Association of cerebral microbleeds with mortality in stroke patients having atrial fibrillation

Neurology

Volumn 83, Issue 15, 2014, Pages 1308-1315

  Song, Tae Jin ^b   Kim, Jinkwon ^c   Song, Dongbeom ^a   Nam, Hyo Suk ^a   Kim, Young Dae ^a   Lee, Hye Sun ^a   Heo, Ji Hoe ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Ewha Womans University School of Medicine   (South Korea)

^c CHA University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; HEART ATRIUM FIBRILLATION; HIGH RISK PATIENT; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MORTALITY; NONVALVULAR ATRIAL FIBRILLATION; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; STROKE PATIENT; ATRIAL FIBRILLATION; CEREBROVASCULAR ACCIDENT; COMPLICATION; KAPLAN MEIER METHOD; MIDDLE AGED; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ATRIAL FIBRILLATION; CEREBRAL HEMORRHAGE; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; STROKE;

EID: 84921978758     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0000000000000862     Document Type: Article

References (27)

1. Fazekas F, Kleinert R, Roob G, et al. Histopathologic analysis of foci of signal loss on gradient-echo T2∗- weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. AJNR Am J Neuroradiol 1999;20:637-642.
2. Lovelock CE, Cordonnier C, Naka H, et al. Antithrombotic drug use, cerebral microbleeds, and intracerebral hemorrhage: A systematic review of published and unpublished studies. Stroke 2010;41:1222-1228.
3. Henneman WJ, Sluimer JD, Cordonnier C, et al. MRI biomarkers of vascular damage and atrophy predicting mortality in a memory clinic population. Stroke 2009; 40:492-498.
4. Altmann-Schneider I, Trompet S, de Craen AJ, et al. Cerebral microbleeds are predictive of mortality in the elderly. Stroke 2011;42:638-644.
5. Lin HJ, Wolf PA, Kelly-Hayes M, et al. Stroke severity in atrial fibrillation. The Framingham Study. Stroke 1996; 27:1760-1764.
6. Nam HS, Kim HC, Kim YD, et al. Long-term mortality in patients with stroke of undetermined etiology. Stroke 2012;43:2948-2956.
7. Kim YD, Cha MJ, Kim J, et al. Long-term mortality in patients with coexisting potential causes of ischemic stroke. Int J Stroke Epub 2013 Mar 12.
8. Pisters R, Lane DA, Nieuwlaat R, de Vos CB, Crijns HJ, Lip GY. A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: The Euro Heart Survey. Chest 2010;138: 1093-1100.
9. Soo YO, Yang SR, Lam WW, et al. Risk vs benefit of antithrombotic therapy in ischaemic stroke patients with cerebral microbleeds. J Neurol 2008;255:1679-1686.
10. Thijs V, Lemmens R, Schoofs C, et al. Microbleeds and the risk of recurrent stroke. Stroke 2010;41:2005-2009.
11. Lee BI, Nam HS, Heo JH, Kim DI; Yonsei Stroke Team. Yonsei Stroke Registry. Analysis of 1, 000 patients with acute cerebral infarctions. Cerebrovasc Dis 2001; 12:145-151.
12. Oh MS, Yu KH, Lee JH, et al. Validity and reliability of a Korean version of the National Institutes of Health Stroke Scale. J Clin Neurol 2012;8:177-183.
13. Song TJ, Kim J, Lee HS, et al. The frequency of cerebral microbleeds increases with Chads(2) scores in stroke patients with non-valvular atrial fibrillation. Eur J Neurol 2013;20:502-508.
14. Cordonnier C, Al-Shahi Salman R, Wardlaw J. Spontaneous brain microbleeds: Systematic review, subgroup analyses and standards for study design and reporting. Brain 2007;130:1988-2003.
15. Rosand J, Hylek EM, O'Donnell HC, Greenberg SM. Warfarin-associated hemorrhage, and cerebral amyloid angiopathy: A genetic and pathologic study. Neurology 2000;55:947-951.
16. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol 1987;149:351-356.
17. Kim HC, Choi DP, Ahn SV, Nam CM, Suh I. Six-year survival and causes of death among stroke patients in Korea. Neuroepidemiology 2009;32:94-100.
18. Boulanger JM, Coutts SB, Eliasziw M, et al. Cerebral microhemorrhages predict new disabling or fatal strokes in patients with acute ischemic stroke or transient ischemic attack. Stroke 2006;37:911-914.
19. Fan YH, Zhang L, Lam WW, Mok VC, Wong KS. Cerebral microbleeds as a risk factor for subsequent intracerebral hemorrhages among patients with acute ischemic stroke. Stroke 2003;34:2459-2462.
20. Lee SH, Bae HJ, Kwon SJ, et al. Cerebral microbleeds are regionally associated with intracerebral hemorrhage. Neurology 2004;62:72-76.
21. Lee SH, Kim BJ, Roh JK. Silent microbleeds are associated with volume of primary intracerebral hemorrhage. Neurology 2006;66:430-432.
22. Greenberg SM, Vernooij MW, Cordonnier C, et al. Cerebral microbleeds: A guide to detection and interpretation. Lancet Neurol 2009;8:165-174.
23. Biffi A, Greenberg SM. Cerebral amyloid angiopathy: A systematic review. J Clin Neurol 2011;7:1-9.
24. Biffi A, Sonni A, Anderson CD, et al. Variants at APOE influence risk of deep and lobar intracerebral hemorrhage. Ann Neurol 2010;68:934-943.
25. Lee SH, Ryu WS, Roh JK. Cerebral microbleeds are a risk factor for warfarin-related intracerebral hemorrhage. Neurology 2009;72:171-176.
26. Fisher M. MRI screening for chronic anticoagulation in atrial fibrillation. Front Neurol 2013;4:137.
27. Charidimou A, Kakar P, Fox Z, Werring DJ. Cerebral microbleeds, and recurrent stroke risk: Systematic review and meta-analysis of prospective ischemic stroke and transient ischemic attack cohorts. Stroke 2013;44: 995-1001.