Protective effects of Crocus Sativus L. extract and crocin against chronic-stress induced oxidative damage of brain, liver and kidneys in rats

Advanced Pharmaceutical Bulletin

Volumn 4, Issue , 2014, Pages 493-499

  Bandegi, Ahmad Reza ^a   Rashidy Pour, Ali ^a   Vafaei, Abbas Ali ^a   Ghadrdoost, Behshid ^a  

^a SEMNAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Brain; Chronic stress; Kidney; Liver; Oxidative stress; Saffron extract and crocin

Indexed keywords

ANTIOXIDANT; CROCIN; CROCUS SATIVUS EXTRACT; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; MALONALDEHYDE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ADULT; AMINO ACID BRAIN LEVEL; AMINO ACID KIDNEY LEVEL; AMINO ACID LIVER LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ANTIOXIDANT ASSAY; ARTICLE; CHRONIC STRESS; CONTROLLED STUDY; DRUG DETERMINATION; ENZYME ACTIVITY; ENZYME ASSAY; LIPID PEROXIDATION; LIVER PROTECTION; MALE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT; RENAL PROTECTION; TISSUE LEVEL;

EID: 84921960684     PISSN: 22285881     EISSN: 22517308     Source Type: Journal    
DOI: 10.5681/apb.2014.073     Document Type: Article

References (49)

