An observational prospective study of topical acidified nitrite for killing methicillin-resistant Staphylococcus aureus (MRSA) in contaminated wounds

BMC Research Notes

Volumn 4, Issue , 2011, Pages

  Ormerod, Anthony D ^a   Shah, Amjad A J ^b   Li, Hong ^c   Benjamin, Nigel B ^d   Ferguson, Gail P ^a   Leifert, Carlo ^e  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b ROYAL LANCASTER INFIRMARY   (United Kingdom)

^c CENTRE FOR ECOLOGY AND HYDROLOGY   (United Kingdom)

^d DERRIFORD HOSPITAL   (United Kingdom)

^e NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

EID: 80054893711     PISSN: None     EISSN: 17560500     Source Type: Journal    
DOI: 10.1186/1756-0500-4-458     Document Type: Article

References (25)

1. Antimicrobial drug use and methicillin-resistant Staphylococcus aureus, Aberdeen, 1996-2000. Monnet DL, MacKenzie FM, Lopez-Lozano JM, Beyaert A, Camacho M, Wilson R, Stuart D, Gould IM, Emerg Infect Dis 2004 10 1432 1441 15496245 (Pubitemid 39014157)
2. Methicillin-resistant staphylococci. Barber M, J Clin Pathol 1961 14 385 393 10.1136/jcp.14.4.385 13686776
3. Trends in sources of meticillin-resistant Staphylococcus aureus (MRSA) bacteraemia: data from the national mandatory surveillance of MRSA bacteraemia in England, 2006-2009. Wilson J, Guy R, Elgohari S, Sheridan E, Davies J, Lamagni T, Pearson A, J Hosp Infect 2011
4. Methicillin-resistant Staphylococcus aureus: the European landscape. Johnson AP, J Antimicrob Chemother 2011 66 Suppl 4 v43 iv48 21521706
5. Surgical site and vascular infections: treatment and prophylaxis. Homer-Vanniasinkam S, Int J Infect Dis 2007 11 Suppl 1 17 S22 18162241
6. Clinical and financial outcomes due to methicillin resistant Staphylococcus aureus surgical site infection: a multi-center matched outcomes study. Anderson DJ, Kaye KS, Chen LF, Schmader KE, Choi Y, Sloane R, Sexton DJ, PLoS One 2009 4 8305 10.1371/journal.pone.0008305 20016850
7. Wound chronicity, inpatient care and chronic kidney disease predispose to MRSA infection in diabetic foot ulcers. Yates CJ, May K, Hale T, Allard B, Rowlings N, Freeman A, Harrison J, McCann J, Wraight P, Diabetes Care 2009
8. The retrospective prevalence of community-acquired methicillin-resistant Staphylococcus aureus in soft tissue abscesses at two military level I trauma centers. Dufresne GW, Wells RD, Pfaff JA, Mil Med 2008 173 945 948 19160610
9. Value of whole-body washing with chlorhexidine for the eradication of methicillin-resistant Staphylococcus aureus: a randomized, placebo-controlled, double-blind clinical trial. Wendt C, Schinke S, Wurttemberger M, Oberdorfer K, Bock-Hensley O, von Baum H, Infect Control Hosp Epidemiol 2007 28 1036 1043 10.1086/519929 17932823 (Pubitemid 47345262)
10. Molluscum contagiosum effectively treated with a topical acidified nitrite, nitric oxide liberating cream. Ormerod AD, White MI, Shah SAA, Benjamin N, British Journal of Dermatology 1999 141 1051 1053 10.1046/j.1365-2133.1999. 03204.x 10606851 (Pubitemid 30046194)
11. A randomized trial of acidified nitrite cream in the treatment of tinea pedis. Weller R, Ormerod AD, Hobson RP, Benjamin NJ, Journal of the American Academy of Dermatology 1998 38 559 563 10.1016/S0190-9622(98)70117-3 9555794 (Pubitemid 28182924)
