Relations among hypoxemia, sleep stage, and bradyarrhythmia during obstructive sleep apnea

American Heart Journal

Volumn 139, Issue 1 I, 2000, Pages 142-148

  Koehler, Ulrich ^a   Becker, Heinrich F ^a   Grimm, Wolfram ^a   Heltmann, Jorg ^a   Peter, Jorg H ^a   Schafer, Harald ^b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; ATRIOVENTRICULAR BLOCK; BODY MASS; BRADYCARDIA; CONTROLLED STUDY; DIABETES MELLITUS; ELECTROCARDIOGRAM; FEMALE; HOLTER MONITORING; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; HYPERURICEMIA; HYPOXEMIA; MAJOR CLINICAL STUDY; MALE; OBESITY; OXYGEN SATURATION; POLYSOMNOGRAPHY; PRIORITY JOURNAL; REM SLEEP; SINUS ARREST; SLEEP APNEA SYNDROME; SLEEP STAGE;

EID: 0033958045     PISSN: 00028703     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-8703(00)90321-1     Document Type: Article

References (19)

1. Miller WP. Cardiac arrhythmias and conduction disturbances in the sleep apnea syndrome. Prevalence and significance. Am J Med 1982;73:317-21.
2. Tilkian AG, Guilleminault C, Schroeder JS. Sleep-induced apnea syndrome. Prevalence of cardiac arrhythmias and their reversal after tracheostomy. Am J Med 1977;63:348-58.
3. Guilleminault C, Connolly SJ, Winkle RA. Cardiac arrhythmia and conduction disturbances during sleep in 400 patients with sleep apnea syndrome. Am J Cardiol 1983;52:490-4.
4. Koehler U, Fus E, Grimm W. Heart block in patients with obstructive sleep apnoea: pathogenetic factors and effects of treatment. Eur Resp J 1998;11:434-9.
5. Zwillich C, Devlin T, White D. Bradycardia during sleep apnea. Characteristics and mechanism. J Clin Invest 1982;69:1286-92.
6. Grimm W, Hoffmann J, Menz V. Electrophysiological evaluation of sinus node function and atrioventricular conduction in patients with prolonged ventricular asystole during obstructive sleep apnea. Am J Cardiol 1996;77:1310-4.
7. Becker H, Brandenburg U, Peter JH. Reversal of sinus arrest and atrioventricular conduction block in patients with sleep apnea during nasal continuous positive airway pressure. Am J Respir Crit Care Med 1995;151:215-8.
8. Becker H, Brandenburg U, Conrad R. Einfluß der nCPAP-therapie auf bradycarde herzrhythmusstörungen bei schlafapnoe (SA). Pneumologie 1993;47:706-10.
9. Rechtschaffen A, Kales A. A manual of standardized terminology: techniques and scoring system for sleep stages of human subjects. Los Angeles: UCLA Brain Information Service/Brain Research Institute; 1968.
10. Stegman SS, Burroughs JM, Henthorn RW. Asymptomatic bradyarrhythmias as a marker for sleep apnea: appropiate recognition and treatment may reduce the need for pacemaker therapy. Pace 1996;19:899-904.
11. Flemons WW, Remmers JE, Gillis AM. Sleep apnea and cardiac arrhythmias. Is there a relationship? Am Rev Respir Dis 1993;148:618-21.
12. Harley SS, Sleight P, Pickering GW. Reflex regulation of arterial pressure during sleep in man. Circ Res 1969;26:109-21.
13. Somers VK, Dyken ME, Mark AL. Parasympathetic hyperresponsiveness and bradyarrhythmias during apnoea in hypertension. Clin Autonom Res 1992;2:171-6.
14. Sato F, Nishimura M, Shinano H. Heart rate during obstructive sleep apnea depends on individual hypoxic chemosensitivity of the carotid body. Circulation 1997;96:274-81.
15. Daly M. de B. The cardiovascular responses to stimulation of the carotid body chemoreceptors in the dog. J Physiol Lond 1963;165:179-97.
16. Kato H, Menon AS, Chen FJ. Contribution of pulmonary receptors to the heart rate response to acute hypoxemia in rabbits. Circulation 1988;78:1260-6.
17. Kato H, Menon AS, Slutsky AS. Mechanisms mediating the heart rate response to hypoxemia. Circulation 1988;77:407-14.
18. Simon PM, Taha BH, Dempsey JA. Role of vagal feedback from the lung in hypoxic-induced tachycardia in humans. J Appl Physiol 1995;78:1522-30.
19. Koehler U, Funck R, Fus E. Bradykarde arrhythmien bei schlafbezogenen atmungsstörungen. Klinische relevanz, pathogenese und therapie. Dtsch Med Wochenschr 1995;120:1369-73.