Ameliorating the effect of astragaloside IV on learning and memory deficit after chronic cerebral hypoperfusion in Rats

Molecules

Volumn 20, Issue 2, 2015, Pages 1904-1921

  Kim, Sooyong ^a   Kang, Il Hwan ^a   Nam, Jung Bum ^a   Cho, Yoonchul ^a   Chung, Doo Young ^a   Kim, Seung Hwan ^a   Kim, Jeong Soo ^a   Cho, Yong Deok ^a   Hong, Eun Ki ^a   Sohn, Nak Won ^a   Shin, Jung Won ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Astragaloside IV; Cerebral hypoperfusion; Glial activation; Memory impairment; Neuronal apoptosis; Oxidative damage

Indexed keywords

ACTIN BINDING PROTEIN; AIF1 PROTEIN, RAT; ANTIOXIDANT; ASTRAGALOSIDE A; CALCIUM BINDING PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; NEUROPROTECTIVE AGENT; SAPONIN; TRITERPENE;

ANIMAL; APOPTOSIS; BRAIN CIRCULATION; CAROTID ARTERY DISEASES; CHRONIC DISEASE; COMPLICATION; DRUG EFFECTS; DRUG SCREENING; GLIA; HIPPOCAMPUS; MALE; MAZE TEST; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; VASCULARIZATION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CALCIUM-BINDING PROTEINS; CAROTID ARTERY DISEASES; CEREBROVASCULAR CIRCULATION; CHRONIC DISEASE; DRUG EVALUATION, PRECLINICAL; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; MALE; MAZE LEARNING; MICROFILAMENT PROTEINS; NEUROGLIA; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; RATS, SPRAGUE-DAWLEY; SAPONINS; TRITERPENES;

EID: 84921788469     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules20021904     Document Type: Article

References (39)

