Genipin as a novel chemical activator of EBV lytic cycle

Journal of Microbiology

Volumn 53, Issue 2, 2015, Pages 155-165

  Son, Myoungki ^a   Lee, Minjung ^a   Ryu, Eunhyun ^a   Moon, Aree ^b   Jeong, Choon Sik ^b   Jung, Yong Woo ^c   Park, Gyu Hwan ^a   Sung, Gi Ho ^d   Cho, Hyosun ^b   Kang, Hyojeung ^a  

^a Kyungpook National University   (South Korea)

^b Duksung Women's University   (South Korea)

^c Korea University   (South Korea)

^d Catholic Kwandong University   (South Korea)

Author keywords

Epstein Barr virus; genipin; lytic activation; methylation

Indexed keywords

GARDENIA ANGUSTA; HUMAN HERPESVIRUS 4; MAGNOLIOPHYTA; RUBIACEAE;

ACTIN BINDING PROTEIN; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; BCL7A PROTEIN, HUMAN; GENIPIN; IRIDOID; ONCOPROTEIN; VIRUS PROTEIN;

APOPTOSIS; CELL CYCLE; CELL CYCLE S PHASE; DNA METHYLATION; DRUG EFFECTS; EPSTEIN BARR VIRUS; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HUMAN; PHYSIOLOGY; PROMOTER REGION; STOMACH NEOPLASMS; TUMOR CELL LINE; VIROLOGY; VIRUS LATENCY; VIRUS REPLICATION;

ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; DNA METHYLATION; GENE EXPRESSION REGULATION, VIRAL; HEK293 CELLS; HERPESVIRUS 4, HUMAN; HUMANS; IRIDOIDS; MICROFILAMENT PROTEINS; ONCOGENE PROTEINS; PROMOTER REGIONS, GENETIC; S PHASE; STOMACH NEOPLASMS; VIRAL PROTEINS; VIRUS LATENCY; VIRUS REPLICATION;

EID: 84921905755     PISSN: 12258873     EISSN: 19763794     Source Type: Journal    
DOI: 10.1007/s12275-015-4672-9     Document Type: Article

References (29)

