메뉴 건너뛰기




Volumn 15, Issue 4, 2014, Pages 670-682

c-MET Inhibitors in the Treatment of Lung Cancer

Author keywords

C MET inhibitors; HGF; HGF antibodies; MET; MET antibodies; Targeted therapy

Indexed keywords

5 (2,6 DICHLOROBENZYLSULFONYL) 3 [3,5 DIMETHYL 4 [2 (1 PYRROLIDINYLMETHYL) 1 PYRROLIDINYLCARBONYL] 1H PYRROL 2 YLMETHYLENE] 1,3 DIHYDRO 2H INDOL 2 ONE; ANTINEOPLASTIC AGENT; C MET INHIBITOR; CABOZANTINIB; CAPMATINIB; CARBOPLATIN; CE 355621; CISPLATIN; CRIZOTINIB; ERLOTINIB; FICLATUZUMAB; FORETINIB; GEFITINIB; K 252A; MONOCLONAL ANTIBODY; N (3 CHLOROPHENYL) 3 [3,5 DIMETHYL 4 (4 METHYL 1 PIPERAZINYLCARBONYL) 1H PYRROL 2 YLMETHYLENE] 2,3 DIHYDRO N METHYL 2 OXO 1H INDOLE 5 SULFONAMIDE; OA 5D5; ONARTUZUMAB; PEMETREXED; PLACEBO; RILOTUMUMAB; TIVANTINIB; UNCLASSIFIED DRUG; PROTEIN KINASE INHIBITOR; SCATTER FACTOR; SCATTER FACTOR RECEPTOR;

EID: 84921937793     PISSN: 15272729     EISSN: 15346277     Source Type: Journal    
DOI: 10.1007/s11864-014-0313-5     Document Type: Review
Times cited : (50)

References (49)
  • 1
    • 84857410524 scopus 로고    scopus 로고
    • A novel classification of lung cancer into molecular subtypes
    • PID: 22363766, COI: 1:CAS:528:DC%2BC38XjsVaqsbo%3D
    • West L, Vidwans SJ, Campbell NP, et al. A novel classification of lung cancer into molecular subtypes. PLoS One. 2012;7:e31906.
    • (2012) PLoS One , vol.7 , pp. e31906
    • West, L.1    Vidwans, S.J.2    Campbell, N.P.3
  • 2
    • 84878356233 scopus 로고    scopus 로고
    • MET targeted therapy for lung cancer: clinical development and future directions
    • This paper clearly presents structure and function of MET receptor as well as its alterations in lung cancer
    • Feng Y, Ma CP. MET targeted therapy for lung cancer: clinical development and future directions. Lung Cancer: Targetes and Ther. 2012;3:53–66. This paper clearly presents structure and function of MET receptor as well as its alterations in lung cancer.
    • (2012) Lung Cancer: Targetes and Ther , vol.3 , pp. 53-66
    • Feng, Y.1    Ma, C.P.2
  • 3
    • 84855993422 scopus 로고    scopus 로고
    • Hepatocyte growth factor(HGF) autocrine activation predicts sensitivity to MET inhibition in glioblastoma
    • PID: 22203985
    • Xie Q, Bradley R, Kang L, et al. Hepatocyte growth factor(HGF) autocrine activation predicts sensitivity to MET inhibition in glioblastoma. Proc Natl Acad Sci U S A. 2012;109(2):570–5.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.2 , pp. 570-575
    • Xie, Q.1    Bradley, R.2    Kang, L.3
  • 4
    • 84997941720 scopus 로고    scopus 로고
    • An overview of the c-MET signaling pathway
    • Organ SL, Tsao MS. An overview of the c-MET signaling pathway. Ther Adv Med Oncol. 2011;3(S1):7–19.
    • (2011) Ther Adv Med Oncol , vol.3 , Issue.S1 , pp. 7-19
    • Organ, S.L.1    Tsao, M.S.2
  • 5
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • PID: 17463250, COI: 1:CAS:528:DC%2BD2sXltlOjt7g%3D
    • Engelman JA, Zejnuliahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007;316:1039–43.
