β-2 Adrenergic receptor gene methylation is associated with decreased asthma severity in inner-city Schoolchildren

Clinical and Experimental Allergy

Volumn 44, Issue 5, 2014, Pages 681-689

  Gaffin, J M ^a   Raby, B A ^b   Petty, C R ^a   Hoffman, E B ^c   Baccarelli, A A ^c   Gold, D R ^b   Phipatanakul, W ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

ADRB2; Adrenergic receptor; Asthma; Epigenetics; Methylation

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BRONCHODILATING AGENT;

ACADEMIC ACHIEVEMENT; ANALYSIS; ARTICLE; ASTHMA; CHILD; DISEASE SEVERITY; DNA METHYLATION; DNA SEQUENCE; DRUG USE; DYSPNEA; FEMALE; GENETIC ASSOCIATION; HUMAN; LIMITED MOBILITY; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; MORBIDITY; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE TRAIT LOCUS; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; SPIROMETRY; ABSENTEEISM; AMBULATORY CARE; BETA 2 ADRENERGIC RECEPTOR GENE; CONTROLLED STUDY; CPG ISLAND; GENE; GENETIC ANALYSIS; MONITORING SPIROMETER; PHYSICAL ACTIVITY; PRESCHOOL CHILD; PYROSEQUENCING; SYMPTOM ASSESSMENT; CITY; GENETIC EPIGENESIS; GENETICS; LUNG FUNCTION TEST; PATHOPHYSIOLOGY; RHINITIS; RISK FACTOR; SEVERITY OF ILLNESS INDEX;

ASTHMA; CHILD; CITIES; CPG ISLANDS; DNA METHYLATION; DYSPNEA; EPIGENESIS, GENETIC; FEMALE; HUMANS; MALE; PHENOTYPE; PROMOTER REGIONS, GENETIC; QUANTITATIVE TRAIT LOCI; RECEPTORS, ADRENERGIC, BETA-2; RESPIRATORY FUNCTION TESTS; RHINITIS; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 84921725165     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/cea.12219     Document Type: Article

References (48)

