메뉴 건너뛰기




Volumn 109, Issue 2, 2012, Pages 570-575

Hepatocyte growth factor (HGF) autocrine activation predicts sensitivity to MET inhibition in glioblastoma

Author keywords

Hepatocyte growth factor autocrine loop; Molecular marker; Oncogene addiction; Targeted therapy

Indexed keywords

ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SGX 523; UNCLASSIFIED DRUG;

EID: 84855993422     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1119059109     Document Type: Article
Times cited : (108)

References (36)
  • 2
    • 0030039519 scopus 로고    scopus 로고
    • Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network
    • Jeffers M, Rong S, Vande Woude GF (1996) Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-MET signalling in human cells concomitant with induction of the urokinase proteolysis network. Mol Cell Biol 16: 1115-1125. (Pubitemid 26061683)
    • (1996) Molecular and Cellular Biology , vol.16 , Issue.3 , pp. 1115-1125
    • Jeffers, M.1    Rong, S.2    Vande, W.G.F.3
  • 3
    • 33746504571 scopus 로고    scopus 로고
    • Invasive growth: A MET-driven genetic programme for cancer and stem cells
    • DOI 10.1038/nrc1912, PII NRC1912
    • Boccaccio C, Comoglio PM (2006) Invasive growth: A MET-driven genetic programme for cancer and stem cells. Nat Rev Cancer 6(8):637-645. (Pubitemid 44140861)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.8 , pp. 637-645
    • Boccaccio, C.1    Comoglio, P.M.2
  • 4
    • 0041737535 scopus 로고    scopus 로고
    • Molecular mechanisms of glioma invasiveness: The role of proteases
    • Rao JS (2003) Molecular mechanisms of glioma invasiveness: The role of proteases. Nat Rev Cancer 3(7):489-501.
    • (2003) Nat Rev Cancer , vol.3 , Issue.7 , pp. 489-501
    • Rao, J.S.1
  • 6
    • 0035256772 scopus 로고    scopus 로고
    • Gliomagenesis: Genetic alterations and mouse models
    • Holland EC (2001) Gliomagenesis: Genetic alterations and mouse models. Nat Rev Genet 2:120-129.
    • (2001) Nat Rev Genet , vol.2 , pp. 120-129
    • Holland, E.C.1
  • 7
    • 33847066415 scopus 로고    scopus 로고
    • TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition
    • Tsuda M, et al. (2007) TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition. Cancer Res 67:919-929.
    • (2007) Cancer Res , vol.67 , pp. 919-929
    • Tsuda, M.1
  • 9
    • 73649102105 scopus 로고    scopus 로고
    • Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC
    • Turke AB, et al. (2010) Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC. Cancer Cell 17:77-88.
    • (2010) Cancer Cell , vol.17 , pp. 77-88
    • Turke, A.B.1
  • 11
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Network CGAR, Cancer Genome Atlas Research Network
    • Network CGAR, Cancer Genome Atlas Research Network (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061-1068.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 12
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Cancer Genome Atlas Research Network
    • Verhaak RG, et al.; Cancer Genome Atlas Research Network (2010) Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17(1):98-110.
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 98-110
    • Verhaak, R.G.1
  • 15
    • 67651174457 scopus 로고    scopus 로고
    • EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts
    • Lal B, et al. (2009) EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts. Mol Cancer Ther 8:1751-1760.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1751-1760
    • Lal, B.1
  • 16
  • 17
    • 43749091506 scopus 로고    scopus 로고
    • Showering c-MET-dependent cancers with drugs
    • DOI 10.1016/j.gde.2008.02.001, PII S0959437X08000269
    • Knudsen BS, Vande Woude G (2008) Showering c-MET-dependent cancers with drugs. Curr Opin Genet Dev 18:87-96. (Pubitemid 351694452)
    • (2008) Current Opinion in Genetics and Development , vol.18 , Issue.1 , pp. 87-96
    • Knudsen, B.S.1    Vande, W.G.2
  • 18
    • 77952555038 scopus 로고    scopus 로고
    • Exciting new advances in neuro-oncology: The avenue to a cure for malignant glioma
    • Van Meir EG, et al. (2010) Exciting new advances in neuro-oncology: The avenue to a cure for malignant glioma. CA Cancer J Clin 60:166-193.
    • (2010) CA Cancer J Clin , vol.60 , pp. 166-193
    • Van Meir, E.G.1
  • 19
    • 61849083102 scopus 로고    scopus 로고
    • A highly invasive human glioblastoma pre-clinical model for testing therapeutics
    • Xie Q, et al. (2008) A highly invasive human glioblastoma pre-clinical model for testing therapeutics. J Transl Med 6:77.
    • (2008) J Transl Med , vol.6 , pp. 77
    • Xie, Q.1
  • 22
    • 35448962430 scopus 로고    scopus 로고
    • Eradication of solid human breast tumors in nude mice with an intravenously injected light-emitting oncolytic vaccinia virus
