Exercise before and during pregnancy prevents the deleterious effects of maternal high-fat feeding on metabolic health of male offspring

Diabetes

Volumn 64, Issue 2, 2015, Pages 427-433

  Stanford, Kristin I ^a,b   Lee, Min Young ^a,b   Getchell, Kristen M ^a   So, Kawai ^a   Hirshman, Michael F ^a   Goodyear, Laurie J ^a,b  

^a JOSLIN DIABETES CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; TRIACYLGLYCEROL; FAT INTAKE; GLUCOSE BLOOD LEVEL;

ADAPTATION; ANIMAL EXPERIMENT; ARTICLE; BODY COMPOSITION; BODY FAT; BODY WEIGHT; CONTROLLED STUDY; EXERCISE; FAT INTAKE; FEMALE; GASTROCNEMIUS MUSCLE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; GLYCOGEN MUSCLE LEVEL; HOMEOSTASIS; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN TOLERANCE TEST; LIPID DIET; MALE; MATERNAL NUTRITION; METABOLISM; MOUSE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROGENY; SOLEUS MUSCLE; TREADMILL; TRICEPS BRACHII MUSCLE; ADMINISTRATION AND DOSAGE; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; GLUCOSE BLOOD LEVEL; LITTER SIZE; PHYSIOLOGY; PRENATAL EXPOSURE; SEX RATIO;

ANIMALS; BLOOD GLUCOSE; DIETARY FATS; FEMALE; GLUCOSE; INSULIN; LITTER SIZE; MALE; MICE; MICE, INBRED C57BL; PHYSICAL CONDITIONING, ANIMAL; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SEX RATIO;

EID: 84921923804     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-1848     Document Type: Article

References (32)

1. Ravelli GP, Stein ZA, Susser MW. Obesity in young men after famine exposure in utero and early infancy. N Engl J Med 1976;295:349-353
2. Hales CN, Barker DJ, Clark PM, et al. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ 1991;303:1019-1022
3. Phipps K, Barker DJ, Hales CN, Fall CH, Osmond C, Clark PM. Fetal growth and impaired glucose tolerance in men and women. Diabetologia 1993;36:225-228
4. Barker DJ, Winter PD, Osmond C, Margetts B, Simmonds SJ. Weight in infancy and death from ischaemic heart disease. Lancet 1989;2:577-580
5. Fall CH, Vijayakumar M, Barker DJ, Osmond C, Duggleby S. Weight in infancy and prevalence of coronary heart disease in adult life. BMJ 1995;310:17-19
6. Pinhas-Hamiel O, Zeitler P. The global spread of type 2 diabetes mellitus in children and adolescents. J Pediatr 2005;146:693-700
7. Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med 1997;337:869-873
8. Hopkins SA, Cutfield WS. Exercise in pregnancy: weighing up the long-term impact on the next generation. Exerc Sport Sci Rev 2011;39:120-127
9. Gniuli D, Calcagno A, Caristo ME, et al. Effects of high-fat diet exposure during fetal life on type 2 diabetes development in the progeny. J Lipid Res 2008;49:1936-1945
10. Masuyama H, Hiramatsu Y. Effects of a high-fat diet exposure in utero on the metabolic syndrome-like phenomenon in mouse offspring through epigenetic changes in adipocytokine gene expression. Endocrinology 2012;153:2823-2830
11. Bayol SA, Simbi BH, Stickland NC. A maternal cafeteria diet during gestation and lactation promotes adiposity and impairs skeletal muscle development and metabolism in rat offspring at weaning. J Physiol 2005;567:951-961
12. Cerf ME. High fat programming of beta-cell failure. Adv Exp Med Biol 2010;654:77-89
13. Desai M, Ross MG. Fetal programming of adipose tissue: effects of intrauterine growth restriction and maternal obesity/high-fat diet. Semin Reprod Med 2011;29:237-245
14. Khan I, Dekou V, Hanson M, Poston L, Taylor P. Predictive adaptive responses to maternal high-fat diet prevent endothelial dysfunction but not hypertension in adult rat offspring. Circulation 2004;110:1097-1102
15. Muhlhausler BS, Ong ZY. The fetal origins of obesity: early origins of altered food intake. Endocr Metab Immune Disord Drug Targets 2011;11:189-197
16. Knowler WC, Barrett-Connor E, Fowler SE, et al.; Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002;346:393-403
17. Physical Activity and Health, 2011. Atlanta, GA, Centers for Disease Control and Prevention. Available from http://www.cdc.gov/physicalactivity/everyone/health/. Accessed 16 February 2011
18. Vanheest JL, Rodgers CD. Effects of exercise in diabetic rats before and during gestation on maternal and neonatal outcomes. Am J Physiol 1997;273:E727-E733
19. Carter LG, Qi NR, De Cabo R, Pearson KJ. Maternal exercise improves insulin sensitivity in mature rat offspring. Med Sci Sports Exerc 2013;45:832-840
20. Carter LG, Lewis KN, Wilkerson DC, et al. Perinatal exercise improves glucose homeostasis in adult offspring. Am J Physiol Endocrinol Metab 2012;303:E1061-E1068
21. Stanford KI, Middelbeek RJ, Townsend KL, et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest 2013;123:215-223
22. Zou M, Arentson EJ, Teegarden D, Koser SL, Onyskow L, Donkin SS. Fructose consumption during pregnancy and lactation induces fatty liver and glucose intolerance in rats. Nutr Res 2012;32:588-598
23. Toyoda T, An D, Witczak CA, et al. Myo1c regulates glucose uptake in mouse skeletal muscle. J Biol Chem 2011;286:4133-4140
24. Lessard SJ, Rivas DA, Alves-Wagner AB, et al. Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. Diabetes 2013;62:2717-272
25. Ferré P, Leturque A, Burnol AF, Penicaud L, Girard J. A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat. Biochem J 1985;228:103-110
26. Morris MJ, Chen H. Established maternal obesity in the rat reprograms hypothalamic appetite regulators and leptin signaling at birth. Int J Obes (Lond) 2009;33:115-122
27. Woo M, Isganaitis E, Cerletti M, et al. Early life nutrition modulates muscle stem cell number: implications for muscle mass and repair. Stem Cells Dev 2011;20:1763-1769
28. Bentham J, Michell AC, Lockstone H, et al. Maternal high-fat diet interacts with embryonic Cited2 genotype to reduce Pitx2c expression and enhance penetrance of left-right patterning defects. Hum Mol Genet 2010;19:3394-3401
29. Mueller BR, Bale TL. Sex-specific programming of offspring emotionality after stress early in pregnancy. J Neurosci 2008;28:9055-9065
30. Mueller BR, Bale TL. Impact of prenatal stress on long term body weight is dependent on timing and maternal sensitivity. Physiol Behav 2006;88:605-614
31. Mueller BR, Bale TL. Early prenatal stress impact on coping strategies and learning performance is sex dependent. Physiol Behav 2007;91:55-65
32. Barker DJ. In utero programming of chronic disease. Clin Sci (Lond) 1998;95:115-128