1. Schuff, N.; Matsumoto, S.; Kmiecik, J.; Studholme, C.; Du, A.; Ezekiel, F.; Miller, B.L.; Kramer, J.H.; Jagust, W.J.; Chui, H.C.; et al. Cerebral Blood Flow in Ischemic Vascular Dementia and Alzheimer's Disease, Measured by Arterial Spin-Labeling Magnetic Resonance Imaging. Alzheimers Dement. 2009, 5, 454-462.
2. Bennett, S.A.; Tenniswood, M.; Chen, J.H.; Davidson, C.M.; Keyes, M.T.; Fortin, T.; Pappas, B.A. Chronic Cerebral Hypoperfusion Elicits Neuronal Apoptosis and Behavioral Impairment. Neuroreport 1998, 9, 161-166.
3. Liu, H.; Zhang, J. Cerebral Hypoperfusion and Cognitive Impairment: The Pathogenic Role of Vascular Oxidative Stress. Int. J. Neurosci. 2012, 122, 494-499.
4. Iadecola, C. The Overlap between Neurodegenerative and Vascular Factors in the Pathogenesis of Dementia. Acta Neuropathol. 2010, 120, 287-296.
5. Butterfield, D.A.; Lauderback, C.M. Lipid Peroxidation and Protein Oxidation in Alzheimer's Disease Brain: Potential Causes and Consequences Involving Amyloid Beta-Peptide-Associated Free Radical Oxidative Stress. Free Radic. Biol. Med. 2002, 32, 1050-1060.
6. Isobe, C.; Abe, T.; Terayama, Y. Levels of Reduced and Oxidized Coenzyme Q-10 and 8-Hydroxy-2'-Deoxyguanosine in the CSF of Patients with Alzheimer's Disease Demonstrate that Mitochondrial Oxidative Damage and/or Oxidative DNA Damage Contributes to the Neurodegenerative Process. J. Neurol. 2010, 257, 399-404.
7. Chong, Z.Z.; Li, F.; Maiese, K. Oxidative Stress in the Brain: Novel Cellular Targets that Govern Survival during Neurodegenerative Disease. Prog. Neurobiol. 2005, 75, 207-246.
8. Fu, J.; Wang, Z.; Huang, L.; Zheng, S.; Wang, D.; Chen, S.; Zhang, H.; Yang, S. Review of the Botanical Characteristics, Phytochemistry, and Pharmacology of Astragalus Membranaceus (Huangqi). Phytother. Res. 2014, 28, 1275-1283.
9. Zhang, Z.G.; Wu, L.; Wang, J.L.; Yang, J.D.; Zhang, J.; Zhang, J.; Li, L.H.; Xia, Y.; Yao, L.B.; Qin, H.Z.; et al. Astragaloside IV Prevents MPP(+)-Induced SH-SY5Y Cell Death Via the Inhibition of Bax-Mediated Pathways and ROS Production. Mol. Cell. Biochem. 2012, 364, 209-216.
10. Li, X.; Wang, X.; Han, C.; Wang, X.; Xing, G.; Zhou, L.; Li, G.; Niu, Y. Astragaloside IV Suppresses Collagen Production of Activated Hepatic Stellate Cells Via Oxidative Stress-Mediated p38 MAPK Pathway. Free Radic. Biol. Med. 2013, 60, 168-176.
11. Hu, J.Y.; Han, J.; Chu, Z.G.; Song, H.P.; Zhang, D.X.; Zhang, Q.; Huang, Y.S. Astragaloside IV Attenuates Hypoxia-Induced Cardiomyocyte Damage in Rats by Upregulating Superoxide Dismutase-1 Levels. Clin. Exp. Pharmacol. Physiol. 2009, 36, 351-357.
12. Wang, S.G.; Xu, Y.; Chen, J.D.; Yang. C.H.; Chen, X.H. Astragaloside IV stimulates angiogenesis and increases nitric oxide accumulation via JAK2/STAT3 and ERK1/2 pathway. Molecules 2013, 18, 12809-12819.
13. Luo, Y.; Qin, Z.; Hong, Z.; Zhang, X.; Ding, D.; Fu, J.H.; Zhang, W.D.; Chen, J. Astragaloside IV Protects Against Ischemic Brain Injury in a Murine Model of Transient Focal Ischemia. Neurosci. Lett. 2004, 363, 218-223.
14. Li, M.; Qu, Y.Z.; Zhao, Z.W.; Wu, S.X.; Liu, Y.Y.; Wei, X.Y.; Gao, L.; Gao, G.D. Astragaloside IV Protects Against Focal Cerebral ischemia/reperfusion Injury Correlating to Suppression of Neutrophils Adhesion-Related Molecules. Neurochem. Int. 2012, 60, 458-465.
15. Liu, G.; Song, J.; Guo, Y.; Wang, T.; Zhou, Z. Astragalus Injection Protects Cerebral Ischemic Injury by Inhibiting Neuronal Apoptosis and the Expression of JNK3 After Cerebral Ischemia Reperfusion in Rats. Behav. Brain Funct. 2013, 9, 36-9081-9-36.
16. Qu, Y.Z.; Li, M.; Zhao, Y.L.; Zhao, Z.W.; Wei, X.Y.; Liu, J.P.; Gao, L.; Gao, G.D. Astragaloside IV Attenuates Cerebral Ischemia-Reperfusion-Induced Increase in Permeability of the Blood-Brain Barrier in Rats. Eur. J. Pharmacol. 2009, 606, 137-141.
17. Sun, Q.; Jia, N.; Wang, W.; Jin, H.; Xu, J.; Hu, H. Protective Effects of Astragaloside IV Against Amyloid beta1-42 Neurotoxicity by Inhibiting the Mitochondrial Permeability Transition Pore Opening. PLoS One 2014, 9, e98866.
18. Pappas, B.A.; de la Torre, J.C.; Davidson, C.M.; Keyes, M.T.; Fortin, T. Chronic Reduction of Cerebral Blood Flow in the Adult Rat: Late-Emerging CA1 Cell Loss and Memory Dysfunction. Brain Res. 1996, 708, 50-58.
19. Farkas, E.; Luiten, P.G.; Bari, F. Permanent, Bilateral Common Carotid Artery Occlusion in the Rat: A Model for Chronic Cerebral Hypoperfusion-Related Neurodegenerative Diseases. Brain Res. Rev. 2007, 54, 162-180.