    • DOI 10.1158/0008-5472.CAN-07-0146
    • Zhang Q, et al. (2007) Eradication of solid human breast tumors in nude mice with an intravenously injected light-emitting oncolytic vaccinia virus. Cancer Res 67: 10038-10046. (Pubitemid 47621255)
    • (2007) Cancer Research , vol.67 , Issue.20 , pp. 10038-10046
    • Zhang, Q.1    Yu, Y.A.2    Wang, E.3    Chen, N.4    Danner, R.L.5    Munson, P.J.6    Marincola, F.M.7    Szalay, A.A.8
  • 23
    • 77956296140 scopus 로고    scopus 로고
    • MET kinase inhibitor SGX523 synergizes with epidermal growth factor receptor inhibitor erlotinib in a hepatocyte growth factor-dependent fashion to suppress carcinoma growth
    • Zhang YW, et al. (2010) MET kinase inhibitor SGX523 synergizes with epidermal growth factor receptor inhibitor erlotinib in a hepatocyte growth factor-dependent fashion to suppress carcinoma growth. Cancer Res 70:6880-6890.
    • (2010) Cancer Res , vol.70 , pp. 6880-6890
    • Zhang, Y.W.1
  • 24
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • Bean J, et al. (2007) MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci USA 104:20932-20937.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 20932-20937
    • Bean, J.1
  • 25
    • 33144462553 scopus 로고    scopus 로고
    • Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752
    • Smolen GA, et al. (2006) Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752. Proc Natl Acad Sci USA 103:2316-2321.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2316-2321
    • Smolen, G.A.1
  • 28
    • 33644769210 scopus 로고    scopus 로고
    • Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts
    • DOI 10.1158/1078-0432.CCR-05-1793
    • Kim KJ, et al. (2006) Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts. Clin Cancer Res 12: 1292-1298. (Pubitemid 43342521)
    • (2006) Clinical Cancer Research , vol.12 , Issue.4 , pp. 1292-1298
    • Kim, K.J.1    Wang, L.2    Su, Y.-C.3    Gillespie, G.Y.4    Salhotra, A.5    Lal, B.6    Laterra, J.7
  • 30
    • 73149091443 scopus 로고    scopus 로고
    • SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo
    • Buchanan SG, et al. (2009) SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol Cancer Ther 8:3181-3190.
    • (2009) Mol Cancer Ther , vol.8 , pp. 3181-3190
    • Buchanan, S.G.1
  • 32
    • 79955766450 scopus 로고    scopus 로고
    • A phase II study evaluating the efficacy and safety of AMG 102 (rilotumumab) in patients with recurrent glioblastoma
    • Wen PY, et al. (2011) A phase II study evaluating the efficacy and safety of AMG 102 (rilotumumab) in patients with recurrent glioblastoma. Neuro Oncol 13:437-446.
    • (2011) Neuro Oncol , vol.13 , pp. 437-446
    • Wen, P.Y.1
  • 33
    • 77956680254 scopus 로고    scopus 로고
    • American Society of Clinical Oncology 2010: Report of selected studies from the CNS tumors section
    • Wen PY (2010) American Society of Clinical Oncology 2010: Report of selected studies from the CNS tumors section. Expert Review of Anticancer Therapy 10(9):1367-1369.
    • (2010) Expert Review of Anticancer Therapy , vol.10 , Issue.9 , pp. 1367-1369
    • Wen, P.Y.1
  • 34
    • 0037096867 scopus 로고    scopus 로고
    • Hepatocyte growth factor is associated with poor prognosis of malignant gliomas and is a predictor for recurrence of meningioma
    • DOI 10.1002/cncr.10594
    • Arrieta O, et al. (2002) Hepatocyte growth factor is associated with poor prognosis of malignant gliomas and is a predictor for recurrence of meningioma. Cancer 94: 3210-3218. (Pubitemid 34670504)
    • (2002) Cancer , vol.94 , Issue.12 , pp. 3210-3218
    • Arrieta, O.1    Garcia, E.2    Guevara, P.3    Garcia-Navarrete, R.4    Ondarza, R.5    Rembao, D.6    Sotelo, J.7
  • 35
    • 77953287543 scopus 로고    scopus 로고
    • Hepatocyte growth factor in cerebrospinal fluid is associated with mortality and recurrence of glioblastoma, and could be of prognostic value
    • Garcia-Navarrete R, Garcia E, Arrieta O, Sotelo J (2010) Hepatocyte growth factor in cerebrospinal fluid is associated with mortality and recurrence of glioblastoma, and could be of prognostic value. J Neurooncol 97:347-351.
    • (2010) J Neurooncol , vol.97 , pp. 347-351
    • Garcia-Navarrete, R.1    Garcia, E.2    Arrieta, O.3    Sotelo, J.4
  • 36
    • 19944430738 scopus 로고    scopus 로고
    • Enhanced growth of human MET-expressing xenografts in a new strain of immunocompromised mice transgenic for human hepatocyte growth factor/scatter factor
    • Zhang YW, et al. (2005) Enhanced growth of human MET-expressing xenografts in a new strain of immunocompromised mice transgenic for human hepatocyte growth factor/scatter factor. Oncogene 24:101-106.
    • (2005) Oncogene , vol.24 , pp. 101-106
    • Zhang, Y.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.