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1    Zejnuliahu, K.2    Mitsudomi, T.3
  • 6
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • PID: 18093943, COI: 1:CAS:528:DC%2BD1cXktlyhsg%3D%3D
    • Bean J, Brennan C, Shih JY, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A. 2007;104:20932–7.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 20932-20937
    • Bean, J.1    Brennan, C.2    Shih, J.Y.3
  • 7
    • 84998153455 scopus 로고    scopus 로고
    • In the clinic: ongoing clinical trials evaluating c-MET-inhibiting drugs
    • Sahrma N, Adjei A. In the clinic: ongoing clinical trials evaluating c-MET-inhibiting drugs. Ther Adv Med Oncol. 2011;3(S1):37–50.
    • (2011) Ther Adv Med Oncol , vol.3 , Issue.S1 , pp. 37-50
    • Sahrma, N.1    Adjei, A.2
  • 8
    • 84902466769 scopus 로고    scopus 로고
    • Emerging molecular targets in oncology: clinical potetial of MET/hepatocyte growth-factor
    • COI: 1:CAS:528:DC%2BC2cXhs1ynurbP, This paper discuss the role of MET’s dysregulation in different cancers and highlight the potential benefits related to the use of MET/HGF inhibitors
    • Smyth EC, Sclafani F, Cunningham D. Emerging molecular targets in oncology: clinical potetial of MET/hepatocyte growth-factor. Oncol Targets Ther. 2014;7:1001–14. This paper discuss the role of MET’s dysregulation in different cancers and highlight the potential benefits related to the use of MET/HGF inhibitors.
    • (2014) Oncol Targets Ther , vol.7 , pp. 1001-1014
    • Smyth, E.C.1    Sclafani, F.2    Cunningham, D.3
  • 9
    • 79955458487 scopus 로고    scopus 로고
    • Activity of Crizotinib (PF02341066), a Dual Mesenchymal-Epithelial Transition (MET) and Anaplastic Lymphoma Kinase (ALK) Inhibitor, in Non-small Cell Lung Cancer Patient with De Novo MET Amplification
    • Ou SI, Kwak EL, Siwak-Tapp C, et al. Activity of Crizotinib (PF02341066), a Dual Mesenchymal-Epithelial Transition (MET) and Anaplastic Lymphoma Kinase (ALK) Inhibitor, in Non-small Cell Lung Cancer Patient with De Novo MET Amplification. J Thorac Oncol. 2011;5:942–6.
    • (2011) J Thorac Oncol , vol.5 , pp. 942-946
    • Ou, S.I.1    Kwak, E.L.2    Siwak-Tapp, C.3
  • 10
    • 80053386829 scopus 로고    scopus 로고
    • Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis
    • PID: 21933749, COI: 1:CAS:528:DC%2BC3MXht1KmtrzL
    • Shaw A, Yeap B, Solomon B, et al. Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis. Lancet Oncol. 2011;12(11):1004–12.
    • (2011) Lancet Oncol , vol.12 , Issue.11 , pp. 1004-1012
    • Shaw, A.1    Yeap, B.2    Solomon, B.3
  • 11
    • 84857822329 scopus 로고    scopus 로고
    • The therapeutic potential of anaplastic lymphoma kinase inhibitors in lung cancer: rationale and clinical evidence
    • COI: 1:CAS:528:DC%2BC3MXhtVyrsbrP
    • Weickhardt AJ, Camidge DR. The therapeutic potential of anaplastic lymphoma kinase inhibitors in lung cancer: rationale and clinical evidence. Clin Invest. 2011;1:1119–26.
    • (2011) Clin Invest , vol.1 , pp. 1119-1126
    • Weickhardt, A.J.1    Camidge, D.R.2
  • 12
    • 84921937357 scopus 로고    scopus 로고
    • Pfizer. A Study Of Oral PF-02341066, A c-Met/hepatocyte growth factor tyrosine kinase inhibitor, in patients with advanced cancer. Available from:. NLM identifier: NCT00585195. Accessed July 3, 2014
    • Pfizer. A Study Of Oral PF-02341066, A c-Met/hepatocyte growth factor tyrosine kinase inhibitor, in patients with advanced cancer. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00585195. NLM identifier: NCT00585195. Accessed July 3, 2014.