1. Szentivanyi A. The β-adrenergic theory of the atopic abnormality in bronchial asthma. J Allergy 1968; 42:203-32.
2. Shelhamer JH, Marom Z, Kaliner M. Abnormal beta-adrenergic responsiveness in allergic subjects. II. The role of selective beta 2-adrenergic hyporeactivity. J Allergy Clin Immunol 1983; 71:57-61.
3. Parker CW, Smith JW. Alterations in cyclic adenosine monophosphate metabolism in human bronchial asthma. I. Leukocyte responsiveness to -adrenergic agents. J Clin Investig 1973; 52:48-59.
4. Brooks SM, McGowan K, Altenau P. Relationship between beta-adrenergic binding in lymphocyte and severity of disease in asthma. Chest 1979; 75:232-83.
5. Kariman K. Beta-adrenergic receptor binding in lymphocytes from patients with asthma. Lung 1980; 158:41-51.
6. Galant SP, Duriseti L, Underwood S, Insel PA. Decreased beta-adrenergic receptors on polymorphonuclear leukocytes after adrenergic therapy. N Engl J Med 1978; 299:933-6.
7. Tashkin DP, Conolly ME, Deutsch RI etal. Subsensitization of beta-adrenoceptors in airways and lymphocytes of healthy and asthmatic subjects. Am Rev Respir Dis 1982; 125:185-93.
8. Marsh DG, Neely JD, Breazeale DR etal. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 1994; 264:1152-6.
9. Noguchi E, Shibasaki M, Arinami T etal. Evidence for linkage between asthma/atopy in childhood and chromosome 5q31-q33 in a Japanese population. Am J Respir Crit Care Med 1997; 156:1390-3.
10. Bleecker ER, Amelung PJ, Levitt RC, Postma DS, Meyers DA. Evidence for linkage of total serum IgE and bronchial hyperresponsiveness to chromosome 5q: a major regulatory locus important in asthma. Clin Exp Allergy 1995; 25(Suppl. 2):84-8; discussion 95-6.
11. Ober C, Tsalenko A, Parry R, Cox NJ. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. Am J Hum Genet 2000; 67:1154-62.
12. Postma DS, Bleecker ER, Amelung PJ etal. Genetic susceptibility to asthma-bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med 1995; 333:894-900.
13. Drazen JM, Israel E, Boushey HA etal. Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. Asthma Clinical Research Network. N Engl J Med 1996; 335:841-7.
14. Hawkins GA, Weiss ST, Bleecker ER. Clinical consequences of ADRβ2 polymorphisms. Pharmacogenomics 2008; 9:349-58.
15. Litonjua AA. The significance of beta2-adrenergic receptor polymorphisms in asthma. Curr Opin Pulm Med 2006; 12:12-7.
16. Raby BA, Weiss ST. Beta2-adrenergic receptor genetics. Curr Opin Mol Ther 2001; 3:554-66.
17. Thakkinstian A, McEvoy M, Minelli C etal. Systematic review and meta-analysis of the association between β2-adrenoceptor polymorphisms and asthma: a HuGE review. Am J Epidemiol 2005; 162:201-11.
18. Contopoulos-Ioannidis DG, Manoli EN, Ioannidis JP. Meta-analysis of the association of beta2-adrenergic receptor polymorphisms with asthma phenotypes. J Allergy Clin Immunol 2005; 115:963-72.
19. Breton CV, Byun HM, Wenten M, Pan F, Yang A, Gilliland FD. Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation. Am J Respir Crit Care Med 2009; 180:462-7.
20. Joubert BR, Haberg SE, Nilsen RM etal. 450K Epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environ Health Perspect 2012; 120:1425-31.
21. Wan ES, Qiu W, Baccarelli A etal. Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome. Hum Mol Genet 2012; 21:3073-82.
22. Fu A, Leaderer BP, Gent JF, Leaderer D, Zhu Y. An environmental epigenetic study of ADRB2 5′-UTR methylation and childhood asthma severity. Clin Exp Allergy 2012; 42:1575-81.
23. Gaffin JM, Raby BA, Hoffman EB, Gold DR, Phipatanakul W. Methylation of the Beta-2 adrenergic receptor gene is associated with decreased asthma severity in inner city school children. Am J Respir Crit Care Med 2012; 1:A5604.
24. Phipatanakul W, Bailey A, Hoffman EB etal. The school Inner-City asthma study: design, methods, and lessons learned. J Asthma 2011; 48:1007-14.
25. Weiss ST. Epidemiology and heterogeneity of asthma. Ann Allergy Asthma Immunol 2001; 87:5-8.
26. Weiss ST, Tager IB, Speizer FE, Rosner B. Persistent wheeze. Its relation to respiratory illness, cigarette smoking, and level of pulmonary function in a population sample of children. Am Rev Respir Dis 1980; 122:697-707.
27. Mitchell H, Senturia Y, Gergen P etal. Design and methods of the National Cooperative Inner-City Asthma Study. Pediatr Pulmonol 1997; 24:237-52.
28. Miller MR, Hankinson J, Brusasco V etal. Standardisation of spirometry. Eur Respir J 2005; 26:319-38.
29. Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med 1999; 159:179-87.
30. Beydon N, Davis SD, Lombardi E etal. An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children. Am J Respir Crit Care Med 2007; 175:1304-45.
31. National Asthma Education and Prevention Program. Expert panel report 3 (EPR-3): guidelines for the diagnosis and management of asthma-summary report 2007. J Allergy Clin Immunol 2007; 120:S94-138.
32. Bai TR, Mak JC, Barnes PJ. A comparison of beta-adrenergic receptors and in vitro relaxant responses to isoproterenol in asthmatic airway smooth muscle. Am J Respir Cell Mol Biol 1992; 6:647-51.
33. Spina D, Rigby PJ, Paterson JW, Goldie RG. Autoradiographic localization of beta-adrenoceptors in asthmatic human lung. Am Rev Respir Dis 1989; 140:1410-5.
34. Sharma RK, Jeffery PK. Airway beta-adrenoceptor number in cystic fibrosis and asthma. Clin Sci (Lond) 1990; 78:409-17.
35. Qing F, Rahman SU, Rhodes CG etal. Pulmonary and cardiac beta-adrenoceptor density in vivo in asthmatic subjects. Am J Respir Crit Care Med 1997; 155:1130-4.
36. Selivanova PA, Kulikov ES, Kozina OV etal. Differential expression of the beta2-adrenoreceptor and M3-cholinoreceptor genes in bronchial mucosa of patients with asthma and chronic obstructive pulmonary disease. Ann Allergy Asthma Immunol 2012; 108:39-43.
37. Selivanova PA, Kulikov ES, Kozina OV, Gereng EA, Freidin MB, Ogorodova LM. Morphological and molecular characteristics of "difficult" asthma. J Asthma 2010; 47:269-75.
38. Agarwal SK, Marshall GD Jr. Beta-adrenergic modulation of human type-1/type-2 cytokine balance. J Allergy Clin Immunol 2000; 105:91-8.
39. Panina-Bordignon P, Mazzeo D, Lucia PD etal. Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12. J Clin Investig 1997; 100:1513-9.
40. McAlees JW, Smith LT, Erbe RS, Jarjoura D, Ponzio NM, Sanders VM. Epigenetic regulation of beta2-adrenergic receptor expression in T(H)1 and T(H)2 cells. Brain Behav Immun 2011; 25:408-15.
41. McGraw DW, Forbes SL, Mak JC etal. Transgenic overexpression of beta(2)-adrenergic receptors in airway epithelial cells decreases bronchoconstriction. Am J Physiol Lung Cell Mol Physiol 2000; 279:L379-89.
42. Szefler SJ, Ando R, Cicutto LC, Surs W, Hill MR, Martin RJ. Plasma histamine, epinephrine, cortisol, and leukocyte beta-adrenergic receptors in nocturnal asthma. Clin Pharmacol Ther 1991; 49:59-68.
43. Vidovic A, Vidovic Juras D, Vucicevic Boras V etal. Determination of leucocyte subsets in human saliva by flow cytometry. Arch Oral Biol 2012; 57:577-83.
44. Cosio BG, Mann B, Ito K etal. Histone acetylase and deacetylase activity in alveolar macrophages and blood monocytes in asthma. Am J Respir Crit Care Med 2004; 170:141-7.
45. Schalkwyk LC, Meaburn EL, Smith R etal. Allelic skewing of DNA methylation is widespread across the genome. Am J Hum Genet 2010; 86:196-212.
46. Shoemaker R, Deng J, Wang W, Zhang K. Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome. Genome Res 2010; 20:883-9.
47. Breton CV, Byun HM, Wang X, Salam MT, Siegmund K, Gilliland FD. DNA methylation in the arginase-nitric oxide synthase pathway is associated with exhaled nitric oxide in children with asthma. Am J Respir Crit Care Med 2011; 184:191-7.
48. Morales E, Bustamante M, Vilahur N etal. DNA hypomethylation at ALOX12 is associated with persistent wheezing in childhood. Am J Respir Crit Care Med 2012; 185:937-43.