1. Johnson EO, Kamilaris TC, Chrousos GP, Gold PW. Mechanisms of stress: a dynamic overview of hormonal and behavioral homeostasis. Neurosci Biobehav Rev 1992;16(2):115-30.
2. Sies H. Oxidative stress: oxidants and antioxidants. Exp Physiol 1997;82(2):291-5.
3. Sahin E, Gümüslü S. Immobilization stress in rat tissues: alterations in protein oxidation, lipid peroxidation and antioxidant defense system. Comp Biochem Physiol C Toxicol Pharmacol 2007;144(4):342-7.
4. Irie M, Asami S, Nagata S, Miyata M, Kasai H. Classical conditioning of oxidative DNA damage in rats. Neurosci Lett 2000;288(1):13-6.
5. Romanova TP, Karpel' GG, Brill' GE, Markov KHM. Mechanism of disorders of the cerebral blood supply during stress in spontaneously hypertensive rats. Patol Fiziol Eksp Ter 1994;(3):5-8.
6. Manning RD Jr, Meng S, Tian N. Renal and vascular oxidative stress and salt-sensitivity of arterial pressure. Acta Physiol Scand 2003;179(3):243-50.
7. Dröge W. Oxidative stress and aging. Adv Exp Med Biol 2003;543:191-200.
8. Halliwell B. Oxidative stress and neurodegeneration: where are we now? J Neurochem 2006;97(6):1634-58.
9. Djordjevic J, Djordjevic A, Adzic M, Niciforovic A, Radojcic MB. Chronic stress differentially affects antioxidant enzymes and modifies the acute stress response in liver of Wistar rats. Physiol Res 2010;59(5):729-36.
10. Dalle-Donne I, Rossi R, Colombo R, Giustarini D, Milzani A. Biomarkers of oxidative damage in human disease. Clin Chem 2006;52(4):601-23.
11. Hu X, Sato J, Oshida Y, Xu M, Bajotto G, Sato Y. Effect of Gosha-jinki-gan (Chinese herbal medicine: Niu-Che-Sen-Qi-Wan) on insulin resistance in streptozotocin-induced diabetic rats. Diabetes Res Clin Pract 2003;59(2):103-11.
12. Abdullaev FI, Espinosa-Aguirre JJ. Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Cancer Detect Prev 2004;28(6):426-32.
13. Rios JL, Recio MC, Ginger RM, Manez S. An update review of saffron and its active constituents. Phytother Res 1996;10(3):189-93.
14. Hosseinzadeh H, Abootorabi A, Sadeghnia HR. Protective effect of Crocus sativus stigma extract and crocin (trans-crocin 4) on methyl methanesulfonate-induced DNA damage in mice organs. DNA Cell Biol 2008;27(12):657-64.
15. Premkumar K, Abraham SK, Santhiya ST, Ramesh A. Protective effects of saffron (Crocus sativus Linn.) on genotoxins-induced oxidative stress in Swiss albino mice. Phytother Res 2003;17(6):614-7.
16. Pitsikas N, Sakellaridis N. Crocus sativus L. extracts antagonize memory impairments in different behavioural tasks in the rat. Behav Brain Res 2006;173(1):112-5.
17. Pitsikas N, Zisopoulou S, Tarantilis PA, Kanakis CD, Polissiou MG, Sakellaridis N. Effects of the active constituents of Crocus sativus L., crocins on recognition and spatial rats' memory. Behav Brain Res 2007;183(2):141-6.
18. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
19. Mihara M, Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978;86(1):271-8.
20. Benzie IF, Strain JJ. Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Methods Enzymol 1999;299:15-27.
21. Delides A, Spooner RJ, Goldberg DM, Neal FE. An optimized semi-automatic rate method for serum glutathione reductase activity and its application to patients with malignant disease. J Clin Pathol 1976;29(1):73-7.
22. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967;70(1):158-69.
23. Ghadrdoost B, Vafaei AA, Rashidy-Pour A, Hajisoltani R, Bandegi AR, Motamedi F, et al. Protective effects of saffron extract and its active constituent crocin against oxidative stress and spatial learning and memory deficits induced by chronic stress in rats. Eur J Pharmacol 2011;667(1-3):222-9.
24. Gümüslü S, Sarikçioglu SB, Sahin E, Yargiçoglu P, Agar A. Influences of different stress models on the antioxidant status and lipid peroxidation in rat erythrocytes. Free Radic Res 2002;36(12):1277-82.
25. Hemnani T, Parihar MS. Reactive oxygen species and oxidative DNA damage. Indian J Physiol Pharmacol 1998;42(4):440-52.
26. Metodiewa D, Koska C. Reactive oxygen species and reactive nitrogen species: relevance to cyto(neuro)toxic events and neurologic disorders. An overview. Neurotox Res 2000;1(3):197-233.
27. Liu J, Wang X, Shigenaga MK, Yeo HC, Mori A, Ames BN. Immobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rats. FASEB J 1996;10(13):1532-8.
28. Videla LA, Fernández V, Tapia G, Varela P. Oxidative stress-mediated hepatotoxicity of iron and copper: role of Kupffer cells. Biometals 2003;16(1):103-11.
29. Vijayavel K, Anbuselvam C, Balasubramanian MP. Naphthalene-induced hematological disturbances and oxidative stress in an estuarine edible crab, Scylla serrata. Environ Toxicol 2005;20(4):464-6.
30. Parola M, Robino G. Oxidative stress-related molecules and liver fibrosis. J Hepatol 2001;35(2):297-306.
31. Davydov VV, Zakharchenko IV, Ovsyannikov VG. Free radical processes in the liver of adult and old rats during stress. Bull Exp Biol Med 2004;137(2):139-42.
32. Martín-Mateo MC, Sánchez-Portugal M, Iglesias S, De Paula A, Bustamante J. Oxidative stress in chronic renal failure. Ren Fail 1999;21(2):155-67.
33. Klahr S. Oxygen radicals and renal diseases. Miner Electrolyte Metab 1997;23(3-6):140-3.
34. Fontella FU, Siqueira IR, Vasconcellos AP, Tabajara AS, Netto CA, Dalmaz C. Repeated restraint stress induces oxidative damage in rat hippocampus. Neurochem Res 2005;30(1):105-11.
35. Hidalgo J, Gasull T, Garcia A, Blanquez A, Armario A. Role of glucocorticoids and catecholamines on hepatic thiobarbituric acid reactants in basal and stress conditions in the rat. Horm Metab Res 1991;23(3):104-9.
36. Patel R, Mcintosh L, Mclaughlin J, Brooke S, Nimon V, Sapolsky R. Disruptive effects of glucocorticoids on glutathione peroxidase biochemistry in hippocampal cultures. J Neurochem 2002;82(1):118-25.
37. Behl C, Lezoualc'h F, Trapp T, Widmann M, Skutella T, Holsboer F. Glucocorticoids enhance oxidative stress-induced cell death in hippocampal neurons in vitro. Endocrinology 1997;138(1):101-6.
38. Kumar JS, Menon VP. Effect of diabetes on levels of lipid peroxides and glycolipids in rat brain. Metabolism 1993;42(11):1435-9.
39. Kawai N, Keep RF, Betz AL, Nagao S. Hyperglycemia induces progressive changes in the cerebral microvasculature and blood-brain barrier transport during focal cerebral ischemia. Acta Neurochir Suppl 1998;71:219-21.
40. Hosseinzadeh H, Sadeghnia HR, Ziaee T, Danaee A. Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. J Pharm Pharm Sci 2005;8(3):387-93.
41. Asdaq SM, Inamdar MN. Potential of Crocus sativus (saffron) and its constituent, crocin, as hypolipidemic and antioxidant in rats. Appl Biochem Biotechnol 2010;162(2):358-72.
42. Pari L, Latha M. Protective role of Scoparia dulcis plant extract on brain antioxidant status and lipidperoxidation in STZ diabetic male Wistar rats. BMC Complement Altern Med 2004;4:16.
43. Ochiai T, Ohno S, Soeda S, Tanaka H, Shoyama Y, Shimeno H. Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of alpha-tocopherol. Neurosci Lett 2004;362(1):61-4.
44. Joukar S, Najafipour H, Khaksari M, Sepehri G, Shahrokhi N, Dabiri S, et al. The effect of saffron consumption on biochemical and histopathological heart indices of rats with myocardial infarction. Cardiovasc Toxicol 2010;10(1):66-71.
45. Zheng YQ, Liu JX, Wang JN, Xu L. Effects of crocin on reperfusion-induced oxidative/nitrative injury to cerebral microvessels after global cerebral ischemia. Brain Res 2007;1138:86-94.
46. Cantuti-Castelvetri I, Shukitt-Hale B, Joseph JA. Neurobehavioral aspects of antioxidants in aging. Int J Dev Neurosci 2000;18(4-5):367-81.
47. Melov S. Animal models of oxidative stress, aging, and therapeutic antioxidant interventions. Int J Biochem Cell Biol 2002;34(11):1395-400.
48. Mcintosh LJ, Hong KE, Sapolsky RM. Glucocorticoids may alter antioxidant enzyme capacity in the brain: baseline studies. Brain Res 1998;791(1-2):209-14.
49. Mcintosh LJ, Cortopassi KM, Sapolsky RM. Glucocorticoids may alter antioxidant enzyme capacity in the brain: kainic acid studies. Brain Res 1998;791(1-2):215-22.