  • 13
    • 84921936904 scopus 로고    scopus 로고
    • Pfizer. An investigational drug, PF-02341066, is being studied in patients with advanced non-small cell lung cancer with a specific gene profile involving the anaplastic lymphoma kinase (ALK) gene. Available from:. NLM identifier: NCT00932451. Accessed July 3, 2014
    • Pfizer. An investigational drug, PF-02341066, is being studied in patients with advanced non-small cell lung cancer with a specific gene profile involving the anaplastic lymphoma kinase (ALK) gene. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00932451. NLM identifier: NCT00932451. Accessed July 3, 2014.
  • 14
    • 84866934606 scopus 로고    scopus 로고
    • Activity and safety of crizotinb in patients ALK-positive non-small-cell lung cancer: updated results from a phase 1 study
    • PID: 22954507, COI: 1:CAS:528:DC%2BC38XhsVCjsb3E, This paper describes the results regarding efficacy and safety of crizotinib compared with standard chemotherapy in patients with NSCLC after the fail of first-line treatment. It provides evidence and points out the benefits from use of crizotynib in this setting
    • Camidge R, Bang Y-J, Kwak E, et al. Activity and safety of crizotinb in patients ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol. 2012;13:1011–9. This paper describes the results regarding efficacy and safety of crizotinib compared with standard chemotherapy in patients with NSCLC after the fail of first-line treatment. It provides evidence and points out the benefits from use of crizotynib in this setting.
    • (2012) Lancet Oncol , vol.13 , pp. 1011-1019
    • Camidge, R.1    Bang, Y.-J.2    Kwak, E.3
  • 15
    • 84921935874 scopus 로고    scopus 로고
    • Pfizer. An investigational drug, PF-02341066, is being studied versus standard of care in patients with advanced non-small cell lung cancer with a specific gene profile involving the anaplastic lymphoma kinase (ALK) Gene. Available from:. NLM identifier: NCT00932893. Accessed July 3, 2014
    • Pfizer. An investigational drug, PF-02341066, is being studied versus standard of care in patients with advanced non-small cell lung cancer with a specific gene profile involving the anaplastic lymphoma kinase (ALK) Gene. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00932893. NLM identifier: NCT00932893. Accessed July 3, 2014.
  • 16
    • 84879071011 scopus 로고    scopus 로고
    • Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
    • PID: 23724913, COI: 1:CAS:528:DC%2BC3sXhtVSnu7%2FM, This paper describes the result of phase 1 study that was the basis to register crizotinib for the treatment of patients suffering from non-small-cell lung carcinoma with the presence of rearrangements within the ALK gene after the failure of previous treatment
    • Shaw A, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013;368:2385–94. This paper describes the result of phase 1 study that was the basis to register crizotinib for the treatment of patients suffering from non-small-cell lung carcinoma with the presence of rearrangements within the ALK gene after the failure of previous treatment.
    • (2013) N Engl J Med , vol.368 , pp. 2385-2394
    • Shaw, A.1    Kim, D.W.2    Nakagawa, K.3
  • 17
    • 84921936273 scopus 로고    scopus 로고
    • Pfizer. A Clinical Trial Testing The Efficacy Of Crizotinib Versus Standard Chemotherapy Pemetrexed Plus Cisplatin Or Carboplatin In Patients With ALK Positive Non Squamous Cancer Of The Lung (PROFILE 1014). Available from:. NLM identifier: NCT01154140. Accessed July 3, 2014
    • Pfizer. A Clinical Trial Testing The Efficacy Of Crizotinib Versus Standard Chemotherapy Pemetrexed Plus Cisplatin Or Carboplatin In Patients With ALK Positive Non Squamous Cancer Of The Lung (PROFILE 1014). Available from: http://www.clinicaltrials.gov/ct2/show/NCT01154140. NLM identifier: NCT01154140. Accessed July 3, 2014.
