IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies

Science Translational Medicine

Volumn 7, Issue 272, 2015, Pages

  Zanella, Eugenia R ^a,b   Galimi, Francesco ^a,b   Sassi, Francesco ^a,b   Migliardi, Giorgia ^a,b   Cottino, Francesca ^b   Leto, Simonetta M ^a,b   Lupo, Barbara ^a,b   Erriquez, Jessica ^b   Isella, Claudio ^a,b   Comoglio, Paolo M ^a,b   Medico, Enzo ^a,b   Tejpar, Sabine ^c   Budinská, Eva ^d,e   Trusolino, Livio ^a,b   Bertotti, Andrea ^a,b,f  

^a UNIVERSITY OF TURIN   (Italy)

^b CANDIOLO CANCER INSTITUTE   (Italy)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^d MASARYK UNIVERSITY   (Czech Republic)

^e MASARYK MEMORIAL CANCER INSTITUTE   (Czech Republic)

^f NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 [4 [(5 CYCLOPROPYL 1H PYRAZOL 3 YL)AMINO]PYRROLO[2,1 F][1,2,4]TRIAZIN 2 YL] N (6 FLUORO 3 PYRIDINYL) 2 METHYL 2 PYRROLIDINECARBOXAMIDE; AMPHIREGULIN; B RAF KINASE; BETACELLULIN; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; EPIREGULIN; ERLOTINIB; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; IRINOTECAN; LAPATINIB; PLACEBO; SOMATOMEDIN B; ANTINEOPLASTIC AGENT; IGF2 PROTEIN, HUMAN; LIGAND; MONOCLONAL ANTIBODY; TUMOR MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAF GENE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER RESISTANCE; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG RESPONSE; DRUG SENSITIVITY; GENE EXPRESSION; GENE MUTATION; HUMAN; LIVER METASTASIS; MAJOR CLINICAL STUDY; MONOTHERAPY; MOUSE; NONHUMAN; ONCOGENE K RAS; ONCOGENE N RAS; PIK3CA GENE; TUMOR REGRESSION; TUMOR XENOGRAFT; ANIMAL; CANCER TRANSPLANTATION; CHEMISTRY; CLINICAL TRIAL (TOPIC); COLORECTAL NEOPLASMS; DRUG RESISTANCE; EXON; IMMUNOHISTOCHEMISTRY; METABOLISM; MUTATION;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS; BIOMARKERS, TUMOR; CETUXIMAB; CLINICAL TRIALS AS TOPIC; COLORECTAL NEOPLASMS; DRUG RESISTANCE, NEOPLASM; EXONS; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN-LIKE GROWTH FACTOR II; LIGANDS; MICE; MUTATION; NEOPLASM TRANSPLANTATION; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84921766164     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3010445     Document Type: Article

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