Pulmonary and cardiac β-adrenoceptor density in vivo in asthmatic subjects

American Journal of Respiratory and Critical Care Medicine

Volumn 155, Issue 3, 1997, Pages 1130-1134

  Qing, Fenc ^b   Rahman, Shakil U ^b   Rhodes, Christopher G ^b   Hayes, Michael J ^b   Sriskandan, Shiranee ^b   Ind, Philip W ^b   Jones, Terry ^b   Hughes, J M B ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR;

ADULT; ARTICLE; ASTHMA; CONTROLLED STUDY; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PREDICTION; PRIORITY JOURNAL; RECEPTOR DENSITY; RECEPTOR OCCUPANCY; TISSUE DISTRIBUTION;

EID: 0030971422     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.155.3.9116998     Document Type: Article

References (26)

1. Barnes, P. J. 1995. Beta-adrenergic receptors and their regulation. Am. J. Respir. Crit. Care Med. 152:838-860.
2. Szentivanyi, A. 1968. The beta-adrenergic theory of the atopic abnormality in bronchial asthma. J. Allergy 42:203-232.
3. Brooks, S. M., K. McGowan, I. L. Bernstein, P. Altenau, and J. Peagler. 1979. Relationship between numbers of beta adrenergic receptors in lymphocytes and disease severity in asthma. J. Allergy Clin. Immunol. 63:401-406.
4. Hauck, R. W., M. Bohm, S. Gengenbach, L. Sunder Plassmann, G. Fruhmann, and E. Erdmann. 1990. Beta 2-adrenoceptors in human lung and peripheral mononuclear leukocytes of untreated and terbutaline-treated patients. Chest 98:376-381.
5. Spina, D., P. J. Rigby, J. W. Paterson, and R. G. Goldie. 1989. Autoradiographic localization of beta-adrenoceptors in asthmatic human lung. Am. Rev. Respir. Dis. 140:1410-1415.
6. Brady, F., S. K. Luthra, H. J. Tochon Danguy, C. J. Steel, S. L. Waters, M. J. Kensett, P. Landais, F. Shah, K. A. Jaeggi, A. Drake, J. C. Clark, and V. W. Pike. 1991. Asymmetric synthesis of a precursor for the automated radiosynthesis of S-(3′-t-butylamino-2′-hydroxypropoxy)-benzimidazol-2-[IIC]one (S-[IIC]CGP 12177) as a preferred radioligand for beta-adrenergic receptors. Int. Rad. Appl. Instrum. [A.] 42:621-628.
7. Ueki, J., C. G. Rhodes, J. M. B. Hughes, R. De Silva, D. C. Lefroy, P. W. Ind, F. Qing, F. Brady, S. K. Luthra, C. J. Steel, S. L. Water, A. A. Lammertsma, P. G. Camici, and T. Jones. 1993. In vivo quantification of pulmonary β-adrenoceptor density in humans with (S)-[IIC]-CGP-12177 and PET. J. Appl. Physiol. 75:559-565.
8. Lefroy, D. C., R. de Silva, L. Choudhury, N. G. Uren, T. Crake, C. G. Rhodes, A. A. Lammertsma, H. Boyd, P. N. Patsalos, P. Nihoyannopoulos, C. M. Oakley, T. Jones, and P. G. Camici. 1993. Diffuse reduction of myocardial beta-adrenoceptors in hypertrophic cardiomyopathy: a study with positron emission tomography. J. Am. Coll. Cardiol. 22:1653-1660.
9. 11C-CGP-12177 to assess β-adrenergic receptor concentration in idiopathic dilated cardiomyopathy. Circulation 87:1169-1178.
10. American Thoracic Society. 1987. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am. Rev. Respir. Dis. 136:225-244.
11. Delforge, J., A. Syrota, J. P. Lancon, K. Nakajima, C. Loc'h, M. Janier, J. M. Vallois, J. Cayla, and C. Crouzel. 1991. Cardiac beta-adrenergic receptor density measured in vivo using PET, CGP 12177, and a new graphical method. J. Nucl. Med. 32:739-748.