  • 18
    • 84906221716 scopus 로고    scopus 로고
    • First-line crizotinib versus pemetrexed–cisplatin or pemetrexed–carboplatin in patients (pts) with advanced ALK-positive non-squamous non-small cell lung cancer (NSCLC): results of a phase III study (PROFILE 1014)
    • Suppl: abstr 8002
    • Mok T, Dong-Wan K, Yi-Long W, et al. First-line crizotinib versus pemetrexed–cisplatin or pemetrexed–carboplatin in patients (pts) with advanced ALK-positive non-squamous non-small cell lung cancer (NSCLC): results of a phase III study (PROFILE 1014). J Clin Oncol. 2014;32:5s. Suppl: abstr 8002.
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • Mok, T.1    Dong-Wan, K.2    Yi-Long, W.3
  • 19
    • 84921937179 scopus 로고    scopus 로고
    • Pfizer. Erlotinib is being studied with or without an investigational drug, PF-02341066, in patients with lung cancer. Available from:. NLM identifier: NCT00965731. Accessed July 3, 2014
    • Pfizer. Erlotinib is being studied with or without an investigational drug, PF-02341066, in patients with lung cancer. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00965731. NLM identifier: NCT00965731. Accessed July 3, 2014.
  • 20
    • 84921938644 scopus 로고    scopus 로고
    • Pfizer. A study of combined C-MET inhibitor and PAN-HER inhibitor (PF-02341066 and PF-00299804) in patients with non- small cell lung cancer. Available from:. NLM identifier: NCT01121575. Accessed July 3, 2014
    • Pfizer. A study of combined C-MET inhibitor and PAN-HER inhibitor (PF-02341066 and PF-00299804) in patients with non- small cell lung cancer. Available from: http://www.clinicaltrials.gov/ct2/show/NCT01121575. NLM identifier: NCT01121575. Accessed July 3, 2014.
  • 21
    • 84902811306 scopus 로고    scopus 로고
    • Efficacy and safety of crizotinib in patients with advanced c-MET-amplified non-small cell lung cancer (NSCLC)
    • Suppl: abstr 8001
    • Camidge DR, Ou SH, Shapiro G, et al. Efficacy and safety of crizotinib in patients with advanced c-MET-amplified non-small cell lung cancer (NSCLC). J Clin Oncol. 2014;32:5s. Suppl: abstr 8001.
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • Camidge, D.R.1    Ou, S.H.2    Shapiro, G.3
  • 22
    • 84921938281 scopus 로고    scopus 로고
    • Nishina T, Hirashima T, Sugio K, et al. The effect of CYP2C19 polymorphism on the tolerability of ARQ 197: results from phase I trial in Japanese patients with metastatic solid tumors [abstract]. J Clin Oncol. 2011;29 Suppl:2516
    • Nishina T, Hirashima T, Sugio K, et al. The effect of CYP2C19 polymorphism on the tolerability of ARQ 197: results from phase I trial in Japanese patients with metastatic solid tumors [abstract]. J Clin Oncol. 2011;29 Suppl:2516.
  • 23
    • 80051974548 scopus 로고    scopus 로고
    • Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer
    • PID: 21768463, COI: 1:CAS:528:DC%2BC3MXht1ajsrnL, This paper presents the results of randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated NSCLC with a detailed analysis of the factors influencing PFS and OS in study population
    • Sequist LV, von Pawel J, Garmey EG, et al. Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer. J Clin Oncol. 2011;29(24):3307–15. This paper presents the results of randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated NSCLC with a detailed analysis of the factors influencing PFS and OS in study population.
    • (2011) J Clin Oncol , vol.29 , Issue.24 , pp. 3307-3315
    • Sequist, L.V.1    von Pawel, J.2    Garmey, E.G.3
  • 24
    • 84865506979 scopus 로고    scopus 로고
    • Rationale and design of MARQUEE: a phase III, randomized, double-blind study of tivantinib plus erlotinib versus placebo plus erlotinib in previously treated patients with locally advanced or metastatic, nonsquamous, non-small-cell lung cancer
    • PID: 22440336, COI: 1:CAS:528:DC%2BC38Xht1GktrrF
    • Scagliotti GV, Novello S, Schiller JH, et al. Rationale and design of MARQUEE: a phase III, randomized, double-blind study of tivantinib plus erlotinib versus placebo plus erlotinib in previously treated patients with locally advanced or metastatic, nonsquamous, non-small-cell lung cancer. Clin Lung Cancer. 2012;13(5):391–5.