20. Ohta, H.; Nishikawa, H.; Kimura, H.; Anayama, H.; Miyamoto, M. Chronic Cerebral Hypoperfusion by Permanent Internal Carotid Ligation Produces Learning Impairment without Brain Damage in Rats. Neuroscience 1997, 79, 1039-1050.
21. Otori, T.; Katsumata, T.; Muramatsu, H.; Kashiwagi, F.; Katayama, Y.; Terashi, A. Long-Term Measurement of Cerebral Blood Flow and Metabolism in a Rat Chronic Hypoperfusion Model. Clin. Exp. Pharmacol. Physiol. 2003, 30, 266-272.
22. Liu, H.X.; Zhang, J.J.; Zheng, P.; Zhang, Y. Altered Expression of MAP-2, GAP-43, and Synaptophysin in the Hippocampus of Rats with Chronic Cerebral Hypoperfusion Correlates with Cognitive Impairment. Brain Res. Mol. Brain Res. 2005, 139, 169-177.
23. Li, W.Z.; Li, W.P.; Zhang, W.; Yin, Y.Y.; Sun, X.X.; Zhou, S.S.; Xu, X.Q.; Tao, C.R. Protective Effect of Extract of Astragalus on Learning and Memory Impairments and Neurons' Apoptosis Induced by Glucocorticoids in 12-Month-Old Male Mice. Anat. Rec. (Hoboken) 2011, 294, 1003-1014.
24. Li, W.Z.; Wu, W.Y.; Huang, D.K.; Yin, Y.Y.; Kan, H.W.; Wang, X.; Yao, Y.Y.; Li, W.P. Protective Effects of Astragalosides on Dexamethasone and Abeta25-35 Induced Learning and Memory Impairments due to Decrease Amyloid Precursor Protein Expression in 12-Month Male Rats. Food Chem. Toxicol. 2012, 50, 1883-1890.
25. De Jong, G.I.; Farkas, E.; Stienstra, C.M.; Plass, J.R.; Keijser, J.N.; de la Torre, J.C.; Luiten, P.G. Cerebral Hypoperfusion Yields Capillary Damage in the Hippocampal CA1 Area that Correlates with Spatial Memory Impairment. Neuroscience 1999, 91, 203-210.
26. Ohtaki, H.; Fujimoto, T.; Sato, T.; Kishimoto, K.; Fujimoto, M.; Moriya, M.; Shioda, S. Progressive Expression of Vascular Endothelial Growth Factor (VEGF) and Angiogenesis after Chronic Ischemic Hypoperfusion in Rat. Acta Neurochir. Suppl. 2006, 96, 283-287.
27. Shao, A.; Guo, S.; Tu, S.; Ammar, A.B.; Tang, J.; Hong, Y.; Wu, H.; Zhang, J. Astragaloside IV Alleviates Early Brain Injury Following Experimental Subarachnoid Hemorrhage in Rats. Int. J. Med. Sci. 2014, 11, 1073-1081.
28. Del Rio, D.; Stewart, A.J.; Pellegrini, N. A Review of Recent Studies on Malondialdehyde as Toxic Molecule and Biological Marker of Oxidative Stress. Nutr. Metab. Cardiovasc. Dis. 2005, 15, 316-328.
29. Benedetti, A.; Comporti, M.; Esterbauer, H. Identification of 4-Hydroxynonenal as a Cytotoxic Product Originating from the Peroxidation of Liver Microsomal Lipids. Biochim. Biophys. Acta 1980, 620, 281-296.
30. Petersen, D.R.; Doorn, J.A. Reactions of 4-Hydroxynonenal with Proteins and Cellular Targets. Free Radic. Biol. Med. 2004, 37, 937-945.
31. Pilger, A.; Rudiger, H.W. 8-Hydroxy-2'-Deoxyguanosine as a Marker of Oxidative DNA Damage Related to Occupational and Environmental Exposures. Int. Arch. Occup. Environ. Health 2006, 80, 1-15.
32. Valko, M.; Izakovic, M.; Mazur, M.; Rhodes, C.J.; Telser, J. Role of Oxygen Radicals in DNA Damage and Cancer Incidence. Mol. Cell. Biochem. 2004, 266, 37-56.
33. Fraga, C.G.; Shigenaga, M.K.; Park, J.W.; Degan, P.; Ames, B.N. Oxidative Damage to DNA during Aging: 8-Hydroxy-2'-Deoxyguanosine in Rat Organ DNA and Urine. Proc. Natl. Acad. Sci. USA 1990, 87, 4533-4537.
34. Mecocci, P.; MacGarvey, U.; Beal, M.F. Oxidative Damage to Mitochondrial DNA is Increased in Alzheimer's Disease. Ann. Neurol. 1994, 36, 747-751.
35. Aliev, G.; Seyidova, D.; Lamb, B.T.; Obrenovich, M.E.; Siedlak, S.L.; Vinters, H.V.; Friedland, R.P.; LaManna, J.C.; Smith, M.A.; Perry, G. Mitochondria and Vascular Lesions as a Central Target for the Development of Alzheimer's Disease and Alzheimer Disease-Like Pathology in Transgenic Mice. Neurol. Res. 2003, 25, 665-674.
36. Minghetti, L. Role of Inflammation in Neurodegenerative Diseases. Curr. Opin. Neurol. 2005, 18, 315-321.
37. Cechetti, F.; Pagnussat, A.S.; Worm, P.V.; Elsner, V.R.; Ben, J.; da Costa, M.S.; Mestriner, R.; Weis, S.N.; Netto, C.A. Chronic Brain Hypoperfusion Causes Early Glial Activation and Neuronal Death, and Subsequent Long-Term Memory Impairment. Brain Res. Bull. 2012, 87, 109-116.
38. Zhang, W.D.; Zhang, C.; Liu, R.H.; Li, H.L.; Zhang, J.T.; Mao, C.; Moran, S.; Chen, C.L. Preclinical pharmacokinetics and tissue distribution of a natural cardioprotective agent astragaloside IV in rats and dogs. Life Sci. 2006, 79, 808-815.
39. Smith, D.H.; Okiyama, K.; Thomas, M.J.; McIntosh, T.K. Effects of the Excitatory Amino Acid Receptor Antagonists Kynurenate and Indole-2-Carboxylic Acid on Behavioral and Neurochemical Outcome Following Experimental Brain Injury. J. Neurosci. 1993, 13, 5383-5392.