:503-510. 10.1016/j.neuroimage.2006.03.045.
64. Pleger B., Tegenthoff M., Ragert P., Förster A.-F., Dinse H.R., Schwenkreis P., Nicolas V., Maier C. Sensorimotor retuning in complex regional pain syndrome parallels pain reduction. Ann. Neurol. 2005, 57:425-429. 10.1002/ana.20394.
65. Pourtois G., Schettino A., Vuilleumier P. Brain mechanisms for emotional influences on perception and attention: what is magic and what is not. Biol. Psychol. 2013, 92:492-512. 10.1016/j.biopsycho.2012.02.007.
66. Ratcliff R., McKoon G. The diffusion decision model: theory and data for two-choice decision tasks. Neural Comput. 2008, 20:873-922. 10.1162/neco.2008.12-06-420.
67. Resnik J., Sobel N., Paz R. Auditory aversive learning increases discrimination thresholds. Nat. Neurosci. 2011, 14:791-796. 10.1038/nn.2802.
68. Romo R., Lemus L., de Lafuente V. Sense, memory, and decision-making in the somatosensory cortical network. Curr. Opin. Neurobiol. 2012, 22:914-919. 10.1016/j.conb.2012.08.002.
69. Rotshtein P., Richardson M.P., Winston J.S., Kiebel S.J., Vuilleumier P., Eimer M., Driver J., Dolan R.J. Amygdala damage affects event-related potentials for fearful faces at specific time windows. Hum. Brain Mapp. 2010, 31:1089-1105. 10.1002/hbm.20921.
70. Sabatinelli D., Fortune E.E., Li Q., Siddiqui A., Krafft C., Oliver W.T., Beck S., Jeffries J. Emotional perception: meta-analyses of face and natural scene processing. Neuroimage 2011, 54:2524-2533. 10.1016/j.neuroimage.2010.10.011.
71. Schechtman E., Laufer O., Paz R. Negative valence widens generalization of learning. J. Neurosci. 2010, 30:10460-10464. 10.1523/JNEUROSCI.2377-10.2010.
72. Schneider C., Palomba D., Flor H. Pavlovian conditioning of muscular responses in chronic pain patients: central and peripheral correlates. Pain 2004, 112:239-247. 10.1016/j.pain.2004.08.025.
73. Sehlmeyer C., Schöning S., Zwitserlood P., Pfleiderer B., Kircher T., Arolt V., Konrad C. Human fear conditioning and extinction in neuroimaging: a systematic review. PLoS ONE 2009, 4:e5865. 10.1371/journal.pone.0005865.
74. Sharma A., Van Oudenhove L., Paine P., Gregory L., Aziz Q. Anxiety increases acid-induced esophageal hyperalgesia. Psychosom. Med. 2010, 72:802-809. 10.1097/PSY.0b013e3181f5c021.
75. Stefanucci J.K., Storbeck J. Don't look down: emotional arousal elevates height perception. J. Exp. Psychol. Gen. 2009, 138:131-145. 10.1037/a0014797.
76. Stockhorst U., Enck P., Klosterhalfen S. Role of classical conditioning in learning gastrointestinal symptoms. World J. Gastroenterol. 2007, 13:3430-3437.
77. Stockhorst U., Steingrueber H.-J., Enck P., Klosterhalfen S. Pavlovian conditioning of nausea and vomiting. Auton. Neurosci. 2006, 129:50-57. 10.1016/j.autneu.2006.07.012.
78. Stolarova M., Keil A., Moratti S. Modulation of the C1 visual event-related component by conditioned stimuli: evidence for sensory plasticity in early affective perception. Cereb. Cortex 2006, 16:876-887. 10.1093/cercor/bhj031.
79. Taylor K.S., Anastakis D.J., Davis K.D. Chronic pain and sensorimotor deficits following peripheral nerve injury. Pain 2010, 151:582-591. 10.1016/j.pain.2010.06.032.
80. Teachman B.A., Stefanucci J.K., Clerkin E.M., Cody M.W., Proffitt D.R. A new mode of fear expression: perceptual bias in height fear. Emotion 2008, 8:296-301. 10.1037/1528-3542.8.2.296.
81. Trost Z., France C.R., Thomas J.S. Pain-related fear and avoidance of physical exertion following delayed-onset muscle soreness. Pain 2011, 152:1540-1547. 10.1016/j.pain.2011.02.038.