    • (2012) Clin Lung Cancer , vol.13 , Issue.5 , pp. 391-395
    • Scagliotti, G.V.1    Novello, S.2    Schiller, J.H.3
  • 25
    • 84881542709 scopus 로고    scopus 로고
    • The emerging role of MET/HGF inhibitors in oncology
    • PID: 23453860, COI: 1:CAS:528:DC%2BC3sXjsFCmsLk%3D
    • Scagliotti GV, Novello S, von Pawel J. The emerging role of MET/HGF inhibitors in oncology. Cancer Treat Rev. 2013;39(7):793–801.
    • (2013) Cancer Treat Rev , vol.39 , Issue.7 , pp. 793-801
    • Scagliotti, G.V.1    Novello, S.2    von Pawel, J.3
  • 26
    • 84921938733 scopus 로고    scopus 로고
    • Kyowa Hakko Kirin Company, Limited. A Phase 3, Randomized, Double-Blinded, Placebo-Controlled Study of ARQ 197 Plus Erlotinib Versus Placebo Plus Erlotinib (ATTENTION). Available from:. NLM identifier: NCT01377376. Accessed July 3, 2014
    • Kyowa Hakko Kirin Company, Limited. A Phase 3, Randomized, Double-Blinded, Placebo-Controlled Study of ARQ 197 Plus Erlotinib Versus Placebo Plus Erlotinib (ATTENTION). Available from: http://clinicaltrials.gov/ct2/show/NCT01377376. NLM identifier: NCT01377376. Accessed July 3, 2014.
  • 27
    • 84921938441 scopus 로고    scopus 로고
    • ArQule. Erlotinib Plus Tivantinib (ARQ 197) Versus Single Agent Chemotherapy in Locally Advanced or Metastatic Non-Small Cell Lung Cancer. Available from:. NLM identifier: NCT01395758. Accessed July 3, 2014
    • ArQule. Erlotinib Plus Tivantinib (ARQ 197) Versus Single Agent Chemotherapy in Locally Advanced or Metastatic Non-Small Cell Lung Cancer. Available from: http://www.clinicaltrials.gov/ct2/show/NCT01395758. NLM identifier: NCT01395758. Accessed July 3, 2014.
  • 28
    • 84921936292 scopus 로고    scopus 로고
    • Bristol-Myers Squibb. Multiple ascending dose study of BMS-907351 (XL184) in patients with solid tumors in Japan. Available from:. NLM identifier: NCT01018745. Accessed July 3, 2014
    • Bristol-Myers Squibb. Multiple ascending dose study of BMS-907351 (XL184) in patients with solid tumors in Japan. Available from: http://www.clinicaltrials.gov/ct2/show/NCT01018745. NLM identifier: NCT01018745. Accessed July 3, 2014.
  • 29
    • 84893870807 scopus 로고    scopus 로고
    • MET inhibitor combination therapy in lung cancer
    • Padda S, Neal JW, Wakelee HA. MET inhibitor combination therapy in lung cancer. Transl Lung Cancer Res. 2012;1(4):238–53.
    • (2012) Transl Lung Cancer Res , vol.1 , Issue.4 , pp. 238-253
    • Padda, S.1    Neal, J.W.2    Wakelee, H.A.3
  • 30
    • 84921938055 scopus 로고    scopus 로고
    • Exelixis. A study of XL184 (Cabozantinib) with or without erlotinib in adults with non-small cell lung cancer. NCT00596648. Available from:. NLM identifier: NCT00596648. Accessed July 3, 2014
    • Exelixis. A study of XL184 (Cabozantinib) with or without erlotinib in adults with non-small cell lung cancer. NCT00596648. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00596648. NLM identifier: NCT00596648. Accessed July 3, 2014.
  • 31
    • 84907561440 scopus 로고    scopus 로고
    • Phase II trial of XL184 (cabozantinib) plus erlotinib in patients (pts) with advanced EGFR-mutant non-small cell lung cancer (NSCLC) with progressive disease (PD) on epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy: A California Cancer Consortium phase II trial (NCI 9303)
    • Suppl: abstr 8014
    • Reckamp KL, Frankel PH, Mack PC, et al. Phase II trial of XL184 (cabozantinib) plus erlotinib in patients (pts) with advanced EGFR-mutant non-small cell lung cancer (NSCLC) with progressive disease (PD) on epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy: A California Cancer Consortium phase II trial (NCI 9303). J Clin Oncol. 2014;32:5s. Suppl: abstr 8014.