12. Robb, R. A., and D. P. Hanson. 1991. A software system for interactive and quantitative visualization of multidimensional biomedical images. Australas. Phys. Eng. Sci. Med. 14:9-30.
13. Qing, F., C. G. Rhodes, M. J. Hayes, T. Krausz, S. W. Fountain, T. Jones, and J. M. B. Hughes. 1996. In vivo quantification of human pulmonary beta-adrenoceptor density using PET: comparison with in vitro radioligand binding. J. Nucl. Med. 37:1275-1281.
14. Hayes M. J., F. Qing, C. G. Rhodes, S. U. Rahman, P. W. Ind, S. Sriskandan, T. Jones, and J. M. B. Hughes. 1996. In vivo quantification of human pulmonary β-adrenoceptors: effect of β-agonist therapy. Am. J. Respir. Crit. Care Med. 154:1277-1283.
15. Carstairs, J. R., A. J. Nimmo, and P. J. Barnes. 1985. Autoradiographic visualization of beta-adrenoceptor subtypes in human lung. Am. Rev. Respir. Dis. 132:541-547.
16. Liggett, S. B., J. C. Marker, S. D. Shah, C. L. Roper, and P. E. Cryer. 1988. Direct relationship between mononuclear leukocyte and lung beta-adrenergic receptors and apparent reciprocal regulation of extravascular, but not intravascular, alpha-and beta-adrenergic receptors by the sympathochromaffin system in humans. J Clin. Invest. 82:48-56.
17. Sharma, R. K., and P. K. Jeffery. 1990. Airway beta-adrenoceptor number in cystic fibrosis and asthma. Clin. Sci. Colch. 78:409-417.
18. Brodde, O. E. 1991. Beta 1-and beta 2-adrenoceptors in the human heart: properties, function, and alterations in chronic heart failure. Pharmacol. Rev. 43:203-242.
19. Lipworth, B. J., R. A. Clark, D. P. Dhillon, and D. G. McDevitt. 1990. Subsensitivity of beta-adrenoceptor responses in asthmatic patients taking regular low-dose inhaled salbutamol. Eur. J. Clin. Pharmacol. 38:203-235.
20. Galant, S. P., L. Duriseti, S. Underwood, and P. A. Insel. 1978. Decreased beta-adrenergic receptors on polymorphonuclear leukocytes after adrenergic therapy. N. Engl. J. Med. 299:933-936.
21. Brodde, O. E., M. Brinkmann, R. Schemuth, N. O'Hara, and A. Daul. 1985. Terbutaline-induced desensitization of human lymphocyte beta 2-adrenoceptors. Accelerated restoration of beta-adrenoceptor responsiveness by prednisone and ketotifen. J. Clin. Invest. 76:1096-1101.
22. Tattersfield, A. E., S. T. Holgate, J. E. Harvey, and H. R. Gribbin. 1983. Is asthma due to partial beta-blockade of airways? Agents Actions (Suppl. 13):265-271.
23. Boushey, H. A., M. J. Holtzman, J. R. Sheller, and J. A. Nadel. 1980. Bronchial hyperreactivity. Am. Rev. Respir. Dis. 121:389-413.
24. Szentivanyi, A., O. Heim, and P. Schultze. 1979. Changes in adrenoceptor densities in membranes of lung tissue and lymphocytes from patients with atopic disease. Ann. N.Y. Acad. Sci. 332:295-298.
25. Bai, T. R., J. C. Mak, and P. J. Barnes. 1992. A comparison of beta-adrenergic receptors and in vitro relaxant responses to isoproterenol in asthmatic airway smooth muscle. Am. J. Respir. Cell Mol. Biol. 6:647-651.
26. Haddad, E. B., M. Nishikawa, J. C. W. Mak, and P. J. Barnes. 1994. Autonomous receptors in peripheral lung from normal and asthmatic patients (abstract). Am. J. Respir. Crit. Care Med. 149:A859.