Chemoreflex physiology and implications for sleep apnoea: Insights from studies in humans

Experimental Physiology

Volumn 100, Issue 2, 2015, Pages 130-135

  Mansukhani, Meghna P ^a   Wang, Shihan ^b   Somers, Virend K ^b  

^a Affiliated Community Medical Centers PA   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOLAMINE; LEPTIN;

ARTERIAL CARBON DIOXIDE TENSION; ARTICLE; AUTONOMIC DYSFUNCTION; BORDERLINE HYPERTENSION; BRADYCARDIA; BREATHING PATTERN; CAROTID BODY CHEMORECEPTOR; CATECHOLAMINE BLOOD LEVEL; CATECHOLAMINE URINE LEVEL; CENTRAL SLEEP APNEA SYNDROME; CHEMORECEPTOR REFLEX; CHEYNE STOKES BREATHING; COMPLETE HEART BLOCK; DIASTOLIC HEART FAILURE; ELEVATED BLOOD PRESSURE; HEART ATRIUM FIBRILLATION; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART RATE VARIABILITY; HUMAN; HYPERCAPNIA; HYPERVENTILATION; HYPOXEMIA; MEAN ARTERIAL PRESSURE; MEDULLA OBLONGATA; MUSCLE SYMPATHETIC NERVE ACTIVITY; NONHUMAN; OBESITY; OXYGEN DESATURATION; PATHOPHYSIOLOGY; POSITIVE END EXPIRATORY PRESSURE; PREHYPERTENSION; PRESSORECEPTOR REFLEX; RESISTANT HYPERTENSION; SLEEP DISORDERED BREATHING; ST SEGMENT; SUDDEN CARDIAC DEATH; SYMPATHETIC TONE; SYSTOLIC DYSFUNCTION; VASOCONSTRICTION; ANIMAL; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM; CAROTID BODY; PHYSIOLOGY; REFLEX;

ANIMALS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; CAROTID BODY; HUMANS; REFLEX; SLEEP APNEA SYNDROMES;

EID: 84921885975     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2014.082826     Document Type: Article

References (43)