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • Reckamp, K.L.1    Frankel, P.H.2    Mack, P.C.3
  • 32
    • 84921937780 scopus 로고    scopus 로고
    • National Cancer Institute. Erlotinib hydrochloride and Cabozantinib-s-Malate alone or in combination as second or third line therapy in treating patients with stage IV Non-Small Cell Lung Cancer. NCT01708954. Available from:. NML identifier: NCT01708954. Accessed August 31, 2014
    • National Cancer Institute. Erlotinib hydrochloride and Cabozantinib-s-Malate alone or in combination as second or third line therapy in treating patients with stage IV Non-Small Cell Lung Cancer. NCT01708954. Available from: http://www.clinicaltrials.gov/ct2/show/NCT01708954. NML identifier: NCT01708954. Accessed August 31, 2014.
  • 33
    • 79955781270 scopus 로고    scopus 로고
    • Synergistic effects of foretinib with HER-targeted agents in MET and HER1- or HER2-coactivated tumor cells
    • PID: 21252284, COI: 1:CAS:528:DC%2BC3MXivVCrsrg%3D
    • Liu L, Shi H, Liu Y, et al. Synergistic effects of foretinib with HER-targeted agents in MET and HER1- or HER2-coactivated tumor cells. Mol Cancer Ther. 2011;10:518–30.
    • (2011) Mol Cancer Ther , vol.10 , pp. 518-530
    • Liu, L.1    Shi, H.2    Liu, Y.3
  • 34
    • 84856540747 scopus 로고    scopus 로고
    • A comparison of the pharmacokinetics of the anticancer MET inhibitor foretinib free base tablet formulation to bisphosphate salt capsule formulation in patients with solid tumors
    • COI: 1:CAS:528:DC%2BC38XotVWgtg%3D%3D
    • Naing A, Kurzrock R, Adams LM, et al. A comparison of the pharmacokinetics of the anticancer MET inhibitor foretinib free base tablet formulation to bisphosphate salt capsule formulation in patients with solid tumors. Investig New Drugs. 2012;30:327–34.
    • (2012) Investig New Drugs , vol.30 , pp. 327-334
    • Naing, A.1    Kurzrock, R.2    Adams, L.M.3
  • 35
    • 77954236265 scopus 로고    scopus 로고
    • A phase I study of foretinib, a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2
    • PID: 20472683, COI: 1:CAS:528:DC%2BC3cXot1Wlt74%3D
    • Eder JP, Shapiro GI, Appleman LJ, et al. A phase I study of foretinib, a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2. Clin Cancer Res. 2010;16:3507–16.
    • (2010) Clin Cancer Res , vol.16 , pp. 3507-3516
    • Eder, J.P.1    Shapiro, G.I.2    Appleman, L.J.3
  • 36
    • 84921937309 scopus 로고    scopus 로고
    • NCIC Clinical Trials Group. MET/VEGFR2 Inhibitor GSK1363089 and Erlotinib Hydrochloride or Erlotinib Hydrochloride Alone in Treating Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer That Has Not Responded to Previous Chemotherapy. Available from:. NLM identifier: NCT01068587. Accessed July 3, 2014
    • NCIC Clinical Trials Group. MET/VEGFR2 Inhibitor GSK1363089 and Erlotinib Hydrochloride or Erlotinib Hydrochloride Alone in Treating Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer That Has Not Responded to Previous Chemotherapy. Available from: http://www.clinicaltrials.gov/ct2/show/NCT01068587. NLM identifier: NCT01068587. Accessed July 3, 2014.
