Cerebral microbleeds are regionally associated with intracerebral hemorrhage

Neurology

Volumn 62, Issue 1, 2004, Pages 72-76

  Lee, S H ^a   Bae, H J ^b   Kwon, S J ^a   Kim, H ^a   Kim, Y H ^a   Yoon, B W ^a   Roh, J K ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University Hospital   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BRAIN CORTEX; BRAIN HEMORRHAGE; BRAIN MICROCIRCULATION; CEREBELLUM; CEREBRAL MICROBLEED; CORRELATION ANALYSIS; DIFFUSION WEIGHTED IMAGING; DISEASE ASSOCIATION; FEMALE; GRAY MATTER; HUMAN; HYPERTENSION; LEUKOARAIOSIS; MAJOR CLINICAL STUDY; MALE; MICROANGIOPATHY; MULTIVARIATE ANALYSIS; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RISK FACTOR; SCORING SYSTEM; STROKE;

EID: 0347092042     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000101463.50798.0D     Document Type: Article

References (23)

1. Tanaka A, Ueno Y, Nakayama Y, Takano K, Takebayashi S. Small chronic hemorrhages and ischemic lesions in association with spontaneous intracerebral hematomas. Stroke 1999;30:1637-1642.
2. Fazekas F, Kleinert R, Roob G, et al. Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. AJNR Am J Neuroradiol 1999;20:637-642.
3. Roob G, Fazekas F. Magnetic resonance imaging of cerebral microbleeds. Curr Opin Neurol 2000;13:69-73.
4. Lee SH, Bae HJ, Yoon BW, Kim H, Kim DE, Roh JK. Low concentration of serum total cholesterol is associated with multifocal signal loss lesions on gradient-echo magnetic resonance imaging: analysis of risk factors for multifocal signal loss lesions. Stroke 2002;33:2845-2849.
5. Nighoghossian N, Hermier M, Adeleine P, et al. Old microbleeds are a potential risk factor for cerebral bleeding after ischemic stroke: a gradient-echo T2*-weighted brain MRI study. Stroke 2002;33:735-742.
6. Kidwell CS, Saver JL, Carneado J, et al. Predictors of hemorrhagic transformation in patients receiving intra-arterial thrombolysis. Stroke 2002;33:717-724.
7. Roob G, Lechner A, Schmidt R, Flooh E, Hartung HP, Fazekas F. Frequency and location of microbleeds in patients with primary intracerebral hemorrhage. Stroke 2000;31:2665-2669.
8. Kim DE, Bae HJ, Lee SH, Kim H, Yoon BW, Roh JK. Gradient echo magnetic resonance imaging in the prediction of hemorrhagic vs ischemic stroke: a need for the consideration of the extent of leukoariosis. Arch Neurol 2002;59:425-429.
9. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol 1987;149:351-356.
10. Offenbacher H, Fazekas F, Schmidt R, Koch M, Fazekas G, Kapeller P. MR of cerebral abnormalities concomitant with primary intracerebral hematomas. AJNR Am J Neuroradiol 1996;17:573-578.
11. Chan S, Kartha K, Yoon SS, Desmond DW, Hilal SK. Multifocal hypointense cerebral lesions on gradient-echo MR are associated with chronic hypertension. AJNR Am J Neuroradiol 1996;17:1821-1827.
12. Roob G, Schmidt R, Kapeller P, Lechner A, Hartung HP, Fazekas F. MRI evidence of past cerebral microbleeds in a healthy elderly population. Neurology. 1999;52:991-994.
13. Tsushima Y, Tamura T, Unno Y, Kusano S, Endo K. Multifocal low-signal brain lesions on T2*-weighted gradient-echo imaging. Neuroradiology 2000;42:499-504.
14. Inzitari D, Giordano GP, Ancona AL, Pracucci G, Mascalchi M, Amaducci L. Leukoaraiosis, intracerebral hemorrhage, and arterial hypertension. Stroke 1990;21:1419-1423.
15. Smith EE, Rosand J, Knudsen KA, Hylek EM, Greenberg SM. Leukoaraiosis is associated with warfarin-related hemorrhage following ischemic stroke. Neurology 2002;59:193-197.
16. Cole FM, Yates PO. The occurrence and significance of intracerebral micro-aneurysms. J Pathol Bacteriol 1967;93:393-411.
17. Cole FM, Yates P. Intracerebral microaneurysms and small cerebrovascular lesions. Brain 1967;90:759-768.
18. Cole FM, Yates PO. Comparative incidence of cerebrovascular lesions in normotensive and hypertensive patients. Neurology 1968;18:255-259.
19. Fisher CM. Pathological observations in hypertensive cerebral hemorrhage. J Neuropathol Exp Neurol 1971;30:536-550.
20. Fisher CM. Cerebral miliary aneurysms in hypertension. Am J Pathol 1972;66:313-330.
21. Greenberg SM. Cerebral amyloid angiopathy: prospects for clinical diagnosis and treatment. Neurology 1998;51:690-694.
22. Greenberg SM, O'Donnell HC, Schaefer PW, Kraft E. MRI detection of new hemorrhages: potential marker of progression in cerebral amyloid angiopathy. Neurology 1999;53:1135-1138.
23. Greenberg SM, Rosand J. Outcome markers for clinical trials in cerebral amyloid angiopathy. Amyloid 2001;8(suppl 1):56-60.