1. Angell-James JE & Daly MB (1975). Some aspects of upper respiratory tract reflexes. Acta Otolaryngol 79, 242-252.
2. 2. J Physiol 588, 2455-2471.
3. Ciriello J & Moreau JM (2012). Leptin signaling in the nucleus of the solitary tract alters the cardiovascular responses to activation of the chemoreceptor reflex. Am J Physiol Regul Integr Comp Physiol 303, R727-R736.
4. Del Rio R, Moya EA & Iturriaga R (2010). Carotid body and cardiorespiratory alterations in intermittent hypoxia: the oxidative link. Eur Respir J 36, 143-150.
5. Del Rio R, Moya EA, Parga MJ, Madrid C & Iturriaga R (2012). Carotid body inflammation and cardiorespiratory alterations in intermittent hypoxia. Eur Respir J 39, 1492-1500.
6. Endeshaw YW, White WB, Kutner M, Ouslander JG & Bliwise DL (2009). Sleep-disordered breathing and 24-hour blood pressure pattern among older adults. J Gerontol A Biol Sci Med Sci 64, 280-285.
7. Fukuda Y, Sato A & Trzebski A (1987). Carotid chemoreceptor discharge responses to hypoxia and hypercapnia in normotensive and spontaneously hypertensive rats. J Auton Nerv Syst 19, 1-11.
8. Gami AS, Howard DE, Olson EJ & Somers VK (2005). Day-night pattern of sudden death in obstructive sleep apnea. N Engl J Med 352, 1206-1214.
9. Gilman MP, Floras JS, Usui K, Kaneko Y, Leung RS & Bradley TD (2008). Continuous positive airway pressure increases heart rate variability in heart failure patients with obstructive sleep apnoea. Clin Sci (Lond) 114, 243-249.
10. Heistad DD, Abboud FM, Mark AL & Schmid PG (1974). Interaction of baroreceptor and chemoreceptor reflexes. Modulation of the chemoreceptor reflex by changes in baroreceptor activity. J Clin Invest 53, 1226-1236.
11. Iturriaga R, Moya EA & Del Rio R (2010). Cardiorespiratory alterations induced by intermittent hypoxia in a rat model of sleep apnea. Adv Exp Med Biol 669, 271-274.
12. Iturriaga R, Rey S & Del Rio R (2005). Cardiovascular and ventilatory acclimatization induced by chronic intermittent hypoxia: a role for the carotid body in the pathophysiology of sleep apnea. Biol Res 38, 335-340.
13. 2 with central sleep apnea and ventricular arrhythmias in ambulatory patients with stable heart failure. Ann Intern Med 128, 204-207.
14. Kara T, Narkiewicz K & Somers VK (2003). Chemoreflexes-physiology and clinical implications. Acta Physiol Scand 177, 377-384.
15. Koehler U, Becker HF, Grimm W, Heitmann J, Peter JH & Schafer H (2000). Relations among hypoxemia, sleep stage, and bradyarrhythmia during obstructive sleep apnea. Am Heart J 139, 142-148.
16. Kuniyoshi FH, Garcia-Touchard A, Gami AS, Romero-Corral A, van der Walt C, Pusalavidyasagar S, Kara T, Caples SM, Pressman GS, Vasquez EC, Lopez-Jimenez F & Somers VK (2008). Day-night variation of acute myocardial infarction in obstructive sleep apnea. J Am Coll Cardiol 52, 343-346.
17. Lanfranchi PA & Somers VK (2003). Sleep-disordered breathing in heart failure: characteristics and implications. Respir Physiol Neurobiol 136, 153-165.
18. Levy P, Ryan S, Oldenburg O & Parati G (2013). Sleep apnoea and the heart. Eur Respir Rev 22, 333-352.
19. Luu M, Stevenson WG, Stevenson LW, Baron K & Walden J (1989). Diverse mechanisms of unexpected cardiac arrest in advanced heart failure. Circulation 80, 1675-1680.
20. Mansfield D, Kaye DM, Brunner La Rocca H, Solin P, Esler MD & Naughton MT (2003). Raised sympathetic nerve activity in heart failure and central sleep apnea is due to heart failure severity. Circulation 107, 1396-1400.
21. Mansukhani MP, Kara T, Caples SM & Somers VK (2014). Chemoreflexes, sleep apnea, and sympathetic dysregulation. Curr Hypertens Rep 16, 476.
22. Mooe T, Franklin KA, Wiklund U, Rabben T & Holmström K (2000). Sleep-disordered breathing and myocardial ischemia in patients with coronary artery disease. Chest 117, 1597-1602.
23. Narkiewicz K, Kato M, Pesek CA & Somers VK (1999). Human obesity is characterized by a selective potentiation of central chemoreflex sensitivity. Hypertension 33, 1153-1158.
24. Narkiewicz K, van de Borne PJ, Cooley RL, Dyken ME & Somers VK (1998a). Sympathetic activity in obese subjects with and without obstructive sleep apnea. Circulation 98, 772-776.
25. Narkiewicz K, van de Borne PJ, Montano N, Dyken ME, Phillips BG & Somers VK (1998b). Contribution of tonic chemoreflex activation to sympathetic activity and blood pressure in patients with obstructive sleep apnea. Circulation 97, 943-945.
26. Patel HM, Heffernan MJ, Ross AJ & Muller MD (2014). Sex differences in forearm vasoconstrictor response to voluntary apnea. Am J Physiol Heart Circ Physiol 306, H309-H316.
27. Patel HM, Mast JL, Sinoway LI & Muller MD (2013). Effect of healthy aging on renal vascular responses to local cooling and apnea. J Appl Physiol 115, 90-96.
28. Pimenta E, Gordon RD & Stowasser M (2013). Salt, aldosterone and hypertension. J Hum Hypertens 27, 1-6.
29. 2 in hyperoxia and hypoxia in older aged humans. J Appl Physiol 75, 2209-2216.
30. Preston ME, Jensen D, Janssen I & Fisher JT (2009). Effect of menopause on the chemical control of breathing and its relationship with acid-base status. Am J Physiol Regul Integr Comp Physiol 296, R722-R727.
31. Schmidt H, Francis DP, Rauchhaus M, Werdan K & Piepoli MF (2005). Chemo- and ergoreflexes in health, disease and ageing. Int J Cardiol 98, 369-378.
32. Solin P, Kaye DM, Little PJ, Bergin P, Richardson M & Naughton MT (2003). Impact of sleep apnea on sympathetic nervous system activity in heart failure. Chest 123, 1119-1126.
33. Somers VK, Dyken ME, Clary MP & Abboud FM (1995). Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 96, 1897-1904.
34. Somers VK, Dyken ME, Mark AL & Abboud FM (1992). Parasympathetic hyperresponsiveness and bradyarrhythmias during apnoea in hypertension. Clin Auton Res 2, 171-176.
35. Somers VK, Mark AL & Abboud FM (1988). Potentiation of sympathetic nerve responses to hypoxia in borderline hypertensive subjects. Hypertension 11, 608-612.
36. Somers VK, Mark AL & Abboud FM (1991). Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans. J Clin Invest 87, 1953-1957.
37. Somers VK, Mark AL, Zavala DC & Abboud FM (1989a). Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans. J Appl Physiol 67, 2101-2106.
38. Somers VK, Mark AL, Zavala DC & Abboud FM (1989b). Influence of ventilation and hypocapnia on sympathetic nerve responses to hypoxia in normal humans. J Appl Physiol 67, 2095-2100.
39. Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, Daniels S, Floras JS, Hunt CE, Olson LJ, Pickering TG, Russell R, Woo M & Young T (2008). Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health). Circulation 118, 1080-1111.
40. Trzebski A, Tafil M, Zoltowski M & Przybylski J (1982). Increased sensitivity of the arterial chemoreceptor drive in young men with mild hypertension. Cardiovasc Res 16, 163-172.
41. van de Borne P, Oren R, Abouassaly C, Anderson E & Somers VK (1998). Effect of Cheyne-Stokes respiration on muscle sympathetic nerve activity in severe congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 81, 432-436.
42. Velez-Roa S, Kojonazarov B, Ciarka A, Godart P, Naeije R, Somers VK & van de Borne P (2003). Dobutamine potentiates arterial chemoreflex sensitivity in healthy normal humans. Am J Physiol Heart Circ Physiol 285, H1356-H1361.
43. Zeidan-Shwiri T, Aronson D, Atalla K, Blich M, Suleiman M, Marai I, Gepstein L, Lavie L, Lavie P & Boulos M (2011). Circadian pattern of life-threatening ventricular arrhythmia in patients with sleep-disordered breathing and implantable cardioverter-defibrillators. Heart Rhythm 8, 657-662.