  • 37
    • 84921938798 scopus 로고    scopus 로고
    • Yi-Long Wu, James Chih-Hsin Yang, Dong-Wan Kim et al. Safety and efficacy of INC280 in combination with gefitinib in patients with EGFR-mutated, MET-positive NSCLC: A single-arm phase Ib/II study. J Clin Oncol. 2014; 32:5s, Suppl: abstr 8017 The abstract shows promising results of combination therapy: INC280 as a MET inhibitor plus gefitynib in EGFR-mutated, MET-positive NSCLC patients
    • Yi-Long Wu, James Chih-Hsin Yang, Dong-Wan Kim et al. Safety and efficacy of INC280 in combination with gefitinib in patients with EGFR-mutated, MET-positive NSCLC: A single-arm phase Ib/II study. J Clin Oncol. 2014; 32:5s, Suppl: abstr 8017 The abstract shows promising results of combination therapy: INC280 as a MET inhibitor plus gefitynib in EGFR-mutated, MET-positive NSCLC patients.
  • 38
    • 84901119457 scopus 로고    scopus 로고
    • A phase I study of the safety and immunogenicity of a therapeutic vaccine, DPX-0907 in patients with advanced-stage ovarian, breast, or prostate cancer [abstract]
    • Berinstein NL, Morse M, Kaufman H, et al. A phase I study of the safety and immunogenicity of a therapeutic vaccine, DPX-0907 in patients with advanced-stage ovarian, breast, or prostate cancer [abstract]. J Clin Oncol. 2011;29 Suppl:e13050.
    • (2011) J Clin Oncol. , vol.29 , pp. e13050
    • Berinstein, N.L.1    Morse, M.2    Kaufman, H.3
  • 39
    • 84921937834 scopus 로고    scopus 로고
    • Genentech. A study of MetMAb administered to patients with advanced non-small cell lung cancer, in combination with Tarceva (Erlotinib). Available from:. NLM identifier: NCT NCT00854308. Accessed July 3, 2014
    • Genentech. A study of MetMAb administered to patients with advanced non-small cell lung cancer, in combination with Tarceva (Erlotinib). Available from: http://www.clinicaltrials.gov/ct2/show/NCT00854308. NLM identifier: NCT NCT00854308. Accessed July 3, 2014.
  • 40
    • 84890108571 scopus 로고    scopus 로고
    • Spigel DR, Ervin TJ, Ramlau R, et al. Randomized phase II trial of Onartuzumab in combination with erlotinib in advanced non-small-cell lung cancer. J Clin Oncol. 2013;31 Suppl abstr 4105. The study resulted in the registration of the immunohistochemical test marking the expression of the MET receptor as a potentially important predictive biomarker
    • Spigel DR, Ervin TJ, Ramlau R, et al. Randomized phase II trial of Onartuzumab in combination with erlotinib in advanced non-small-cell lung cancer. J Clin Oncol. 2013;31 Suppl abstr 4105. The study resulted in the registration of the immunohistochemical test marking the expression of the MET receptor as a potentially important predictive biomarker.
  • 41
    • 84921938291 scopus 로고    scopus 로고
    • Genentech. A study of Onartuzumab (MetMAb) in combination with Tarceva (Erlotinib) in patients with Met diagnostic-positive non-small cell lung cancer who have received chemotherapy for advanced or metastatic disease (MetLung). Available from:. NLM identifier: NCT NCT01456325. Accessed July 3, 2014
    • Genentech. A study of Onartuzumab (MetMAb) in combination with Tarceva (Erlotinib) in patients with Met diagnostic-positive non-small cell lung cancer who have received chemotherapy for advanced or metastatic disease (MetLung). Available from: http://www.clinicaltrials.gov/ct2/show/NCT01456325. NLM identifier: NCT NCT01456325. Accessed July 3, 2014.
  • 42
    • 84921937487 scopus 로고    scopus 로고
    • Inman S. Onartuzumab Falters in late-stage NSCLC. Available from:. Accessed July 11, 2014
    • Inman S. Onartuzumab Falters in late-stage NSCLC. Available from: http://www.onclive.com. Accessed July 11, 2014.
  • 43
    • 84904679830 scopus 로고    scopus 로고
    • Onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIb or IV NSCLC: Results from the pivotal phase III randomized, multicenter, placebo-controlled METLung (OAM4971g) global trial
    • Suppl: abstr 8000
    • Spigel DR, Edelman MJ, O'Byrne K, et al. Onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIb or IV NSCLC: Results from the pivotal phase III randomized, multicenter, placebo-controlled METLung (OAM4971g) global trial. J Clin Oncol. 2014;32:5s. Suppl: abstr 8000.
