Model-driven identication of dosing regimens that maximize the antimicrobial activity of nitric oxide

Metabolic Engineering Communications

Volumn 1, Issue 1, 2014, Pages 12-18

  Robinson, Jonathan L ^a   Miller, Richard V ^b   Brynildsen, Mark P ^a,b  

^a Princeton University   (United States)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

Antimicrobial; Escherichia coli; Hmp; Kinetic model; Nitric oxide; Nitric oxide dioxygenase; Respiration

Indexed keywords

NITRIC OXIDE;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM CULTURE; BIOREACTOR; CYTOTOXICITY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DOSE REGIMEN; DRUG RELEASE; ESCHERICHIA COLI; KINETICS; MICROBIAL RESPIRATION; MODEL; MOLECULAR DYNAMICS; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RESPIRATION DEPRESSION; VALIDATION STUDY;

ESCHERICHIA COLI;

EID: 84921935037     PISSN: None     EISSN: 22140301     Source Type: Journal    
DOI: 10.1016/j.meteno.2014.08.001     Document Type: Article

References (36)

1. Atlung, T., Brondsted, L., 1994. Role of the transcriptional activator AppY in regulation of the Cyx AppA operon of Escherichia coli by anaerobiosis, phosphate starvation, and growth-phase. J. Bacteriol. 176, 5414-5422.
2. Bogdan, C., 2001. Nitric oxide and the immune response. Nat. Immunol. 2, 907-916.
3. Bowman, L.A.H., McLean, S., Poole, R.K., Fukuto, J.M., 2011. The diversity of microbial responses to nitric oxide and agents of nitrosative stress: close cousins but not identical twins. Adv. Microb. Physiol. 59, 135-219.
4. Crack, J.C., Smith, L.J., Stapleton, M.R., Peck, J., Watmough, N.J., Buttner, M.J., Buxton, R.S., Green, J., Oganesyan, V.S., Thomson, A.J., et al., 2011. Mechanistic insight into the nitrosylation of the [4Fe-4S] cluster of WhiB-like proteins. J. Am. Chem. Soc. 133, 1112-1121.
5. Crack, J.C., Green, J., Thomson, A.J., Le Brun, N.E., 2012. Iron-sulfur cluster sensor-regulators. Curr. Opin. Chem. Biol. 16, 35-44.
6. Dassa, J., Fsihi, H., Marck, C., Dion, M., Kieffer-Bontemps, M., Boquet, P.L., 1991. A new oxygen-regulated operon in Escherichia coli comprises the genes for a putative third cytochrome oxidase and for pH 2.5 acid phosphatase (appA). Mol. Gen. Genet. 229, 341-352.
7. Euro, L., Bloch, D.A., Wikstrom, M., Verkhovsky, M.I., Verkbovskaya, M., 2008. Electrostatic interactions between FeS clusters in NADH: ubiquinone oxidor-eductase (complex I) from Escherichia coli. Biochemistry 47, 3185-3193.
8. Fang, F.C., 2004. Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Nat. Rev. Microbiol. 2, 820-832.
9. Foster, H.W., Cowan, J.A., 1999. Chemistry of nitric oxide with protein-bound iron sulfur centers. Insights on physiological reactivity. J. Am. Chem. Soc. 121, 4093-4100.
10. Friedman, A., Blecher, K., Sanchez, D., Tuckman-Vernon, C., Gialanella, P., Friedman, J.M., Martinez, L.R., Nosanchuk, J.D., 2011. Susceptibility of Gram-positive and -negative bacteria to novel nitric oxide-releasing nanoparticle technology. Virulence 2, 217-221.
11. Friedman, A.J., Han, G., Navati, M.S., Chacko, M., Gunther, L., Aleri, A., Friedman, J. M., 2008. Sustained release nitric oxide releasing nanoparticles: characteriza-tion of a novel delivery platform based on nitrite containing hydrogel/glass composites. Nitric Oxide 19, 12-20.
12. Friedman, A.J., Blecher, K., Schairer, D., Tuckman-Vernon, C., Nacharaju, P., Sanchez, D., Gialanella, P., Martinez, L.R., Friedman, J.M., Nosanchuk, J.D., 2011. Improved antimicrobial efcacy with nitric oxide releasing nanoparticle generated S-nitrosoglutathione. Nitric Oxide 25, 381-386.
13. Gardner, A.M., Martin, L.A., Gardner, P.R., Dou, Y., Olson, J.S., 2000. Steady-state and transient kinetics of Escherichia coli nitric-oxide dioxygenase (avohemoglobin) - the B10 tyrosine hydroxyl is essential for dioxygen binding and catalysis. J. Biol. Chem. 275, 12581-12589.
14. Gardner, P.R., Costantino, G., Szabo, C., Salzman, A.L., 1997. Nitric oxide sensitivity of the aconitases. J. Biol. Chem. 272, 25071-25076.
15. Gardner, P.R., Gardner, A.M., Martin, L.A., Salzman, A.L., 1998. Nitric oxide dioxygenase: an enzymic function for avohemoglobin. Proc. Natl. Acad. Sci. USA 95, 10378-10383.
16. Han, G., Martinez, L.R., Mihu, M.R., Friedman, A.J., Friedman, J.M., Nosanchuk, J.D., 2009. Nitric oxide releasing nanoparticles are therapeutic for Staphylococcus aureus Abscesses in a murine model of infection. PLoS One 4, e7804.