12. Antimicrobial effect of acidified nitrite on dermatophyte fungi, Candida and bacterial skin pathogens. Weller R, Price RJ, Ormerod AD, Benjamin N, Leifert C, Journal of Applied Microbiology 2001 90 648 652 10.1046/j.1365-2672. 2001.01291.x 11309079 (Pubitemid 32291268)
13. Pilot randomized double-blind trial of treatment of Mycobacterium ulcerans disease (Buruli ulcer) with topical nitrogen oxides. Phillips R, Adjei O, Lucas S, Benjamin N, Wansbrough-Jones M, Antimicrob Agents Chemother 2004 48 2866 2870 10.1128/AAC.48.8.2866-2870.2004 15273093 (Pubitemid 38989148)
14. The effects of topical treatment with acidified nitrite on wound healing in normal and diabetic mice. Weller R, Finnen MJ, Nitric Oxide 2006 15 395 399 10.1016/j.niox.2006.04.002 16731016 (Pubitemid 44754941)
15. Efficacy of nitric oxide-liberating cream on pityriasis versicolor. Jowkar F, Jamshidzadeh A, Pakniyat S, Namazi MR, J Dermatolog Treat 2010 21 93 96 10.3109/09546630902887229 19878037
16. Molluscum contagiosum effectively treated with a topical acidified nitrite, nitric oxide liberating cream. Ormerod AD, White MI, Shah SA, Benjamin N, Br J Dermatol 1999 141 1051 1053 10.1046/j.1365-2133.1999.03204.x 10606851 (Pubitemid 30046194)
17. Food mutagens. Goldman R, Shields PG, J Nutr 2003 133 Suppl 3 965S 973S 12612183 (Pubitemid 36262805)
18. Pilot randomized double-blind trial of treatment of Mycobacterium ulcerans disease (Buruli ulcer) with topical nitrogen oxides. Phillips R, Adjei O, Lucas S, Benjamin N, Wansbrough-Jones M, Antimicrobial Agents and Chemotherapy 2004 48 2866 2870 10.1128/AAC.48.8.2866-2870.2004 15273093 (Pubitemid 38989148)
19. Control of methicillin-resistant Staphylococcus aureus in the UK. Gould IM, Gould IM, European Journal of Clinical Microbiology & Infectious Diseases 2005 24 789 793 10.1007/s10096-005-0060-4 14757004 (Pubitemid 43042785)
20. Helicobacter pylori is killed by nitrite under acidic conditions. Dykhuizen RS, Fraser A, McKenzie H, Golden M, Leifert C, Benjamin N, Gut 1998 42 334 337 10.1136/gut.42.3.334 9577337 (Pubitemid 28197020)
21. Antimicrobial effect of acidified nitrite on gut pathogens: Importance of dietary nitrate in host defense. Dykhuizen RS, Frazer R, Duncan C, Smith CC, Golden M, Benjamin N, Leifert C, Antimicrobial Agents and Chemotherapy 1996 40 1422 1425 8726013 (Pubitemid 26169053)
22. Potential application of gaseous nitric oxide as a topical antimicrobial agent. Ghaffari A, Miller CC, McMullin B, Ghahary A, Nitric Oxide 2006 14 21 29 16188471 (Pubitemid 43063504)
23. Efficacy of gaseous nitric oxide in the treatment of skin and soft tissue infections. Ghaffari A, Jalili R, Ghaffari M, Miller C, Ghahary A, Wound Repair Regen 2007 15 368 377 10.1111/j.1524-475X.2007.00239.x 17537124 (Pubitemid 46817413)
24. Gaseous nitric oxide bactericidal activity retained during intermittent high-dose short duration exposure. Miller C, McMullin B, Ghaffari A, Stenzler A, Pick N, Roscoe D, Ghahary A, Road J, Av-Gay Y, Nitric Oxide 2009 20 16 23 10.1016/j.niox.2008.08.002 18789393
25. Antimicrobial and Healing Efficacy of Sustained Release Nitric Oxide Nanoparticles Against Staphylococcus Aureus Skin Infection. Martinez LR, Han G, Chacko M, Mihu MR, Jacobson M, Gialanella P, Friedman AJ, Nosanchuk JD, Friedman JM, J Invest Dermatol 2009