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • Spigel, D.R.1    Edelman, M.J.2    O'Byrne, K.3
  • 44
    • 84921936055 scopus 로고    scopus 로고
    • Genetech. A Study of Onartuzumab (MetMAb) in combination with bevacizumab (Avastin) plus platinum and paclitaxel or with pemetrexed plus platinum in patients with non-squamous non-small cell lung cancer. Available from:. NLM identifier: NCT 01496742. Accessed July 3, 2014
    • Genetech. A Study of Onartuzumab (MetMAb) in combination with bevacizumab (Avastin) plus platinum and paclitaxel or with pemetrexed plus platinum in patients with non-squamous non-small cell lung cancer. Available from: http://www.clinicaltrials.gov/ct2/show/NCT01496742. NLM identifier: NCT 01496742. Accessed July 3, 2014.
  • 45
    • 84921938621 scopus 로고    scopus 로고
    • Genetech. A study of onartuzumab (MetMAb) versus placebo in combination with paclitaxel plus platinum in patients with squamous non-small cell lung cancer. Available from:. NLM identifier: NCT 01519804. Accessed August 31, 2014
    • Genetech. A study of onartuzumab (MetMAb) versus placebo in combination with paclitaxel plus platinum in patients with squamous non-small cell lung cancer. Available from: http://www.clinicaltrials.gov/ct2/show/NCT01519804. NLM identifier: NCT 01519804. Accessed August 31, 2014.
  • 46
    • 84875914687 scopus 로고    scopus 로고
    • MET as a possible target for non-small-cell lung cancer
    • Sadig AA, Salgia R. MET as a possible target for non-small-cell lung cancer. J Clin Oncol. 2013;31:1089–96.
    • (2013) J Clin Oncol , vol.31 , pp. 1089-1096
    • Sadig, A.A.1    Salgia, R.2
  • 47
    • 84872214179 scopus 로고    scopus 로고
    • Phase Ib study of ficlatuzumab (formerly AV-299), an anti-hepatocyte growth factor (HGF) monoclonal antibody (MAb) in combination with gefitinib (G) in Asian patients (pts) with NSCLC [abstract]
    • Tan E, Park K, Lim WT, et al. Phase Ib study of ficlatuzumab (formerly AV-299), an anti-hepatocyte growth factor (HGF) monoclonal antibody (MAb) in combination with gefitinib (G) in Asian patients (pts) with NSCLC [abstract]. J Clin Oncol. 2011;29 Suppl:7571.
    • (2011) J Clin Oncol , vol.29 Suppl , pp. 7571
    • Tan, E.1    Park, K.2    Lim, W.T.3
  • 48
    • 84921937281 scopus 로고    scopus 로고
    • A randomized phase (Ph) 2 study with exploratory biomarker analysis of ficlatuzumab (F) a humanized hepatocyte growth factor (HGF) inhibitory MAB in combination with gefitinib (G) versus G in Asian patients (pts) with lung adenocarcinoma (LA)
    • Mok T, Park K, Geater SL. A randomized phase (Ph) 2 study with exploratory biomarker analysis of ficlatuzumab (F) a humanized hepatocyte growth factor (HGF) inhibitory MAB in combination with gefitinib (G) versus G in Asian patients (pts) with lung adenocarcinoma (LA). Ann Oncol. 2012;23 Suppl 9:1198P.
    • Ann Oncol. 2012;23 Suppl , vol.9 , pp. 1198
    • Mok, T.1    Park, K.2    Geater, S.L.3
  • 49
    • 84921937244 scopus 로고    scopus 로고
    • Ahmad Tarhini. AMG 102 and erlotinib for advanced non-small cell lung cancer. Available from:. NLM identifier: NCT NCT01233687. Accessed July 3, 2014
    • Ahmad Tarhini. AMG 102 and erlotinib for advanced non-small cell lung cancer. Available from: http://www.clinicaltrials.gov/ct2/show/NCT01233687. NLM identifier: NCT NCT01233687. Accessed July 3, 2014.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.