1. Blake, N. 2010. Immune evasion by gammaherpesvirus genome maintenance proteins. J. Gen. Virol.91, 829–846.
2. Bonfoco, E., Krainc, D., Ankarcrona, M., Nicotera, P., and Lipton, S.A. 1995. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with n-methyl-d-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. Natl. Acad. Sci. USA92, 7162–7166.
3. Brulois, K. and Jung, J.U. 2014. Interplay between kaposi’s sarcoma-associated herpesvirus and the innate immune system. Cytokine Growth Factor Rev.25, 597–609.
4. Dai, M.M., Wu, H., Li, H., Chen, J., Chen, J.Y., Hu, S.L., and Shen, C. 2014. Effects and mechanisms of Geniposide on rats with adjuvant arthritis. Int. Immunopharmacol.20, 46–53.
5. Dinda, B., Debnath, S., and Harigaya, Y. 2007. Naturally occurring secoiridoids and bioactivity of naturally occurring iridoids and secoiridoids. A review, part 2. Chem. Pharm. Bull. (Tokyo)55, 689–728.
6. Forrest, J.C. and Speck, S.H. 2008. Establishment of b-cell lines latently infected with reactivation-competent murine gammaherpesvirus 68 provides evidence for viral alteration of a DNA damage-signaling cascade. J. Virol.82, 7688–7699.
7. Haruhiko, O. 2002. Methylation-specific PCR, pp. 91–97. In Bing-Yuan, C.H.W.J. (ed.), PCR cloning protocols, Humana, New York, USA.
8. Hino, R., Uozaki, H., Murakami, N., Ushiku, T., Shinozaki, A., Ishikawa, S., Morikawa, T., Nakaya, T., Sakatani, T., Takada, K.,et al. 2009. Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma. Cancer Res.69, 2766–2774.
9. Hughes, D.J., Dickerson, C.A., Shaner, M.S., Sample, C.E., and Sample, J.T. 2011. Trans-repression of protein expression dependent on the epstein-barr virus promoter Wp during latency. J. Virol.85, 11435–11447.
10. Ishiyama, M., Miyazono, Y., Sasamoto, K., Ohkura, Y., and Ueno, K. 1997. A highly water-soluble disulfonated tetrazolium salt as a chromogenic indicator for NADH as well as cell viability. Talanta44, 1299–1305.
11. Kang, H., Wiedmer, A., Yuan, Y., Robertson, E., and Lieberman, P.M. 2011. Coordination of KSHV latent and lytic gene control by CTCF-cohesin mediated chromosome conformation. PLoS Pathog.7, e1002140.
12. Kitano, A., Saika, S., Yamanaka, O., Reinach, P. S., Ikeda, K., Okada, Y., Shirai, K., and Ohnishi, Y. 2006. Genipin suppression of fibrogenic behaviors of the alpha-TN4 lens epithelial cell line. J. Cataract Refract. Surg.32, 1727–1735.
13. Leonard, S., Wei, W., Anderton, J., Vockerodt, M., Rowe, M., Murray, P.G., and Woodman, C.B. 2011. Epigenetic and transcriptional changes which follow Epstein-Barr virus infection of germinal center B cells and their relevance to the pathogenesis of hodgkin’s lymphoma. J. Virol.85, 9568–9577.
14. Liang, C., Lee, J.S., and Jung, J.U. 2008. Immune evasion in Kaposi’s sarcoma-associated herpes virus associated oncogenesis. Semin. Cancer Biol.18, 423–436.
15. Lin, C.H., Chang, T.T., Sun, M.F., Chen, H.Y., Tsai, F.J., Chang, K.L., Fisher, M., and Chen, C.Y. 2011. Potent inhibitor design against H1N1 swine influenza: Structure-based and molecular dynamics analysis for M2 inhibitors from traditional Chinese medicine database. J. Biomol. Struct. Dyn.28, 471–482.
16. Liu, H., Chen, Y.F., Li, F., and Zhang, H.Y. 2013. Fructus gardenia (Gardenia jasminoides j. Ellis) phytochemistry, pharmacology of cardiovascular, and safety with the perspective of new drugs development. J. Asian Nat. Prod. Res.15, 94–110.
17. Moon, S.H., Choi, H.J., Lee, S.J., and Choi, K.H. 1997. Novel genipin derivative having anti hepatitis B virus activity. Korea, Republic.
18. Moore, S.M., Cannon, J.S., Tanhehco, Y.C., Hamzeh, F.M., and Ambinder, R.F. 2001. Induction of Epstein-Barr virus kinases to sensitize tumor cells to nucleoside analogues. Antimicrob. Agents Chemother.45, 2082–2091.
19. Oliver, F.J., de la Rubia, G., Rolli, V., Ruiz-Ruiz, M.C., de Murcia, G., and Murcia, J.M. 1998. Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant. J. Biol. Chem.273, 33533–33539.
20. Papa, S., Bubici, C., Zazzeroni, F., Pham, C.G., Kuntzen, C., Knabb, J.R., Dean, K., and Franzoso, G. 2006. The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease. Cell Death Differ.13, 712–729.
21. Roizman, B., Carmichael, L.E., Deinhardt, F., de-The, G., Nahmias, A.J., Plowright, W., Rapp, F., Sheldrick, P., Takahashi, M., and Wolf, K. 1981. Herpesviridae. Definition, provisional nomenclature, and taxonomy. The herpesvirus study group, the international committee on taxonomy of viruses. Intervirology16, 201–217.
22. Son, M., Lee, M., Sung, G.H., Lee, T., Shin, Y.S., Cho, H., Lieberman, P.M., and Kang, H. 2013. Bioactive activities of natural products against herpesvirus infection. J. Microbiol.51, 545–551.
23. Tempera, I., Klichinsky, M., and Lieberman, P.M. 2011. EBV latency types adopt alternative chromatin conformations. PLoS Pathog.7, e1002180.
24. Tempera, I., Wiedmer, A., Dheekollu, J., and Lieberman, P.M. 2010. CTCF prevents the epigenetic drift of EBV latency promoter Qp. PLoS Pathog.6, e1001048.
25. Tseng, T.H., Chu, C.Y., Huang, J.M., Shiow, S.J., and Wang, C.J. 1995. Crocetin protects against oxidative damage in rat primary hepatocytes. Cancer Lett.97, 61–67.
26. Tundis, R., Loizzo, M.R., Menichini, F., Statti, G.A., and Menichini, F. 2008. Biological and pharmacological activities of iridoids: Recent developments. Mini Rev. Med. Chem.8, 399–420.
27. Ueda, S., Iwahashi, Y., and Tokuda, H. 1991. Production of antitumor-promoting iridoid glucosides in Genipa americana and its cell cultures. J. Nat. Prod.54, 1677–1680.
28. Wille, C.K., Nawandar, D.M., Panfil, A.R., Ko, M.M., Hagemeier, S.R., and Kenney, S.C. 2013. Viral genome methylation differentially affects the ability of BZLF1 versus BRLF1 to activate Epstein-Barr virus lytic gene expression and viral replication. J. Virol.87, 935–950.
29. Young, L.S. and Rickinson, A.B. 2004. Epstein-Barr virus: 40 years on. Nat. Rev. Cancer4, 757–768.