82. Van Damme S., Crombez G., Eccleston C., Koster E.H.W. Hypervigilance to learned pain signals: a componential analysis. J. Pain 2006, 7:346-357. 10.1016/j.jpain.2005.12.006.
83. Van Diest I., Ceunen E., Sarafanova E., Weltens N., Coen S., Tack J., Van Oudenhove L., Vlaeyen J. Interoceptive fear conditioning with esophageal distensions. Psychophysiology 2013, 50:S113.
84. Van Oudenhove L., Aziz Q. The role of psychosocial factors and psychiatric disorders in functional dyspepsia. Nat. Rev. Gastroenterol. Hepatol. 2013, 10:158-167. 10.1038/nrgastro.2013.10.
85. Vandekerckhove J., Tuerlinckx F., Lee M.D. Hierarchical diffusion models for two-choice response times. Psychol. Methods 2011, 16:44-62. 10.1037/a0021765.
86. Vlaeyen J.W., Linton S.J. Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. Pain 2000, 85:317-332.
87. Vlaeyen J.W., Morley S., Linton S.J., Boersma K., de Jong J. Pain-related Fear: Exposure Based Treatment for Chronic Pain 2012, IASP Press. 1st ed.
88. Vlaeyen J.W.S., De Jong J.R., Onghena P., Kerckhoffs-Hanssen M., Kole-Snijders A.M.J. Can pain-related fear be reduced? The application of cognitive-behavioural exposure in vivo. Pain Res. Manag. 2002, 7:144-153.
89. Vlaeyen J.W.S., Linton S.J. Fear-avoidance model of chronic musculoskeletal pain: 12 years on. Pain 2012, 153:1144-1147. 10.1016/j.pain.2011.12.009.
90. Vuilleumier P. How brains beware: neural mechanisms of emotional attention. Trends Cogn. Sci. 2005, 9:585-594. 10.1016/j.tics.2005.10.011.
91. Vuilleumier P., Richardson M.P., Armony J.L., Driver J., Dolan R.J. Distant influences of amygdala lesion on visual cortical activation during emotional face processing. Nat. Neurosci. 2004, 7:1271-1278. 10.1038/nn1341.
92. Wand B.M., Abbaszadeh S., Smith A.J., Catley M.J., Moseley G.L. Acupuncture applied as a sensory discrimination training tool decreases movement-related pain in patients with chronic low back pain more than acupuncture alone: a randomised cross-over experiment. Br. J. Sports Med. 2013, 47:1085-1089. 10.1136/bjsports-2013-092949.
93. Wand B.M., Di Pietro F., George P., O'Connell N.E. Tactile thresholds are preserved yet complex sensory function is impaired over the lumbar spine of chronic non-specific low back pain patients: a preliminary investigation. Physiotherapy 2010, 96:317-323. 10.1016/j.physio.2010.02.005.
94. Wassim F.H., Ayache S.S., Mylius V., Zouari H.G., Goujon C., Lefaucheur J.P. The use of repetitive transcranial magnetic stimulation to produce analgesic effects in patients with chronic pain syndromes. Neurophysiol. Clin. Neurophysiol. 2013, 43:71. 10.1016/j.neucli.2012.11.013.
95. Weiss T., Dietrich C., Preissler S., Miltner W.H.R., Hofmann G.O. Effects of a somatosensory discrimination training on phantom limb pain in arm amputes. Eur. J. Pain Suppl. 2010, 4:135. 10.1016/S1754-3207(10)70482-X.
96. Wiech K., Lin C., Brodersen K.H., Bingel U., Ploner M., Tracey I. Anterior insula integrates information about salience into perceptual decisions about pain. J. Neurosci. 2010, 30:16324-16331. 10.1523/JNEUROSCI.2087-10.2010.
97. Wiech K., Vandekerckhove J., Zaman J., Tuerlinckx F., Vlaeyen J.W.S., Tracey I. Influence of prior information on pain involves biased perceptual decision-making. Curr. Biol. 2014, 24:R679-R681. 10.1016/j.cub.2014.06.022.
98. Wilder-Smith C., Hill L. IBS patients with constipation and diarrhea offer in their discrimination of and sensitivity to visceral sensory crimination. Gastroenterology 2003, 124:A392-A393.
99. Yágüez L., Coen S., Gregory L.J., Amaro E., Altman C., Brammer M.J., Bullmore E.T., Williams S.C.R., Aziz Q. Brain response to visceral aversive conditioning: a functional magnetic resonance imaging study. Gastroenterology 2005, 128:1819-1829. 10.1053/j.gastro.2005.02.068.