17. Hyduke, D.R., Jarboe, L.R., Tran, L.M., Chou, K.J.Y., Liao, J.C., 2007. Integrated network analysis identies nitric oxide response networks and dihydroxyacid dehydra-tase as a crucial target in Escherichia coli. Proc. Natl. Acad. Sci. USA 104, 8484-8489.
18. Jarboe, L.R., Hyduke, D.R., Tran, L.M., Chou, K.J.Y., Liao, J.C., 2008. Determination of the Escherichia coli S-nitrosoglutathione response network using integrated biochemical and systems analysis. J. Biol. Chem. 283, 5148-5157.
19. Jones, M.L., Ganopolsky, J.G., Labbe, A., Wahl, C., Prakash, S., 2010. Antimicrobial properties of nitric oxide and its application in antimicrobial formulations and medical devices. Appl. Microbiol. Biotechnol. 88, 401-407.
20. Martinez, L.R., Han, G., Chacko, M., Mihu, M.R., Jacobson, M., Gialanella, P., Fried-man, A.J., Nosanchuk, J.D., Friedman, J.M., 2009. Antimicrobial and healing efcacy of sustained release nitric oxide nanoparticles against Staphylococcus aureus skin infection. J. Investig. Dermatol. 129, 2463-2469.
21. Mason, M.G., Shepherd, M., Nicholls, P., Dobbin, P.S., Dodsworth, K.S., Poole, R.K., Cooper, C.E., 2009. Cytochrome bd confers nitric oxide resistance to Escherichia coli. Nat. Chem. Biol. 5, 94-96.
22. Mihu, M.R., Sandkovsky, U., Han, G., Friedman, J.M., Nosanchuk, J.D., Martinez, L.R., 2010. Nitric oxide releasing nanoparticles are therapeutic for Acinetobacter baumannii wound infections. Virulence 1, 62-67.
23. Nablo, B.J., Prichard, H.L., Butler, R.D., Klitzman, B., Schoensch, M.H., 2005. Inhibition of implant-associated infections via nitric oxide release. Biomaterials 26, 6984-6990.
24. Nathan, C., 1992. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6, 3051-3064.
25. Ormerod, A.D., Shah, A.A., Li, H., Benjamin, N.B., Ferguson, G.P., Leifert, C., 2011. An observational prospective study of topical acidied nitrite for killing methicillin-resistant Staphylococcus aureus (MRSA) in contaminated wounds. BMC Res. Notes 4, 458.
26. Phillips, R., Adjei, O., Lucas, S., Benjamin, N., Wansbrough-Jones, M., 2004. Pilot randomized double-blind trial of treatment of Mycobacterium ulcerans disease (Buruli ulcer) with topical nitrogen oxides. Antimicrob. Agents Chemother. 48, 2866-2870.
27. Poole, R.K., Anjum, M.F., MembrilloHernandez, J., Kim, S.O., Hughes, M.N., Stewart, V., 1996. Nitric oxide, nitrite, and Fnr regulation of hmp (Flavohemoglobin) gene expression in Escherichia coli K-12. J. Bacteriol. 178, 5487-5492.
28. Pullan, S.T., Gidley, M.D., Jones, R.A., Barrett, J., Stevanin, T.A., Read, R.C., Green, J., Poole, R.K., 2007. Nitric oxide in chemostat-cultured Escherichia coli is sensed by Fnr and other global regulators: unaltered methionine biosynthesis indicates lack of S nitrosation. J. Bacteriol. 189, 1845-1855.
29. Robinson, J.L., Brynildsen, M.P., 2013. A kinetic platform to determine the fate of nitric oxide in Escherichia coli. PLoS. Comput. Biol. 9, e1003049.
30. Robinson, J.L., Adolfsen, K.J., Brynildsen, M.P., 2014. Deciphering nitric oxide stress in bacteria with quantitative modeling. Curr. Opin. Microbiol. 19C, 16-24.
31. Schairer, D.O., Chouake, J.S., Nosanchuk, J.D., Friedman, A.J., 2012. The potential of nitric oxide releasing therapies as antimicrobial agents. Virulence 3, 271-279.
32. Stevanin, T.M., Ioannidis, N., Mills, C.E., Kim, S.O., Hughes, M.N., Poole, R.K., 2000. Flavohemoglobin Hmp affords inducible protection for Escherichia coli respira-tion, catalyzed by cytochromes bo0 or bd, from nitric oxide. J. Biol. Chem. 275, 35868-35875.
33. Sulemankhil, I., Ganopolsky, J.G., Dieni, C.A., Dan, A.F., Jones, M.L., Prakash, S., 2012. Prevention and treatment of virulent bacterial biolms with an enzymatic nitric oxide-releasing dressing. Antimicrob. Agents Chemother. 56, 6095-6103.
34. Sun, B, Slomberg, DL, Chudasama, SL, Lu, Y, Schoensch, MH, 2012. Nitric oxide-releasing dendrimers as antibacterial agents. Biomacromolecules 13, 3343-3354.
35. Toledo Jr., J.C., Augusto, O., 2012. Connecting the chemical and biological properties of nitric oxide. Chem. Res. Toxicol. 25, 975-989.
36. Varghese, S., Tang, Y., Imlay, J.A., 2003. Contrasting sensitivities of Escherichia coli aconitases A and B to oxidation and iron depletion. J. Bacteriol. 185, 221-230.